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| 1 | Prevalence of Autism Spectrum Disorder in China:A Nationwide Multi-center Population-based Study Among Children Aged 6 to 12 Years显示文摘This study aimed to obtain the first national estimate of the prevalence of autism spectrum disorder(ASD) in Chinese children.We targeted the population of 6 to 12-year-old children for this prevalence study by multistage convenient cluster sampling.The Modified Chinese Autism Spectrum Rating Scale was used for the screening process.Of the target population of 142,086 children,88.5%(n=125,806) participated in the study.A total of 363 children were confirmed as having ASD.The observed ASD prevalence rate was 0.29%(95% CI:0.26%-0.32%) for the overall population.After adjustment for response rates,the estimated number of ASD cases was867 in the target population sample,thereby achieving an estimated prevalence of 0.70%(95% CI:0.64%-0.74%).The prevalence was significantly higher in boys than in girls(0.95%;95% CI:0.87%-1.02% versus 0.30%;95%CI:0.26%-0.34%;P <0.001).Of the 363 confirmed ASD cases,43.3% were newly diagnosed,and most of those(90.4%) were attending regular schools,and 68.8% of the children with ASD had at least one neuropsychiatric comorbidity.Our findings provide reliable data on the estimated ASD prevalence and comorbidities in Chinese children. | Hao Zhou Xiu Xu Weili Yan Xiaobing Zou Lijie Wu Xuerong Luo Tingyu Li Yi Huang Hongyan Guan Xiang Chen Meng Mao Kun Xia Lan Zhang Erzhen Li Xiaoling Ge Lili Zhang Chunpei Li Xudong Zhang Yuanfeng Zhou Ding Ding Andy Shih Eric Fombonne Yi Zheng Jisheng Han Zhongsheng Sun Yong-hui Jiang Yi Wang LATENT-NHC Study Team | 2020 | Neuroscience Bulletin2020，36，9： | 158 |
| 2 | Clinical Study on 136 Children with Sudden Sensorineural Hearing Loss显示文摘 | Feng-Jiao Li Da-Yong Wang Hong-Yang Wang Li Wang Feng-Bo Yang Lan Lan Jing Guan Zi-Fang Yin UII Rosenhall Lan Yu Sten Hellstrom Xi-Jun Xu Mao-Li Duan Qiu-Ju Wang | 2016 | Chinese Medical Journal2016，，8： | 15 |
| 3 | Comparison between Bilateral and Unilateral Sudden Sensorineural Hearing Loss显示文摘 | Dan Bing Da-Yong Wang Lan Lan Li-Dong Zhao Zi-Fang Yin Lan Yu Guo-Hui Chen Jing Guan Qiu-Ju Wang | 2018 | Chinese Medical Journal2018，，3： | 12 |
| 4 | Reproductive management through integration of PGD and MPS-based noninvasive prenatal screening/diagnosis for a family with GJB2-associated hearing impairment显示文摘A couple with a proband child of GJB2(encoding the gap junction protein connexin 26)-associated hearing impairment and a previous pregnancy miscarriage sought for a reproductive solution to bear a healthy child. Our study aimed to develop a customized preconception-to-neonate care trajectory to fulfill this clinical demand by integrating preimplantation genetic diagnosis(PGD), noninvasive prenatal testing(NIPT), and noninvasive prenatal diagnosis(NIPD) into the strategy. Auditory and genetic diagnosis of the proband child was carried out to identify the disease causative mutations. The couple then received in-vitro-fertilization treatment, and eight embryos were obtained for day 5 biopsy. PGD was performed by short-tandem-repeat linkage analysis and Sanger sequencing of GJB2 gene. Transfer of a GJB2 c.235del C heterozygous embryo resulted in a singleton pregnancy. At the 13 th week of gestation, genomic DNA(g DNA) from the trio family and cell-free DNA(cf DNA) from maternal plasma were obtained for assessment of fetal chromosomal aneuploidy and GJB2 mutations. NIPT and NIPD showed the absence of chromosomal aneuploidy and GJB2-associated disease in the fetus, which was later confirmed by invasive procedures and postnatal genetic/auditory diagnosis. This strategy successfully prevented the transmission of hearing impairment in the newborn, thus providing a valuable experience in reproductive management of similar cases and potentially other monogenic disorders. | XIONG WenPing WANG DaYong GAO Yuan GAO Ya WANG HongYang GUAN Jing LAN Lan YAN JunHao ZONG Liang YUAN Yuan DONG Wei HUANG SeXin WU KeLiang WANG YaoShen WANG ZhiLi PENG HongMei LU YanPing XIE LinYi ZHAO Cui WANG Li ZHANG QiuJing GAO Yun LI Na YANG Ju YIN ZiFang HAN Bing WANG Wei CHEN Zi-Jiang WANG QiuJu | 2015 | Science China(Life Sciences)2015，58，9： | 12 |
| 5 | Innate, innate-like and adaptive lymphocytes in the pathogenesis of MS and EAE显示文摘Multiple sclerosis(MS)is a chronic inflammatory disease of the central nervous system(CNS)in which the immune system damages the protective insulation surrounding the nerve fibers that project from neurons.A hallmark of MS and its animal model,experimental autoimmune encephalomyelitis(EAE),is autoimmunity against proteins of the myelin sheath.Most studies in this field have focused on the roles of CD4^(+)T lymphocytes,which form part of the adaptive immune system as both mediators and regulators in disease pathogenesis.Consequently,the treatments for MS often target the inflammatory CD4^(+)T-cell responses.However,many other lymphocyte subsets contribute to the pathophysiology of MS and EAE,and these subsets include CD8^(+)T cells and B cells of the adaptive immune system,lymphocytes of the innate immune system such as natural killer cells,and subsets of innate-like T and B lymphocytes such asγδT cells,natural killer T cells,and mucosal-associated invariant T cells.Several of these lymphocyte subsets can act as mediators of CNS inflammation,whereas others exhibit immunoregulatory functions in disease.Importantly,the efficacy of some MS treatments might be mediated in part by effects on lymphocytes other than CD4^(+)T cells.Here we review the contributions of distinct subsets of lymphocytes on the pathogenesis of MS and EAE,with an emphasis on lymphocytes other than CD4^(+)T cells.A better understanding of the distinct lymphocyte subsets that contribute to the pathophysiology of MS and its experimental models will inform the development of novel therapeutic approaches. | Luc Van Kaer Joshua L.Postoak Chuan Wang Guan Yang Lan Wu | 2019 | Cellular & Molecular Immunology2019，16，6： | 10 |
| 6 | Mechanism of over-activation in direct pathway mediated by dopamine D_1 receptor in rats with levodopa-induced dyskinesias显示文摘Objective To study the changes of prodynorphin (PDyn) gene expression and dopamine and cAMP-regulated phosphoprotein of 32 kDa (DARPP-32) phosphorylation in rats with levodopa-induced dyskinesias (LID),and to explore the mechanism of over-activation in direct pathway mediated by dopamine D1 receptor. Methods Parkinson’s disease (PD) rats were received levodopa (10 mg/kg,i.p.) for 28 d to get the LID rats. According to the behavior scale,LID rats were divided into mild (n=8) and severe (n=16) groups. On day 29,8 rats in severe LID group were given an acute intraperitoneal injection of MK-801 (0.1 mg/kg) 15 min before levodopa treatment (MK-801 group,n=8). The normal rats received same course and dosage of levodopa as the control group (n=8). Hybridization in situ was used to measure the expression of PDyn mRNA in striatum. Protein and mRNA levels of total DARPP-32 and phospho-Thr-34 DARPP-32 level were measured by immunoblotting and RT-PCR,respectively. Results The levels of PDyn mRNA and phospho-Thr-34 DARPP-32 increased significantly in LID rats compared with control rats (P<0.01),and they also increased markedly in severe LID group compared with mild group (P<0.01). Conclusion Phospho-Thr-34 DARPP-32 level was increased in LID rats,which contributed to the over-activation of direct pathway mediated by dopamine D1 receptor. | Xue-Bing CAO Qiang GUAN Yan XU Lan WANG Sheng-Gang SUN | 2006 | Neuroscience Bulletin2006，22，3： | 9 |
| 7 | Malnutrition and Quality of Life in Chinese Cancer Patients: a Clinical Study of 23,994 Subjects显示文摘Background Malnutrition is common in patients with cancer,and can negatively impact their quality of life(QoL)and even survival.However,there is currently no large data available on the prevalence of malnutrition in Chinese cancer patients.This study evaluated the prevalence of malnutrition and the QoL of Chinese patients with locoregional,recurrent or metastatic cancer.Methods We conducted a nationwide observational,multi-center,hospital-based cross-sectional study within the Chinese Society of Nutritional Oncology(CSNO)Network.All of the patients were diagnosed with one of the following 18 different types of malignant tumors:lung cancer,gastric cancer,liver cancer,colorectal cancer,breast cancer,esophageal cancer,cervical cancer,endometrial cancer,nasopharyngeal carcinoma,malignant lymphoma,leukemia,pancreatic cancer,ovarian cancer,prostate cancer,bladder cancer,brain cancer,biliary tract malignant tumors or gastrointestinal stromal tumors.These patients were enrolled from 72 hospitals located in different regions of China.The patients’nutritional status was evaluated based on the body mass index(BMI),loss of bodyweight,laboratory measurements and patient generated-subjective global assessment(PG-SGA)scores.The cancer patients’physical status and QoL were assessed by the Karnofsky Performance Status(KPS)questionnaire and the European Organization for Research and Treatment of Cancer(EORTC)QLQ-C30 questionnaire,respectively.Results From December 2013 to April 2016,23,994 patients hospitalized for cancer treatment(such as surgery,chemotherapy or radiotherapy)were enrolled in the study.The patients included 12,494(52.9%)males and 11,124(47.1%)females.The mean age was 55.8±13.7 years.The proportions of patients in cancer stagesⅠ,Ⅱ,Ⅲ,Ⅳand uncertain were 11.5%,20.3%,27.5%,30.2%and 10.5%,respectively.Among the 23,994 inpatients,the proportions of patients who were underweight(BMI<18.5 kg/m2),normal(18.5 kg/m2 | Hong Xia Xu Chun Hua Song Zhen Ming Fu Chang Wang Zeng Qing Guo Yuan Lin Ying Ying Shi Wen Hu Yi Ba Su Yi Li Zeng Ning Li Kun Hua Wang Jing Wu Ying He Jia Jun Yang Cong Hua Xie Fu Xiang Zhou Xin Xia Song Gong Yan Chen Wen Jun Ma Su Xia Luo Zi Hua Chen Ming Hua Cong Hu Ma Chun Ling Zhou Wei Wang Qi Luo Yong Mei Shi Yu Mei Qi Hai Ping Jiang Wen Xian Guan Jun Qiang Chen Jia Xin Chen Yu Fang Lan Zhou Yong Dong Feng Rong Shao Tan Tao Li Jun Wen Ou Qing Chuan Zhao Jian Xiong Wu Min Weng Qing Hua Yao Jiu Wei Cui Wei Li Han Ping Shi the Investigation on Nutrition Status and Clinical Outcome of Common Cancers(INSCOC)Group | 2021 | Journal of Nutritional Oncology2021，6，1： | 8 |
| 8 | Guiding T lymphopoiesis from pluripotent stem cells by defined transcription factors显示文摘Achievement of immunocompetent and therapeutic T lymphopoiesis from pluripotent stem cells(PSCs)is a central aim in T cell regenerative medicine.To date,preferentially reconstituting T lymphopoiesis in vivo from PSCs remains a practical challenge.Here we documented that synergistic and transient expression of Runx1 and Hoxa9 restricted in the time window of endothelial-to-hematopoietic transition and hematopoietic maturation stages in a PSC differentiation scheme(iR9-PSC)in vitro induced preferential generation of engraftable hematopoietic progenitors capable of homing to thymus and developing into mature T cells in primary and secondary immunodeficient recipients.Single-cell transcriptome and functional analyses illustrated the cellular trajectory of T lineage induction from PSCs,unveiling the T-lineage specification determined at as early as hemogenic endothelial cell stage and identifying the bona fide pre-thymic progenitors.The induced T cells distributed normally in central and peripheral lymphoid organs and exhibited abundant TCRαβrepertoire.The regenerative T lymphopoiesis restored immune surveillance in immunodeficient mice.Furthermore,gene-edited iR9-PSCs produced tumor-specific T cells in vivo that effectively eradicated tumor cells.This study provides insight into universal generation of functional and therapeutic T cells from the unlimited and editable PSC source. | Rongqun Guo Fangxiao Hu Qitong Weng Cui Lv Hongling Wu Lijuan Liu Zongcheng Li Yang Zeng Zhijie Bai Mengyun Zhang Yuting Liu Xiaofei Liu Chengxiang Xia Tongjie Wang Peiqing Zhou Kaitao Wang Yong Dong Yuxuan Luo Xiangzhong Zhang Yuxian Guan Yang Geng Juan Du Yangqiu Li Yu Lan Jiekai Chen Bing Liu Jinyong Wang | 2020 | Cell Research2020，30，1： | 7 |
| 9 | Validity of the Chinese Version of the Patient-Generated Subjective Global Assessment (PG-SGA) in Lung Cancer Patients显示文摘The prevalence of malnutrition is high among oncology patients in China. Although the Patient- Generated Subjective Global Assessment (PG-SGA) is widely recognized as an important nutritional assessment tool, it has not been validated for Chinese cancer patients. The purpose of this study was to conduct an analysis of nutrition screening and assessment data to validate the Chinese version of the PG-SGA in Chinese patients with lung cancer. This was an observational, cross-sectional study of 2,000 consecutive adult patients with lung cancer treated at several tertiary hospitals in China. Anthropometric and patient descriptive data were collected. The PG-SGA generated a score for the nutritional risk and a global rating for the nutritional status. The internal consistency, external consistency, and construct validity were evaluated, and a known-groups comparison and principal component analyses were conducted to evaluate the reliability and validity of the PG-SGA. The known-groups comparison demonstrated the ability of the PG-SGA to differentiate lung cancer patients of different nutritional and body mass index (BMI) groups. A confirmatory factor analysis supported the original four-factor structure of the PG-SGA. In terms of the internal and external consistency, the PG-SGA demonstrated intra-class correlation coefficients (ICC) up to 0.987. Alternative form validity was also demonstrated between Box 4 of the PG-SGA and the Karnofsky Performance Status score, with excellent external consistency (r = 0.972, P < 0.001). The construct validity was supported, and selected questionnaire dimensions were evident in the principal component analysis. Significant Spearman correlations (P < 0.001) were demonstrated. The Chinese version of the PG-SGA demonstrated significant reliability and sufficient exploratory properties to support its validity. It seems to be a valid tool that can be used to access the nutritional status of Chinese lung cancer patients. The validity of the PG-SGA in Chinese cancer patients warrants further investigation in other cancer types. | Zhen Ming Fu Hong Xia Xu Chun Hua Song Wei Li Zeng Qing Guo Yuan Lin Ying Ying Shi Wen Hu Yi Ba Su Yi Li Zeng Ning Li Kun Hua Wang Jing Wu Ying He Jia Jun Yang Cong Hua Xie Xin Xia Song Gong Yan Chen Wen Jun Ma Su Xia Luo Zi Hua Chen Ming Hua Cong Hu Ma Chun Ling Zhou Wei Wang Qi Luo Yong Mei Shi Yu Mei Qi Hai Ping Jiang Wen Xian Guan Jun Qiang Chen Jia Xin Chen Yu Fang Lan Zhou Yong Dong Feng Rong Shao Tan Tao Li Jun Wen Ou Qing Chuan Zhao Jian Xiong Wu Chang Wang Han Ping Shi The Investigation on Nutrition Status and Clinical Outcome of Common Cancers (INSCOC) Group | 2016 | Journal of Nutritional Oncology2016，1，1： | 7 |
| 10 | Regulatory effects of hydrogen sulfide on alveolar epithelial cell endoplasmic reticulum stress in rats with acute lung injury显示文摘BACKGROUND: The present study was undertaken to examine the regulatory effect of hydrogen sulfide(H2S) on endoplasmic reticulum stress in alveolar epithelial cells of rats with acute lung injury(ALI) induced by oleic acid(OA).METHODS: Seventy-two male Sprague Dawley(SD) rats were divided into control group, oleic acid-induced ALI group(OA group), oleic acid-induced ALI with sodium hydrosulfide(Na HS) pretreatment group(OA+Na HS group), and sodium hydrosulfide treatment group(Na HS group). Rats of each group were further subdivided into 3 subgroups. Index of quantitative assessment of histological lung injury(IQA), wet/dry weight ratio(W/D) and H2 S level of lung tissues were measured. The expressions of endoplasmic reticulum stress markers including glucose-regulated protein 78(GRP78) and α-subunit of eukaryotic translation initiation factor-2(el F2α) in lung tissues were measured by immunohistochemical staining and Western blotting.RESULTS: The IQA score and W/D ratio of lung tissues at the three time points significantly increased in rats injected with OA, but significantly decreased in other rats injected with OA and Na HS. The level of H2 S in lung tissue at the three time points significantly decreased in rats injected with OA, but significantly increased in other rats injected with both OA and Na HS. GRP78 and el F2α decreased in rats injected with OA, but increased in other rats injected with both OA and Na HS, especially at 4-hour and 6-hour time points.CONCLUSION: The results suggested that H2 S could promote alveolar epithelial cell endoplasmic reticulum stress in rats with ALI. | Zhi-wei Liu Hai-ying Wang Lan Guan Bin Zhao | 2015 | World Journal of Emergency Medicine2015，6，1： | 6 |
| 11 | Blockade of 4-1BB/4-1BB ligand interactions prevents acute rejection in rat liver transplantation显示文摘背景堵住 4-1BB/4-1BB ligand (4-1BBL ) 信号可以调制 Th1/Th2 cytokines 的分泌物并且延长接枝的幸存,它在机关移植忍耐起一个关键作用。这研究的目的是在老鼠 orthotopic 肝移植的尖锐拒绝与 4-1 BBL monoclonal 抗体(mAB ) 调查 4-1BB/4-1BBL co-stimulatory 小径的封锁的角色。orthotopic 肝移植模型被建立的方法,当男路易斯老鼠作为接受者被用作肝施主和棕色挪威的老鼠时。接受者老鼠静脉内地与反 4-1BBL mAB 或适应于不同地区生活的动物控制抗体被注射。组们在移植以后为接枝幸存被监视。血浆化学,包括的 aspartate transaminase (著名计算机生产厂商) ,丙氨酸 aminotransferase (中高音) ,和 bilirubin (BIL ) ,是 assayed。interleukin (IL ) 的集中 -2, IL-10 和干扰素(IFN )- 在里面血浆被连接酶的 immunosorbent 也测量试金。Allograft 组织学图象在轻显微镜和电子显微镜下面被收集。对待的接受者展出了的结果适应于不同地区生活的动物抗体提高了肝损害标记的血浆层次包括著名计算机生产厂商,中高音和 BIL,进步的门和静脉的发炎和肝 allografts 的细胞的渗入,和吝啬的接枝幸存预定(山区标准时间) 10.9 天。反 4-1 BBL mAB 的管理在肝损害标记的血浆层次和 IL-2, IL-10 和 IFN- 的集中导致了减少。白天 7 上的拒绝的组织学的等级减少了,山区标准时间(17.3 天) 增加了这些结果表明的 substantially.Conclusions 尖锐拒绝的那变细与 4-1BBL monoclonal 抗体并且强烈跟随 4-1BB/4-1BBL co-stimulatory 小径的封锁建议由压制 T 阻止接枝拒绝的前进是有希望的策略调停房间的免疫。 | QIN Lei GUAN Hong-geng ZHOU Xiao-jun YIN Jun LAN Jing QIAN Hai-xin | 2010 | Chinese Medical Journal2010，，2： | 6 |
| 12 | Identification of Two Disease-causing Genes TJP2 and GJB2 in a Chinese Family with Unconditional Autosomal Dominant Nonsyndromic Hereditary Hearing Impairment显示文摘 | Hong-YangWang Ya-Li Zhao Qiong Liu Hu Yuan Yun Gao Lan Lan Da-Yong Wang Jing Guan Qiu-Ju Wang | 2015 | Chinese Medical Journal2015，，24： | 6 |
| 13 | Expression of Peroxiredoxins and Pulmonary Surfactant Protein A Induced by Silica in Rat Lung Tissue显示文摘Silicosis is one of the most serious occupational diseases in China and dates back to centuries ago.In this study,we successfully established a rat model of silicosis by intratracheal silica injection for28 days and determined hydroxyproline levels to evaluate collagen metabolism in lung homogenates.Oxidative stress status was evaluated by detecting catalase and glutathione peroxidase activities. | LIU Nan XUE Ling GUAN Yi LI Qing Zhao CAO Fu Yuan PANG Shu Lan GUAN Wei Jun | 2016 | Biomedical and Environmental Sciences2016，29，8： | 6 |
| 14 | Upregulation of annexin A5 affects the biological behaviors of lung squamous carcinoma cells in vitro显示文摘Annexin A5 is a Ca2?-dependent phospholipidbinding protein and protein kinase C inhibitory protein. It has a potential role in cellular signal transduction, inflammation, growth and differentiation. In this study, we evaluated the expression of this protein in lung tumor tissues and subsequently established a NCI-H520 cell line that stably expresses the wild-type ANXA5 gene to determine the effects of annexin A5 upregulation on the cell morphology, proliferation and metastasis potential in vitro.The effects of annexin A5 on NCI-H520 cells were tested by crystal violet staining, CCK-8 assay, scratch wound assay, and Transwell assay. The expressions of Akt,PCNA, vimentin, and E-cadherin were examined by Western blot assay. In this study, we demonstrated that annexin A5 is expressed at lower levels in tumor tissues compared with normal tissues. Additionally, the upregulation of this protein may inhibit the proliferation, migration, and invasion abilities of NCI-H520 cells in vitro. The transfected cells were arrested in the G1/S phase of the cell cycle, and the expression levels of Akt, PCNA and Vimentin were downregulated, while E-cadherin was upregulated. | Linlin Gong Haoqi Zhao Lan Wang Bing Sun Lijun Yu Xiaoyu Qi Xin Zhou Liyuan Zhang Hongwei Guan Shujuan Shao | 2014 | Chinese Science Bulletin2014，59，28： | 6 |
| 15 | Osteogenic fate of hypertrophic chondrocytes显示文摘 | Guan Yang Liang Zhu Ning Hou Yu Lan Xi-Mei Wu Bin Zhou Yan Teng Xiao Yang | 2014 | Cell Research2014，24，10： | 6 |
| 16 | Chronic nicotine treatment enhances vascular smooth muscle relaxation in rats显示文摘瞄准: 在脉管的功能上调查长期的烟碱处理的效果并且识别内在的机制。 | Tian-ying XU Xiao-hong LAN Yun-feng GUAN Sai-long ZHANG Xia WANG Chao-yu MIAO | 2015 | Acta Pharmacologica Sinica2015，36，4： | 5 |
| 17 | A novel mouse model of hyperuricemia and gouty nephropathy显示文摘To the Editor:Hyperuricemia,the second most common metabolic disease after diabetes mellitus in China,is characterized by the elevated serum uric concentration which is due to the overactive uric acid production or underexcretion.[1]Recent study supported the notion that hyperuricemia is implicated in renal tubular injury,subsequent tubulointerstitial fibrosis,and finally gouty nephropathy.[2]However,the lack of a suitable and stable mouse model to study hyperuricemia and gout nephropathy delays and limits the development of mechanism research and new drugs.Further understanding of the pathogenesis of hyperuricemia and gouty nephropathy has been largely hampered by a lack of preclinical animal models that reliably capture the characteristic phenotypes of hyperuricemia and gouty nephropathy.In this study,we aimed to develop a novel mouse model for hyperuricemia and gouty nephropathy. | Jin Guan Xiao-Qi Huang Jia-Le Dong Hui-Min Lu Yue-Wei Lin Mei Liu Zhi-Biao Yi Li-Min Wu Yong-Ming Huang Tian Lan | 2020 | Chinese Medical Journal2020，，16： | 5 |
| 18 | The Hippo signalling pathway and its implications in human health and diseases显示文摘As an evolutionarily conserved signalling network,the Hippo pathway plays a crucial role in the regulation of numerous biological processes.Thus,substantial efforts have been made to understand the upstream signals that influence the activity of the Hippo pathway,as well as its physiological functions,such as cell proliferation and differentiation,organ growth,embryogenesis,and tissue regeneration/wound healing.However,dysregulation of the Hippo pathway can cause a variety of diseases,including cancer,eye diseases,cardiac diseases,pulmonary diseases,renal diseases,hepatic diseases,and immune dysfunction.Therefore,therapeutic strategies that target dysregulated Hippo components might be promising approaches for the treatment of a wide spectrum of diseases.Here,we review the key components and upstream signals of the Hippo pathway,as well as the critical physiological functions controlled by the Hippo pathway.Additionally,diseases associated with alterations in the Hippo pathway and potential therapies targeting Hippo components will be discussed. | Minyang Fu Yuan Hu Tianxia Lan Kun-Liang Guan Ting Luo Min Luo | 2022 | Signal Transduction and Targeted Therapy2022，7，12： | 5 |
| 19 | A POU3F4 Mutation Causes Nonsyndromic Hearing Loss in a Chinese X-linked Recessive Family显示文摘 | Wan Du Ming-Kun Han Da-Yong Wang Bing Han Liang Zong Lan Lan Ju Yang Qi Shen Lin-Yi Xie Lan Yu Jing Guan Qiu-Ju Wang | 2017 | Chinese Medical Journal2017，，1： | 5 |
| 20 | COVID-19: Antiviral Agents, Antibody Development and Traditional Chinese Medicine显示文摘The World Health Organization(WHO) has declared coronavirus disease 2019(COVID-19) is the first pandemic caused by coronavirus named severe acute respiratory syndrome coronavirus 2(SARS-CoV-2). Currently, there is no effective anti-SARS-CoV-2 drug approved worldwide for treatment of patients with COVID-19. Therapeutic options in response to the COVID-19 outbreak are urgently needed. To facilitate the better and faster development of therapeutic COVID-19 drugs, we present an overview of the global promising therapeutic drugs, including repurposing existing antiviral agents,network-based pharmacology research, antibody development and traditional Chinese medicine. Among all these drugs,we focus on the most promising drugs(such as favipiravir, tocilizumab, SARS-CoV-2 convalescent plasma, hydroxychloroquine, Lianhua Qingwen, interferon beta-1 a, remdesivir, etc.) that have or will enter the final stage of human testing—phase Ⅲ–Ⅳ clinical trials. | Wenyi Guan Wendong Lan Jing Zhang Shan Zhao Junxian Ou Xiaowei Wu Yuqian Yan Jianguo Wu Qiwei Zhang | 2020 | Virologica Sinica2020，35，6： | 5 |
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