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| 1 | Comparison of nonhuman primates identified the suitable model for COVID-19显示文摘Identification of a suitable nonhuman primate(NHP)model of COVID-19 remains challenging.Here,we characterized severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)infection in three NHP species:Old World monkeys Macaca mulatta(M.mulatta)and Macaca fascicularis(M.fascicularis)and New World monkey Callithrix jacchus(C.jacchus).Infected M.mulatta and M.fascicularis showed abnormal chest radiographs,an increased body temperature and a decreased body weight.Viral genomes were detected in swab and blood samples from all animals.Viral load was detected in the pulmonary tissues of M.mulatta and M.fascicularis but not C.jacchus.Furthermore,among the three animal species,M.mulatta showed the strongest response to SARS-CoV-2,including increased inflammatory cytokine expression and pathological changes in the pulmonary tissues.Collectively,these data revealed the different susceptibilities of Old World and New World monkeys to SARS-CoV-2 and identified M.mulatta as the most suitable for modeling COVID-19. | Shuaiyao Lu Yuan Zhao Wenhai Yu Yun Yang Jiahong Gao Junbin Wang Dexuan Kuang Mengli Yang Jing Yang Chunxia Ma Jingwen Xu Xingli Qian Haiyan Li Siwen Zhao Jingmei Li Haixuan Wang Haiting Long Jingxian Zhou Fangyu Luo Kaiyun Ding Daoju Wu Yong Zhang Yinliang Dong Yuqin Liu Yinqiu Zheng Xiaochen Lin Li Jiao Huanying Zheng Qing Dai Qiangming Sun Yunzhang Hu Changwen Ke Hongqi Liu Xiaozhong Peng | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 5 |
| 2 | MiR146a-loaded engineered exosomes released from silk fibroin patch promote diabetic wound healing by targeting IRAK1显示文摘Unhealable diabetic wounds need to be addressed with the help of newer,more efficacious strategies.Exosomes combined with biomaterials for sustained delivery of therapeutic agents are expected to bring new hope for chronic wound treatment.Here,the engineered exosomes modified for efficiently loading miR146a and attaching to silk fibroin patch(SFP)were demonstrated to promote diabetic wound healing.Silk fibroin binding peptide(SFBP)was screened through phage display,and SFBP-Gluc-MS2(SGM)and pac-miR146a-pac fusion protein were constructed.The designed exosomes(SGM-Exos,miR146a-Exos,and SGM-miR146a-Exos)were isolated from the engineered placental mesenchymal stem cells(PMSCs)transduced with SGM or/and pac-miR146a-pac protein.Gluc signals indicated SGM-Exo@SFP markedly increased the binding rate and the stability of SGM-Exo.Moreover,the loading efficiency of miR146a in SGM-miR146a-Exos was ten-fold higher than that in miR146a-Exos.Superior to untreated,SGM-miR146a-Exo-only treated,and SFP-only treated groups,SGM-miR146a-Exo@SFP drived wound healing associated with less inflammation,collagen deposition,and neovascularization.The transcriptomics analysis suggested anti-inflammatory and regenerative effects with SGM-miR146a-Exo@SFP treatment.Here,we show efficient exosome@biomaterial-based miRNA delivery systems for regenerative medicine and tissue engineering. | Qiankun Li Wenzhi Hu Qilin Huang Jie Yang Bingmin Li Kui Ma Qian Wei Yaxi Wang Jianlong Su Mengli Sun Shengnan Cui Rungong Yang Haihong Li Xiaobing Fu Cuiping Zhang | 2023 | Signal Transduction and Targeted Therapy2023，8，3： | 2 |
| 3 | Characterization of microbial diversity and community in water flooding oil reservoirs in China显示文摘 | Lingxia Zhao Ting Ma Mengli Gao Peike Gao Meina Cao Xudong Zhu Guoqiang Li | 2012 | World Journal of Microbiology and Biotechnology2012，，10： | 1 |
| 4 | Effects of Two Step Calcination Process on Reaction Sintering Properties of Cordierite Materials显示文摘Cordierite materials were synthesized using natural mineral materials via the two step calcination process.The phase composition and microstructure of the specimens were analysized by X-ray diffraction( XRD) and scanning electron microscopy( SEM),respectively. The sintering properties of cordierite materials were also characterized. The effect of two step calcination process on the reaction sintering properties of cordierite materials was investigated. The results show that the two step calcination process can significantly increase the reaction sintering properties of the cordierite materials. When the weight ratio of the presynthesized cordierite to the premixed raw mineral materials is 2 1,the cordierite materials obtained by the two step calcination process have the higher bulk density and the lower apparent porosity( 2. 18 g·cm-3and 13. 85%,respectively). Furthermore,the addition of presynthesized cordierite clinker in the process of synthesizing cordierite materials can promote the growth of cordierite crystalline size. | QIN Mengli WANG Xitang WANG Zhoufu MA Yan LIU Hao | 2017 | China's Refractories2017，26，3： | 0 |
| 5 | A Empirical Study on Impact Factors of Employee's Knowledge Capital in Supply Chain: Social NetworkPerspective显示文摘 | Chen Limin Ma Mengli Sun Lixin | 2014 | International Journal of Technology Management2014，，7： | 0 |
| 6 | The olfactory route is a potential way for SARS-CoV-2 to invade the central nervous system of rhesus monkeys显示文摘Neurological manifestations are frequently reported in the COVID-19 patients.Neuromechanism of SARS-CoV-2 remains to be elucidated.In this study,we explored the mechanisms of SARS-CoV-2 neurotropism via our established non-human primate model of COVID-19.In rhesus monkey,SARS-CoV-2 invades the CNS primarily via the olfactory bulb.Thereafter,viruses rapidly spread to functional areas of the central nervous system,such as hippocampus,thalamus,and medulla oblongata.The infection of SARS-CoV-2 induces the inflammation possibly by targeting neurons,microglia,and astrocytes in the CNS.Consistently,SARS-CoV-2 infects neuro-derived SK-N-SH,glial-derived U251,and brain microvascular endothelial cells in vitro.To our knowledge,this is the first experimental evidence of SARS-CoV-2 neuroinvasion in the NHP model,which provides important insights into the CNS-related pathogenesis of SARS-CoV-2. | Li Jiao Yun Yang Wenhai Yu Yuan Zhao Haiting Long Jiahong Gao Kaiyun Ding Chunxia Ma Jingmei Li Siwen Zhao Haixuan Wang Haiyan Li Mengli Yang Jingwen Xu Junbin Wang Jing Yang Dexuan Kuang Fangyu Luo Xingli Qian Longjiang Xu Bin Yin Wei Liu Hongqi Liu Shuaiyao Lu Xiaozhong Peng | 2021 | Signal Transduction and Targeted Therapy2021，6，5： | 0 |
| 7 | Sound management may sequester methane in grazed rangeland ecosystems显示文摘 | Chengjie Wang Guodong Han Shiping Wang Xiajie Zhai Joel Brown Kris M. Havstad Xiuzhi Ma Andreas Wilkes Mengli Zhao Shiming Tang Pei Zhou Yuanyuan Jiang Tingting Lu Zhongwu Wang Zhiguo Li | 2014 | 内蒙古农业大学学报(自然科学版)2014，35，4： | 0 |
| 8 | Heterogeneousα-Diimine Nickel Catalysts with Improved Catalytic Performance in Ethylene Polymerization显示文摘Heterogenization can improve the thermal tolerance of olefin polymerization catalysts and result in good product morphology con-trol,which are two important parameters for industrial polyethylene production.In this work,α-diimine nickel catalysts bearing-OH or-ONa anchoring groups were designed and prepared.The anchoring groups can enable facile heterogenization of the cata-lysts on silica.The heterogeneous catalysts demonstrated enhanced thermal stabilities,along with high catalytic activity at 120℃(up to 5.5×10^(6)g·PE·mol·Ni^(-1)·h^(-1)).Furthermore,the heterogenization process results in the improvements of many other parame-ters,including polymer morphology control,catalytic activity(up to 1.9×10^(7)g·PE·mol·Ni^(-1)·h^(-1))and polyethylene molecular weight(Mn up to 2.3×10^(6)g·mol^(-1)).More importantly,the structure and properties of the polymer products can be controlled by catalyst structures,polymerization conditions and heterogenization to achieve good mechanical properties and elasticity. | Zhanshan Ma Mengli Xu Ningning Zhu Chen Tan Changle Chen | 2023 | Chinese Journal of Chemistry2023，41，10： | 0 |
| 9 | Antifungal Activity of Schinifoline Against Candida Albicans in Caenorhabditis Elegans显示文摘Zanthoxylum schinifolium has been used as spices and traditional medicine in China for hundreds of years.A variety of active substances have been isolated from Zanthoxylum schinifolium using biological and chemical techniques.Among these substances,the effect of schinifoline has gradually attracted much attention.Candida albicans is one of the most common pathogens isolated from the gastrointestinal tract,vagina,and mouth in healthy individuals.In a healthy population,there are various mechanisms in host,such as the microbial flora,the epithelial barriers,and the innate immune system,that can control the presence of Candida albicans.However,when host immunity is compromised,an invasive fungal infection is more likely to occur.In this study,we explored the antifungal activity of schinifoline against Candida albicans in Caenorhabditis elegans.To determine the optimal concentration of schinifoline,we investigated the lifespan,defecation cycle and locomotion behavior of Caenorhabditis elegans after treatment with schinifoline.In addition,we examined colony formation in the intestine of Caenorhabditis elegans after Candida albicans infection.The results indicated that 100 and 200 mg/L of schinifoline could prolonged the lifespan,shorten the defecation cycle and increased the locomotion behavior of Caenorhabditis elegans,with 100 mg/L of schinifoline being the optimal concentration.Moreover,100 mg/L of schinifoline increased the lifespan of Caenorhabditis elegans after infection and inhibited the colony formation of Candida albicans in Caenorhabditis elegans intestine.Therefore,we concluded that schinifoline exhibits anti-fungal effects and its potential use as natural drugs should be further explored in future studies. | Chengjie Shu Mengli Zhang Weiming Zhang Shihong Ma Guoqing Chen Baojun Shi | 2019 | Phyton-International Journal of Experimental Botany2019，88，3： | 0 |
| 10 | Spatial Analysis of Rural Landscape Place Names in Anhui Province Based on GIS显示文摘Based on the village-level place names in Anhui Province,the formation mechanism and distribution characteristics of place names were discussed from the aspects of culture and nature using thematic maps obtained with the combination of kernel density estimation and mathematical statistics in GIS.The results showed that the place names of villages in Anhui Province are closely related to the local cultural landscape and natural landscape,and are the products of thousands of years of continuous exploration and cultural exchanges by local people.It not only reflects the relationship between place names and Anhui natural landform and cultural landscapes,but also combines them from different perspectives,reflecting the complexity and similarities of the formation of place names. | Chunyu LIU Shanlian YANG Mengli ZHENG Youhua MA Qiang WANG | 2019 | Agricultural Biotechnology2019，8，3： | 0 |
| 11 | A facile construction of heterostructured ZnO/Co_(3)O_(4) mesoporous spheres and superior acetone sensing performance显示文摘The rapid development of internet and internet of things brings new opportunities for the expansion of intelligent sensors,and acetone as a major disease detection indicator(i.e.,diabetes)making it become extremely important clinical indicator.Herein,uniform mesoporous ZnO spheres were successfully synthesized via novel formaldehyde-assisted metal-ligand crosslinking strategy.In order to adjust the pore structure of mesoporous ZnO,various mesoporous ZnO spheres were synthesized by changing weight percentage of Zn(NO_(3))_(2)·6 H_(2)O to tannic acid(TA).Moreover,highly active heterojunction mesoporous ZnO/Co_(3)O_(4)has been fabricated based on as-prepared ultra-small Co_(3)O_(4)nanocrystals(ca.3 nm)and mesoporous ZnO spheres by flexible impregnation technique.Profit from nano-size effect and synergistic effect of p-n heterojunction,mesoporous ZnO/Co_(3)O_(4)exhibited excellent acetone sensing performance with high selectivity,superior sensitivity and responsiveness.Typically,5 wt%Co_(3)O_(4)embedded mesoporous ZnO sphere showed prominent acetone response(ca.46 for 50 ppm),which was about 11.5 times higher than that in pure ZnO sensing device,and it was also endowed high cyclic stability.The nanocrystals embedded hybrid material is expected to be used as promising efficient material in the field of catalysis and gas sensing. | Mengli Lei Xinran Zhou Yidong Zou Junhao Ma Fahad AAlharthi Abdulaziz Alghamdi Xuanyu Yang Yonghui Deng | 2021 | Chinese Chemical Letters2021，32，6： | 0 |
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