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| 1 | Elevated plasma levels of selective cytokines in COVID-19 patients reflect viral load and lung injury显示文摘A recent outbreak of pneumonia in Wuhan,China was found to be caused by a 2019 novel coronavirus(2019-nCoV or SARS-CoV-2 or HCoV-19).We previously reported the clinical features of 12 patients with2019-n Co V infections in Shenzhen,China.To further understand the pathogenesis of COVID-19 and find better ways to monitor and treat the disease caused by 2019-n Co V,we measured the levels of 48 cytokines in the blood plasma of those 12 COVID-19 patients.Thirty-eight out of the 48 measured cytokines in the plasma of 2019-n Co V-infected patients were significantly elevated compared to healthy individuals.Seventeen cytokines were linked to 2019-nCoV loads.Fifteen cytokines,namely M-CSF,IL-10,IFN-α2,IL-17,IL-4,IP-10,IL-7,IL-1 ra,G-CSF,IL-12,IFN-γ,IL-1α,IL-2,HGF and PDGF-BB,were strongly associated with the lung-injury Murray score and could be used to predict the disease severity of2019-n Co V infections by calculating the area under the curve of the receiver-operating characteristics.Our results suggest that 2019-nCoV infections trigger extensive changes in a wide array of cytokines,some of which could be potential biomarkers of disease severity of 2019-n Co V infections.These findings will likely improve our understanding of the immunopathologic mechanisms of this emerging disease.Our results also suggest that modulators of cytokine responses may play a therapeutic role in combating the disease once the functions of these elevated cytokines have been characterized. | Yingxia Liu Cong Zhang Fengming Huang Yang Yang Fuxiang Wang Jing Yuan Zheng Zhang Yuhao Qin Xiaoyun Li Dandan Zhao Shunwang Li Shuguang Tan Zhaoqin Wang Jinxiu Li Chenguang Shen Jianming Li Ling Peng Weibo Wu Mengli Cao Li Xing Zhixiang Xu Li Chen Congzhao Zhou William J Liu Lei Liu Chengyu Jiang | 2020 | National Science Review2020，7，6： | 6 |
| 2 | Comparison of nonhuman primates identified the suitable model for COVID-19显示文摘Identification of a suitable nonhuman primate(NHP)model of COVID-19 remains challenging.Here,we characterized severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)infection in three NHP species:Old World monkeys Macaca mulatta(M.mulatta)and Macaca fascicularis(M.fascicularis)and New World monkey Callithrix jacchus(C.jacchus).Infected M.mulatta and M.fascicularis showed abnormal chest radiographs,an increased body temperature and a decreased body weight.Viral genomes were detected in swab and blood samples from all animals.Viral load was detected in the pulmonary tissues of M.mulatta and M.fascicularis but not C.jacchus.Furthermore,among the three animal species,M.mulatta showed the strongest response to SARS-CoV-2,including increased inflammatory cytokine expression and pathological changes in the pulmonary tissues.Collectively,these data revealed the different susceptibilities of Old World and New World monkeys to SARS-CoV-2 and identified M.mulatta as the most suitable for modeling COVID-19. | Shuaiyao Lu Yuan Zhao Wenhai Yu Yun Yang Jiahong Gao Junbin Wang Dexuan Kuang Mengli Yang Jing Yang Chunxia Ma Jingwen Xu Xingli Qian Haiyan Li Siwen Zhao Jingmei Li Haixuan Wang Haiting Long Jingxian Zhou Fangyu Luo Kaiyun Ding Daoju Wu Yong Zhang Yinliang Dong Yuqin Liu Yinqiu Zheng Xiaochen Lin Li Jiao Huanying Zheng Qing Dai Qiangming Sun Yunzhang Hu Changwen Ke Hongqi Liu Xiaozhong Peng | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 5 |
| 3 | Ubiquitin-mediated NFκB degradation pathway显示文摘原子因素 κ B (NFκ B ) 抄写因素在发炎和免疫起关键作用。NFκ 的 dysregulation; B 与煽动性、自体免疫的疾病和癌症被联系。NFκ B 激活被 ubiquitin 依赖的 proteasomal 降级小径否定地调整。在现在的评论,我们在我们理解讨论最近的进展 ubiquitin ligases 调整 NFκ B 降级小径。 | Huimin Xu Mengli You Haifeng Shi Yongzhong Hou | 2015 | Cellular & Molecular Immunology2015，12，6： | 2 |
| 4 | A chromosome-scale genome assembly of Dasypyrum villosum provides insights into its application as a broad-spectrum disease resistance resource for wheat improvement显示文摘Dasypyrum villosum is one of the most valuable gene resources in wheat improvement,especially for disease resistance.The mining of favorable genes from D.villosum is frustrated by the lack of a whole genome sequence.In this study,we generated a doubled-haploid line,91C43^(DH),using microspore culture and obtained a 4.05-GB high-quality,chromosome-scale genome assembly for D.villosum.The assembly contains39727 high-confidence genes,and 85.31% of the sequences are repetitive.Two reciprocal translocation events were detected,and 7VS-4VL is a unique translocation in D.villosum.The prolamin seed storage protein-coding genes were found to be duplicated;in particular,the genes encoding low-molecular-weight glutenin at the Glu-V3 locus were significantly expanded.RNA sequencing(RNA-seq)analysis indicated that,after Blumeria graminearum f.sp tritici(Bgt)inoculation,there were more upregulated genes involved in the pattern-triggered immunity and effector-triggered immunity defense pathways in D.villosum than in Triticum urartu.MNase hypersensitive sequencing(MH-seq)identified two Bgt-inducible MH sites(MHSs),one in the promoter and one in the 3'terminal region of the powdery mildew resistance(Pm)gene NLR1-V.Each site had two subpeaks and they were termed MHS1(MHS1.1/1.2)and MHS2(MHS2.1/2.2).Bgt-inducible MHS2.2 was uniquely present in D.villosum,and MHS1.1 was more inducible in D.villosum than in wheat,suggesting that MHSs may be critical for regulation of NLR1-V expression and plant defense.In summary,this study provides a valuable genome resource for functional genomics studies and wheat-D.villosum introgression breeding.The identified regulatory mechanisms may also be exploited to develop new strategies for enhancing Pm resistance by optimizing gene expression in wheat. | Xu Zhang Haiyan Wang Haojie Sun Yingbo Li Yilong Feng Chengzhi Jiao Mengli Li Xinying Song Tong Wang Zongkuan Wang Chunxia Yuan Li Sun Ruju Lu Wenli Zhang Jin Xiao Xiue Wang | 2023 | Molecular Plant2023，16，2： | 1 |
| 5 | Asymmetric non-Gaussian effects in a tumor growth model with immunization显示文摘 | Mengli Hao Jinqiao Duan Renming Song Wei Xu | 2014 | Applied Mathematical Modelling2014，，： | 1 |
| 6 | Efficient Catalytic Conversion of Polysulfides by Biomimetic Design of “Branch‑Leaf” Electrode for High‑Energy Sodium–Sulfur Batteries显示文摘Rechargeable room temperature sodium–sulfur(RT Na–S)batteries are seriously limited by low sulfur utilization and sluggish electrochemical reaction activity of polysulfide intermediates.Herein,a 3D“branch-leaf”biomimetic design proposed for high performance Na–S batteries,where the leaves constructed from Co nanoparticles on carbon nanofibers(CNF)are fully to expose the active sites of Co.The CNF network acts as conductive“branches”to ensure adequate electron and electrolyte supply for the Co leaves.As an effective electrocatalytic battery system,the 3D“branch-leaf”conductive network with abundant active sites and voids can effectively trap polysulfides and provide plentiful electron/ions pathways for electrochemical reaction.DFT calculation reveals that the Co nanoparticles can induce the formation of a unique Co–S–Na molecular layer on the Co surface,which can enable a fast reduction reaction of the polysulfides.Therefore,the prepared“branch-leaf”CNF-L@Co/S electrode exhibits a high initial specific capacity of 1201 mAh g^−1 at 0.1 C and superior rate performance. | Wenyan Du Kangqi Shen Yuruo Qi Wei Gao Mengli Tao Guangyuan Du Shu‑juan Bao Mingyang Chen Yuming Chen Maowen Xu | 2021 | Nano-Micro Letters2021，13，3： | 1 |
| 7 | A“Catalyst+Support”Strategy for Salicylaldimine Nickel Catalyzed Ethylene Polymerization and Copolymerization with Polar Monomers显示文摘Polyolefins,as one of the most productive synthetic polymer materials,have been widely used in industry and daily life[1-2].However,due to their'non-polar'nature,polyolefins have poor compatibility and adhesion to polar materials,limiting their application in many fields[3-5]. | WANG Zihao YANG Lei XU Mengli TAN Chen CHEN Changle | 2023 | Chemical Research in Chinese Universities2023，39，5： | 0 |
| 8 | The olfactory route is a potential way for SARS-CoV-2 to invade the central nervous system of rhesus monkeys显示文摘Neurological manifestations are frequently reported in the COVID-19 patients.Neuromechanism of SARS-CoV-2 remains to be elucidated.In this study,we explored the mechanisms of SARS-CoV-2 neurotropism via our established non-human primate model of COVID-19.In rhesus monkey,SARS-CoV-2 invades the CNS primarily via the olfactory bulb.Thereafter,viruses rapidly spread to functional areas of the central nervous system,such as hippocampus,thalamus,and medulla oblongata.The infection of SARS-CoV-2 induces the inflammation possibly by targeting neurons,microglia,and astrocytes in the CNS.Consistently,SARS-CoV-2 infects neuro-derived SK-N-SH,glial-derived U251,and brain microvascular endothelial cells in vitro.To our knowledge,this is the first experimental evidence of SARS-CoV-2 neuroinvasion in the NHP model,which provides important insights into the CNS-related pathogenesis of SARS-CoV-2. | Li Jiao Yun Yang Wenhai Yu Yuan Zhao Haiting Long Jiahong Gao Kaiyun Ding Chunxia Ma Jingmei Li Siwen Zhao Haixuan Wang Haiyan Li Mengli Yang Jingwen Xu Junbin Wang Jing Yang Dexuan Kuang Fangyu Luo Xingli Qian Longjiang Xu Bin Yin Wei Liu Hongqi Liu Shuaiyao Lu Xiaozhong Peng | 2021 | Signal Transduction and Targeted Therapy2021，6，5： | 0 |
| 9 | Dynamical analysis of an SDOF quasi‐linear system with jump noises and multitime‐delayed feedback forces显示文摘In this paper,stochastic dynamics of a single degree‐of‐freedom quasi‐linear system with multitime delays and Poisson white noises are investigated using an approximate procedure based on the stochastic averaging method.The simplified equations,including the averaged stochastic differential equation and the averaged generalized Fokker–Planck–Kolmogorov equation,are obtained to calculate the probability density functions(PDFs)to explore stationary responses.The expression of the Lyapunov exponent is presented to examine the asymptotic stochastic Lyapunov stability.An illustrative example of a quasi‐linear oscillator with two Poisson white noises controlled by two time‐delayed feedback forces is worked out to demonstrate the validity of the proposed method.The approximate stationary PDFs of stochastic responses and asymptotic stochastic stability are demonstrated numerically and theoretically.The results show that the Gaussian white noise has a stronger influence on the dynamics than the Poisson white noise with a small mean arrival rate.Moreover,the influence of the time delay and noise parameters on stochastic dynamics is investigated.It is found that the PDFs under the Poisson white noise approach those under Gaussian white noise as the mean arrival rate increases.The time delay can induce stochastic P‐bifurcation of the system.It is also found that the increase of time delay and the mean arrival rates of the Poisson white noises will broaden the unstable parameter region.The comparison between numerical and theoretical results shows the effectiveness of the proposed method. | Wantao Jia Mingxia Luo Mengli Hao Yong Xu | 2022 | International Journal of Mechanical System Dynamics2022，2，2： | 0 |
| 10 | Heterogeneousα-Diimine Nickel Catalysts with Improved Catalytic Performance in Ethylene Polymerization显示文摘Heterogenization can improve the thermal tolerance of olefin polymerization catalysts and result in good product morphology con-trol,which are two important parameters for industrial polyethylene production.In this work,α-diimine nickel catalysts bearing-OH or-ONa anchoring groups were designed and prepared.The anchoring groups can enable facile heterogenization of the cata-lysts on silica.The heterogeneous catalysts demonstrated enhanced thermal stabilities,along with high catalytic activity at 120℃(up to 5.5×10^(6)g·PE·mol·Ni^(-1)·h^(-1)).Furthermore,the heterogenization process results in the improvements of many other parame-ters,including polymer morphology control,catalytic activity(up to 1.9×10^(7)g·PE·mol·Ni^(-1)·h^(-1))and polyethylene molecular weight(Mn up to 2.3×10^(6)g·mol^(-1)).More importantly,the structure and properties of the polymer products can be controlled by catalyst structures,polymerization conditions and heterogenization to achieve good mechanical properties and elasticity. | Zhanshan Ma Mengli Xu Ningning Zhu Chen Tan Changle Chen | 2023 | Chinese Journal of Chemistry2023，41，10： | 0 |
| 11 | 下肢单纯疱疹伴复发性多形红斑一例显示文摘患者女,28岁,双下肢反复出现红斑、水疱2年。2年前,患者多次出现双下肢红斑、水疱伴疼痛(约20次),右臀部群集性小水疱伴瘙痒(约24次),臀部皮损于劳累后或月经期出现。在过去1年半中,患者曾6次出现舌、颊黏膜糜烂。就诊前1个月,患者左臀新发红色丘疹,上覆少许鳞屑,边界不清。过去2年病程中,患者上肢、躯干偶见散在红斑、水疱。 | Min Zhang Mengli Zhang Mei Ju Haoxiang Xu 张敏(译) 徐浩翔(校) | 2022 | 英国医学杂志中文版2022，25，3： | 0 |
| 12 | Distributed optimization based on improved push-sum framework for optimization problem with multiple local constraints and its application in smart grid显示文摘In this paper,the optimization problem subject to N nonidentical closed convex set constraints is studied.The aim is to design a corresponding distributed optimization algorithm over the fixed unbalanced graph to solve the considered problem.To this end,with the push-sum framework improved,the distributed optimization algorithm is newly designed,and its strict convergence analysis is given under the assumption that the involved graph is strongly connected.Finally,simulation results support the good performance of the proposed algorithm. | Qian XU Chutian YU Xiang YUAN Mengli WEI Hongzhe LIU | 2023 | Frontiers of Information Technology & Electronic Engineering2023，24，9： | 0 |
| 13 | Three-dimensional structure of liver vessels and spatial distribution of hepatic immune cells显示文摘As the largest internal organ of the human body,the liver has an extremely complex vascularnetwork and multiple types of immune cells.It plays an important role in blood circulation,material metabolism,and immune response.Optical imaging is an effective tool for studying finevascular structure and immunocyte distribution of the liver.Here,we provide an overview of thestructure and composition of liver vessels,the threedimensional(3D)imaging of the liver,andthe spatial distribution and immune function of various cell components of the liver.Especially,we emphasize the 3D imaging methods for visualizing fine structure in the liver.Finally,wesummarize and prospect the development of 3D imaging of liver vesels and immune cells. | Mengli Xu Zheng Liu Xinlin Li Xinru Wang Xuenan Yuan Chenlu Han Zhihong Zhang | 2023 | Journal of Innovative Optical Health Sciences2023，16，3： | 0 |
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