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| 1 | AFAP1-AS1: a rising star among oncogenic long non-coding RNAs显示文摘Long non-coding RNAs(lncRNAs)have become a hotspot in biomedical research.This interest reflects their extensive involvement in the regulation of the expression of other genes,and their influence on the occurrence and development of a variety of human diseases.Actin filament associated protein 1-Antisense RNA 1(AFAP1-AS1)is a recently discovered oncogenic lncRNA.It is highly expressed in a variety of solid tumors,and regulates the expression of downstream genes and signaling pathways through adsorption and competing microRNAs,or by the direct binding to other proteins.Ultimately,AFAP1-AS1 promotes proliferation,chemotherapy resistance,and resistance to apoptosis,maintains stemness,and enhances invasion and migration of tumor cells.This paper summarizes the research concerning AFAP1-AS1 in malignant tumors,including the clinical application prospects of AFAP1-AS1 as a potential molecular marker and therapeutic target of malignant tumors.We also discuss the limitations in the knowledge of AFAP1-AS1 and directions of further research.AFAP1-AS1 is expected to provide an example for studies of other lncRNA molecules. | Fang Xiong Kunjie Zhu Su Deng Hongbin Huang Liting Yang Zhaojian Gong Lei Shi Yi He Yanyan Tang Qianjin Liao Jianjun Yu Xiaoling Li Yong Li Guiyuan Li Zhaoyang Zeng Wei Xiong Shanshan Zhang Can Guo | 2021 | Science China(Life Sciences)2021，64，10： | 4 |
| 2 | Effects of electroacupuncture at Zusanli (ST 36) on neurons in the colonic myenteric plexus in rats with irritable bowel syndrome with constipation显示文摘We studied the effects of electroacupuncture at Zusanli (ST 36) on neurons in the colonic myenteric plexus and on defecation in rats with irritable bowel syndrome with constipation (IBS-C). We also used intragastric administration of pinaverium bromide as a positive control treatment to reveal the pathway mediating the onset of IBS-C. Both electroacupuncture and pinaverium bromide greatly improved defecation in rats with IBS-C. Immunohistochemical staining of the enteric nervous system neuronal marker protein gene product 9.5 in the colonic myenteric plexus showed that electroacupuncture by itself, or in combination with pinaverium bromide, increased the number of neurons and the staining intensity of protein gene product 9.5 in the colonic myenteric plexus. We conclude that visceral hypersensitivity is likely to be a primary cause of constipation in IBS-C rats. | Liting Zhu Zhonghan Li Bin Xu Chen Xia Jie Cheng Xiaoren Xiang Yi Zhu | 2011 | Neural Regeneration Research2011，6，33： | 3 |
| 3 | Single-cell transcriptomes of peripheral blood cells indicate and elucidate severity of COVID-19显示文摘The blood and immune system of coronavirus disease 2019(COVID-19)infected patients are dysfunctional,and numerous studies have been conducted to resolve their characteristics and pathogenic mechanisms.Nevertheless,the variations of immune responses along with disease severity have not been comprehensively documented.Here,we profiled the single-cell transcriptomes of 96,313 peripheral blood mononuclear cells(PBMCs)derived from 12 COVID-19 patients(including four moderate,four severe and four critical cases)and three healthy donors.We showed that proliferative CD8 effector T cells with declined immune functions and cytotoxicity accumulated in the critical stage.By contrast,the quantity of natural killer(NK)cells was significantly reduced,while they exhibited enhanced immune activities.Notably,a gradually attenuated responseto COVID-19 along with disease severity was observed in monocytes,in terms of cellular composition,transcriptional discrepancy and transcription factor regulatory network.Furthermore,we identified immune cell-type dependent cytokine signatures distinguishing the severity of COVID-19 patients.In addition,cell interactions between CD8 effector T/NK cells and monocytes mediated by inflammatory cytokines were enhanced in moderate and severe stages,but weakened in critical cases.Collectively,our work uncovers the cellular and molecular players underlying the disordered and heterogeneous immune responses associated with COVID-19 severity,which could provide valuable insights for the treatment of critical COVID-19 patients. | Xiaowei Xie Xuelian Cheng Gaoxiang Wang Biao Zhang Mengyao Liu Liting Chen Hui Cheng Sha Hao Jianfeng Zhou Ping Zhu Tao Cheng | 2021 | Science China(Life Sciences)2021，64，10： | 3 |
| 4 | Outcome of aggressive B-cell lymphoma with TP53 alterations administered with CAR T-cell cocktail alone or in combination with ASCT显示文摘TP53 gene alteration confers inferior prognosis in refractory/relapse aggressive B-cell non-Hodgkin lymphoma(r/r B-NHL).From September 2016 to September 2020,257 r/r B-NHL patients were assessed for eligibility for two trials in our center,assessing anti-CD19 and anti-CD22 chimeric antigen receptor(CAR19/22)T-cell cocktail treatment alone or in combination with autologous stem cell transplantation(ASCT).TP53 alterations were screened in 123 enrolled patients and confirmed in 60.CAR19/22 T-cell administration resulted in best objective(ORR)and complete(CRR)response rate of 87.1%and 45.2%in patients with TP53 alterations. | Jia Wei Min Xiao Zekai Mao Na Wang Yang Cao Yi Xiao Fankai Meng Weimin Sun Ying Wang Xingcheng Yang Liting Chen Yicheng Zhang Haichuan Zhu Shangkun Zhang Tongcun Zhang Jianfeng Zhou Liang Huang | 2022 | Signal Transduction and Targeted Therapy2022，7，5： | 2 |
| 5 | Cell Membrane-camouflaged Multi-functional Dendritic Large Pore Mesoporous Silica Nanoparticles for Combined Photothermal Therapy and Radiotherapy of Cancer显示文摘Combining photothermal therapy and radiotherapy(PTT-RT) with reducing tumor hypoxia acts as an important antitumor modality. However, it is a great challenge to realize photothermal therapy, radiotherapy and exogenous oxygen supply in one nanosystem. To realize a combination of the three functions, we fabricated a red blood cell membrane(RBCm)-camouflaged, red blood cell content(RBCc) and the copper sulfide(CuS) co-loaded dendritic large pore mesoporous silica nanoparticle(DLMSN/CuS/RBCc/ RBCm). The cell membrane coating endowed the nanoparticles with good stability in the physiological environment, and CuS allowed the nanoparticle exhibiting good photothermal and radiosensitization properties. RBCc loaded nanoparticle DLMSN/CuS/RBCc enhanced superior anti-tumor effect than DLMSN/CuS during combined PTT-RT therapy because the introduction of RBCc increased the exogenous oxygen supply. The in vitro study further demonstrated that the combination of photothermal therapy and radiotherapy induced superior antitumor efficacy than single therapy. Our work thus presents a unique multifunctional nanoscale platform favorable for combined PTT and RT. | WU Liting XIN Yujia GUO Zhaoyang GAO Wei ZHU Yanpeng WANG Yinsong RAN Ruixue YANG Xiaoying | 2022 | Chemical Research in Chinese Universities2022，38，2： | 1 |
| 6 | Poly (styrene-co-maleic anhydride) microspheres prepared in ethanol/water using a photochemical method and their application in Ni 2+ adsorption显示文摘 | Zhimin Zhu Fengqiang Sun Liting Yang Kaiyuan Gu Weishan Li | 2013 | Chemical Engineering Journal2013，，： | 1 |
| 7 | Poly(styrene-co-maleic anhydride) microspheres prepared in ethanol/ water using a photochemical method and their application in Ni2+ adsorption显示文摘 | Zhu Zhimin Sun Fengqiang Yang Liting | 2013 | Chemical Engineering Journal2013，223，： | 1 |
| 8 | Development of an antigen-capture ELISA for the detection of avian leukosis virus p27 antigen显示文摘 | Bingling Yun Delong Li Haibo Zhu Wen Liu Liting Qin Zaisi Liu Guan Wu Yongqiang Wang Xiaole Qi Honglei Gao Xiaomei Wang Yulong Gao | 2013 | Journal of Virological Methods2013，，2： | 1 |
| 9 | Effects of di-(2-ethylhexyl) phthalate on the hypothalamus-pituitary-ovarian axis in adult female rats显示文摘 | Te Liu Na Li Jian Zhu Guangyan Yu Kun Guo Liting Zhou Dongchun Zheng Xiaofeng Qu Jian Huang Xin Chen Shuyue Wang Lin Ye | 2014 | Reproductive Toxicology2014，，： | 1 |
| 10 | A polymorphism in metallothionein 1A ( MT1A ) is associated with cadmium-related excretion of urinary beta 2‐microglobulin显示文摘 | Lijian Lei Xiuli Chang Gerda Rentschler Liting Tian Guoying Zhu Xiao Chen Taiyi Jin Karin Broberg | 2012 | Toxicology and Applied Pharmacology2012，，3： | 1 |
| 11 | Wear Characteristics of the Nuclear Control Rod Drive Mechanism(CRDM)Movable Latch Serviced in High Temperature Water显示文摘The current research of nuclear control rod drive mechanism(CRDM)movable latch only makes a simple measurement of wear mass.The wear volume and difference in various claw surfaces are ignored and the degradation mechanism of each claw surface is not clear.In this paper,a detailed degradation analysis was carried out on each claw surface of movable latch combined with wear result and worn morphology.Results indicate that the boundary of carbide is preferred for corrosion because carbide presents a nobler Volta potential compared to the metal matrix or boundary region.Due to the oscillation of drive shaft between the claw surfaces of movable latch,the dominant wear mechanism on the upper surface of claw(USC)and lower surface of claw(LSC)is plastic deformation caused by impact wear.Mechanical impact wear will cause the fragmentation of carbides because of the high hardness and low ductility of carbides.Corrosion promotes the broken carbides to fall off from the metal matrix.The generated fine carbides(abrasive particles)cause extra abrasive wear on USC when the movable brings the drive shaft upward or downward.As a result,USC has a higher wear volume than LSC.This research proposes a method to evaluate the wear on the whole movable latches using a 3D full-size scanner. | Tianda Yu Guozhong Fu Yanqing Yu Liting Zhu Maofu Liu Wei Li Qiang Deng Zhenbing Cai | 2022 | Chinese Journal of Mechanical Engineering2022，35，2： | 1 |
| 12 | X-ray sensitive high-Z metal nanocrystals for cancer imaging and therapy显示文摘Radiotherapy(RT)based on X-ray irradiation is a widely applied cancer treatment strategy in the clinic.However,treating cancer based on RT alone usually results in insufficient radiation energy deposition,which inevitably has serious side effects on healthy parts of the body.Interestingly,high atomic number(high-Z)metal nanocrystals as X-ray sensitizers can reduce the radiation dose effectively due to their high X-ray absorption,which has attracted increased attention in recent years.High-Z metal nanocrystals produce Auger and photoelectrons electrons under X-ray irradiation,which could generate large amounts of reactive oxygen species,and induce cellular damages.The sensitization effect of high-Z metal nanocrystals is closely related with their composition,morphologies,and size,which would strongly impact their performances in the application of cancer imaging and therapy.In this review,we summarize diverse types of X-ray sensitizers such as bismuth,hafnium,gold,and gadolinium for cancer RT and imaging applications.In addition,current challenges and the outlook of RT based on high-Z metal nanocrystals are also discussed. | Liting Zheng Rong Zhu Lanlan Chen Qinrui Fu Jingying Li Chen Chen Jibin Song Huanghao Yang | 2021 | Nano Research2021，14，11： | 0 |
| 13 | Intrinsic spin shielding effect in platinum-rare-earth alloy boosts oxygen reduction activity显示文摘Oxygen reduction reactions(ORRs)involve a multistep proton-coupled electron process accompanied by the conversion of the apodictic spin configuration.Understanding the role of spin configurations of metals in the adsorption and desorption of oxygen intermediates during ORRs is critical for the design of efficient ORR catalysts.Herein,a platinum-rare-earth-metal-based alloy catalyst,Pt_(2)Gd,is introduced to reveal the role of spin configurations in the catalytic activity of materials.The catalyst exhibits a unique intrinsic spin reconfiguration because of interactions between the Gd-4f and Pt-5d orbitals.The adsorption and desorption of the oxygen species are optimized by modifying the spin symmetry and electronic structures of the material for increased ORR efficiency.The Pt_(2)Gd alloy exhibits a half-wave potential of 0.95 V and a superior mass activity of 1.5 A·mg Pt^(−1)in a 0.1 M HClO_(4)electrolyte,as well as higher durability than conventional Pt/C catalysts.Theoretical calculations have proven that the spin shielding effect of Gd pairs increases the spin symmetry of Pt-5d orbitals and adsorption preferences toward spin-polarized intermediates to facilitate ORR.This work clarifies the impact of modulating the intrinsic spin state of Pt through the interaction with the local high spin 4f orbital electrons in rare-earth metals,with the aim of boosting the spin-related oxygen reduction reaction,thus fundamentally contributing to the understanding of new descriptors that control ORR activity. | Siyuan Zhu Mingzi Sun Bingbao Mei Liting Yang Yuyi Chu Zhaoping Shi Jingsen Bai Xian Wang Zheng Jiang Changpeng Liu Bolong Huang Junjie Ge Wei Xing | 2023 | National Science Review2023，10，9： | 0 |
| 14 | Metatranscriptomic analysis of host response and vaginal microbiome of patients with severe COVID-19显示文摘Dear Editor,The pandemic of coronavirus disease 2019(COVID-19)caused by severe acute respiratory syndrome coronavirus 2(SARS-Co V-2)has become a global public health threat.Here we use a TRACE-seq-based metatranscriptomic analysis to compare host responses and vaginal microbiome of postmenopausal female patients with underlying severe COVID-19 disease with those of healthy females,thereby providing insights into the changes in the microenvironment of women's reproductive system. | Meng Xiao Bo Lu Rui Ding Xia Liu Xian Wu Yaqian Li Xudong Liu Lin Qiu Zhibo Zhang Jing Xie Yu Chen Dong Zhang Liting Dong Meiling Zhang Jinying Peng Hua Yang Timothy Kudihna Yingchun Xu Taisheng Li Chengqi Yi Lan Zhu | 2022 | Science China(Life Sciences)2022，65，7： | 0 |
| 15 | Reciprocal interaction between vascular niche and sweat gland promotes sweat gland regeneration显示文摘The incorporation of vasculature is known to be effective in tissue or organ functional regeneration.However,a vague understanding of the interaction between epidermal appendages and their vascular niches is a foremost obstacle to obtaining sweat gland(SG)-specific vasculature units.Here,we map their precise anatomical con-nections and report that the interplay between SG cells(SGCs)and the surrounding vascular niche is key for glandular development and homeostasis maintenance.To replicate this interplay in vitro,we used three-dimensional(3D)bioprinting to generate reproducible SGC spheroids from differentiated adipose-derived mesenchymal stem cells(ADSCs).With dermal microvascular endothelial cells(DMECs),sacrificial templates made from poly(ε-caprolactone)(PCL)were fabricated to pattern the vascular niche.This interplay model promoted physiologically relevant vascularized glandular morphogenesis in vitro and in vivo.We identified a reciprocal regulatory mechanism for promoting SGs regeneration via contact-independent cell communication and direct cell-cell interactions between SGs and the vasculature.We envision the successful use of our approach for vascularized organ regeneration in the near future. | Xingyu Yuan Xianlan Duan Enhejirigala Zhao Li Bin Yao Wei Song Yuzhen Wang Yi Kong Shijun Zhu Fanliang Zhang Liting Liang Mengde Zhang Chao Zhang Deling Kong Meifeng Zhu Sha Huang Xiaobing Fu | 2023 | Bioactive Materials2023，，3： | 0 |
| 16 | Collagen triple helix repeat containing-1 promotes functional recovery of sweat glands by inducing adjacent microvascular network reconstruction in vivo显示文摘Background:Sweat glands(SGs)have low regenerative potential after severe burns or trauma and their regeneration or functional recovery still faces many obstacles.In practice,restoring SG function requires not only the structural integrity of the gland itself,but also its neighboring tissues,especially blood vessels.Collagen triple helix repeat containing-1(CTHRC1)was first identified in vascular repair,and increasing reports showed a close correlation between cutaneous appendage specification,patterning and regeneration.The purpose of the present study was to clarify the role of CTHRC1 in SGs and their adjacent microvessels and find therapeutic strategies to restore SG function.Methods:The SGs and their adjacent microvascular network of Cthrc^(1−/−)mice were first inves-tigated using sweat test,laser Doppler imaging,tissue clearing technique and transcriptome analysis.The effects of CTHRC1 on dermal microvascular endothelial cells(DMECs)were further explored with cell proliferation,DiI-labeled acetylated low-density lipoprotein uptake,tube for-mation and intercellular junction establishment assays.The effects of CTHRC1 on SG function restoration were finally confirmed by replenishing the protein into the paws of Cthrc(1−/−)mice.Results:CTHRC1 is a key regulator of SG function in mice.At the tissue level,Cthrc1 deletion resulted in the disorder and reduction of the microvascular network around SGs.At the molecular level,the knockout of Cthrc1 reduced the expression of vascular development genes and functional proteins in the dermal tissues.Furthermore,CTHRC1 administration considerably enhanced SG function by inducing adjacent vascular network reconstruction.Conclusions:CTHRC1 promotes the development,morphogenesis and function execution of SGs and their neighboring vasculature.Our study provides a novel target for the restoration or regeneration of SG function in vivo. | Xingyu Yuan Xianlan Duan Zhao Li Bin Yao Enhejirigala Wei Song Yi Kong Yuzhen Wang Fanliang Zhang Liting Liang Shijun Zhu Mengde Zhang Chao Zhang Sha Huang Xiaobing Fu | 2022 | Burns & Trauma2022，10，1： | 0 |
| 17 | Large Eddy Simulation of the Particle Coagulation in High Concentration Particle-Laden Planar Jet Flow显示文摘Particle coagulation by Brownian motion is an important but difficult research topic.When particle volume concentration is larger than 0.1%,the classic SMOLUCHOWSKI equation is not applicative anymore.The high concentration coagulation,with HEINE's correction,source terms for the Taylor-series expansion method of moments(TEMOM) are firstly driven in this paper.Ultra-fine particle(d0?100 mm) with initial volume fraction f?1% coagulation in a planar jet turbulence flow is simulated via the large eddy simulation(LES).The instantaneous and time-averaged particle distributions and the high concentration enhancement are given out.The particle number concentration distribution results show that the coagulation is more intense comparing to dilute case in previous research,especially near the nozzle exit.After jet flow is fully developed,the effect is much more obvious at the region between vortexes.The time-averaged γ(the high concentration enhance factor) distributes sharply and symmetrically about the jet centerline at the upstream,but becomes broad and flat at downstream where the cross-stream averaged γ fluctuates drastically.As a new attempt,this paper shows Brownian coagulation with high concentration also can be calculated via TEMOM appropriately,and the coagulation at the region between vortexes is about 1.38 times intensive of the dilute result calculated by the classic Smoluchowski theory. | LIN Peifeng WU Dichong YU Mingzhou WANG Chao ZHANG Lite ZHU Zefei | 2011 | Chinese Journal of Mechanical Engineering2011，24，6： | 0 |
| 18 | Gottfried Konecny:our best friend in photogrammetry and remote sensing of China显示文摘Preface Lebenslauf Prof.Dr.-Ing.mult Gottfried Konecny is one of the most respected names in photogrammetry.He is an Honorary Member of International Society for Photogrammetry and Remote Sensing(ISPRS),Honorary Professor of Wuhan Technical University of Surveying and Mapping,and our best friend. | Deren Li Yixuan Zhu Lite Shi | 2021 | Geo-Spatial Information Science2021，24，1： | 0 |
| 19 | Ultra-stable Pt_(5)La intermetallic compound towards highly efficient oxygen reduction reaction显示文摘Designing feasible electrocatalysts towards oxygen reduction reaction(ORR)requires advancement in both activity and stability,where attaining high stability is of extreme importance as the catalysts are expected to work efficiently under frequent start-up/shut down circumstances for at least several thousand hours.Alloying platinum with early transition metals(i.e.,Pt–La alloy)is revealed as efficient catalysts construction strategy to potentially satisfy these demands.Here we report a Pt5La intermetallic compound synthesized by a novel and facile strategy.Due to the strong electronic interactions between Pt and La,the resultant Pt5La alloy catalyst exhibits enhanced activity with half wave of 0.92 V and mass activity of 0.49 A·mgPt^(−1),which strictly follows the 4e transfer pathway.More importantly,the catalyst performs superior stability during 30,000 cycles of accelerated stressed test(AST)with mass activity retention of 93.9%.This study provides new opportunities for future applications of Pt-rare earth metal alloy with excellent electrocatalytic properties. | Siyuan Zhu Liting Yang Jingsen Bai Yuyi Chu Jie Liu Zhao Jin Changpeng Liu Junjie Ge Wei Xing | 2023 | Nano Research2023，16，2： | 0 |
| 20 | Combined inhibition of Notch and FLT3 produces synergistic cytotoxic effects in FLT3/ITD^(+)acute myeloid leukemia显示文摘Internal tandem duplication(ITD)mutations of FMS-like tyrosine kinase-3(FLT3)are the most frequent genetic alterations in acute myeloid leukemia(AML)and predict a poor prognosis.FLT3 tyrosine kinase inhibitors(TKIs)provide short-term clinical responses,but the long-term prognosis of FLT3/ITD^(+)AML patients remains poor.Notch signaling is important in numerous types of tumors.However,the role of Notch signaling in FLT3/ITD^(+)AML remains to be elucidated.In the current study,we found that Notch signaling was activated upon FLT3-TKI treatment in FLT3/ITD^(+)cell lines and primary cells.As Notch signaling can be blocked byγ-secretase inhibitors(GSIs),we examined the combinatorial antitumor efficacy of FLT3-TKIs and GSIs against FLT3/ITD^(+)AML and explored the underlying molecular mechanisms.As a result,we observed synergistic cytotoxic effects,and the treatment preferentially reduced cell proliferation and induced apoptosis in FLT3/ITD^(+)AML cell lines and in primary AML cells.Furthermore,the combination of FLT3-TKI and GSI eradicated leukemic cells and prolonged survival in an FLT3/ITD^(+)patient-derived xenograft AML model.Mechanistically,differential expression analysis suggested that CXCR3 may be partially responsible for the observed synergy,possibly through ERK signaling.Our findings suggest that combined therapies of FLT3-TKIs with GSI may be exploited as a potential therapeutic strategy to treat FLT3/ITD^(+)AML. | Dan Li Tongjuan Li Zhen Shang Lei Zhao Qian Xu Jiaqi Tan Yun Qin Yuanyuan Zhang Yang Cao Na Wang Liang Huang Xiaojian Zhu Kuangguo Zhou Liting Chen Chunrui Li Ting Xie Yi Yang Jue Wang Jianfeng Zhou | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 0 |
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