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| 1 | Abnormal Effective Connectivity of the Anterior Forebrain Regions in Disorders of Consciousness显示文摘A number of studies have indicated that disorders of consciousness result from multifocal injuries as well as from the impaired functional and anatomical connectivity between various anterior forebrain regions.However, the specific causal mechanism linking these regions remains unclear. In this study, we used spectral dynamic causal modeling to assess how the effective connections(ECs) between various regions differ between individuals. Next, we used connectome-based predictive modeling to evaluate the performance of the ECs in predicting the clinical scores of DOC patients. We found increased ECs from the striatum to the globus pallidus as well as from the globus pallidus to the posterior cingulate cortex, and decreased ECs from the globus pallidus to the thalamus and from the medial prefrontal cortex to the striatum in DOC patients as compared to healthy controls.Prediction of the patients' outcome was effective using the negative ECs as features. In summary, the present study highlights a key role of the thalamo-basal ganglia-cortical loop in DOCs and supports the anterior forebrain mesocircuit hypothesis. Furthermore, EC could be potentially used to assess the consciousness level. | Ping Chen Qiuyou Xie Xiaoyan Wu Huiyuan Huang Wei Lv Lixiang Chen Yequn Guo Shufei Zhang Huiqing Hu You Wang Yangang Nie Ronghao Yu Ruiwang Huang | 2018 | Neuroscience Bulletin2018，34，4： | 4 |
| 2 | Discovery of Late Carboniferous strata and their tectonic significance in the southern margin of the North China Block(Huoqiu and Gushi areas)显示文摘Late Carboniferous fossils(such as Boultonia? sp., Tabulata, and spiriferoid specimens with smooth shells), bioclastic material(such as crinoid stems and sponge fragments), and Late Ordovician microfossils of the conodont Belodina have been discovered in the lower part of the strata typically referred to as the Neoproterozoic on the boundary of the provinces of Anhui and Henan in the southern margin of the North China Block. These findings prove that the strata contain macrofossils belonging to the Late Carboniferous, which belonged to a carbonate debris flow deposit that was formed under a carbonate slope environment. The conodont fossils might belong to a detrital deposit. Thus, it is possible to reset the stratigraphic sequences and tectonic attributes belonging to the North Huaiyang tectonic belt and limit the Shouxian fault to the boundary between the Dabie Orogen and North China Block. | Shuangying Li Zaifei Ji Song Wang Cheng Cheng Lixiang Guo Dongdong Yang Hao Niu | 2014 | Chinese Science Bulletin2014，59，7： | 3 |
| 3 | Single-cell transcriptomic landscape of human blood cells显示文摘High throughput single-cell RNA-seq has been successfully implemented to dissect the cellular and molecular features underlying hematopoiesis.However,an elaborate and comprehensive transcriptome reference of the whole blood system is lacking.Here,we profiled the transcriptomes of 7551 human blood cells representing 32 immunophenotypic cell types,including hematopoietic stem cells,progenitors and mature blood cells derived from 21 healthy donors.With high sequencing depth and coverage,we constructed a single-cell transcriptional atlas of blood cells(ABC) on the basis of both protein-coding genes and long noncoding RNAs(lncRNAs),and showed a high consistence between them.Notably,putative lncRNAs and transcription factors regulating hematopoietic cell differentiation were identified.While common transcription factor regulatory networks were activated in neutrophils and monocytes,lymphoid cells dramatically changed their regulatory networks during differentiation.Furthermore,we showed a subset of nucleated erythrocytes actively expressing immune signals,suggesting the existence of erythroid precursors with immune functions.Finally,a web portal offering transcriptome browsing and blood cell type prediction has been established.Thus,our work provides a transcriptional map of human blood cells at single-cell resolution,thereby offering a comprehensive reference for the exploration of physiological and pathological hematopoiesis. | Xiaowei Xie Mengyao Liu Yawen Zhang Bingrui Wang Caiying Zhu Chenchen Wang Qing Li Yingying Huo Jiaojiao Guo Changlu Xu Linping Hu Aiming Pang Shihui Ma Una Wang Wenbin Cao Shulian Chen Qiuling Li Sudong Zhang Xueying Zhao Wen Zhou Hongbo Luo Guoguang Zheng Erlie Jiang Sizhou Feng Lixiang Chen Lihong Shi Hui Cheng Sha Hao Ping Zhu Tao Cheng | 2021 | National Science Review2021，8，3： | 3 |
| 4 | Transcriptomic analysis reveals the molecular mechanisms of rumen wall morphological and functional development induced by different solid diet introduction in a lamb model显示文摘Background:This study aimed to elucidate the molecular mechanisms of solid diet introduction initiating the cellular growth and maturation of rumen tissues and characterize the shared and unique biological processes upon different solid diet regimes.Methods:Twenty-four Hu lambs were randomly allocated to three groups fed following diets:goat milk powder only(M,n=8),goat milk powder+alfalfa hay(MH,n=8),and goat milk powder+concentrate starter(MC,n=8).At 42 days of age,the lambs were slaughtered.Ruminal fluid sample was collected for analysis of concentration of volatile fatty acid(VFA)and microbial crude protein(MCP).The sample of the rumen wall from the ventral sac was collected for analysis of rumen papilla morphology and transcriptomics.Results:Compared with the M group,MH and MC group had a higher concentration of VFA,MCP,rumen weight,and rumen papilla area.The transcriptomic results of rumen wall showed that there were 312 shared differentially expressed genes(DEGs)between in“MH vs.M”and“MC vs.M”,and 232 or 796 unique DEGs observed in“MH vs.M”or“MC vs.M”,respectively.The shared DEGs were most enriched in VFA absorption and metabolism,such as peroxisome proliferator-activated receptor(PPAR)signaling pathway,butanoate metabolism,and synthesis and degradation of ketone bodies.Additionally,a weighted gene co-expression network analysis identified M16(2,052 genes)and M18(579 genes)modules were positively correlated with VFA and rumen wall morphology.The M16 module was mainly related to metabolism pathway,while the M18 module was mainly associated with signaling transport.Moreover,hay specifically depressed expression of genes involved in cytokine production,immune response,and immunocyte activation,and concentrate starter mainly altered nutrient transport and metabolism,especially ion transport,amino acid,and fatty acid metabolism.Conclusions:The energy production during VFA metabolism may drive the rumen wall development directly.The hay introduction facilitated establishment of immune function,while the concentrate starter enhanced nutrient transport and metabolism,which are important biological processes required for rumen development. | Daming Sun Yuyang Yin Changzheng Guo Lixiang Liu Shengyong Mao Weiyun Zhu Junhua Liu | 2021 | Journal of Animal Science and Biotechnology2021，12，3： | 2 |
| 5 | Vegetation Phenology in Permafrost Regions of Northeastern China Based on MODIS and Solar-induced Chlorophyll Fluorescence显示文摘Vegetation phenology is an indicator of vegetation response to natural environmental changes and is of great significance for the study of global climate change and its impact on terrestrial ecosystems.The normalized difference vegetation index(NDVI)and enhanced vegetation index(EVI),extracted from the Moderate Resolution Imaging Spectrometer(MODIS),are widely used to monitor phenology by calculating land surface reflectance.However,the applicability of the vegetation index based on‘greenness'to monitor photosynthetic activity is hindered by poor observation conditions(e.g.,ground shadows,snow,and clouds).Recently,satellite measurements of solar-induced chlorophyll fluorescence(SIF)from OCO-2 sensors have shown great potential for studying vegetation phenology.Here,we tested the feasibility of SIF in extracting phenological metrics in permafrost regions of the northeastern China,exploring the characteristics of SIF in the study of vegetation phenology and the differences between NDVI and EVI.The results show that NDVI has obvious SOS advance and EOS lag,and EVI is closer to SIF.The growing season length based on SIF is often the shortest,while it can represent the true phenology of vegetation because it is closely related to photosynthesis.SIF is more sensitive than the traditional remote sensing indices in monitoring seasonal changes in vegetation phenology and can compensate for the shortcomings of traditional vegetation indices.We also used the time series data of MODIS NDVI and EVI to extract phenological metrics in different permafrost regions.The results show that the length of growing season of vegetation in predominantly continuous permafrost(zone I)is longer than in permafrost with isolated taliks(zone II).Our results have certain significance for understanding the response of ecosystems in cold regions to global climate change. | WEN Lixiang GUO Meng YIN Shuai HUANG Shubo LI Xingli YU Fangbing | 2021 | Chinese Geographical Science2021，31，3： | 1 |
| 6 | Simulation of preload- ing water-filled spiral case structure with weak simulation algo rithm显示文摘 | Tao Guo Lixiang Zhang Jun Zhou | 2012 | Procedia Engineering2012，31，1： | 1 |
| 7 | Numerical simulation of three - dimensional incompressible fluid in a box flow pas- sage considering fluid - structure interaction by differential quadrature method 显示文摘 | Zhang Lixiang Guo Yakun He Shihua | 2007 | Applied Mathematical Modelling2007，31，： | 1 |
| 8 | Analysis of Dynamic Characteristics of the Main Shaft System in a Hydro-turbine Based on Ansys显示文摘 | Bing Bai Lixiang Zhang Tao Guo Chaoqun Liu | 2012 | Procedia Engineering2012，32，： | 1 |
| 9 | A robust well-balanced finite volume model for shallow water flows with wetting and drying over irregular terrain 显示文摘 | SONG Lixiang ZHOU Jianzhong GUO Jun | 2011 | Advances in Water Resources2011，34，7： | 1 |
| 10 | New results of periodic so- lutions for Rayleigh type p-Laplacian equation with a variable coeffi- cient ahead of the nonlinear term 显示文摘 | LIANG Feng GUO Lixiang LU Shiping | 2009 | Nonlinear Analysis:Theory Methods & Applications2009，70，： | 1 |
| 11 | Analysis of Dynamic Characteristics of the Main Shaft System in a Hydro-turbine Based on ANSYS显示文摘 | Bing Bai Lixiang Zhang Tao Guo Chaoqun Liu | 2012 | Procedia Engineering2012，，： | 1 |
| 12 | Prevalence of diabetes among menand women in China显示文摘 | Yang Wenying Lu Juming Weng Jianping Jia Weiping Ji Linong Xiao Jianzhong Shan Zhongyan Liu Jie Tian Ha- oming Ji Qiuhe Zhu Dalong Ge Jiapu Lin Lixiang Chen Li Guo Xiaohui Zhao Zhigang Li Qiang Zhou Zhiguang Shan Guangliang He Jiang | 2010 | N Engl J Med2010，362，： | 1 |
| 13 | Comprehensive flood risk assessment based on set pair analysisvariable fuzzy sets model and fuzzy AHP显示文摘 | Qiang Zou Jianzhong Zhou Chao Zhou Lixiang Song Jun Guo | 2013 | Stochastic Environmental Research and Risk Assessment2013，27，2： | 1 |
| 14 | Computational investigation of typhoon-induced storm surge Hangzhou Bay显示文摘 | GUO Yakun ZHANG Jisheng ZHANG Lixiang | 2009 | Estuarine Coastal and Shelf Science2009，85，4： | 1 |
| 15 | Heterogeneous photocatalytic degradation of methyl orange in schwertmannite/oxalate suspension under UV irradiation显示文摘 | Yong Wu Jing Guo Danjun Jiang Pei Zhou Yeqing Lan Lixiang Zhou | 2012 | Environmental Science and Pollution Research2012，，6： | 1 |
| 16 | Serum Lipids and Lipoproteins in Chinese Men and Women显示文摘 | Wenying Yang Jianzhong Xiao Zhaojun Yang Linong Ji Weiping Jia Jianping Weng Juming Lu Zhongyan Shan Jie Liu Haoming Tian Qiuhe Ji Dalong Zhu Jiapu Ge Lixiang Lin Li Chen Xiaohui Guo Zhigang Zhao Qiang Li Zhiguang Zhou Guangliang Shan Jiang He | 2012 | Circulation2012，，18： | 1 |
| 17 | Se- cure Network Coding against Wiretapping and Byzantine Attacks显示文摘 | GUO Qin LUO Mingxing LI Lixiang | 2010 | EURASIP Journal on Wire- less Communications and Networking2010，，21： | 1 |
| 18 | Large eddy simulation of turbulent flow in a true 3D Francis hydro turbine passage with dynamical fluid-structure interaction显示文摘 | Zhang Lixiang Guo Yakun Wang Wenquan | 2007 | International Journal for Numerical Methods in Fluids2007，54，5： | 1 |
| 19 | FEM simulation of turbulent flow in a turbine blade passage with dynamical fluid-structure interaction显示文摘 | Zhang Lixiang Guo Yakun Wang Wenquan | 2009 | International Journal for Numerical Methods in Fluids2009，61，12： | 1 |
| 20 | The practical research on flood risk analysis based on IIOSM and fuzzy α -cut technique显示文摘 | Qiang Zou Jianzhong Zhou Chao Zhou Lixiang Song Jun Guo Yi Liu | 2011 | Applied Mathematical Modelling2011，，7： | 1 |
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