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| 1 | Drone remote sensing for forestry research and practices显示文摘Drones of various shapes, sizes, and functionalities have emerged over the past few decades, and their civilian applications are becoming increasingly appealing.Flexible, low-cost, and high-resolution remote sensing systems that use drones as platforms are important for filling data gaps and supplementing the capabilities of crewed/manned aircraft and satellite remote sensing systems. Here, we refer to this growing remote sensing initiative as drone remote sensing and explain its unique advantages in forestry research and practices. Furthermore,we summarize the various approaches of drone remote sensing to surveying forests, mapping canopy gaps, measuring forest canopy height, tracking forest wildfires, and supporting intensive forest management. The benefits of drone remote sensing include low material and operational costs, flexible control of spatial and temporal resolution,high-intensity data collection, and the absence of risk to crews. The current forestry applications of drone remote sensing are still at an experimental stage, but they are expected to expand rapidly. To better guide the development of drone remote sensing for sustainable forestry, it is important to systematically and continuously conduct comparative studies to determine the appropriate drone remote sensing technologies for various forest conditions and/or forestry applications. | Lina Tang Guofan Shao | 2015 | Journal of Forestry Research2015，26，4： | 20 |
| 2 | A review of the end-effector of large space manipulator with capabilities of misalignment tolerance and soft capture显示文摘The space manipulator which has advantages of high dexterity and universality, is used to the space capturing usually. According to the different types of mechanical interfaces of targets, the on orbit capturing operation includes capturing of cooperative target and capturing of uncooperative target. The performances of the famous large space manipulators named space shuttle remote manipulator system(SRMS), the space station remote manipulator system(SSRMS) and the Europe robotic arm(ERA) are reviewed and studied respectively. Moreover, the space manipulators being developed by China for space station is also surveyed. Based on the performance analysis of the large space manipulators and end-effectors, which are adapted to the construction and daily maintenance for the large space structure such as the space station, the basic requirements of large misalignment tolerance capability, soft capturing capability and hard docking capability for the end-effector of large space manipulator are proposed in this paper. According to these requirements, the capture mechanism and methods that can enable the end-effector to have the capability of misalignment tolerance and soft capturing are presented. The development trend and key technologies of the large space manipulators and the end-effectors are also reviewed. | FENG Fei TANG LiNa XU JianFeng LIU Hong LIU YiWe | 2016 | Science China(Technological Sciences)2016，59，11： | 15 |
| 3 | A commentary review on the use of normalized diff erence vegetation index(NDVI)in the era of popular remote sensing显示文摘The Normalized Diff erence Vegetation Index(NDVI),one of the earliest remote sensing analytical products used to simplify the complexities of multi-spectral imagery,is now the most popular index used for vegetation assessment.This popularity and widespread use relate to how an NDVI can be calculated with any multispectral sensor with a visible and a near-IR band.Increasingly low costs and weights of multispectral sensors mean they can be mounted on satellite,aerial,and increasingly—Unmanned Aerial Systems(UAS).While studies have found that the NDVI is effective for expressing vegetation status andquantified vegetation attributes,its widespread use and popularity,especially in UAS applications,carry inherent risks of misuse with end users who received little to no remote sensing education.This article summarizes the progress of NDVI acquisition,highlights the areas of NDVI application,and addresses the critical problems and considerations in using NDVI.Detailed discussion mainly covers three aspects:atmospheric eff ect,saturation phenomenon,and sensor factors.The use of NDVI can be highly eff ective as long as its limitations and capabilities are understood.This consideration is particularly important to the UAS user community. | Sha Huang Lina Tang Joseph P.Hupy Yang Wang Guofan Shao | 2021 | Journal of Forestry Research2021，32，1： | 12 |
| 4 | TOPICS AND TRENDS OF THE ON-LINE PUBLIC CONCERNS BASED ON TIANYA FORUM显示文摘Many social events spread fast through the Intemet and arouse wide community discussions.Those on-line public opinions emerge into diverse topics along the time.Moreover,the strength of the topics is fluctuating.How to catch both primary topics and trend of topics over the shifting on-line discussions are not only of theoretical importance for scientific research,but also of practical importance for societal management especially in current China.To try the cutting-edge text analytic technologies to deal with unstructured on-line public opinions and provide support for social problem-solving in the big data era is worth an endeavour.This paper applies dynamic topic model(DTM)to explore the changing topics of new posts collected from Tianya Zatan Board of Tianya Club,the most influential Chinese BBS in China's Mainland.By analysis of the hot and cold terms trends,we catch the topics shift of main on-line concerns with illustrations of topics of school bus and environment in December of 2011.An algorithm is proposed to compute the strength fluctuation of each topic.With visualized analysis of the respective main topics in several months of 2012,some patterns of the topics fluctuation on the board are summarized. | Lina Cao Xijin Tang | 2014 | Journal of Systems Science and Systems Engineering2014，23，2： | 11 |
| 5 | A Resource for Inactivation of MicroRNAs Using Short Tandem Target Mimic Technology in Model and Crop Plants显示文摘microRNAs (miRNAs)are endogenous small non-coding RNAs that bind to mRNAs and target them for cleavage and/or translational repression,leading to gene silencing.We previously developed short tandem target mimic (STTM)technology to deactivate endogenous miRNAs in Arabidopsis.Here,we created hundreds of STTMs that target both conserved and species-specific miRNAs in Arabidopsis,tomato,rice,and maize,providing a resource for the functional interrogation of miRNAs.We not only revealed the functions of several miRNAs in plant development,but also demonstrated that tissue-specific inactivation of a few miRNAs in rice leads to an increase in grain size without adversely affecting overall plant growth and development.RNA-seq and small RNAseq analyses of STTM156/157 and STTM165/166 transgenic plants revealed the roles of these miRNAs in plant hormone biosynthesis and activation,secondary metabolism,and ion-channel activity-associated electrophysiology,demonstrating that STTM technology is an effective approach for studying miRNA functions.To facilitate the study and application of STTM transgenic plants and to provide a useful platform for storing and sharing of information about miRNA-regulated gene networks,we have established an online Genome Browser (http://gffzzc750bc0108fa4044sw590pbovnf956w0o.ffgz.tsg.suse.edu.cn/designindex2.php) to display the transcriptomic and miRNAomic changes in STTMinduced miRNA knockdown plants. | Ting Peng Mengmeng Qiao Haiping Liu Sachin Teotia Zhanhui Zhang Yafan Zhao Bobo Wang Dongjie Zhao Lina Shi Cui Zhang Brandon Le Kestrel Rogers Chathura Gunasekara Haitang Duan Yiyou Gu Lei Tian Jinfu Nie Jian Qi Fanrong Meng Lan Huang Qinghui Chen Zhenlin Wang Jinshan Tang Xiaoqing Tang Ting Lan Xuemei Chen Hairong Wei Quanzhi Zhao Guiliang Tang | 2018 | Molecular Plant2018，11，11： | 7 |
| 6 | Interaction mechanism between niobium-silicide-based alloy melt and Y_2O_3 refractory crucible in vacuum induction melting process显示文摘Y2O3 坩锅在真空正式就职融化多部件 Nb-16Si-22Ti-2Al-2Hf-17Cr (at.%) 合金作为传统的陶器的一种选择在学习被介绍,到表明在合金之间的可能的相互作用融化并且倔强的坩锅。多重融化时间长度和二冷却计划被设计并且为实验使用了。测试合金和融化坩锅相互作用的化学作文和微观结构被调查并且评估。在实验, Y2O3 坩锅显示好物理化学药品的相容性。结果显示在当演员组铸块锭的 O 元素的增长是 0.03at .%-0.04at.%(72-97 ppm ) , Y 元素的增长是很不足道的。合金的特色融化与 Y2O3 陶艺交往在纸被分析并且得出结论。由于溶解反应 xY2O3 (在熔融的合金)+( 1-x ) HfO2 (杂质) Hf1x Y2x O2x ,一部连续双层固体电影由 HfO2 稳固的答案( 2 下午)组成了,在在坩锅凉下来以后,纯 RfO2 ( 5 下午)在测试铸块锭的表面上被形成。Y2O3 坩锅对真空正式就职适用 NbSi 融化的试验性的结果表演基于合金。 | Gao Ming Jia Lina Tang Xiaoxia Li Xiaojian Cui Renjie Zhang Hu | 2011 | China Foundry2011，8，2： | 4 |
| 7 | The compactness of spatial structure in Chinese cities:measurement,clustering patterns and influencing factors显示文摘Rapid urbanization in China has led to an excessive urban expansion of built-up areas,which makes quantitative research on compact city important.We adopted density and the degree of mixed land use to measure the compactness of 160 Chinese cities.Spatial autocorrelation analysis was performed to identify spatial clustering patterns,and the relationships between compactness and five variables were explored through regression models.The result shows that in nearly half of the cases,the calculated values of two indices are less than the average.The high or low values of density and the degree of mixed land use tend to be spatially clustered.The hot spot regions of density and the degree of mixed land use lie mainly in the south of China,while the north present as cold spots or the insignificant regions.Urban compactness can be affected by multifaceted factors and the relationships between compactness and five variables are not consistent throughout the areas of analysis.The GWR model can identify this phenomenon and provides a better fit than the OLS model.This study proposed a new approach to measure the compactness,and the results of GWR analysis can conducive to appropriate policy-making based on different local conditions. | Fangqi Zhao Lina Tang Quanyi Qiu Gang Wu | 2020 | Ecosystem Health and Sustainability2020，6，1： | 3 |
| 8 | The blue light receptor CRY1 interacts with GID1 and DELLA proteins to repress GA signaling during photomorphogenesis in Arabidopsis显示文摘Light is a critical environmental cue that regulates a variety of diverse plant developmental processes.Cryptochrome 1(CRY1)is the major photoreceptor that mediates blue light-dependent photomorphogenic responses such as the inhibition of hypocotyl elongation.Gibberellin(GA)participates in the repression of photomorphogenesis and promotes hypocotyl elongation.However,the antagonistic interaction between blue light and GA is not well understood.Here,we report that blue light represses GA-induced degradation of the DELLA proteins(DELLAs),which are key negative regulators in the GA signaling pathway,via CRY1,thereby inhibiting the GA response during hypocotyl elongation.Both in vitro and in vivo biochemical analyses demonstrated that CRY1 physically interacts with GA receptors-GA-INSENSITIVE DWARF 1 proteins(GID1s)-and DELLAs in a blue light-dependent manner.Furthermore,we showed that CRY1 inhibits the association between GID1s and DELLAs.Genetically,CRY1 antagonizes the function of GID1s to repress the expression of cell elongation-related genes and thus hypocotyl elongation.Taken together,our findings demonstrate that CRY1 coordinates blue light and GA signali ng for plant photomorphogenesis by stabilizing DELLAs through the binding and in activation of GID1s,providing new in sights into the mechanism by which blue light antagonizes the function of GA in photomorphogenesis. | Ming Zhong Bingjie Zeng Dongying Tang Jiaxin Yang Lina Qu Jindong Yan Xiaochuan Wang Xin Li Xuanming Liu Xiaoying Zhao | 2021 | Molecular Plant2021，14，8： | 3 |
| 9 | Destabilization of linker histone H1.2 is essential for ATM activation and DNA damage repair显示文摘连接器 histone H1 在 DNA 损坏反应是更高的顺序染色质结构,而是它的参与的一个主人管理者,修理是不清楚的。这里,我们报导连接器 histone H1.2 是混乱毛细管扩张的一个必要管理者变异(ATM ) 激活。我们证明 H1.2 通过和 ATM 热重复领域和 MRE11-RAD50-NBS1 (MRN ) 的抑制的直接相互作用保护染色质免受异常 ATM 激活的伤害复杂依赖者的 ATM 招募。在 DNA 损坏之上, H1.2 通过它的 C 终点和进一步的 proteasomal 降级的 poly-ADP-ribosylation (PARylation ) 经历快速的 PARP1 依赖的染色质分离。由 PARylation 死了的变化妥协 ATM 激活和 DNA 损坏修理的 PARP1 弄空或 H1.2 的 H1.2 排水量的抑制,因此导致损害了房间幸存。一起拿,我们的调查结果建议连接器 histone H1.2 作为一个生理的障碍工作因为指向染色质的 ATM,和调停 PARylation 的活跃 H1.2 周转为柔韧的 ATM 激活和 DNA 损坏修理被要求。 | Zhiming Li Yinglu Li Ming Tang Bin Peng Xiaopeng Lu Qiaoyan Yang Qian Zhu Tianyun Hou Meiting Li Chaohua Liu Lina Wang Xingzhi Xu Ying Zhao Haiying Wang Yang Yang Wei-Guo Zhu | 2018 | Cell Research2018，28，7： | 3 |
| 10 | Phenotypic characterization of patients with activated PI3Kδ syndrome 1 presenting with features of systemic lupus erythematosus显示文摘Activated phosphoinositide 3-kinase d syndrome 1(APDS1)is a primary immunode-ficiency disease caused by gain-of-function mutations in PIK3CD.Clinical features of autoimmune disease have been reported in patients with APDS1.In this study,we reported three patients with APDS1 presenting with systemic lupus erythematosus(SLE)phenotype.The clinical manifestations included recurrent respiratory tract infection,lymphoproliferation,Coombs-positive hemolytic anemia,decreased complement fractions,positive antinuclear antibodies,renal complications related to SLE associated diseases,which met the clinical spectrum of APDS1 and the classification criteria of SLE.The immunological phenotype included an inversion in the CD4:CD8 ratio,an increase in both non-circulating Tfh CD4^(+)memory T and circulating Tfh populations,a low level of recent thymic emigrant T cells,overexpression of CD57 on T cells,and a decrease in B cells with fewer antibody class switch recombination.These phenotypes detected in patients with APDS1 presenting with SLE were resemble that in patients with APDS1 presenting without SLE.Meanwhile,we described the effect of glucocorticoids and rapamycin therapy on patients with APDS1.The phosphorylation of S6 at Ser235/236 was inhibited in patients with APDS1 who underwent glucocorticoids therapy,including two who presented with SLE phenotype.The phosphorylation of AKT at Ser473 and phosphorylation of S6 at Ser235/236 were inhibited in other patients with APDS1 who underwent rapamycin therapy.Here,we showed the coexistence of immunodeficiency and SLE phenotype in APDS1,and the inhibition of rapamycin in activated Akt-mTOR signaling pathway. | Yanping Wang Qiuyun Yang Xuemei Chen Wenjing Tang Lina Zhou Zhi Chen Yunfei An Zhiyong Zhang Xuemei Tang Xiaodong Zhao | 2021 | Genes & Diseases2021，8，6： | 3 |
| 11 | Phylogenetic Analysis of the Dengue Virus Strains Causing the 2019 Dengue Fever Outbreak in Hainan,China显示文摘Dengue virus is an arthropod-borne pathogen that is transmitted to humans primarily by Aedes spp.mosquitos,causing the acute infectious disease,dengue fever(DF).Until 2019,no dengue outbreak had been reported in Hainan Province for over 20 years.However,in early September of 2019,an increasing number of infected cases appeared and the DF outbreak lasted for over one month in Haikou City,Hainan Province.In our study,we collected 97 plasma samples from DF patients at three hospitals,as well as 1585 mosquito larvae samples from puddles in different areas of Haikou.There were 49(50.5%)plasma samples found to be strongly positive and 9(9.3%)plasma samples were weakly positive against the NS1 antigen.We discovered DENV both in the patient's plasma samples and mosquito larvae samples,and isolated the virus from C6/36 cells inoculated with the acute phase serum of patients.Phylogenetic analysis revealed that the new strains were the most closely related to the epidemic strain in the southern regions of China,belonging to lineageⅣ,genotypeⅠ,DENV-1.Compared to the seven closest strains from neighboring countries and provinces,a total of 18 amino acid mutations occurred in the coding sequences(CDS)of the new isolated strain,DENV1 HMU-HKU-2.Our data shows that dengue virus is re-emerged in Hainan,and pose new threats for public health.Thus regular molecular epidemiological surveillance is necessary for control and prevention of DENV transmission. | Jiang Du Liyuan Zhang Xiaoyuan Hu Ruoyan Peng Gaoyu Wang Yi Huang Wenqi Wang Kunliang Wu Qiang Wang Haoxiang Su Fan Yang Yun Zhang Chuanning Tang Xiuji Cui Lina Niu Gang Lu Meifang Xiao Yongguo Du Feifei Yin | 2021 | Virologica Sinica2021，36，4： | 2 |
| 12 | Theoretical investigation on Raman induced Kerr effect spectroscopy in nonlinear confocal microscopy显示文摘The imaging theory of Raman induced Kerr effect spectroscopy (RIKES) in nonlinear confocal microscopy is presented in this paper. Three-dimensional point spread function (3D-PSF) of RIKES nonlinear confocal microscopy in isotropic media is derived with Fourier imaging theory and RIKES theory. The impact of nonlinear property of RIKES on the spatial resolution and imaging properties of confocal microscopy have been analyzed in detail. It is proved that RIKES nonlinear confocal microscopy can simultaneously provide more information than two-photon confocal microscopy concerning molecular vibration mode, vibration orientation and optically induced molecular reorientation, etc. It is shown that RIKES nonlinear confocal microscopy significantly enhances the spatial resolution and imaging quality of confocal microscopy and achieves much higher resolution than that of two-photon confocal microscopy. | GUO LiNa TANG ZhiLie XING Da | 2008 | Science China(Physics,Mechanics & Astronomy)2008，51，7： | 2 |
| 13 | Heterologous expression of Hp BHY and Cr BKT increases heat tolerance in Physcomitrella patens显示文摘Heat stress can restrict plant growth,development,and crop yield.As essential plant antioxidants,carotenoids play significant roles in plant stress resistance.b-carotene hydroxylase(BHY)and b-carotene ketolase(BKT),which catalyze the conversions of b-carotene to zeaxanthin and b-carotene to canthaxanthin,respectively,are key enzymes in the carotenoid biosynthetic pathway,but little is known about their potential functions in stress resistance.Here,we investigated the roles of b-carotene hydroxylase and b-carotene ketolase during heat stress in Physcomitrella patens through expressing a b-carotene ketolase gene from Chlamydomonas reinhardtii(Cr BKT)and a b-carotene hydroxylase gene from Haematococcus pluvialis(Hp BHY)in the moss P.patens.In transgenic moss expressing these genes,carotenoids content increased(especially lutein content),and heat stress tolerance increased,with reduced leafy tissue necrosis.To investigate the mechanism of this heat stress resistance,we measured various physiological indicators and found a lower malondialdehyde level,higher peroxidase and superoxide dismutase activities,and higher endogenous abscisic acid and salicylate content in the transgenic plants in response to high-temperature stress.These results demonstrate that Cr BKT and Hp BHY increase plant heat stress resistance through the antioxidant and damage repair metabolism,which is related to abscisic acid and salicylate signaling. | Jianfang He Ping Li Heqiang Huo Lina Liu Ting Tang Mingxia He Junchao Huang Li Liu | 2019 | Plant Diversity2019，41，4： | 2 |
| 14 | The Msi1-mTOR pathway drives the pathogenesis of mammary and extramammary Paget’s disease显示文摘Mammary and extramammary Paget’s Diseases(PD)are a malignant skin cancer characterized by the appearance of Paget cells.Although easily diagnosed,its pathogenesis remains unknown.Here,single-cell RNA-sequencing identified distinct cellular states,novel biomarkers,and signaling pathways—including mTOR,associated with extramammary PD.Interestingly,we identified MSI1 ectopic overexpression in basal epithelial cells of human PD skin,and show that Msi1 overexpression in the epidermal basal layer of mice phenocopies human PD at histopathological,single-cell and molecular levels.Using this mouse model,we identified novel biomarkers of Paget-like cells that translated to human Paget cells.Furthermore,single-cell trajectory,RNA velocity and lineage-tracing analyses revealed a putative keratinocyte-to-Paget-like cell conversion,supporting the in situ transformation theory of disease pathogenesis.Mechanistically,the Msi1-mTOR pathway drives keratinocyte-Paget-like cell conversion,and suppression of mTOR signaling with Rapamycin significantly rescued the Paget-like phenotype in Msi1-overexpressing transgenic mice.Topical Rapamycin treatment improved extramammary PD-associated symptoms in humans,suggesting mTOR inhibition as a novel therapeutic treatment in PD. | Yongli Song Christian F.Guerrero-Juarez Zhongjian Chen Yichen Tang Xianghui Ma Cong Lv Xueyun Bi Min Deng Lina Bu Yuhua Tian Ruiqi Liu Ran Zhao Jiuzhi Xu Xiaole Sheng Sujuan Du Yeqiang Liu Yunlu Zhu Shi-jun Shan Hong-duo Chen Yiqiang Zhao Guangbiao Zhou Jianwei Shuai Fazheng Ren Lixiang Xue Zhaoxia Ying Xing Dai Christopher J.Lengner Bogi Andersen Maksim V.Plikus Qing Nie Zhengquan Yu-Show | 2020 | Cell Research2020，30，10： | 2 |
| 15 | Photocatalytic Carboxylation of Phenyl Halides with CO_(2) by Metal-Organic Frameworks Materials显示文摘In this work,important commercial pharmaceutical intermediates,phenylpropionic acid compounds,are successfully obtained by catalyzing the reaction of carbon dioxide with phenyl halides using MOF-5,a typical metal-organic framework(MOF)material.The influence of temperature,pressure,catalyst type and light on the reaction is investigated,and a 90.3%selectivity towards fluorophenylpropionic acid is reached.Significantly,the catalysts are effective for varied benzyl compounds containing different substituent groups.The catalysts are stable and remain active after three cycles. | Lina Su Yin Zhang Xueying Qiu Jianyu Han Zhiyong Tang | 2021 | Chinese Journal of Chemistry2021，39，2： | 2 |
| 16 | A single-center retrospective study on epidemiological and Traditional Chinese Medicine syndrome characteristics of 21010 patients with reflux/heartburn symptoms显示文摘OBJECTIVE:To provide a basis for the clinical identification of true and false reflux,integrated traditional Chinese and Western medicine,and psychosomatic treatment,we conducted a retrospective study of the etiology and epidemiological and Traditional Chinese Medicine(TCM) syndrome characteristics of patients with reflux/heartburn symptoms.METHODS:The 210 10 patients with reflux/heartburn treated at Tianjin Nankai Hospital from January 1,2016,to December 31,2019,were divided into four groups according to their pathogenesis.Sex,age,course of disease,incidence rate,gastroscopy,24-h p Himpedance,esophageal manometry,Hamilton Anxiety Scale(HAMA)/Hamilton Depression Scale(HAMD) score,8-week proton pump inhibitor(PPI) treatment effect,and TCM syndrome characteristics were statistically analyzed.RESULTS:A total of 21010 patients(8864 men and 12146 women),with reflux/heartburn symptoms were screened,including 6284(29.9%) patients with reflux esophagitis(RE),10427(49.6%) patients with nonerosive reflux esophagitis(NERD),2430(11.6%) patients with reflux hypersensitivity(RH),and 1870(8.9%) patients with functional heartburn(FH).The incidence of the disease was higher in women than in men(P <0.0001).The ranking of the incidence of anxiety and depression in these four groups was FH > RH > NERD > RE(P < 0.0001).There were more women than men in the groups with anxiety and more men than women in the groups with depression(P < 0.0001),and there was no significant difference in the distribution of anxiety and depression between men and women(P = 0.5689).There were significant differences in TCM syndrome characteristics between NERD,RE,and functional esophageal diseases(P < 0.01).The highest proportion of functional esophageal disease TCM symptoms was Qi stagnation and phlegm obstruction syndrome(36.16%),and there was no significant difference between RH and FH.The effective rates of PPI treatment at 8 weeks in patients in the RE,NERD,RH,and FH groups were 89%,72%,54%,and 0%,respectively.RE was classified into grades A,B,C,and D according to the Los Angeles grading system.The ranking of the incidence of these four grades was A > B > C > D(P < 0.0001).The effective rates of PPI treatment at 8 weeks were 91%,81%,69%,and 63% in patients with grade A,B,C,and D RE,respectively(P < 0.0001).The highest proportion of TCM syndrome types of NERD and RE was the stagnated heat syndrome in the liver and stomach syndrome,38.99% and 33.90%,respectively.CONCLUSION:Reflux/heartburn symptoms are relatively common in middle-aged women,and NERD is the most common etiology,followed by RE,RH,and FH.The most common TCM syndrome characteristics in NERD and RE were stagnated heat syndrome in the liver and stomach syndrome,and Qi stagnation and phlegm obstruction syndrome in functional esophageal diseases.Most patients with reflux/heartburn symptoms also experienced anxiety and depression. | TANG Yanping LI Peicai LIU Xi LIU Lei GONG Yanxia WEI Xiaodong LIU Lina YANG Li | 2023 | Journal of Traditional Chinese Medicine2023，43，3： | 2 |
| 17 | Hyperactive PI3Kδ predisposes naive T cells to activation via aerobic glycolysis programs显示文摘Activated phosphoinositide 3-kinaseδsyndrome(APDS)is an autosomal-dominant combined immunodeficiency disorder resulting from pathogenic gain-of-function(GOF)mutations in the PIK3CD gene.Patients with APDS display abnormal T cell homeostasis.However,the mechanisms by which PIK3CD GOF contributes to this feature remain unknown.Here,with a cohort of children with PIK3CD GOF mutations from multiple regions of China and a corresponding CRISPR/Cas9 gene-edited mouse model,we reported that hyperactive PI3Kδdisrupted TNaive cell homeostasis in the periphery by intrinsically promoting the growth,proliferation,and activation of TNaive cells.Our results showed that PIK3CD GOF resulted in loss of the quiescence-associated gene expression profile in naive T cells and promoted naive T cells to overgrow,hyperproliferate and acquire an activated functional status.Naive PIK3CD GOF T cells exhibited an enhanced glycolytic capacity and reduced mitochondrial respiration in the resting or activated state.Blocking glycolysis abrogated the abnormal splenic T cell pool and reversed the overactivated phenotype induced by PIK3CD GOF in vivo and in vitro.These results suggest that enhanced aerobic glycolysis is required for PIK3CD GOF-induced overactivation of naive T cells and provide a potential therapeutic approach for targeting glycolysis to treat patients with APDS as well as other immune disorders. | Yanjun Jia Qiuyun Yang Yanping Wang Wenyan Li Xuemei Chen Tao Xu Zhirui Tian Minxuan Feng Liang Zhang Wenjing Tang Na Tian Lina Zhou Wenxia Song Xiaodong Zhao | 2021 | Cellular & Molecular Immunology2021，18，7： | 2 |
| 18 | Superhydrophobic self-extinguishing cotton fabrics for electromagnetic interference shielding and human motion detection显示文摘Multifunctional intelligent fire-safe cotton fabric promises next-generation fire-fighting uniform and sen-sor applications.However,cotton fabrics’hygroscopicity and intrinsic flammability significantly impede their potential applications in industries.Herein,we report a superhydrophobic fireproof cotton fabric(PEI-APP-PEI-MXene)generated via sequential layer-by-layer deposition of polyethyleneimine(PEI),am-monium polyphosphate(APP),and titanium carbide(MXene),followed by hydrophobic treatment with silicone elastomer.Compared to untreated cotton,the treated cotton fabric with 10 polymolecular layers exhibits∼43%and∼42%reductions in the peak heat release rate and total heat release,respectively,a desired UL-94 V-0 rating,and a high limiting oxygen index(LOI)value of 39.5 vol.%.In addition to that,the treated fabrics displayed improved electromagnetic interference(EMI)shielding and motion-sensing abilities.The presented work provides a facile and effective surface modification approach to generate multifunctional cotton fabrics with promising practical applications. | Lei Liu Zhewen Ma Menghe Zhu Lina Liu Jinfeng Dai Yongqian Shi Jiefeng Gao Toan Dinh Thanh Nguyen Long-Cheng Tang Pingan Song | 2023 | Journal of Materials Science & Technology2023，，1： | 2 |
| 19 | Sex-specific association between coffee consumption and incident chronic kidney disease: a population-based analysis of 359,906 participants from the UK Biobank显示文摘Background:The risk for chronic kidney disease(CKD)is influenced by genetic predisposition,sex,and lifestyle.Previous research indicates that coffee is a potentially protective factor in CKD.The current study aims to investigate whether sex disparity exists in the coffee–CKD association,and whether genetic risk of CKD or genetic polymorphisms of caffeine metabolism affect this association.Methods:A total of 359,906 participants from the UK Biobank who were enrolled between 2006 and 2010 were included in this prospective cohort study,which aimed to estimate the hazard ratios for coffee intake and incident CKD using a Cox proportional hazard model.Allele scores of CKD and caffeine metabolism were additionally adjusted for in a subsample with qualified genetic data(n=255,343).Analyses stratified by genetic predisposition,comorbidities,and sex hormones were performed.Tests based on Bayesian model averaging were conducted to ascertain the robustness of the results.Results:Coffee was inversely associated with CKD in a dose-dependent manner.The effects of coffee did not differ across different strata of genetic risk for CKD,but were more evident among slower genetically predicted caffeine metabolizers.Significant sex disparity was observed(P value for interaction=0.013),in that coffee drinking was only associated with the risk reduction of CKD in females.Subgroup analysis revealed that testosterone and sex hormone-binding globulin(SHBG),but not estradiol,modified the coffee–CKD association.Conclusions:In addition to the overall inverse coffee–CKD association that was observed in the general population,we could also establish that a sex disparity existed,in that females were more likely to experience the benefit of the association.Testosterone and SHBG may partly account for the sex disparity. | Lei Tang Lina Yang Wenwen Chen Chunyang Li Yu Zeng Huazhen Yang Yao Hu Yuanyuan Qu Huan Song Xiaoxi Zeng Ping Fu | 2022 | Chinese Medical Journal2022，，12： | 2 |
| 20 | Root exudates increased arsenic mobility and altered microbial community in paddy soils显示文摘Root exudates are crucial for plants returning organic matter to soils,which is assumed to be a major source of carbon for the soil microbial community.This study investigated the influence of root exudates on the fate of arsenic(As)with a lab simulation experiment.Our findings suggested that root exudates had a dose effect on the soil physicochemical properties,As speciation transformation and the microbial community structure at different concentrations.The addition of root exudates increased the soil pH while decreased the soil redox potential(Eh).These changes in the soil pH and Eh increased As and ferrous(Fe(Ⅱ))concentrations in soil porewater.Results showed that 40 mg/L exudates addition significantly increased arsenite(As(Ⅲ))and arsenate(As(Ⅴ))by 541 and 10 times respectively within 30 days in soil porewater.The relative abundance of Fe(Ⅲ)-reducing bacteria Geobacter and Anaeromyxobacter increased with the addition of root exudates,which enhanced microbial Fe reduction.Together these results suggest that investigating how root exudates affect the mobility and transformation of As in paddy soils is helpful to systematically understand the biogeochemical cycle of As in soil-rice system,which is of great significance for reducing the health risk of soil As contamination. | Ouyuan Jiang Lvyao Li Guilan Duan Williamson Gustave Weiwei Zhai Lina Zou Xia An Xianjin Tang Jianming Xu | 2023 | Journal of Environmental Sciences2023，，5： | 2 |
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