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| 1 | Distribution Characteristics of Effective Source Rocks and Their Control on Hydrocarbon Accumulation: A Case Study from the Dongying Sag, Eastern China显示文摘The exploration conducted in the Bohai Bay basin, eastern China has demonstrated that the abundant petroleum resources have close affinities to the hydrocarbon kitchen with rich organic matter. A number of oil-generating associations with various characteristics of organic geochemistry and assemblages of multiple reservoir facies are developed due to the multi-center sedimentation, multi-source supply and multi-cycle evolution of filling, which have resulted in the formation of multiple oil and gas accumulation zones of various layers and trap styles. Among them the Paleogene Shahejie Formation is the most important hydrocarbon accumulation combination in the Dongying sag.Heretofore, its proved reserve has reached nearly 1.8×109 t, which accounts for more than 90% of the total proved reserves of the Dongying sag. Based on previous studies, more than 600 source rock samples and 186 crude oil samples of the Shahejie Formation, collected from 30 oilfields, have been treated with organic geochemical testing. By combining the sedimentary sequence characteristics and geochemical analysis results, the source rocks of the Shahejie Formation can be divided into three genetic types, i.e. the saline lake facies (the upper Es4), brackish water deep lake facies (the lower Es3)and fresh-water lake facies (the middle Es3), which correspond to the under-filling, balanced-filling and over-filling lake types respectively and represent the three most essential genetic models for source rocks of non-marine fault basins in China. Based on a thorough oil-source correlation, the source rocks of the saline lake and brackish deep lake facies are determined to be the most contributive source rocks in the Dongying sag. Furthermore, by probing into the accumulation of organic matter and hydrocarbon migration pattern, it can be inferred that the hydrocarbons, generated from source rocks of the saline lake facies with relatively low maturity, have mainly accumulated in the uplifted parts of the basin's margin via lateral migration and the reservoirs are dominated by the buried hill and stratigraphic types, while hydrocarbons generated from source rocks of the brackish lake facies are mainly distributed in the basin's center via vertical migration and characterized by forming lithologic reservoirs. Also, the reservoirs located in the transitional belts have complex types and mostly controlled by faults, characterized by block (structural-lithologic) reservoirs, and the crude oils mainly come from source beds of Es13 and Es24 respectively. | ZHUGuangyou JINQiang ZHANGShuichang DAIJinxing ZHANGLinye LIJian | 2004 | Acta Geologica Sinica(English Edition)2004，78，6： | 32 |
| 2 | MAPK signaling in inflammation-associated cancer development显示文摘Mitogen-activated protein(MAP)kinases comprise a family of protein-serine/threonine kinases,which are highly conserved in protein structures from unicellular eukaryotic organisms to multicellular organisms,including mammals.These kinases,including ERKs,JNKs and p38s,are regulated by a phosphorelay cascade,with a prototype of three protein kinases that sequentially phosphorylate one another.MAPKs transduce extracellular signals into a variety of cellular processes,such as cell proliferation,survival,death,and differentiation.Consistent with their essential cellular functions,MAPKs have been shown to play critical roles in embryonic development,adult tissue homeostasis and various pathologies.In this review,we discuss recent findings that reveal the profound impact of these pathways on chronic inflammation and,particularly,inflammation-associated cancer development. | Pengyu Huang Jiahuai Han Lijian Hui | 2010 | Protein & Cell2010，1，3： | 25 |
| 3 | High salt primes a specific activation state of macrophages, M(Na)显示文摘 | Wu-Chang Zhang Xiao-Jun Zheng Lin-Juan Du Jian-Yong Sun Zhu-Xia Shen Chaoji Shi Shuyang Sun Zhiyuan Zhang Xiao-qing Chen Mu Qin Xu Liu Jun Tao Lijun Jia Heng-yu Fan Bin Zhou Ying Yu Hao Ying Lijian Hui Xiaolong Liu Xianghua Yi Xiaojing Liu Lanjing Zhang Sheng-Zhong Duan | 2015 | Cell Research2015，25，8： | 15 |
| 4 | IMPROVED SINGULAR VALUE DECOMPOSITION TECHNIQUE FOR DETECTING AND EXTRACTING PERIODIC IMPULSE COMPONENT IN A VIBRATION SIGNAL显示文摘Vibration acceleration signals are often measured from case surface of a running machine to monitor its condition. If the measured vibration signals display to have periodic impulse components with a certain frequency, there may exist a corresponding local fault in the machine, and if further extracting the periodic impulse components from the vibration signals, the severity of the local fault can be estimated and tracked. However, the signal-to-noise ratios (SNRs) of the vibration acceleration signals are often so small that the periodic impulse components are submersed in much background noises and other components, and it is difficult or inconvenient for us to detect and extract the periodic impulse components with the current common analyzing methods for vibration signals. Therefore, another technique, called singular value decomposition (SVD), is tried to be introduced to solve the problem. First, the principle of detecting and extracting the signal periodic components using singular value decomposition is summarized and discussed. Second, the infeasibility of the direct use of the existing SVD based detecting and extracting approach is pointed out. Third, the approach to construct the matrix for SVD from the signal series is improved largely, which is the key program to improve the SVD technique; Other associated improvement is also proposed. Finally, a simulating application example and a real-life application example on detecting and extracting the periodic impulse components are given, which showed that the introduced and improved SVD technique is feasible. | LiuHongxing LiJian ZhaoYing QuLiangsheng | 2004 | Chinese Journal of Mechanical Engineering2004，17，3： | 15 |
| 5 | Effect of minor Sc addition on microstructure and stress corrosion cracking behavior of medium strength Al–Zn–Mg alloy显示文摘Influence of Sc content on microstructure and stress corrosion cracking behavior of medium strength Al–Zn–Mg alloy have been investigated by optical microscopy, scanning electron microscopy, electron backscatter diffraction, transmission electron microscopy and slow strain rate test. The results indicate that the addition of Sc results in the formation of the quaternary coherent Al_3(Sc, Zr, Ti) dispersoids during homogenization treatment, which will inhibit the dynamic recrystallization behavior. The number density of Al_3(Sc, Zr, Ti) particles increases with the increase of Sc content, and thus the recrystallization fraction of hot-extruded alloy is reduced and the peak strength in two-stage artificial aging sample is enhanced. At the same time, the wide of precipitation free zone is reduced, and the content of Zn and Mg in grain boundary particles and precipitation free zone is increased with the increase of Sc content. In peak-aged state, the 0.06 wt% Sc added alloy shows the better stress corrosion cracking resistance than the Sc-free alloy because of the reduction of recrystallization fraction and the interrupted distribution of grain boundary precipitates along grain boundary. However, the further addition of Sc to 0.11 wt% will result in the deterioration of stress corrosion cracking resistance due to the increase of electrochemical activity of grain boundary particles and precipitation free zone as well as hydrogen embrittlement. | Zhaoming Li Haichang Jiang Yunli Wang Duo Zhang Desheng Yan Lijian Rong | 2018 | Journal of Materials Science & Technology2018，34，7： | 14 |
| 6 | Treatment of osteoporotic vertebral compressive fractures with percutaneous kyphoplasty and oral Zishengukang显示文摘OBJECTIVE:To observe the therapeutic effect of percutaneous kyphoplasty(PKP) and oral Zishengukang(ZSGK) for the treatment of osteoporotic vertebral compression fractures(OVCFs).METHODS:Seventy patients were randomly divided into a control group(PKP group) and an experimental group(PKP plus ZSGK group).The 35 patients in the experimental group were prescribed 6 g oral ZSGK three times a day for 90 days after PKP.Visual analog pain scale(VAS),Oswestry functional score,vertebral height and Cobb's angle were recorded and compared before treatment and at one week,one month and three months after treatment.RESULTS:Vertebral height and Cobb's angle significantly improved and VAS and Oswestry functional score were significantly lower in both groups after PKP than pre-operatively(P<0.01).Three months after treatment,VAS and Oswestry functional score in the experimental group were lower than controls(P<0.05),even though vertebral height and Cobb's angle were comparable(P>0.05).CONCLUSION:PKP combined with oral ZSGK provide superior short-term and long-term symptom control after OVCF than PKP alone. | Zhenjun Huang Lijian Zhang | 2012 | Journal of Traditional Chinese Medicine2012，32，4： | 13 |
| 7 | Preparation of folate-conjugated starch nanoparticles and its application to tumor-targeted drug delivery vector显示文摘Anion starch nanoparticles (StNP) were prepared in water-in-oil microemulsion. Folate modi-fied with PEG was conjugated to the surface of StNP to obtain the folate-conjugated starch nanoparticles (FA-PEG/StNP). The average diameter of FA-PEG/ StNP determined by AFM and Zeta-Sizer apparatus was about 130 nm. Doxorubicin (DOX)-loaded FA- PEG/StNP was obtained via infiltrating combination. The result of UV spectrophotometer showed that the saturation concentration of DOX-loaded FA-PEG/ StNP was 28 μg/mg, which was effective for the con-trolled release of anticancer drug DOX. The cell ex-periments showed that the Lc50 of DOX-loaded FA-PEG/StNP and DOX-loaded StNP was higher than that of DOX, which indicates that FA-PEG/StNP and StNP can decrease the toxicity of DOX; while the lethal rate of DOX-loaded FA-PEG/StNP was 3 times that of DOX-loaded StNP with the same quantity of DOX, which indicates that FA in FA-PEG/StNP is ef-fective for improving the targeting function of nanoparticles, thus enhancing the inhibition effect of anticancer drug to cancer cell. This work demon-strates that the FA-PEG/StNP system is a potentially useful system for the targeted delivery of anticancer drug DOX. | XlAO Suyao TONG Chunyi LIU Xuanming YU Danmi LIU Qiaoling XUE Changgang TANG Dongyin ZHAO Lijian | 2006 | Chinese Science Bulletin2006，51，14： | 12 |
| 8 | Generation of iPS cells using defined factors linked via the self-cleaving 2A sequences in a single open reading frame显示文摘导致的 pluripotent 的产生从体的细胞的茎(iPS ) 细胞被定义 reprogramming 抄写因素(TF ) 的同时的病毒的 transduction 成功地完成了。然而,这个过程为基因交货要求多重病毒的向量。作为结果,产生了 iPS 房间港口在他们的染色体的众多的病毒的集成地点。这能增加基因 mutagenesis 和 genomic 不稳定性的概率,并且介绍重要障碍给研究和 iPS 房间的临床的申请研究。在这篇论文,我们在场定义因素是的一个简单 lentivirus reprogramming 在系统经由自我劈开的 2A 序列熔化了在里面框架进一个单个开的读物框架(ORF ) 。一个 GFP 标记下游地被放 transgene 启用 transgene 表示追踪。我们证明这个 polycistronic 表示系统高效地产生 iPS 房间。产生 iPS 房间有正常 karyotypes 并且类似于鼠标在形态学和基因表示的胚胎的干细胞。而且,他们能在 vitro 并且在 vivo 试金在两个区分进三胚胎的细菌层的房间类型。显著地,大多数这些 iPS 房间仅仅怀有病毒的向量的一个单个拷贝。这个系统提供一个珍贵工具因为 iPS 房间的产生,和我们的数据建议在每个房间的 transduced reprogramming TF 的表示的平衡为 reprogramming 进程是必要的。更重要地,当由非集成的基因交货系统交付了时,这重新设计的单个 ORF 将没有基因修正便于人的 iPS 房间的有效产生。 | Lijian Shao Wei Feng Yan Sun Hao Bai Jun Liu Caroline Currie Jaejung Kim Rafael Gama Zack Wang Zhijian Qian Lucy Liaw Wen-Shu Wu | 2009 | Cell Research2009，19，3： | 12 |
| 9 | Stability analysis of liver cancer-related microRNAs显示文摘MicroRNAs (miRNAs ) 是非编码的, 22 nt 的搁浅单人赛的 RNA 并且组成在植物和动物被发现的基因管理者的一个新奇的班。几研究证明了浆液 miRNAs 能为各种各样的癌症和另外的疾病的察觉用作潜在的 biomarkers。关于肝的稳定性的一些文件在浆液的癌症相关的 miRNAs 是可得到的。在浆液的 miRNA 的稳定性的全身的分析是相当必要的。这研究的目的是在不同试验性的条件下面从三不同来源,有教养的肝癌症 Huh-7 房间行,临床的肝癌症,和浆液评估 miRNAs 的稳定性,包括不同温度,时间持续时间, pH 价值, RNase A 消化, DNase 我消化,并且各种各样的 freezethaw 骑车。qRT-PCR 分析表明了癌症相关的 miRNAs 是的那个肝在每测试条件下面可检测,显示 miRNAs 在严厉环境条件下面对破坏和降级极其稳定、抵抗。然而, ribosomal RNA 由在非生理的测试条件下面表明相对表示的锋利的减少易碎、容易降级。我们也极大地为浆液 RNA 抽取建立了一个柔韧的过程,它是不仅为介绍研究的 miRNA 而且为疾病预后重要基于反常 miRNA 表示。 | Yan Li Zhenggang Jiang Lijian Xu Hu Yao Jiangfeng Guo Xianfeng Ding | 2011 | Acta Biochimica et Biophysica Sinica2011，43，1： | 12 |
| 10 | Complement 5a receptor-mediated neutrophil dysfunction is associated with a poor outcome in sepsis显示文摘补充 5a (C5a ) 被导致 neutrophils 的功能的缺陷在败血的致病含有;然而, C5a 受体的用途(C5aRs;C5aR 和 C5L2 ) 因为为败血的管理的 biomarkers 是不明确的。这研究在嗜中性的功能上在 neutrophils 和他们的效果上调查了 C5aR 和 C5L2 的动态表示。我们发现败血病人与健康、全身的煽动性的反应相比在 neutrophils 上显示了 C5aR 和 C5L2 的低表示层次症候群(先生) 题目,和这个表示模式与疾病严厉被相关。另外, C5aR 和 C5L2 的表示层次与败血病人的幸存被联系。在 vitro, C5a 的增加显著地从败血病人在 neutrophils 减少了 C5aR 和 C5L2 表示层次和 IL-8 生产。那些调查结果建议 C5aRs 的减少的表示为败血病人与 neutrophils 和差的预后的功能的缺陷被联系。总的来说,这些调查结果可以帮助作为早标记建立 C5aRs 表示层次预言败血的严厉。 | Ruonan Xu Fang Lin Chunmei Bao Huihuang Huang Chengcheng Ji Siyu Wang Lei Jin Lijian Sun Ke Li Zheng Zhang Fu-Sheng Wang | 2016 | Cellular & Molecular Immunology2016，13，1： | 10 |
| 11 | Higher PD-1 expression concurrent with exhausted CD8+ T cells in patients with de novo acute myeloid leukemia显示文摘Objective: To investigate the association between the T cell inhibitory receptor programmed death 1(PD-1)and T cell exhaustion status in T cells from patients with de novo acute myeloid leukemia(AML) and AML in complete remission(CR).Methods:Surface expression of PD-1 and the exhaustion and immunosenescence markers CD244 and CD57 on CD3+,CD4+ and CD8+ T cells from peripheral blood samples from 20 newly diagnosed,untreated AML patients and 10 cases with AML in CR was analyzed by flow cytometry.Twenty-three healthy individuals served as control.Results:A significantly higher percentage of PD-1+ cells were found for CD3+ T cells in the de novo AML group compared with healthy controls.In addition,an increased level of PD-1+ CD8+ T cells,but not PD-1+ CD4+,was found for CD3+ T cells in the de novo AML and AML-CR samples.A higher percentage of CD244+ CD4+,CD244+ CD8+,CD57+ CD4+ and CD57+ CD8+ T cells was found in CD3+ T cells in samples from those with de novo AML compared with those from healthy controls.Strong increased PD-1+ CD244+ and PD-1+ CD57+ coexpression was found for CD4+ and CD8+ T cells in the de novo AML group compared with healthy controls.Conclusions:We characterized the major T cell defects,including co-expression of PD-1 and CD244,CD57-exhausted T cells in patients with de novo AML,and found a particular influence on CD8+ T cells,suggesting a poor anti-leukemia immune response in these patients. | Jiaxiong Tan Shaohua Chen Yuhong Lu Danlin Yao Ling Xu Yikai Zhang Lijian Yang Jie Chen Jing Lai Zhi Yu Kanger Zhu Yangqiu Li | 2017 | Chinese Journal of Cancer Research2017，29，5： | 10 |
| 12 | Effect of Sc addition on microstructure and mechanical properties of 1460 alloy显示文摘The effect of minor addition of Sc on microstructure,age hardening behavior,tensile properties and fracture morphology of 1460 alloy have been studied. It is found that Sc content increase from 0.11 wt% to 0.22 wt% is favorable for grain refinement in as-cast alloy but results in a coarsening of Cu-rich particles. The alloy with 0.11 wt% Sc exhibits enhanced mechanical properties and age hardening effect. Transmission electron microscopy(TEM) investigations on the alloy with 0.11 wt% Sc have suggested that a large amount of Al3(Sc,Zr) particles precipitated at the earlier aging may inhibit recrystallization effectively. | Juan Ma Desheng Yan Lijian Rong Yiyi Li | 2014 | Progress in Natural Science:Materials International2014，24，1： | 10 |
| 13 | Degree of Brine Evaporation and Origin of the Mengyejing Potash Deposit:Evidence from Fluid Inclusions in Halite显示文摘The Mengyejing potash deposit is located in the southern port of the Simao Basin, Yunnan Province, and is hosted in mid-Cretaceous strata. The chemical compositions of fluid inclusions in halite crystals, collected from the level-610 adit in the deposit, were analysed by laser ablation inductively coupled plasma mass spectrometry(LA-ICP-MS). The results show that the brine is of the Na-K-Mg-Ca-Cl type and has K concentrations that are distinctly higher than those of Mg and Ca, unlike normal brines associated with Cretaceous halite. The high K concentrations indicate that the degree of evaporation of the ancient Mengyejing saline lake was very high, reaching the sylvite deposition stage but rarely reaching the carnallite deposition stage. The trajectory of the H and O isotopic compositions of the brines in the halite-hosted fluid inclusions corresponds to intense evaporation, indicating that the net evaporation exceeded the net inflow of brines. These brine compositions in halite-hosted fluid inclusions were likely formed by the dissolution of previously deposited K-bearing minerals by fresh continental and/or seawater, forming a type of modified seawater, with deep hydrothermal fluids potentially supplying additional potassium. The basin likely experienced multiple seawater incursion, dissolution and redeposition events in a high-temperature environment with high evaporation rates. | SHEN Lijian LIU Chenglin WANG Licheng HU Yufei HU Mingyue FENG Yuexing | 2017 | Acta Geologica Sinica(English Edition)2017，91，1： | 9 |
| 14 | Ubiquitylation of p62/sequestosome1 activates its autophagy receptor function and controls selective autophagy upon ubiquitin stress显示文摘在细胞的 ubiquitin (Ub ) 的改变动态平衡,作为 Ub 知道强调,展示并且影响处于多重条件的细胞的回答,然而,内在的机制不完全地被理解。这里,我们报导 autophagy 受体 p62/sequestosome-1 与结合酶, UBE2D2 和 UBE2D3 的 E2 Ub 交往。内长的 p62 在 Ub 动态平衡的 upregulation 期间经历 E2 依赖的 ubiquitylation,一个条件作为 Ub + 应力称为,那对由 bortezomib 的 Ub overexpression,热吃惊或延长 proteasomal 抑制内在,化学疗法的药。p62 的 Ubiquitylation 破坏 p62 的 UBA 领域的 dimerization,解放它的能力认出为选择 autophagy 的 polyubiquitylated 货物。我们进一步证明这机制可能为在 Ub + 压力条件之上的 autophagy 激活是批评的。机制的描述和在察觉到 Ub 应力并且控制选择 autophagy 的 p62 的规章的角色能帮助理解并且调制细胞的回答到许多内长、环境的挑战,潜在地对 autophagy 相关的病为治疗学的策略的发展打开一条新大街。 | Hong Peng Jiao Yang Guangyi Li Qing You Wen Han Tianrang Li Darning Gao Xiaoduo Xie Byung-Hoon Lee Juan Du Jian Hou Tao Zhang Hai Rao Ying Huang Qinrun Li Rong Zeng Lijian Hui Hongyan Wang Qin Xia Xuemin Zhang Yongning He Masaaki Komatsu Ivan Dikic Daniel Finley Ronggui Hu | 2017 | Cell Research2017，27，5： | 9 |
| 15 | Finite p-groups with a minimal non-abelian subgroup of index p(Ⅱ)显示文摘We classify completely three-generator finite p-groups G such that Ф(G)≤Z(G)and|G′|≤p2.This paper is a part of the classification of finite p-groups with a minimal non-abelian subgroup of index p,and solve partly a problem proposed by Berkovich. | AN LiJian LI LiLi QU HaiPeng ZHANG QinHai | 2014 | Science China Mathematics2014，57，4： | 9 |
| 16 | Microstructure and Mechanical Properties of 06Cr13Ni4Mo Steel Treated by Quenching–Tempering–Partitioning Process显示文摘A heat treatment process,quenching-tempering-partitioning(Q-T-P),has been applied to a low carbon martensitic stainless steel 06Cr13Ni4 Mo.By using this process,ultrafine reversed austenite can be obtained at room temperature.The microstructures of the reversed austenite and the martensite matrix were characterized by transmission electron microscopy(TEM) and energy dispersive spectroscopy(EDS)in detail.The results show that the ultrafine reversed austenite is enriched in Ni resulting in the austenite stability at room temperature.Two new types of nano-scale carbide precipitates are found in the martensite matrix.Detailed analysis suggests that the two nano-scale precipitates can be identified asω phase and λ phase carbides,respectively.The orientation relationship between the ω phase and matrix is[011]α//[2110]ω and(211)α//(0110)ω,while that between the λ phase precipitate and matrix is[011]α//[0001]λ and(200)α//(1210)λ.For the present steel,the ultrafine reversed austenite and carbide precipitates obtained by Q-T-P treatment provide a good combination of high strength and toughness. | Yuanyuan Song Jingping Cui Lijian Rong | 2016 | Journal of Materials Science & Technology2016，32，2： | 8 |
| 17 | Model Predictive Current Control with Adaptive-adjusting Timescales for PMSMs显示文摘A model predictive current control(MPCC)with adaptive-adjusting method of timescales for permanent magnet synchronous motors(PMSMs)is proposed in this paper to improve the dynamic response and prediction accuracy in transient-state,while lessening the computational burden and improving the control performance in steady-state.The timescale characteristics of different parts of MPCC,such as signal sampling,prediction calculation,control output,model error correction,are analyzed,and the algorithm architecture of MPCC with multi-timescale is proposed.The difference between reference and actual speed,and the change rate of actual speed are utilized to discriminate the transient state of speed change and load change,respectively.Adaptive-adjusting method of control period and prediction stepsize are illustrated in detail after operation condition discrimination.Experimental results of a PMSM are presented to validate the effectiveness of proposed MPCC.In addition,comparative evaluation of single-step MPCC with fixed timescale and proposed MPCC is conducted,which demonstrates the superiority of proposed control strategy. | Feng Niu Xi Chen Shaopo Huang Xiaoyan Huang Lijian Wu Kui Li Youtong Fang | 2021 | CES Transactions on Electrical Machines and Systems2021，5，2： | 8 |
| 18 | Energy dependence on modes of electric activities of neuron driven by different external mixed signals under electromagnetic induction显示文摘Energy supply and release play an important role in individual neuron and neural network. In this paper, the electrical activities and Hamilton energy of neuron are investigated when external mixed signals(i.e., the periodic stimulus current and the periodic electromagnetic field) are imposed on the neuron under the electromagnetic induction. As a result, the Hamilton energy is much dependent on the mode transition, the multiple electric activity modes and the numerical analysis of Hamilton energy are more complicated under various parameters. When the periodic high-low frequency electromagnetic radiation is imposed in neuron, it is found that the electrical activities are more complex, and the changing of energy is obvious. In addition, the response of electrical activity and Hamilton energy is much dependent on the changing of amplitude A, B when the external high-low frequency signal is imposed on the neuron, meanwhile, the energy of bursting state is lower than the one of spiking state. It can be used for investigation about the energy coding in the neuron even the neuron networks. | LU LuLu JIA Ya XU Ying GE MengYan YANG LiJian ZHAN Xuan | 2019 | Science China(Technological Sciences)2019，62，3： | 8 |
| 19 | Robust secure transmission for multiuser MISO systems with probabilistic QoS constraints显示文摘This paper considers a unicast multiuser multiple-input single-output(MISO) downlink system overheard by multiple single-antenna eavesdroppers. The objective is to jointly design the beamforming vectors and the artificial noise(AN) covariance matrix with imperfect channel state information(CSI) at the transmitter,such that the total transmit power is minimized while satisfying probabilistic quality of service(Qo S) constraints at legitimate users and the eavesdroppers. Using Bernstein-type inequalities and the S-procedure, we recast the non-convex power minimization problem as two different convex semidefinite programs(SDPs) which can be solved using interior-point methods. Simulation results show that the proposed methods outperform a nonrobust method and the ones using the isotropic AN. | Lijian ZHANG Liang JIN Wenyu LUO Chunming WANG Yanqun TANG | 2016 | Science China(Information Sciences)2016，59，2： | 7 |
| 20 | Pathways related to PMA-differentiated THP1 human monocytic leukemia cells revealed by RNA-Seq显示文摘Previous analyses have reported that the human monocytic cell line THP1 can be differentiated into cells with macrophage-like characteristics by phorbol 12-myristate 13-acetate(PMA). However, little is known about the mechanism responsible for regulating this differentiation process. Here, we performed high-throughput RNA-Seq analysis to investigate the genes differently expressed in THP1 cells treated with and without PMA and examined those that may be responsible for the PMA-induced differentiation of monocytes into macrophages. We found 3,000 genes to be differentially expressed after PMA treatment. Gene ontology analysis revealed that genes related to cellular processes and regulation of biological processes were significantly enriched. KEGG analysis also demonstrated that the differentially expressed genes(DEGs) were significantly enriched in the PI3K/AKT signaling pathway and phagosome pathway. Importantly, we reveal an important role of the PI3K/AKT pathway in PMA-induced THP1 cell differentiation. The identified DEGs and pathways may facilitate further study of the detailed molecular mechanisms of THP1 differentiation. Thus, our results provide numerous potential therapeutic targets for modulation of the differentiation of this disease. | ZENG ChengWu WANG WenTao YU XiBao YANG LiJian CHEN ShaoHua LI YangQiu | 2015 | Science China(Life Sciences)2015，58，12： | 7 |
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