7篇
您的检索式：作者名="Lieming Li"
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| 1 | Vorolanib,an oral VEGFR/PDGFR dual tyrosine kinase inhibitor for treatment of patients with advanced solid tumors:An open-label,phaseⅠdose escalation and dose expansion trial显示文摘Objective:This study evaluated the safety and preliminary efficacy of vorolanib,a novel tyrosine kinase inhibitor,for treatment of patients with advanced solid tumors.Methods:During dose escalation,patients received increasing doses of oral vorolanib(50-250 mg once daily)in cycles of four weeks for up to one year.During dose expansion,patients received recommended doses(100 and 200 mg)in 4-week cycles.The primary endpoint was to determine the safety and maximum tolerated dose and/or the recommended phase II dose(RP2 D).The severity and type of adverse drug reactions(ADRs)were assessed using the Common Terminology Criteria for Adverse Events version 4.0.The second endpoint was preliminary efficacy in terms of objective response and progression-free survival(PFS).Results:No dose-limiting toxicity occurred during dose escalation(50-250 mg).Five(26.3%)patients in the escalation cohort(n=19)and 12(48.0%)in the expansion cohort(n=25)experienced grade 3 ADRs.The most common ADRs were hair color changes,fatigue,portal hypertension,hypertriglyceridemia,and proteinuria.During dose expansion,the patients treated with 200 mg and 100 mg(once daily)showed an objective response rate of 22.2%and 5.9%,respectively;the disease control rate was 88.9%and 73.3%,respectively;the median PFS was9.9[95%confidence interval(95%CI):7.4-not reached]months and 3.8(95%CI:1.9-not reached)months,respectively.Conclusions:Oral vorolanib at a dose of 200 mg(once daily)exhibited an acceptable safety profile and favorable clinical benefit for patients with advanced solid tumors.The RP2 D for vorolanib was determined to be 200 mg as a daily regimen. | Yan Song Jinwan Wang Xiubao Ren Jie Jin Li Mao Chris Liang Lieming Ding Lin Yang | 2021 | Chinese Journal of Cancer Research2021，33，1： | 2 |
| 2 | Defect and transmission properties of two- dimensional quasiperiodic photonic band- gap systems 显示文摘 | CHENG SAMUEL S M LI Lieming CHAN C T | 1999 | Phys Rev B1999，59，6： | 1 |
| 3 | Learning and scientific reasoning显示文摘 | Lei Bao Tianfan Cai Kathy Koenig Kai Fang Jing Han Jing Wang Qing Liu Lin Ding Lili Cui Ying Luo Yufeng Wang Lieming Li & Nianle Wu | 2009 | Science2009，323，： | 1 |
| 4 | Salvianolic Acid B Inhibits ERK and p38 MAPK Signaling in TGF- β 1-Stimulated Human Hepatic Stellate Cell Line (LX-2) via Distinct Pathways显示文摘 | Zhigang Lv Lieming Xu Xiu-Min Li | 2011 | Evidence-Based Complementary and Alternative Medicine2011，，： | 1 |
| 5 | Viable Transgenic Goats Derived from Skin Cells显示文摘 | Esmail Behboodi Erdogan Memili David T. Melican Margaret M. Destrempes Susan A. Overton Jennifer L. Williams Peter A. Flanagan Robin E. Butler Hetty Liem Li How Chen Harry M. Meade William G. Gavin Yann Echelard | 2004 | Transgenic Research2004，，3： | 1 |
| 6 | 显示文摘 | Li Lieming Zhang Zhaoqing | 1998 | Phys Rev1998，58，： | 1 |
| 7 | Spectrum of Third Harmonic Generation of MX Complex显示文摘The theory of third harmonic generation of MX complex is presented on the basis of charge density wave model.The recently observed spectrum x^((3))(ω)of Pt-Cl complex can be well interpreted by this theory,which shows that the experimental peak at 1.8eV is produced by the two-photon resonance between the bottom of valence band and the top of conduction band.Besides,our theory predicts that there exist another peak below the observed region. | LI Lieming SUN Xin KNasu | 1992 | Chinese Physics Letters1992，9，8： | 0 |
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