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| 1 | Sintilimab versus docetaxel as second-line treatment in advanced or metastatic squamous non-small-cell lung cancer:an open-label,randomized controlled phase 3 trial(ORIENT-3)显示文摘Background:Treatment options for Chinese patients with locally advanced or metastatic squamous-cell non-small-cell lung cancer(sqNSCLC)after failure of first-line chemotherapy are limited.This study(ORIENT-3)aimed to evaluate the efficacy and safety of sintilimab versus docetaxel as second-line treatment in patients with locally advanced or metastatic sqNSCLC.Methods:ORIENT-3 was an open-label,multicenter,randomized controlled phase 3 trial that recruited patients with stage IIIB/IIIC/IV sqNSCLC after failure with first-line platinum-based chemotherapy.Patients were randomized in a 1:1 ratio to receive either 200 mg of sintilimab or 75 mg/m^(2) of docetaxel intravenously every 3 weeks,stratified by the Eastern Cooperative Oncology Group performance status.The primary endpoint was overall survival(OS)in the full analysis set(FAS).Secondary endpoints included progression-free survival(PFS),objective response rate(ORR),disease control rate(DCR),duration of response(DoR)and safety.Results:Between August 25,2017,and November 7,2018,290 patients were randomized.For FAS,10 patients fromthe docetaxel armwere excluded.Themedian OS was 11.79(n=145;95%confidence interval[CI],10.28-15.57)months with sintilimab versus 8.25(n=135;95%CI,6.47-9.82)months with docetaxel(hazard ratio[HR]:0.74;95%CI,0.56-0.96;P=0.025).Sintilimab treatment significantly prolonged PFS(median 4.30 vs.2.79 months;HR:0.52;95%CI,0.39-0.68;P<0.001)and showed higher ORR(25.50%vs.2.20%,P<0.001)and DCR(65.50%vs.37.80%,P<0.001)than the docetaxel arm.The median DoRwas 12.45(95%CI,4.86-25.33)months in the sintilimab arm and 4.14(95%CI,1.41-7.23)months in the docetaxel arm(P=0.045).Treatment-related adverse events of grade≥3were reported in 26(18.1%)patients in the sintilimab arm and 47(36.2%)patients in the docetaxel arm.Exploratory biomarker analysis showed potential predictive values of expression levels of two transcription factors,including OVOL2(HR:0.35;P<0.001)and CTCF(HR:3.50;P<0.001),for sintilimab treatment.Conclusions:Compared with docetaxel,sintilimab significantly improved the OS,PFS,and ORR of Chinese patients with previously treated locally advanced or metastatic sqNSCLC. | Yuankai Shi Lin Wu Xinmin Yu Puyuan Xing Yan Wang Jianying Zhou Airong Wang Jianhua Shi Yi Hu Ziping Wang Guangyu An Yong Fang Sanyuan Sun Caicun Zhou Changli Wang Feng Ye Xingya Li Junye Wang Mengzhao Wang Yunpeng Liu Yanqiu Zhao Ying Yuan Jifeng Feng Zhendong Chen Jindong Shi Tao Sun Gang Wu Yongqian Shu Qisen Guo Yi Zhang Yong Song Shucai Zhang Yuan Chen Wei Li Hongrui Niu Wenwei Hu Lijun Wang Jianan Huang Yang Zhang Ying Cheng Zhengdong Wu Bo Peng Jiya Sun Christoph Mancao Yanqi Wang Luyao Sun | 2022 | Cancer Communications2022，42，12： | 8 |
| 2 | Submicrosecond electro-optical switching of one-dimensional soft photonic crystals显示文摘Soft photonic crystals are appealing due to their self-assembly ability,wide tunability,and multistimuli-responsiveness.However,their response time is relatively slow,ranging from milliseconds to minutes.Here,we report submicrosecond switching of chiral liquid crystals(LCs)with 1D photonic microstructures,where electric fields modify the orientational order of molecules and quench their fluctuations,rather than altering the orientation.Thus,the adjusted refractive indices result in a fast shift of the photonic bandgap,on the order of 100 ns,which is four orders of magnitude faster than conventional electro-optic switching in cholesterics.This work offers tremendous opportunities for soft photonic applications. | Lingling Ma Chaoyi Li Luyao Sun Zhenpeng Song Yanqing Lu Bingxiang Li | 2022 | Photonics Research2022，10，3： | 2 |
| 3 | NSUN2-mediated mRNA m^(5)C Modification Regulates the Progression of Hepatocellular Carcinoma显示文摘RNA modifications affect many biological processes and physiological diseases.The 5-methylcytosine(m^(5)C)modification regulates the progression of multiple tumors.However,its characteristics and functions in hepatocellular carcinoma(HCC)remain largely unknown.Here,we found that HCC tissues had a higher m^(5)C methylation level than the adjacent normal tissues.Transcriptome analysis revealed that the hypermethylated genes mainly participated in the phosphokinase signaling pathways,such as the Ras and PI3K-Akt pathways.The m^(5)C methyltransferase NSUN2 was highly expressed in HCC tissues.Interestingly,the expression of many genes was positively correlated with the expression of NSUN2,including GRB2,RNF115,AATF,ADAM15,RTN3,and HDGF.Real-time PCR assays further revealed that the expression of the mRNAs of GRB2,RNF115,and AATF decreased significantly with the down-regulation of NSUN2 expression in HCC cells.Furthermore,NSUN2 could regulate the cellular sensitivity of HCC cells to sorafenib via modulating the Ras signaling pathway.Moreover,knocking down NSUN2 caused cell cycle arrest.Taken together,our study demonstrates the vital role of NSUN2 in the progression of HCC. | Dan Song Ke An Wenlong Zhai Luyao Feng Yingjie Xu Ran Sun Yueqin Wang Yun-Gui Yang Quancheng Kan Xin Tian | 2023 | Genomics, Proteomics & Bioinformatics2023，21，4： | 1 |
| 4 | Preparation of superoleophobic and superhydrophobic titanium surfaces via an environmentally friendly electrochemical etching method显示文摘 | LUYao SONG Jinlong LIU Xin | 2013 | ACS Sustainable Chemistry & Engineering2013，1，： | 1 |
| 5 | Ultrasonic vibration enabled under-liquid forming of metallic glasses显示文摘Advancements in forming technology offer significant advantages for the manufacturing industry,including enhanced efficiency,energy conservation,and improved material utilization[1].However,traditional additive manufacturing[2],thermoplastic forming[3],and laser cutting[4]encounter challenges when applied in under-liquid environments,mainly due to difficulties in temperature control and heat source provision. | Xin Li Luyao Li Sajad Sohrabi Jia'nan Fu Zhen Li Zhe Chen Rongce Sun Yu Zhang Jinbiao Huang Heting Zhang Jian Zhu Xiangyan Chen Kaikai Song Jiang Ma | 2024 | Science Bulletin2024，69，2： | 0 |
| 6 | Awakening Sleeping Beauty:Vinyl Esters for Macrolactonization显示文摘Macrolactones play a critical role in pharmaceuticals and agrochemicals.Numerous efforts have been devoted to developing synthetic methods for them.We highlighted a recent progress for building macrocycles(≥12-membered)via bench-stable vinyl ester(VE)intermediates,which have been underdeveloped for half century. | Qi Song Luyao Kong Lili Zhu Ran Hong Sha-Hua Huang | 2021 | Chinese Journal of Chemistry2021，39，4： | 0 |
| 7 | Reconfigurable Vortex-like Paramagnetic Nanoparticle Swarm with Upstream Motility and High Body-length Ratio Velocity显示文摘Drug delivery systems with high-targeted doses can minimize excipients,reduce side effects,and improve efficacy.Human blood circulation is a complex circulatory system,and the motion control of microrobots in the static flow field in vitro is completely different from in vivo.How to achieve precise counterflow motion for targeted drug delivery without vascular blockage and immune rejection is the biggest challenge for micro-nano robots.Here,we propose a control method that enables vortex-like paramagnetic nanoparticle swarm(VPNS)to move upstream against the flow.By mimicking the clustering motion of wild herring schools and the rolling of leukocytes,VPNS are incredibly stable even when subjected to high-intensity jet impacts in the blood environment,can travel upstream,anchor at the target location,and dissipate when the magnetic field is withdrawn,which greatly reduces the risk of thrombosis.VPNS can also upstream along the vessel wall without an additional energy source and has a marked targeted therapeutic effect on subcutaneous tumors. | Luyao Wang Han Gao Hongyan Sun Yiming Ji Li Song Lina Jia Chutian Wang Chan Li Deyuan Zhang Ye Xu Huawei Chen Lin Feng | 2023 | Research2023，，4： | 0 |
| 8 | Transcriptomic but not genomic variability confers phenotype of breast cancer stem cells显示文摘Background:Breast cancer stem cells(BCSCs)are considered responsible for cancer relapse and drug resistance.Understanding the identity of BCSCs may open new avenues in breast cancer therapy.Although several discoveries have been made on BCSC characterization,the factors critical to the origination of BCSCs are largely unclear.This study aimed to determine whether genomic mutations contribute to the acquisition of cancer stem-like phenotype and to investigate the genetic and transcriptional features of BCSCs.Methods:We detected potential BCSC phenotype-associated mutation hotspot regions by using whole-genome sequencing on parental cancer cells and derived serial-generation spheres in increasing order of BCSC frequency,and then performed target deep DNA sequencing at bulk-cell and single-cell levels.To identify the transcriptional program associated with BCSCs,bulk-cell and single-cell RNA sequencing was performed.Results:By using whole-genome sequencing of bulk cells,potential BCSC phenotype-associated mutation hotspot regions were detected.Validation by target deep DNA sequencing,at both bulk-cell and single-cell levels,revealed no genetic changes specifically associated with BCSC phenotype.Moreover,single-cell RNA sequencing showed profound transcriptomic variability in cancer cells at the single-cell level that predicted BCSC features.Notably,this transcriptomic variability was enriched during the transcription of 74 genes,revealed as BCSC markers.Breast cancer patients with a high risk of relapse exhibited higher expression levels of these BCSC markers than those with a low risk of relapse,thereby highlighting the clinical significance of predicting breast cancer prognosis with these BCSC markers.Conclusions:Transcriptomic variability,not genetic mutations,distinguishes BCSCs from non-BCSCs.The identified 74 BCSC markers have the potential of becoming novel targets for breast cancer therapy. | Mengying Tong Ziqian Deng Mengying Yang Chang Xu Xiaolong Zhang Qingzheng Zhang Yuwei Liao Xiaodi Deng Dekang Lv Xuehong Zhang Yu Zhang Peiying Li Luyao Song Bicheng Wang Aisha Al-Dherasi Zhiguang Li Quentin Liu | 2018 | Cancer Communications2018，38，1： | 0 |
| 9 | Interaction between MAPKs and MKPs in hexaploid chrysanthemum illuminates functional paralogue diversification in polyploids显示文摘Mitogen-activated protein kinases(MAPKs,also known as MPKs)regulate diverse cellular and physiological functions,and dual-specificity MAPK phosphatases(MKPs)modulate MAPK signalling through MAPK dephosphorylation and inactivation.Due to lacking of overall understanding for the regulatory networks between Chrysanthemum morifolium MKPs(CmMKPs)and C.morifolium MAPKs(CmMPKs),we systematically studied the interactions between four groups of CmMPKs and eight identified CmMKPs in chrysanthemum and found that the interaction between the specific CmMKP and the specific CmMPK differed from those in other plants.Furthermore,the expression of CmMKP1 and CmMKP1-LIKE1showed opposite trends during the development of chrysanthemum flower buds under salt treatment and Alternaria alternata inoculation,but these genes could interact with the same CmMPKs,providing insight into the subfunctionalization of paralogues.Amino acid variations(M87V,T277P and V6L)in dual-specificity protein phosphatases(DsPTP1)-LIKE1/2/3 changed the interactions of these proteins with the four CmMPK groups in chrysanthemum,providing evidence for the de/neofunctionalization of paralogues in polyploids,suggesting that we can identify the key functional sites of proteins by studying polyploid paralogues. | Qi Yu Luyao Zhang Daojin Sun Yueheng Hu Peiling Li Xue Zhang Lian Ding Lijie Zhou Zhiyong Guan Weimin Fang Fadi Chen Aiping Song | 2023 | Horticultural Plant Journal2023，9，1： | 0 |
| 10 | Genome-wide association study of micronaire using a natural population of representative upland cotton(Gossypium hirsutum L.)显示文摘Background: Micronaire is a comprehensive index reflecting the fineness and maturity of cotton fiber.Micronaire is one of the important internal quality indicators of the cotton fiber and is closely related to the value of the cotton fiber.Understanding the genetic basis of micronaire is required for the genetic improvement of the trait.However,the genetic architecture of micronaire at the genomic level is unclear.The present genome-wide association study(GWAS)aimed to identify the genetic mechanism of the micronaire trait in 83 representa:tive upland cotton lines grown in multiple environments.Results GWAS of micronaire used 83 upland cotton accessions assayed by a Cotton 63 K Illumina Infinium single nucleotide polymorphism(SNP)array.A total of 11 quantitative trait loci(QTLs)for micronaire were detected on 10 chromosomes.These 11 QTLs included 27 identified genes with specific expression patterns.A novel QTL,qFM-A12–1,included 12 significant SNPs,and GhFLA9 was identified as a candidate gene based on haplotype block analysis and on strong and direct linkage disequilibrium between the significantly related SNPs and gene.GhFLA9 was expressed at a high level during secondary wall thickening at 20∼25 days post-anthesis.The expression level of GhFLA9 was significantly higher in the low micronaire line(Msco-12)than that in the high micronaire line(Chuangyou-9).Conclusions: This study provides a genetic reference for genetic improvement of cotton fiber micronaire and a foundation for verification of the functions of GhFLA9. | SONG Jikun PEI Wenfeng MA Jianjiang YANG Shuxian JIA Bing BIAN Yingying XIN Yue WU Luyao ZANG Xinshan QU Yanying ZHANG Jinfa WU Man YU Jiwen | 2021 | Journal of Cotton Research2021，4，2： | 0 |
| 11 | Rational design of an AIE-active metal-organic framework for highly sensitive and portable sensing nitroaromatic explosives显示文摘Herein,we report a new metal-organic framework with an AIE ligand (H_(4)TCPP=2,3,5,6-tetra-(4-carboxyphenyl)pyrazine) and Mg^(2+) ions,that is,[Mg_(2)(H_(2)O)_(4)TCPP]·DMF·5CH_(3)CN (Mg-TCPP,TCPP=tetra-(4-carboxyphenyl)pyrazine) for detection of nitroaromatic explosives.Due to the coordination effect and restricted intramolecular rotation,Mg-TCPP exhibits bright blue light.As a fluorescent sensor,Mg-TCPP exhibits high selectivity and sensitivity for sensing 2,4,6-trinitrophenol (TNP) by quenching behaviors with the Stern-Volmer quenching constant (K_(SV)) of 3.63×10^(5)L/mol and achieves the low limit of detection of 25.6 ppb,which is beyond most of the previously reported fluorescent materials.Notably,the portable Mg-TCPP films are prepared and it can be used for rapid and sensitive TNP detection in a variety of environments including organic solvent and aqueous solution.Moreover,TNP vapor can be detected within 3 min by naked eye and the film could be regenerated under simple solvent cleaning. | Luyao Wang Weichao Chen Weilin Song Jingjing Tian Jing Sun Lili Wen Chunyi Sun Xinlong Wang Zhongmin Su Guo-Gang Shan | 2023 | Chinese Chemical Letters2023，34，3： | 0 |
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