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| 1 | Hyperthermic intraperitoneal chemotherapy for gastric cancer with peritoneal metastasis:A multicenter propensity scorematched cohort study显示文摘Objective:Systemic chemotherapy has limited efficacy in the treatment of peritoneal metastasis(PM)in gastric cancer(GC).Hyperthermic intraperitoneal chemotherapy(HIPEC)combined with complete cytoreductive surgery(CRS)has shown promising outcomes but remains controversial.The present study aimed to evaluate the safety and efficacy of HIPEC without CRS in GC patients with PM.Methods:This retrospective propensity score-matched multicenter cohort study included GC patients with PM treated with either chemotherapy alone(Cx group)or with HIPEC combined with chemotherapy(HIPEC-Cx group)in four Chinese high-volume gastric medical centers between 2010 and 2017.The primary outcomes were median survival time(MST)and 3-year overall survival(OS).Propensity score matching was performed to compensate for controlling potential confounding effects and selection bias.Results:Of 663 eligible patients,498 were matched.The MST in the Cx and HIPEC-Cx groups was 10.8 and 15.9 months,respectively[hazard ratio(HR)=0.71,95%confidence interval(95%CI),0.58-0.88;P=0.002].The 3-year OS rate was 10.1%(95%CI,5.4%-14.8%)and 18.4%(95%CI,12.3%-24.5%)in the Cx and HIPEC-Cx groups,respectively(P=0.017).The complication rates were comparable.The time to first flatus and length of hospital stay for patients undergoing HIPEC combined with chemotherapy was longer than that of chemotherapy alone(4.6±2.4 d vs.2.7±1.8 d,P<0.001;14.2±5.8 d vs.11.4±7.7 d,P<0.001),respectively.The median follow-up period was 33.2 months.Conclusions:Compared with standard systemic chemotherapy,HIPEC combined with chemotherapy revealed a statistically significant survival benefit for GC patients with PM,without compromising patient safety. | Ziying Lei Jiahong Wang Zhi Li Baozhong Li Jiali Luo Xuejun Wang Jin Wang MingchenBa Hongsheng Tang Qingjun He Quanxing Liao Xiansheng Yang Tianpei Guan Han Liang Shuzhong Cui | 2020 | Chinese Journal of Cancer Research2020，32，6： | 11 |
| 2 | Comparison of nonhuman primates identified the suitable model for COVID-19显示文摘Identification of a suitable nonhuman primate(NHP)model of COVID-19 remains challenging.Here,we characterized severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)infection in three NHP species:Old World monkeys Macaca mulatta(M.mulatta)and Macaca fascicularis(M.fascicularis)and New World monkey Callithrix jacchus(C.jacchus).Infected M.mulatta and M.fascicularis showed abnormal chest radiographs,an increased body temperature and a decreased body weight.Viral genomes were detected in swab and blood samples from all animals.Viral load was detected in the pulmonary tissues of M.mulatta and M.fascicularis but not C.jacchus.Furthermore,among the three animal species,M.mulatta showed the strongest response to SARS-CoV-2,including increased inflammatory cytokine expression and pathological changes in the pulmonary tissues.Collectively,these data revealed the different susceptibilities of Old World and New World monkeys to SARS-CoV-2 and identified M.mulatta as the most suitable for modeling COVID-19. | Shuaiyao Lu Yuan Zhao Wenhai Yu Yun Yang Jiahong Gao Junbin Wang Dexuan Kuang Mengli Yang Jing Yang Chunxia Ma Jingwen Xu Xingli Qian Haiyan Li Siwen Zhao Jingmei Li Haixuan Wang Haiting Long Jingxian Zhou Fangyu Luo Kaiyun Ding Daoju Wu Yong Zhang Yinliang Dong Yuqin Liu Yinqiu Zheng Xiaochen Lin Li Jiao Huanying Zheng Qing Dai Qiangming Sun Yunzhang Hu Changwen Ke Hongqi Liu Xiaozhong Peng | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 5 |
| 3 | A multi-institutional retrospective study of hyperthermic plus intravesical chemotherapy versus intravesical chemotherapy treatment alone in intermediate and high risk nonmuscle-invasive bladder cancer显示文摘Objective:To compare the efficacy and safety of hyperthermic intravesical chemotherapy(HIVEC)and intravesical chemotherapy(IVEC)in patients with intermediate and high risk nonmuscle-invasive bladder cancer(NMIBC)after transurethral resection.Methods:We included 560 patients diagnosed with primary or recurrent NMIBC between April 2009 and December 2015 at 1 of 6 tertiary centers.We matched 364 intermediate or high risk cases and divided them into 2 groups:the HIVEC+IVEC group[chemohyperthermia(CHT)composed of 3 consecutive sessions followed by intravesical instillation without hyperthermia]and the IVEC group(intravesical instillation without hyperthermia).The data were recorded in the database.The primary endpoint was 2-year recurrence-free survival(RFS)in all NMIBC patients(n=364),whereas the secondary endpoints were the assessment of radical cystectomy(RC)and 5-year overall survival(OS).Results:There was a significant difference in the 2-year RFS between the two groups in all patients(n=364;HIVEC+IVEC:82.42%vs.IVEC:74.18%,P=0.038).Compared with the IVEC group,the HIVEC+IVEC group had a lower incidence of RC(P=0.0274).However,the 5-year OS was the same between the 2 groups(P=0.1434).Adverse events(AEs)occurred in 32.7%of all patients,but none of the events was serious(grades 3–4).No difference in the incidence or severity of AEs between each treatment modality was observed.Conclusions:This retrospective study showed that HIVEC+IVEC had a higher 2-year RFS and a lower incidence of RC than IVEC therapy in intermediate and high risk NMIBC patients.Both treatments were well-tolerated in a similar manner. | Qiang Ruan Degang Ding Bin Wang Chaohong He Xuequn Ren Zhenhua Feng Zhigang Pang Jin Wang Xiangliang Zhang Hongsheng Tang Jiahong Wang Qingjun He Ziying Lei Quanxing Liao Jiali Luo Shuzhong Cui | 2021 | Cancer Biology & Medicine2021，18，1： | 4 |
| 4 | Mapping the elastic properties of two-dimensional MoS_(2) via bimodal atomic force microscopy and finite element simulation显示文摘Elasticity is a fundamental mechanical property of two-dimensional(2D)materials,and is critical for their application as well as for strain engineering.However,accurate measurement of the elastic modulus of 2D materials remains a challenge,and the conventional suspension method suffers from a number of drawbacks.In this work,we demonstrate a method to map the in-plane Young’s modulus of mono-and bi-layer MoS_(2) on a substrate with high spatial resolution.Bimodal atomic force microscopy is used to accurately map the effective spring constant between the microscope tip and sample,and a finite element method is developed to quantitatively account for the effect of substrate stiffness on deformation.Using these methods,the in-plane Young’s modulus of monolayer MoS_(2) can be decoupled from the substrate and determined as 265±13 GPa,broadly consistent with previous reports though with substantially smaller uncertainty.It is also found that the elasticity of mono-and bi-layer MoS_(2) cannot be differentiated,which is confirmed by the first principles calculations.This method provides a convenient,robust and accurate means to map the in-plane Young’s modulus of 2D materials on a substrate. | Yuhao Li Chuanbin Yu Yingye Gan Peng Jiang Junxi Yu Yun Ou Dai-Feng Zou Cheng Huang Jiahong Wang Tingting Jia Qian Luo Xue-Feng Yu Huijuan Zhao Cun-Fa Gao Jiangyu Li | 2018 | npj Computational Materials2018，，1： | 3 |
| 5 | Accelerated discovery of a large family of quaternary chalcogenides with very low lattice thermal conductivity显示文摘The development of efficient thermal energy management devices such as thermoelectrics and barrier coatings often relies on compounds having low lattice thermal conductivity(κl).Here,we present the computational discovery of a large family of 628 thermodynamically stable quaternary chalcogenides,AMM′Q_(3)(A=alkali/alkaline earth/post-transition metals;M/M′=transition metals,lanthanides;Q=chalcogens)using high-throughput density functional theory(DFT)calculations.We validate the presence of lowκl in these materials by calculatingκl of several predicted stable compounds using the Peierls–Boltzmann transport equation.Our analysis reveals that the lowκl originates from the presence of either a strong lattice anharmonicity that enhances the phononscatterings or rattler cations that lead to multiple scattering channels in their crystal structures.Our thermoelectric calculations indicate that some of the predicted semiconductors may possess high energy conversion efficiency with their figure-of-merits exceeding 1 near 600 K.Our predictions suggest experimental research opportunities in the synthesis and characterization of these stable,low κ_(l) compounds. | Koushik Pal Yi Xia Jiahong Shen Jiangang He Yubo Luo Mercouri G.Kanatzidis Chris Wolverton | 2021 | npj Computational Materials2021，，1： | 1 |
| 6 | Enhanced N_(2)-to-NH_(3)conversion efficiency on Cu3P nanoribbon electrocatalyst显示文摘Ambient electroreduction of nitrogen(N_(2))is considered as a green and feasible approach for ammonia(NH_(3))synthesis,which urgently demands for efficient electrocatalyst.Morphology has close relationship with catalytic activity of heterogeneous catalysts.Nanoribbon is attractive nanostructure,which possesses the flexibility of one-dimensional nanomaterials,the large surface area of two-dimensional nanomaterials,and lateral size confinement effects.In this work,Cu_(3)P nanoribbon is proposed as a highly efficient electrocatalyst for N_(2)-to-NH_(3)conversion under benign conditions.When measured in N_(2)-saturated 0.1 M HCl,such Cu_(3)P nanoribbon achieves high performance with an excellent Faradaic efficiency as high as 37.8%and a large yield of 18.9μg·h^(−1)·mgcat.−1 at−0.2 V.It also demonstrates outstanding stability in long-term electrolysis test at least for 45 h. | Qian Liu Yiting Lin Shuang Gu Ziqiang Cheng Lisi Xie Shengjun Sun Longcheng Zhang Yongsong Luo Abdulmohsen Ali Alshehri Mohamed SHamdy Qingquan Kong Jiahong Wang Xuping Sun | 2022 | Nano Research2022，15，8： | 1 |
| 7 | Recent progress in perovskite solar cells:from device to commercialization显示文摘Perovskite solar cells(PSCs) are undergoing rapid development and the power conversion efficiency reaches 25.7% which attracts increasing attention on their commercialization recently.In this review,we summarized the recent progress of PSCs based on device structures,perovskite-based tandem cells,large-area modules,stability,applications and industrialization.Last,the challenges and perspectives are discussed,aiming at providing a thrust for the commercialization of PSCs in the near future. | Xinhui Luo Xuesong Lin Feng Gao Yang Zhao Xiaodong Li Liqing Zhan Zexiong Qiu Jin Wang Cong Chen Lei Meng Xiaofeng Gao Yu Zhang Zijian Huang Rundong Fan Huifen Liu Yanrun Chen Xiaoxue Ren Jiahong Tang Chun-Hao Chen Dong Yang Yongguang Tu Xiao Liu Dongxue Liu Qing Zhao Jingbi You Junfeng Fang Yongzhen Wu Hongwei Han Xiaodan Zhang Dewei Zhao Fuzhi Huang Huanping Zhou Yongbo Yuan Qi Chen Zhaokui Wang Shengzhong(Frank)Liu Rui Zhu Jotaro Nakazaki Yongfang Li Liyuan Han | 2022 | Science China Chemistry2022，65，12： | 1 |
| 8 | Detection of FLT3/ITD gene mutations in patients with hematologic malignancy and their clinical significance显示文摘分析象 Fms 一样酷氨酸激酶的目的 3 (FLT3 ) 在 hematologic 恶意病人的各种各样的类型的 /internal-tandem 复制(ITD ) 变化。方法 FLT3/ITD 基因变化被聚合酶链反应( PCR )在 103 尖锐 myeloid ( AML )检测盒子, 63 个尖锐淋巴球的白血病(所有)盒子,在长期的阶段( CML-CP )的 53 个长期的骨髓内产生的白血病(电流型逻辑)盒子,在强风危机( CML-BC )的 34 个电流型逻辑盒子, 11 个长期的淋巴性白血病( CLL )盒子, 36 个 myelodysplastic 症候群( MDS )盒子, 9 个多发性骨髓瘤(公里)盒子和 13 non-hodgkin 是有髓渗入的淋巴瘤( NHL )盒子。结果 FLT3/ITD 基因变化的表情在 22.3% AML 盒子中被检测,在 6.5% CML-BC 盒子中,在 5.6% MDS 盒子中并且在 2.6% 所有情况中。有 FLT3/ITD 变化的二种所有情况与骨髓的抗原表示与形态学和两个作为 ALL-L2 被诊断,但是最后在免疫学检查以后作为尖锐混合系白血病被诊断。FLT3/ITD 基因变化没在 CML-CP,公里, NHL 和 CLL 盒子被检测。在有 FLT3/ITD 基因变化的 23 个 AML 病人,包括 8 M1 (2.5%)中的 2 个, 33 M2 (24.2%)中的 8 个, 24 M3 (29.3%)中的 7 个, 11 M4 (18.2%)中的 2 个, 21 M5 (14.3%)中的 3 个, 5 M6 (20%)中的 1 个,和 1 个 M7 盒子中的 0 个,并且处于在 FAB 子类型之间的 FLT3/ITD 变化的积极的率没有有效差量( P >
0.05 )。统计分析证明在 AML 病人, FLT3/ITD 与血白人房间(白血球)数的更高的外设被联系[( 41.23 ± 32.56 )× 10 9 /L 对( 11.36 ± 9.89 )× 10 9 /L ( P <
0.01 )],骨髓胚细胞的更高的百分比[( 72.78 ± 21.79 )%对( 51.26 ± 20.78 )%( P <
0.05 )],并且更高累积的恶化率(63.6%对27.7%, P <
0.025 )比那些否定。结论 FLT3/ITD 基因变化主要发生在 AML 病人,和力量是在 AML 与高外部的白血球计数,骨髓强风房间比例和增加的恶化风险被联系的一个强壮的预示的因素。FLT3/ITD 基因变化的察觉可能提供卓见探索白血病的更精确的 genotyping,在 AML 和所有之间的鉴别诊断,在 AML 和白血病的估计预后细分风险水平。 | Bing Xu Guoshu Ghen Xiaodan Luo Jiahong Tang | 2009 | The Chinese-German Journal of Clinical Oncology2009，8，2： | 1 |
| 9 | A multifunctional optoelectronic device based on 2D material with wide bandgap显示文摘Low-dimensional materials exhibit unique quantum confinement effects and morphologies as a result of their nanoscale size in one or more dimensions,making them exhibit distinctive physical properties compared to bulk counterparts.Among all low-dimensional materials,due to their atomic level thickness,two-dimensional materials possess extremely large shape anisotropy and consequently are speculated to have large optically anisotropic absorption.In this work,we demonstrate an optoelectronic device based on the combination of two-dimensional material and carbon dot with wide bandgap.High-efficient luminescence of carbon dot and extremely large shape anisotropy(>1500)of two-dimensional material with the wide bandgap of>4 eV cooperatively endow the optoelectronic device with multi-functions of optically anisotropic blue-light emission,visible light modulation,wavelength-dependent ultraviolet-light detection as well as blue fluorescent film assemble.This research opens new avenues for constructing multi-function-integrated optoelectronic devices via the combination of nanomaterials with different dimensions. | Hongwei Xu Jingwei Liu Sheng Wei Jie Luo Rui Gong Siyuan Tian Yiqi Yang Yukun Lei Xinman Chen Jiahong Wang Gaokuo Zhong Yongbing Tang Feng Wang Hui-Ming Cheng Baofu Ding | 2023 | Light(Science & Applications)2023，12，12： | 0 |
| 10 | Application of the Double-difference Relocation Method Combined with Waveform Cross-correlation on the Three Gorges Reservoir Seismicity显示文摘In this paper,we use the double difference location method based on waveform crosscorrelation algorithm for precise positioning of the Three Gorges Reservoir( TGR)earthquakes and analysis of seismic activity. First,we use the bi-spectrum cross-correlation method to analyze the seismic waveform data of TGR encrypted networks from March,2009 to December,2010,and evaluate the quality of waveform cross-correlation analysis.Combined with the waveform cross-correlation of data obtained, we use the double difference method to relocate the earthquake position. The results show that location precision using bi-spectrum verified waveform cross-correlation data is higher than that by using other types of data,and the mean 2 sig-error in EW,NS and UD are 3.2 m,3.9 m and 6.2 m,respectively. For the relocation of the Three Gorges Reservoir earthquakes,the results show that the micro-earthquakes along the Shenlongxi river in the Badong reservoir area obviously show the characteristics of three linear zones with nearly east-west direction,which is in accordance with the small faults and carbonate strata line of the neotectonic period,revealing the reservoir water main along the underground rivers or caves permeated and induced seismic activity. The stronger earthquakes may have resulted from small earthquakes through the active layers. | Luo Jiahong Ma Wentao Li Chunzheng | 2017 | Earthquake Research in China2017，31，3： | 0 |
| 11 | Whirligig‑Inspired Hybrid Nanogenerator for Multi‑strategy Energy Harvesting显示文摘Portable energy solutions are highly desired in the era of the Internet of Things for powering various distributed micro-electronic devices.At the same time,the energy crisis and catastrophic global warming are becoming serious problems in the world,emphasizing the urgent need for clean and renewable energy.Here,we report a low-cost,high-performance,and portable hand-driven whirligig structured triboelectric–electromagnetic hybrid nanogenerator(whirligig-HNG)for multi-strategy energy harvesting.The whirligig-HNG comprises a dynamic supercoiling TENG via the pulling-strings and inner-distributed EMGs(variable number)in the rotator.The whirligig structure can readily convert linear displacement in low frequency into rotary motion in extremely high frequency.Based on this ingenious design,the whirligig-HNG is capable to harvest the triboelectric energy from the supercoiling/uncoiling process from the pulling strings and simultaneously utilize the high-frequency rotation energy via electromagnetic induction.We have systematically investigated the working mecha-nism of the whirligig-HNG for coupled energy harvesting and compared the individual characteristics of TENG and EMG.The whirligig-HNG is successfully demonstrated to light up more than 100 commercial light-emitting diodes(LEDs)and drive portable electronics.This research presents the enormous potential of whirligig-HNG as a manual and portable power supply for powering various portable electronics. | Xiaozhen Dan Ran Cao Xiaole Cao Yifei Wang Yao Xiong Jing Han Lan Luo Jiahong Yang Nuo Xu Jia Sun Qijun Sun Zhong Lin Wang | 2023 | Advanced Fiber Materials2023，5，1： | 0 |
| 12 | China's HY-2 Shore-to-Ship Missile System显示文摘The paper describes the main tactical and technical performances as well as the leading features of China’s HY-2 shore-to-ship missile system.From this paper,the readers can get better understanding of the missile’s aerodynamic configuration,guidance and control modes and its warhead,engines and follow-on versions The article also deals with the fire and technical position facilities and equipment of the weapon system. | By Yang Xinsheng, Luo Jiahong | 1995 | Aerospace China1995，，2： | 0 |
| 13 | The olfactory route is a potential way for SARS-CoV-2 to invade the central nervous system of rhesus monkeys显示文摘Neurological manifestations are frequently reported in the COVID-19 patients.Neuromechanism of SARS-CoV-2 remains to be elucidated.In this study,we explored the mechanisms of SARS-CoV-2 neurotropism via our established non-human primate model of COVID-19.In rhesus monkey,SARS-CoV-2 invades the CNS primarily via the olfactory bulb.Thereafter,viruses rapidly spread to functional areas of the central nervous system,such as hippocampus,thalamus,and medulla oblongata.The infection of SARS-CoV-2 induces the inflammation possibly by targeting neurons,microglia,and astrocytes in the CNS.Consistently,SARS-CoV-2 infects neuro-derived SK-N-SH,glial-derived U251,and brain microvascular endothelial cells in vitro.To our knowledge,this is the first experimental evidence of SARS-CoV-2 neuroinvasion in the NHP model,which provides important insights into the CNS-related pathogenesis of SARS-CoV-2. | Li Jiao Yun Yang Wenhai Yu Yuan Zhao Haiting Long Jiahong Gao Kaiyun Ding Chunxia Ma Jingmei Li Siwen Zhao Haixuan Wang Haiyan Li Mengli Yang Jingwen Xu Junbin Wang Jing Yang Dexuan Kuang Fangyu Luo Xingli Qian Longjiang Xu Bin Yin Wei Liu Hongqi Liu Shuaiyao Lu Xiaozhong Peng | 2021 | Signal Transduction and Targeted Therapy2021，6，5： | 0 |
| 14 | Differential Transcriptomic Landscapes of SARS-CoV-2 Variants in Multiple Organs from Infected Rhesus Macaques显示文摘Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)caused the persistent coronavirus disease 2019(COVID-19)pandemic,which has resulted in millions of deaths worldwide and brought an enormous public health and global economic burden.The recurring global wave of infections has been exacerbated by growing variants of SARS-CoV-2.In this study,the virological characteristics of the original SARS-CoV-2 strain and its variants of concern(VOCs;including Alpha,Beta,and Delta)in vitro,as well as differential transcriptomic landscapes in multiple organs(lung,right ventricle,blood,cerebral cortex,and cerebellum)from the infected rhesus macaques,were elucidated.The original strain of SARS-CoV-2 caused a stronger innate immune response in host cells,and its VOCs markedly increased the levels of subgenomic RNAs,such as N,Orf9b,Orf6,and Orf7ab,which are known as the innate immune antagonists and the inhibitors of antiviral factors.Intriguingly,the original SARS-CoV-2 strain and Alpha variant induced larger alteration of RNA abundance in tissues of rhesus monkeys than Beta and Delta variants did.Moreover,a hyperinflammatory state and active immune response were shown in the right ventricles of rhesus monkeys by the up-regulation of inflammation-and immune-related RNAs.Furthermore,peripheral blood may mediate signaling transmission among tissues to coordinate the molecular changes in the infected individuals.Collectively,these data provide insights into the pathogenesis of COVID-19 at the early stage of infection by the original SARS-CoV-2 strain and its VOCs. | Tingfu Du Chunchun Gao Shuaiyao Lu Qianlan Liu Yun Yang Wenhai Yu Wenjie Li Yong Qiao Sun Cong Tang Junbin Wang Jiahong Gao Yong Zhang Fangyu Luo Ying Yang Yun-Gui Yang Xiaozhong Peng | 2023 | Genomics, Proteomics & Bioinformatics2023，21，5： | 0 |
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