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| 1 | Natural history of cytomegalovirus infection in a series of patients diagnosed with moderate-severe ulcerative colitis显示文摘AIM:To evaluate the natural history of human cytomegalovirus(HCMV) infection in a series of 28 ulcerative colitis patients in whom the search for HCMV was positive.METHODS:A series of 85 patients with moderate-severe ulcerative colitis flare-up were evaluated for a HCMV search by performing a haematoxylin and eosin stain,immunohistochemical assay and nested polymerase chain reaction on rectal biopsies.Among 85 screened patients(19 of whom were steroid resistant/dependant),28 were positive for HCMV;after remission the patients were followed up clinically and histologically.RESULTS:Among the 22 patients with complete followup,in 8(36%) patients HCMV-DNA persisted in the intestinal specimens.Among the HCMV positive patients,4(50%) experienced at least one moderate-severe flare-up of colitis without evidence of peripheral HCMV.Among the 14 HCMV negative patients,3 with pouches developed pouchitis and 5 out of 11(45%) experienced a colitis flare-up.CONCLUSION:Our preliminary results suggest that HCMV may remain in the colon after an acute colitis flareup despite remission;it seems that the virus is not responsible for the disease relapse. | Valeria Criscuoli Maria Rosa Rizzuto Luigi Montalbano Elena Gallo Mario Cottone | 2011 | World Journal of Gastroenterology2011，17，5： | 20 |
| 2 | Percutaneous electrochemotherapy in the treatment of portal vein tumor thrombosis at hepatic hilum in patients with hepatocellular carcinoma in cirrhosis: A feasibility study显示文摘AIM To treated with electrochemotherapy(ECT) a prospective case series of patients with liver cirrhosis and Vp3-Vp4- portal vein tumor thrombus(PVTT) from hepatocellular carcinoma(HCC), in order to evaluate the feasibility, safety and efficacy of this new non thermal ablative technique in those patients. METHODS Six patients(5 males and 1 female), aged 61-85 years(mean age, 70 years), four in Child-Pugh A and two in Child-Pugh B class, entered our study series. All patients were studied with three-phase computed tomography(CT), contrast enhanced ultrasound(CEUS) and ultrasound-guided percutaneous biopsy of the thrombus before ECT. All patients underwent ECT treatment(Cliniporator Vitae?, IGEA Sp A, Carpi, Modena, Italy) of Vp3-Vp4 PVTT in a single session. At the end of the procedure a post-treatment biopsy of the thrombus was performed. Scheduled follow-up in all patients entailed: CEUS within 24 h after treatment; triphasic contrastenhanced CT and CEUS at 3 mo after treatment and every six months thereafter.RESULTS Post-treatment CEUS showed complete absence of enhancement of the treated thrombus in all cases. Post-treatment biopsy showed apoptosis and necrosis of tumor cells in all cases. The follow-up ranged from 9 to 20 mo(median, 14 mo). In 2 patients, the followup CT and CEUS demonstrated complete patency of the treated portal vein. Other 3 patients showed a persistent avascular non-tumoral shrinked thrombus at CEUS and CT during follow-up. No local recurrence was observed at follow-up CT and CEUS in 5/6 patients. One patient was lost to follow-up because of death from gastrointestinal hemorrage 5 wk after ECT. CONCLUSION In patients with cirrhosis, ECT seems effective and safe for curative treatment of Vp3-Vp4 PVTT from HCC. | Luciano Tarantino Giuseppina Busto Aurelio Nasto Raffaele Fristachi Luigi Cacace Maria Talamo Catello Accardo Sara Bortone Paolo Gallo Paolo Tarantino Riccardo Aurelio Nasto Matteo Nicola Dario Di Minno Pasquale Ambrosino | 2017 | World Journal of Gastroenterology2017，23，5： | 7 |
| 3 | Update on the treatment of focal segmental glomerulosclerosis in renal transplantation显示文摘Focal segmental glomerulosclerosis(FSGS) represents one of the most severe glomerular diseases, with frequent progression to end-stage renal disease and a high rate of recurrence in renal allografts(30%-50%). Recurrent FSGS portends a negative outcome, with the hazard ratio of graft failure being two-fold higher then that of other glomerulonephritis. Two patterns of clinical presentations are observed: Early recurrence, which is characterized by massive proteinuria within hours to days after implantation of the renal graft, and late recurrence, which occurs several months or years after the transplantation. Many clinical conditions have been recognized as risk factors for recurrence, including younger age, rapid progression of the disease to end-stage renal disease on native kidneys, and loss of previous renal allografts due to recurrence. However, much less is known about the incidence and risk factors of the so-called 'de novo ' type of FSGS, for which sufferers are transplanted patients without disease on native kidneys; but, rapid development of allograft failure is frequently observed. Management of both forms is challenging, and none of the approaches proposed to date have been demonstrated as consistently beneficial or effective. In the present review we report an update on the available therapeutic strategies for FSGS in renal transplantation within the context of a critical overview of the current literature. | Maria Messina Ester Gallo Alberto Mella Fabiola Pagani Luigi Biancone | 2016 | World Journal of Transplantation2016，6，1： | 5 |
| 4 | Is human hepatocellular carcinoma a hormone-responsive tumor?显示文摘Before the positive results recently obtained with multitarget tyrosine kinase inhibitor sorafenib,there was no standard systemic treatment for patients with advanced hepatocellular carcinoma(HCC).Sex hormones receptors are expressed in a significant proportion of HCC samples.Following preclinical and epidemiological studies supporting a relationship between sex hormones and HCC tumorigenesis,several randomized controlled trials (RCTs)tested the efficacy of the anti-estrogen tamoxifen as systemic treatment.Largest among these trials showed no survival advantage from the administration of tamoxifen,and the recent Cochrane systematic review produced a completely negative result.This questions the relevance of estrogen receptor-mediated pathways in HCC.However,a possible explanation for these disappointing results is the lack of proper patients selection according to sex hormones receptors expression,but unfortunately the interaction between this expression and efficacy of tamoxifen has not been studied adequately.It has been also proposed that negative results might be explained if tamoxifen acts in HCC via an estrogen receptor-independent pathway,that requires higher doses than those usually administered, but an Asian RCT conducted to assess dose-response effect was completely negative.Interesting,preliminaryresults have been obtained when hormonal treatment (tamoxifen or megestrol)has been selected according to the presence of wild-type or variant estrogen receptors respectively,but no large RCTs are available to support this strategy.Negative results have been obtained also with anti-androgen therapy.In conclusion,there is no robust evidence to consider HCC a hormone-responsive tumor.Hormonal treatments should not be part of the current management of HCC. | Massimo Di Maio Bruno Daniele Sandro Pignata Ciro Gallo Ermelinda De Maio Alessandro Morabito Maria Carmela Piccirillo Francesco Perrone | 2008 | World Journal of Gastroenterology2008，14，11： | 2 |
| 5 | Mesenchymal stromal cell secretome in liver failure:Perspectives on COVID-19 infection treatment显示文摘Due to their immunomodulatory potential and release of trophic factors that promote healing,mesenchymal stromal cells(MSCs)are considered important players in tissue homeostasis and regeneration.MSCs have been widely used in clinical trials to treat multiple conditions associated with inflammation and tissue damage.Recent evidence suggests that most of the MSC therapeutic effects are derived from their secretome,including the extracellular vesicles,representing a promising approach in regenerative medicine application to treat organ failure as a result of inflammation/fibrosis.The recent outbreak of respiratory syndrome coronavirus,caused by the newly identified agent severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),has forced scientists worldwide to use all available instruments to fight the infection,including the inflammatory cascade caused by this pandemic disease.The use of MSCs is a valid approach to combat organ inflammation in different compartments.In addition to the lungs,which are considered the main inflammatory target for this virus,other organs are compromised by the infection.In particular,the liver is involved in the inflammatory response to SARS-CoV-2 infection,which causes organ failure,leading to death in coronavirus disease 2019(COVID-19)patients.We herein summarize the current implications derived from the use of MSCs and their soluble derivatives in COVID-19 treatment,and emphasize the potential of MSCbased therapy in this clinical setting. | Cinzia Maria Chinnici Giovanna Russelli Matteo Bulati Vitale Miceli Alessia Gallo Rosalia Busà Rosaria Tinnirello Pier Giulio Conaldi Gioacchin Iannolo | 2021 | World Journal of Gastroenterology2021，27，17： | 1 |
| 6 | Generation of high titer antisera in rabbits by DNA immunization显示文摘 | Partha S Chowdhury Maria Gallo | 2001 | J Immunol Methods2001，249，12： | 1 |
| 7 | The expression ratios of estrogen receptor α (ERα) to estrogen receptor β1 (ERβ1) and ERα to ERβ2 identify poor clinical outcome in endometrioid endometrial cancer显示文摘 | Gian Franco Zannoni Giorgia Monterossi Ilaria De Stefano Antonio Gargini Maria Giovanna Salerno Ilaria Farulla Daniele Travaglia Valerio Gaetano Vellone Giovanni Scambia Daniela Gallo | 2013 | Human Pathology2013，，6： | 1 |
| 8 | ME-PCR for the identification of mutated K-ras in serum and bile of pancreatic cancer patients: an unsatisfactory technique for clinical applications显示文摘 | Carlo-Federico Zambon Filippo Navaglia Daniela Basso Nicoletta Gallo Eliana Greco Maria Grazia Piva Paola Fogar Claudio Pasquali Sergio Pedrazzoli Mario Plebani | 2000 | Clinica Chimica Acta2000，，1： | 1 |
| 9 | Bacterial Vaginosis, Gonorrhea, and Chlamydial Infection Among Women Attending a Sexually Transmitted Disease Clinic: A Longitudinal Analysis of Possible Causal Links显示文摘 | Maria F. Gallo Maurizio Macaluso Lee Warner Michael E. Fleenor Edward W. Hook Ilene Brill Mark A. Weaver | 2012 | Annals of Epidemiology2012，，3： | 1 |
| 10 | Remote ischemic postconditioning as a strategy to reduce acute kidney injury during primary PCI: A post-hoc analysis of a randomized trial显示文摘 | Gabriele Crimi Marco Ferlini Fabio Gallo Maria Pia Sormani Claudia Raineri Ezio Bramucci Gaetano M. De Ferrari Silvia Pica Barbara Marinoni Alessandra Repetto Arturo Raisaro Sergio Leonardi Paolo Rubartelli Luigi Oltrona Visconti Maurizio Ferrario | 2014 | International Journal of Cardiology2014，，： | 1 |
| 11 | Analysis of transgene integration and expression following biolistic transfer of different quantities of minimal expression cassette into sugarcane ( Saccharum spp. hybrids)显示文摘 | Jae Yoon Kim Maria Gallo Fredy Altpeter | 2012 | Plant Cell Tissue and Organ Culture (PCTOC)2012，，2： | 1 |
| 12 | VHL-Regulated MiR-204 Suppresses Tumor Growth through Inhibition of LC3B-Mediated Autophagy in Renal Clear Cell Carcinoma显示文摘 | Olga Mikhaylova Yiwen Stratton Daniel Hall Emily Kellner Birgit Ehmer Angela F. Drew Catherine A. Gallo David R. Plas Jacek Biesiada Jarek Meller Maria F. Czyzyk-Krzeska | 2012 | Cancer Cell2012，，4： | 1 |
| 13 | Stress urinary incontinence: usefulness of perineal ultrasound显示文摘 | Marco Torella Pasquale Franciscis Claudia Russo Pasquale Gallo Antonio Grimaldi Domenico Ambrosio Nicola Colacurci Maria Teresa Schettino | 2014 | La radiologia medica2014，，3： | 1 |
| 14 | Catestatin Improves Post-Ischemic Left Ventricular Function and Decreases Ischemia/Reperfusion Injury in Heart显示文摘 | Claudia Penna Giuseppe Alloatti Maria Pia Gallo Maria Carmela Cerra Renzo Levi Francesca Tullio Eleonora Bassino Serena Dolgetta Sushil K. Mahata Bruno Tota Pasquale Pagliaro | | 0，2010，： | 1 |
| 15 | Carboplatin plus paclitaxel once a week versus every 3 weeks in patients with advanced ovarian cancer (MITO-7): a randomised, multicentre, open-label, phase 3 trial显示文摘 | Sandro Pignata Giovanni Scambia Dionyssios Katsaros Ciro Gallo Eric Pujade-Lauraine Sabino De Placido Alessandra Bologna Beatrice Weber Francesco Raspagliesi Pierluigi Benedetti Panici Gennaro Cormio Roberto Sorio Maria Giovanna Cavazzini Gabriella Ferran | 2014 | Lancet Oncology2014，，： | 1 |
| 16 | Mutational Analysis Identifies Residues Crucial for Homodimerization of Myeloid Differentiation Factor 88 (MyD88) and for Its Function in Immune Cells显示文摘 | Maria Loiarro Elisabetta Volpe Vito Ruggiero Grazia Gallo Roberto Furlan Chiara Maiorino Luca Battistini Claudio Sette | 2013 | Journal of Biological Chemistry2013，，42： | 1 |
| 17 | Contemporary techniques and outcomes of surgery for locally advanced renal cell carcinoma with focus on inferior vena cava thrombectomy:The value of a multidisciplinary team显示文摘Objective:To report the outcomes of surgery for a contemporary series of patients with locally advanced non-metastatic renal cell carcinoma(RCC)treated at a referral academic centre,focusing on technical nuances and on the value of a multidisciplinary team.Methods:We queried our prospective institutional database to identify patients undergoing surgical treatment for locally advanced(cT3-T4 N0-1 M0)renal masses suspected of RCC at our centre between January 2017 and December 2020.Results:Overall,32 patients were included in the analytic cohort.Of these,12(37.5%)tumours were staged as cT3a,8(25.0%)as cT3b,5(15.6%)as cT3c,and 7(21.9%)as cT4;6(18.8%)patients had preoperative evidence of lymph node involvement.Nine(28.1%)patients underwent nephron-sparing surgery while 23(71.9%)received radical nephrectomy.A template-based lymphadenectomy was performed in 12 cases,with evidence of disease in 3(25.0%)at definitive histopathological analysis.Four cases of RCC with level IV inferior vena cava thrombosis were successfully treated using liver transplant techniques without the need for extracorporeal circulation.While intraoperative complications were recorded in 3(9.4%)patients,no postoperative major complications(Clavien-Dindo3)were observed.At histopathological analysis,2(6.2%)patients who underwent partial nephrectomy harboured oncocytoma,while the most common malignant histotype was clear cell RCC(62.5%),with a median Leibovich score of 6(interquartile range 5e7).Conclusion:Locally advanced RCC is a complex and heterogenous disease posing several challenges to surgical teams.Our experience confirms that provided careful patient selection,surgery in experienced hands can achieve favourable perioperative,oncological,and functional outcomes. | Riccardo Campi Paolo Barzaghi Alessio Pecoraro Maria Lucia Gallo Damiano Stracci Alberto Mariotti Saverio Giancane Simone Agostini Vincenzo Li Marzi Arcangelo Sebastianelli Pietro Spatafora Mauro Gacci Graziano Vignolini Francesco Sessa Paolo Muiesan Sergio Serni | 2022 | Asian Journal of Urology2022，9，3： | 1 |
| 18 | Psychological Stress and Recurrent Aphthous Stomatitis 显示文摘 | Camila de Barros Gallo Maria Angela Martins Mimura Norberto Nobuo Sugaya | 2009 | Oral Pathol Med2009，38，10： | 1 |
| 19 | The effect of auxin type and cytokinin concentration on callus induction and plant regeneration frequency from immature inflorescence segments of seashore paspalum (Paspalum vaginatum Swartz)显示文摘 | Isaac Neibaur Maria Gallo Fredy Altpeter | 2008 | In Vitro Cellular & Developmental Biology - Plant2008，，6： | 1 |
| 20 | Comparison of the compositional, microbiological, biochemical and volatile profile characteristics of three Italian PDO fermented sausages显示文摘 | Raffaella Di Cagno Clemencia Chaves Lòpez Rosanna Tofalo Giovanna Gallo Maria De Angelis Antonello Paparella Walter P. Hammes Marco Gobbetti | 2007 | Meat Science2007，，2： | 1 |
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