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| 1 | Homology-mediated end joining-based targeted integration using CRISPR/Cas9显示文摘 | Yao, Xuan Wang, Xing Hu, Xinde Liu, Zhen Liu, Junlai Zhou, Haibo Shen, Xiaowen Wei, Yu Huang, Zijian Ying, Wenqin Wang, Yan Nie, Yan-Hong Zhang, Chen-Chen Li, Sanlan Cheng, Leping Wang, Qifang Wu, Yan Huang, Pengyu Sun, Qiang Shi, Linyu Yang, Hui | 2017 | Cell Research2017，27，6： | 28 |
| 2 | An investigation on tether-tugging de-orbit of defunct geostationary satellites显示文摘In recent years,defunct satellites mitigation in the geostationary orbit(GEO) has become a hot issue in the space field.How to transfer defunct geostationary satellites to the graveyard orbit safely,economically and efficiently presents new challenges to spacecraft dynamics and control.This paper conducts an in-depth investigation on tether-tugging de-orbit issues of defunct geostationary satellites.Firstly,a four-phase tether-tugging de-orbit scheme including acceleration,equilibrium,rotation and return is proposed.This scheme takes into consideration how to avoid the risks of tether ripping,tug-target collision,and tether twist,and how to achieve the mission objective of fuel saving.Secondly,the dynamics model of the tether combination system is established based on Lagrange equation,and the four phases of tether-tugging de-orbit scheme are simulated respectively.Simulation results indicate that the scheme is theoretically feasible and satisfies the design objectives of safety,economy and efficiency,providing a technical approach for engineering application. | LIU HaiTao YANG LePing ZHANG QingBin ZHU YanWei | 2012 | Science China(Technological Sciences)2012，55，7： | 18 |
| 3 | Environmental change since mid-Pleistocene recorded in Shangshan achaeological site of Zhejiang显示文摘在迟了的时期的大约 173 ka BP 中间 -- 更新世,河的第二个平台被形成了由于因为气候,海水平变化和构造行动,高举发生在 Shangshan 区域。在 173 75 ka BP 之间。 | MAO Longjiang MO Duowen JIANG Leping JIA Yaofeng LIU Xiaoyan LI Minglin ZHOU Kunshu SHI Chenxi | 2008 | Journal of Geographical Sciences2008，18，2： | 6 |
| 4 | SLC1A1-mediated cellular and mitochondrial influx of R-2-hydroxyglutarate in vascular endothelial cells promotes tumor angiogenesis in IDH1-mutant solid tumors显示文摘Muta nt isocitrate dehydrog en ase 1(mlDH1)drives tumorigenesis via produci ng on cometabolite R-2-hydroxyglutarate(R-2-HG)across various tumor types.However,mlDHl in hibitors appear only effective in hematological tumors.The therapeutic ben efit in solid tumors remains elusive,likely due to the complex tumor microenvironment.In this study,we discover that R-2-HG produced by IDH1-mutant tumor cells is preferentially imported into vascular endothelial cells and remodels mitochondrial respiration to promote tumor angiogenesis,conferring a therapeutic vulnerability in IDH1-mutant solid tumors.Mechanistically,SLC1 Alz a Na'-depe ndent glutamate tran sporter that is prefere ntially expressed in en dothelial cells,facilitates the in flux of R-2-HG from the tumor microenvironment into the endothelial cells as well as the intracellular trafficking of R-2-HG from cytoplasm to mitochondria.R-2-HG hijacks SLC1A1 to promote mitochondrial Na^(+)/Ca^(2+)exchange,which activates the mitochondrial respiratory chain and fuels vascular en dothelial cell migratio n in tumor an giogenesis.SLC1A1 deficiency in mice abolishes mlDHl-promoted tumor an giogenesis as well as the therapeutic benefit of mlDHl in hibitor in solid tumors.Moreover,we report that HH2301,a newly discovered mlDHl inhibitor,shows promising efficacy in treating IDH1-mutant cholangiocarcinoma in preclinical models.Together,we identify a new role of SLC1A1 as a gatekeeper of R-2-HG-mediated crosstalk between IDH1-mutant tumor cells and vascular en dothelial cells,and dem on strate the therapeutic potential of mlDHl in hibitors in treating IDH1-muta nt solid tumors via disrupting R-2-HG-promoted tumor angiogenesis. | Xiaomin Wang Ziqi Chen Jun Xu Shuai Tang Nan An Lei Jiang Yixiang Zhang Shaoying Zhang Qingli Zhang Yanyan Shen Shijie Chen Xiaojing Lan Ting Wang Linhui Zhai Siyuwei Cao Siqi Guo Yingluo Liu Aiwei Bi Yuehong Chen Xiameng Gai Yichen Duan Ying Zheng Yixian Fu Yize Li Liang Yuan Linjiang Tong Kun Mo Mingcheng Wang Shu-Hai Lin Minjia Tan Cheng Luo Yi Chen Jia Liu Qiansen Zhang Leping Li Min Huang | 2022 | Cell Research2022，32，7： | 2 |
| 5 | On a Half-Discrete Reverse Mulholland-Type Inequality and an Extension显示文摘 | LIU Tuo YANG Bicheng HE Leping | 2014 | Journal of Inequalities and Applications2014，，1： | 1 |
| 6 | On a Multidimensional Hilbert-Type Integral Inequality with Logarithe Function 显示文摘 | LIU Tuo YANG Bicheng HE Leping | 2015 | Mathematical Inequalities ~ Applications2015，18，4： | 1 |
| 7 | Unsupervised Anomaly Detection Based on an Evolutionary Artificial Immune Network 显示文摘 | Liu Fang Lin Leping | 2005 | LNCS 34492005，6，12： | 1 |
| 8 | Degenerative alterations in noradrenergic neurons of the locus coeruleus in Alzheimer's disease显示文摘Mice carrying mutant amyloid-β precursor protein and presenilin-1 genes (APP/PS1 double transgenic mice) have frequently been used in studies of Alzheimer's disease; however, such studies have focused mainly on hippocampal and cortical changes. The severity of Alzheimer's disease is known to correlate with the amount of amyloid-β protein deposition and the number of dead neurons in the locus coeruleus. In the present study, we assigned APP/PS1 double transgenic mice to two groups according to age: young mice (5-6 months old) and aged mice (16-17 months old). Age-matched wild-type mice were used as controls. Immunohistochemistry for tyrosine hydroxylase (a marker of catecholaminergic neurons in the locus coeruleus) revealed that APP/PS1 mice had 23% fewer cells in the locus coeruleus compared with aged wild-type mice. APP/PS1 mice also had increased numbers of cell bodies of neurons positive for tyrosine hydroxylase, but fewer tyrosine hydroxylase-positive fibers, which were also short, thick and broken. Quantitative analysis using unbiased stereology showed a significant age-related increase in the mean volume of tyrosine hydroxylase-positive neurons in aged APP/PS1 mice compared with young APP/PS1 mice. Moreover, the mean volume of tyrosine hydroxylase-positive neurons was positively correlated with the total volume of the locus coeruleus. These findings indicate that noradrenergic neurons and fibers in the locus coeruleus are predisposed to degenerative alterations in APP/PS1 double transgenic mice. | Lihua Liu Saiping Luo Leping Zeng Weihong Wang Liming Yuan Xiaohong Jian | 2013 | Neural Regeneration Research2013，8，24： | 1 |
| 9 | On a Half-Discrete Reverse Mulholland-Type Inequality and an Extension显示文摘 | LIU Tuo YANG Bicheng HE Leping | 2014 | Journal of Inequalities and Applications2014，，1： | 1 |
| 10 | A Solar Radio Spectrometer at 5.2–7.6?GHz显示文摘 | Huirong Ji Qijun Fu Yuying Liu Congling Cheng Zhijun Chen Yihua Yan Leping Zheng Zongjun Ning Chengmin Tan Debang Lao Shuke Li Jiyong Gao Zhiqiang Wang Minhong Yu | 2003 | Solar Physics2003，，2： | 1 |
| 11 | Characterization of chemosynthetic A1203-2SIO2 geopolymers 显示文摘 | CUI Xuemin LIU Leping ZHENG Guangjian | 2010 | J Non-Cryst Solids2010，356，2： | 1 |
| 12 | Preparation of phosphoric acid-based porous geopolymers 显示文摘 | LIU Leping CUI Xuemin QIU Shuheng | 2010 | Appl Clay Sci2010，50，4： | 1 |
| 13 | Development of a PDRA Method for Detection of the D614G Mutation in COVID-19 Virus—Worldwide,2021显示文摘ABSTRACT Background:COVID-19 infection is a major public health problem worldwide,and the D614G mutation enhances the infectivity of COVID-19.Methods:A probe-directed recombinase amplification(PDRA)assay was discussed to detect the D614G mutation at 39℃for 30 min.The sensitivity,specificity,and reproducibility of the PDRA were evaluated by D614 and G614 recombinant plasmids.The clinical performance of PDRA assay was validated by testing of 53 previously confirmed COVID-19 positive RNAs and 10 negative samples.Direct sequencing was carried out in parallel for comparison.Result:With good reproducibility and specificity,the PDRA assay worked well with the concentration in the range of 103–107 copies/reaction.Compared with direct sequencing as a reference,the recombinase-aided amplification(RAA)assay obtained 100%sensitivity and 100%specificity using clinical samples. | Ziwei Chen Xinxin Shen Ji Wang Xiang Zhao Yuan Gao Ruiqin Zhang Jinrong Wang Leping Liu Xinmin Nie Xuejun Ma | 2021 | China CDC weekly2021，3，21： | 1 |
| 14 | On a Half-Discrete Reverse Mulholland-Type Inequality and an Extension显示文摘 | LIU Tuo YANG Bicheng HE Leping | 2014 | Journal of Inequalities and Applications2014，，1： | 1 |
| 15 | Uncertainty Analysis in CFD for Resistance显示文摘基于数字在 CFD (计算液体动力学) 作为无常的三个主要因素被拿的统计,第一边界层的厚度,骚乱模型和房间的拉丁方形的设计。壳的全部的抵抗被计算,在壳附近的流动地被 CFD 方法模仿。然后,壳抵抗上的无常因素的影响被回归分析与整修网孔讨论并且搅乱网孔。通过一系列计算和分析,最佳的计算方法被提出,并且计算的相关参数是坚定的。第三,不同速度的全部的抵抗被使用这些二种格子计算,它在对试验性的结果的好同意。最后,根据 ITTC 推荐了过程,在 CFD 的无常分析被格子的三个集合与一致精炼比率 rG = 与全部的抵抗的数字结果执行 2。当时,修改抵抗与试验性的结果相比,它改进了抵抗预言的精确性。 | WANG Zhongcheng LIU Xiaoyu ZHANG Shenglong XU Leping ZHOU Peilin | 2017 | Journal of Shipping and Ocean Engineering2017，7，5： | 0 |
| 16 | Comparing the effects of Bassini versus tension-freehernioplasty: 3 years’ follow-up显示文摘In order to compare the effects of Bassini and tension-free mesh hernioplasty,a total of 552 patients with inguinal hernia who were subjected to surgical treatment in our hospital were randomly divided into the following two groups:the Bassini group(n=269)and the tension-free mesh group(n=283).The recurrence rates,pain,dis-comfort,and other complications were recorded,and the causes of the complications were explored.The recurrence rate in the Bassini group was 8.9%(24/269),significantly higher than that in the tension-free repair group(2.8%,8/283).In addition,the recurrence rates in the Bassini and tension-free groups before 2004 were 12.6%and 5.6%,respectively,which were markedly higher than the rates after 2004(5.3%and 0.7%,respectively).The rate of post-operative discomfort and pain within thefirst three months was higher in the Bassini group compared to the tension-free group(25.7%vs 18.5%,respectively).However,there was no difference after three months in the rate of post-operative discomfort and pain,incidence of infection,or scrotal edema between the two groups.The average hospital stay in the Bassini group was longer than that in the tension-free repair group(7.6�1.2 vs 4.5�2.2 days,respectively),but the cost was lower(4518.0�510 vs 6221.3�578 yuan,respectively).Thus,tension-free mesh hernioplasty is indicated for most inguinal hernia patients due to the low recurrence rate,rapid recovery time,and treatment success,but the traditional Bassini procedure has lower cost and other beneficial effects and is still suitable for some patients. | Yulong SHI Zhongxue SU Leping LI Hongjun LIU Changqing JING | 2010 | Frontiers of Medicine2010，4，4： | 0 |
| 17 | Comparison analysis of sampling methods to estimate regional precipitation based on the Kriging interpolation methods: A case of northwestern China显示文摘The accuracy of spatial interpolation of precipitation data is determined by the actual spatial variability of the precipitation, the interpolation method, and the distribution of observatories whose selections are particularly important. In this paper, three spatial sampling programs, including spatial random sampling, spatial stratified sampling, and spatial sandwich sampling, are used to analyze the data from meteorological stations of northwestern China. We compared the accuracy of ordinary Kriging interpolation methods on the basis of the sampling results. The error values of the regional annual precipitation interpolation based on spatial sandwich sampling, including ME(0.1513), RMSE(95.91), ASE(101.84), MSE(-0.0036), and RMSSE(1.0397), were optimal under the premise of abundant prior knowledge. The result of spatial stratified sampling was poor, and spatial random sampling was even worse. Spatial sandwich sampling was the best sampling method, which minimized the error of regional precipitation estimation. It had a higher degree of accuracy compared with the other two methods and a wider scope of application. | JinKui Wu ShiWei Liu LePing Ma Jia Qin JiaXin Zhou Hong Wei | 2016 | Research in Cold and Arid Regions2016，8，6： | 0 |
| 18 | Polar plumes observed at the total solar eclipse in 2009显示文摘During the total solar eclipse of July 22, 2009, we carried out a white-light observation in Anji, Zhejiang, China. The aim wasto observe the polar plumes (PPs) with high spatial and temporal resolutions in white-light. With the observational data, weinvestigate the properties and evolution of the PPs and compare them with those of the low-latitude plumes (LPs). We find thatboth the PPs and the LPs have comparable lengths and widths, and the mean length and width are 300 Mm and 16 Mm, re-spectively. The average inclination angle (13 degree) of the PPs is smaller than that (32 degree) of the LPs. Generally, theplumes which are closer to the coronal hole center are more vertical. We trace the PPs and the LPs in the sequence of imagesand find that none of them disappears and no new one is created. Additionally, neither plasma outflow nor transverse oscilla-tion is observed. These imply that the evolution process of plumes is much longer than the timescale of eclipse. | YANG ShuHong ZHANG Jun ZHANG ZhiYong ZHAO ZhaoWang LIU YangBing SONG Qian YANG ShangBin BAO XingMing LI LePing CHU Zhe LI Ting | 2011 | Science China(Physics,Mechanics & Astronomy)2011，54，10： | 0 |
| 19 | Integrated genomic analyses identify high-risk factors and actionable targets in T-cell acute lymphoblastic leukemia显示文摘T cell acute lymphoblastic leukemia(T-ALL)is an aggressive hematologic malignancy often associated with poor outcomes.To identify high-risk factors and potential actionable targets for T-ALL,we perform integrated genomic and transcriptomic analyses on samples from 165 Chinese pediatric and adult T-ALL patients,of whom 85%have outcome information.The genomic mutation landscape of this Chinese cohort is very similar to the Western cohort published previously,except that the rate of NOTCH1 mutations is significant lower in the Chinese T-ALL patients.Among 47 recurrently mutated genes in 7 functional categories,we identify RAS pathway and PTEN mutations as poor survival factors for non-TAL and TAL subtypes,respectively.Mutations in the PI3K pathway are mutually exclusive with mutations in the RAS and NOTCH1 pathways as well as transcription factors.Further analysis demonstrates that approximately 43%of the high-risk patients harbor at least one potential actionable alteration identified in this study,and T-ALLs with RAS pathway mutations are hypersensitive to MEKi in vitro and in vivo.Thus,our integrated genomic analyses not only systematically identify high-risk factors but suggest that these high-risk factors are promising targets for T-ALL therapies. | Haichuan Zhu Bingjie Dong Yingchi Zhang Mei Wang Jianan Rao Bowen Cui Yu Liu Qian Jiang Weitao Wang Lu Yang Anqi Yu Zongru Li Chao Liu Leping Zhang Xiaojun Huang Xiaofan Zhu Hong Wu | 2022 | Blood Science2022，4，1： | 0 |
| 20 | Combining forms of heavy metal elements in Dianshan Lake sediments and their spatial and temporal variations显示文摘 | Leping ZHENG Yuliang LIU Xiaoyan SHI Xianwen QIAN Lihua ZHOU Xiaoyan LIU Xinxin WU Weimin SUN | 2006 | Chinese Journal Of Geochemistry2006，25，B08： | 0 |
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