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| 1 | Mortality and Morbidity of Extremely Low Birth Weight Infants in the Mainland of China: A Multi-center Study显示文摘 | Hui-Jia Lin Li-Zhong Du Xiao-Lu Ma Li-Ping Shi Jia-Hua Pan Xiao-Mei Tong Qiu-Ping Li Jian-Guo Zhou Bing Yi Ling Liu Yun-Bing Chen Qiu-Fen Wei Hui-Qing Wu Mei Li Cui-Qing Li Xi-Rong Gao Shi-Wen Xia Wen-Bin Li Chao-Ying Ya Ling He Kun Liang Xiao-Yu Zhou Shu-Ping Han Qin Lyu Yin-Ping Qiu Wen Li Dong-Mei Chen Hong-Ru Lu Xiao-Hong Liu Hong Liu Zhen-Lang Lin Li Liu Jia-Jun Zhu Hong Xiong Shao-Jie Yue Si-Qi Zhuang | 2015 | Chinese Medical Journal2015，，20： | 49 |
| 2 | Constraints of (U-Th)/He ages on early Paleozoic tectonothermal evolution of the Tarim Basin,China显示文摘The thermal evolution of source rocks in the Paleozoic stratigraphic sequences has been an outstanding problem for petroleum exploration in the Tarim Basin, as the thermal history of the Paleozoic could not be reconstructed objectively due to the lack of effective thermal indicators in the early Paleozoic carbonate successions. The (U-Th)/He thermochronometry of apatite and zircon has recently been used as an effective tool to study the structural uplift and thermal history of sedimentary basins. The Paleozoic tectonothermal histories of two typical wells in the Tarim Basin were modeled using the thermal indicators of (U-Th)/He, apatite fission track (AFT), and vitrinite reflectance (Ro) data in this paper. The Paleozoic strata in the two wells were shallow due to persistent uplift and significant erosion during the Hercynian tectonic events (from Devonian to Triassic). Therefore, the paleothermal indicators in the Paleozoic strata may retain the original thermal evolution and can be used to re- construct the Paleozoic thermal history of the Tarim Basin. The apatite and zircon helium ages from core and cuttings samples were analyzed and the Paleozoic thermal histories of wells KQ1 and T1 were modeled by combining helium ages, AFT, and equivalence vitrinite reflectance (VRo) data. The modeling results show that the geothermal gradient evolution is different in the Kongquehe Slop and Bachu Uplift of Tarim Basin during the Paleozoic. The thermal gradient in Well T1 on the Bachu Up- lift was only 28–30°C/km in Cambrian, and it increased to 30–33°C/km in Ordovician and 31–34°C/km during the Silurian and Devonian. The thermal gradient of Ordovician in Well KQ1 on the Kongquehe Slope was 35°C/km and decreased to 32–35°C/km during the Silurian and Devonian. Therefore, the combined use of (U-Th)/He ages and other thermal indicators appears to be useful in reconstructing the basin thermal history and provides new insight into the understanding of the early Paleozoic thermal history of the Tarim Basin. | QIU NanSheng WANG JiYang MEI QingHua JIANG Guang TAO Cheng | 2010 | Science China Earth Sciences2010，53，7： | 22 |
| 3 | Resistin induces insulin resistance, but does not affect glucose output in rat-derived hepatocytes显示文摘目的: 现在的学习的目的是观察效果抵抗在在在导出老鼠的 hepatocytes.Methods 的胰岛素敏感度和葡萄糖输出上: 老鼠肝细胞瘤房间线 H4IIE 与有教养、刺激抵抗在; supernant 葡萄糖和肝糖内容被检测。胰岛素受体底层(红外)-1 和 IRS-2,蛋白质激酶 B/Akt,肝糖 synthase kinase-3 (3 (GSK-3p ) , suppress 或表明 3 的 cytokine (SOCS-3 ) ,蛋白质内容,以及磷酸化地位被西方的弄污估计。对 SOCS-3 指导的特定的反感觉 oligodeoxynucleotides 习惯于击倒的 SOCS-3.Results :抵抗素导致了抗胰岛素性,但是在老鼠肝细胞瘤房间的affect 葡萄糖输出没衬里 H4IIE.Resistin 胰岛素的稀释多重效果包括刺激胰岛素的肝糖合成和红外的磷酸化,蛋白质激酶 B/Akt ,象 GSK-3beta.Resistin 一样,处理显著地导致了基因和 SOCS-3 的蛋白质表示,胰岛素发信号的一个已知的禁止者。而且,对 SOCS-3 处理指导的特定的反感觉 oligodeoxynucleotide 阻止了抵抗在从反对胰岛素 action.Conclusion : 主要功能抵抗在在肝上是导致胰岛素 resistance.SOCS-3 感应的可以贡献胰岛素在 H4HE hepatocytes 发信号的调停 resistin 的抑制。 | Feng LIU Tao YANG Bin WANG Min ZHANG Nan GU Jie QIU Hong-qi FAN Chun-mei ZHANG Li FEI Xiao- qing PAN Mei GUO Rong-hua CHEN Xi-rong GUO | 2008 | Acta Pharmacologica Sinica2008，29，1： | 21 |
| 4 | Effects of four regulating-intestine prescriptions on pathology and ultrastructure of colon tissue in rats with ulcerative colitis显示文摘AIM: To observe different histomorphologic changes of ulcerative colitis (UC) rats that were treated with four regulating-intestine prescriptions (FRIP), to investigate the curative effects of FRIP and to analyze their treatment mechanism.METHODS: The UC rat model was made by the method of 2,4-dinitro chloro benzene (DNCB) immunity and acetic acid local enema. Ninety-eight SD rats were randomly divided into seven groups, namely, the normal control group, model group, salicylazosulfapyridine (SASP) group,Wumeiwan (WMW) group, Baitouwengtang (BTWT) group,Senglingbaishusan (SLBSS) group, and Tongxieyaofang (TXYF) group. Each group had 14 rats (with equal ratio of male and female). The six animal model groups of UC-SASP, TXYF, WMW, BTWT, SLBSS, TXYF-were treated by distilled water except the normal control group. Changes of the rat's general conditions after treatment were respectively observed, the colon tissue damage scores were given out, the pathology of colonic mucosa and changes of ultrastructure were analyzed.RESULTS: Different pathological changes on histology were shown after treatment by FRIP. The colon tissue damage score in model group was higher than that of FRIP groups and SASP group (q = 4.59, 4.77, P<0.05 or q = 5.48,6.25, 5.97, P<0.01). The scores of WMW group, BTWT group and SLBSS group were lower than that of SASP (q = 4.13, P<0.05 or q = 5.31, 5.12, P<0.01). There was no remarkable difference between the damage score of TXYF group and SASP group (q = 3.75, P>0.05). In addition, some apoptosis cells were found in the pathologic control group.CONCLUSION: The model made with DNCB and acetic acid was successful, and FRIP had better curative effect and WMW was the best curative effect, BTW, SLBSS and TXYF were similar to SASP, and we discovered that apoptosis was possibly related to UC. | Heng Fan Ming-Yi Qiu Jia-Jun Mei Guan-Xin Shen Song-Lin Liu Rui Chen | 2005 | World Journal of Gastroenterology2005，11，31： | 19 |
| 5 | Celecoxib induces apoptosis and cell-cycle arrest in nasopharyngeal carcinoma cell lines via inhibition of STAT3 phosphorylation显示文摘瞄准: 调查在鼻咽的癌(NPC ) 上位于 celecoxib 的 anticancer 效果下面的机制。 | Dong-bo LIU Guang-yuan HU Guo-xian LONG Hong QIU Qi MEI Guo-qing HU | 2012 | Acta Pharmacologica Sinica2012，33，5： | 16 |
| 6 | Relationship between Fas/ FasL expression and apoptosis of colon adenocarcinoma cell lines显示文摘INTRODUCTIONFas/ FasL system has been identified as a keymediator of apoptosis in tumor cells[1-4]. Theoccurrence and development of neoplasm are closelyrelated to apoptosis[5-7] Most chemotherapeuticdrugs kill cancer cells mainly by inducingapoptosis[8-14].' | Zhi Hai Peng Tong Hai Xing Guo Qiang Qiu Hua Mei Tang Shanghai No. 1 People’s Hospital, Shanghai 200080, China | 2001 | World Journal of Gastroenterology2001，7，1： | 15 |
| 7 | Human placenta-derived mesenchymal stem cells loaded on linear ordered collagen scaffold improves functional recovery after completely transected spinal cord injury in canine显示文摘Traumatic spinal cord injury(SCI) is a major challenge in the clinic. In this study, we sought to examine the synergistic effects of linear ordered collagen scaffold(LOCS) and human placenta-derived mesenchymal stem cells(hPMSCs) when transplanted into completely transected beagle dogs. After 36 weeks observation, we found that LOCS+hPMSCs implants promoted better hindlimb locomotor recovery than was observed in the non-treatment(control) group and LOCS group. Histological analysis showed that the regenerated tissue after treatment was well integrated with the host tissue, and dramatically reduced the volume of cystic and chondroitin sulfate proteoglycans(CSPGs) expression. Furthermore, the LOCS+hPMSCs group also showed more neuron-specific βIII-tubulin(Tuj-1)-and NeuN-positive neurons in the lesion area, as well as axonal regeneration, remyelination and synapse formation in the lesion site. Additionally, dogs in the LOCS+hPMSCs group experienced enhanced sprouting of both ascending(CGRP-positive) sensory fibers and descending(5-HT-and TH-positive) motor fibers at the lesion area. All these data together suggested that the combined treatment had beneficial effects on neuronal regeneration and functional improvement in a canine complete transection model. Therefore, LOCS+hPMSCs implantation holds a great promise for bridging the nerve defect and may be clinically useful in the near future. | Sufang Han Zhifeng Xiao Xing Li Huan Zhao Bin Wang Zhixue Qiu Zhi Li Xin Mei Bai Xu Caixia Fan Bing Chen Jin Han Yanzheng Gu Huilin Yang Qin Shi Jianwu Dai | 2018 | Science China(Life Sciences)2018，61，1： | 15 |
| 8 | Excessive UBE3A dosage impairs retinoic acid signaling and synaptic plasticity in autism spectrum disorders显示文摘孤独性光谱混乱(ASD ) 是有异构的病原学的许多人的神经病学的混乱。E3 ubiquitin (Ub ) 的活动过度 ligase UBE3A,不完全地源自 15q11-q13 拷贝数字变化,为世界范围的 ASD 盒子的 1%-3% 的报道,而是内在的机制遗体描绘了。这里,我们报导 ALDH1A2 的功能, retinoic 酸(RA ) 的限制率的酶合成,被 UBE3A 否定地以一种 ubiquitylation 依赖的方式调整。过多的 UBE3A 剂量被发现损害调停 RA 的 neuronal homeostatic synaptic 粘性。象 ASD 一样症状被 overexpressing UBE3A 在前额的外皮或由一个 ALDH1A 对手的管理在老鼠概括,而 RA 补充显著地减轻了过多的 UBE3A 导致剂量的象 ASD 一样显型。由识别在 ASD 作为内在的机制发信号的减少的 RA,显型连接了到 UBE3A 活动过度,我们的调查结果介绍 ASD 病原学的新远景并且对这逐渐地流行的疾病便于治疗学的开发的一个模式。 | Xingxing Xu Chuanyin Li Xiaobo Gao Kun Xia Hui Guo Yali Li ZijianHao Lei Zhang Daming Gao Chenfan Xu Huatai Xu Zhi-Qi Xiong Zilong Qiu Ling Mei Xiaoduo Xie Kangcheng Ruan Ronggui Hu | 2018 | Cell Research2018，28，1： | 13 |
| 9 | Epidemiological Data of Work-Related Musculoskeletal Disorders—China,2018–2020显示文摘Summary What is already known about this topic?In recent decades,work-related musculoskeletal disorders(WMSDs)have become increasingly prominent and have become an important issue that is of universal concern and an urgent need to be solved in all countries of the world.What is added by this report?The top three industries or occupational groups with the highest standardized prevalence rate of WMSDs were flight attendants,medical staff,and vegetable greenhouses in that order.Women workers were 1.5 times more likely to suffer from WMSDs than men workers. | Ning Jia Huadong Zhang Ruijie Ling Yimin Liu Gang Li Zaoliang Ren Yan Yin Hua Shao Hengdong Zhang Bing Qiu Meibian Zhang Dayu Wang Qiang Zeng Rugang Wang Jianchao Chen Danying Zhang Liangying Mei Yongquan Liu Jixiang Liu Chengyun Zhang Tianlai Li Qing Xu Ying Qu Xueyan Zhang Xin Sun Zhongxu Wang | 2021 | China CDC weekly2021，3，18： | 13 |
| 10 | Investigation on Work-Related Musculoskeletal Disorders--China, 2018−2019显示文摘What is already known about this topic?Work-related musculoskeletal disorders(WMSDs)have a high prevalence and seriously harmful,which has attracted extensive attention in various countries in the world.Currently,the occurrence and rules of WMSDs in key industries are not known in China.What is added by this report?The prevalence of WMSDs is relatively high among professional populations in key industries in China,with the most commonly affected body parts concentrated in neck,shoulders,and low back and increasing with age and working years.What are the implications for public health practice?This study determined the prevalence and distribution characteristics of WMSDs in key industries in China and provided scientific evidence to recommend for inclusion of WMSDs in the new revision of the list of occupational diseases in China. | Ning Jia Huadong Zhang Ruijie Ling Yimin Liu Gang Li Zaoliang Ren Yan Yin Hua Shao Hengdong Zhang Bing Qiu Meibian Zhang Dayu Wang Qiang Zeng Rugang Wang Jianchao Chen Danying Zhang Liangying Mei Yongquan Liu Jixiang Liu Chengyun Zhang Tianlai Li Qing Xu Ying Qu Xueyan Zhang Xin Sun Zhongxu Wang | 2020 | China CDC weekly2020，2，18： | 11 |
| 11 | CO_2 gas emplacement age in the Songliao Basin: Insight from volcanic quartz ^(40)Ar-^(39)Ar stepwise crushing显示文摘Due to a lack of suitable minerals, the gas/oil emplacement ages have never been accurately obtained before. CH4-CO2-saline- bearing secondary inclusions are found in quartz from the volcanic rocks of the Yingcheng Formation, the container rocks of the deep CO2 gas reservoir in the Songliao Basin. The inclusion fluid was trapped into microcracks in quartz during the gas em- placement and accumulation, providing an optimal target for the 40Ar-39Ar stepwise crushing technique to determine the CO2 gas emplacement age. 40Ar-39Ar dating results of a quartz sample by stepwise crushing yield a highly linear-regression isochron with an age of 78.4±1.3 Ma, indicating that the accumulation of the deep CO2 gas reservoir in the Songliao Basin occurred in the late Cretaceous. This is the first time to report an exact isotopic age for a CO2 gas reservoir, which indicates that the 40Ar-39Ar dating can serve as a new technique to date the oil/gas emplacement ages. | YUN JianBing WU HeYong FENG ZiHui MEI LianFu QIU HuaNing | 2010 | Chinese Science Bulletin2010，55，17： | 11 |
| 12 | A de novo Genome of a Chinese Radish Cultivar显示文摘Here, we report a high-quality draft genome of a Chinese radish(Raphanus sativus) cultivar. This draft contains 387.73 Mb of assembled scaffolds, 83.93% of the scaffolds were anchored onto nine pseudochromosomes and 95.09% of 43 240 protein-coding genes were functionally annotated. 184.75 Mb(47.65%) of repeat sequences was identified in the assembled genome. By comparative analyses of the radish genome against 10 other plant genomes, 2 275 genes in 780 gene families were found unique to R. sativus. This genome is a good reference for genomic study and of great value for genetic improvement of radish. | ZHANG Xiaohui YUE Zhen MEI Shiyong QIU Yang YANG Xinhua CHEN Xiaohua CHENG Feng WU Zhangyan SUN Yuyan JING Yi LIU Bo SHEN Di WANG Haiping CUI Na DUAN Yundan WU Jian WANG Jinglei GAN Caixia WANG Jun WANG Xiaowu LI Xixiang | 2015 | Horticultural Plant Journal2015，1，3： | 10 |
| 13 | Specific targeting of nasopharyngeal carcinoma cell line CNE1 by C225-conjugated ultrasmall superparamagnetic iron oxide particles with magnetic resonance imaging显示文摘临床的目标体积(CTV ) 的一个精确定义为在鼻咽的癌(NPC ) 的放射疗法的应用程序是必要的处理。指向对比代理人(C225-USPIO ) 的新奇表皮的生长因素受体(EGFR ) 被结合 ultrasmall superparamagnetic 设计有 cetuximab (C225 ) 的氧化铁(USPIO ) nanoparticles, non-invasively 定义肿瘤的 CTV。到 NPC 房间线 CNE1 的 C225-USPIO 的 immunobinding 活动被流动 cytometry 和 immunofluorescence 证实。在 CNE1 房间的 C225-USPIO 的时间依赖者累积用普鲁士的蓝染色被评估。指向的成为主观和 C225-USPIO 的 subcellular 本地化被传播电子显微镜证实。结果显示了明确地在 CNE1 房间的表面上绑在 EGFR 的那 C225-USPIO 并且被收起进房间。由 CNE1 房间的 C225-USPIO 的举起与时间显著地增加了,当时与人的 IgG-USPIO 相比。另外, 4.7 T 磁性的回声成像(MRI ) 随着时间的过去表明 C225-USPIO 有一个能力在 CNE1 房间积累,与在 MRI T2 加权的信号紧张的结果的显著减少。这些调查结果当一个 MRI 对比代理人和罐头被采用 non-invasively 与 EGFR overexpression 检测早阶段的 NPC,暗示 C225-USPIO 有潜力。这为与混合物在 vivo 实验开始提供足够的理论基础。 | Dongbo Liu Chunli Chen Guangyuan Hu Qi Mei Hong Qiu Guoxian Long Guoqing Hu | 2011 | Acta Biochimica et Biophysica Sinica2011，43，4： | 10 |
| 14 | Automatic ^(40)Ar/^(39)Ar Dating Techniques Using Multicollector ARGUS VI Noble Gas Mass Spectrometer with Self-Made Peripheral Apparatus显示文摘A new fully automatic ^(40)Ar/^(39)Ar laboratory with a Thermo Scientific~? ARGUS Ⅵ mass spectrometer has been established in China University of Geosciences(Wuhan). We designed and developed a mini efficient preparation system(80 mL), a CO_2 laser for heating samples, a crusher for extracting fluid inclusions within K-poor minerals and an air reservoir(31 L) and pipette(0.1 mL) system. The ARGUS Ⅵ mass spectrometer is operated by the Qtegra Noble Gas software, which can control the peripheral accessories, such as pneumatic valves, CO_2 laser and crusher through a PeriCon(peripheral controller). The experimental procedures of atmospheric argon analyses, ^(40) Ar/^(39)Ar dating by laser stepwise heating and by progressive crushing in vacuo, can be fully automatically performed. The weighted mean of atmospheric ^(40)Ar/^(36)Ar ratios is 302.22±0.03(1σ, MSWD=0.74, n=200), indicating that air reservoir and pipette system and the whole instrument system are very stable. This laboratory is a successful pioneer example in China to establish a new noble gas laboratory with self-made peripheral accessories expect for the mass spectrometer. | Xiu-Juan Bai Hua-Ning Qiu Wen-Gui Liu Lian-Fu Mei | 2018 | Journal of Earth Science2018，29，2： | 10 |
| 15 | Study on fire-retardant nanocrystalline Mg-Al layered double hydroxides synthesized by microwavecrystallization method显示文摘Nanocrystalline Mg-Al layered double hydroxides with the particle size being 10—40 nm were firstly prepared by the technology of the microwave-crystallization and the vari- able-speed addition of the alkali. The obtained samples were characterized by TEM and XRD. The roles of the microwave and addition rate of the alkali were also discussed in the present work. The thermal decomposition activation energy of the nano-LDHs was calculated according to their TG, DTG and DSC curves by the Ozawa method. The results showed that the thermal decom- position of the nano-LDHs had four steps. Thereby the decomposition model of the nano-LDHs was supposed according to the analysis of their thermal decomposition. After PS, ABS, HDPE and PVC were filled with the nano-LDHs, their LOI values could be increased up to 28, 27, 26 and 33, respectively. When the fire-retardant coating contained 1.9% of the nano-LDHs that was 0.27 times the dosage of the conventional TiO2, its fire endurance time reached 32.75min that was 7.05 min longer than that of the best coating containing TiO2 according to the model big-panel combustion test method. | ZHANG Zejiang1, XU Chenghua1, QIU Fali1, MEI Xiujuan2, LAN Bin2 & ZHANG Shuosheng2 1. Chengdu Institute of Organic Chemistry, Chinese Academy of Sciences, Chengdu 610041, China 2. Sichuan Fire Research Institute of Public Safety Ministry, Chengdu 611830, China | 2004 | Science China Chemistry2004，47，6： | 9 |
| 16 | Analysis of In-hospital Neonatal Death in the Tertiary Neonatal Intensive Care Unit in China: A Multicenter Retrospective Study显示文摘 | Chen-Hong Wang Li-Zhong Du Xiao-Lu Ma Li-Ping Shi Xiao-Mei Tong Hong Liu Guo-Fang Ding Bin Yi Xin-Nian Pan Dan-Ni Zhong Ling Liu Mei Li Cui-Qing Li Shi-Wen Xia Hong-Yun Wang Ling He Kun Liang Xiao-Yu Zhou Shu-Ping Han Qin Lyu Yin-Ping Qiu Ruo-Bing Shan De-Zhi Mu Xiao-Hong Liu Si-Qi Zhuang Jing Guo Li Liu Jia-Jun Zhu Hong Xiong | 2016 | Chinese Medical Journal2016，，22： | 8 |
| 17 | Arsenic trioxide promotes senescence and regulates the balance of adipogenic and osteogenic differentiation in human mesenchymal stem cells显示文摘砷三氧化物(ATO ) 能在肿瘤房间作为反肿瘤药导致区别和 apoptosis。间充质的干细胞(MSC ) 在骨头髓的造血作用起重要作用。许多报告证明了 MSC adipogenic 和 osteogenic 区别的混乱发生在一些疾病。然而,关于 MSC 上的 ATO 的效果的报告是有限的。在这研究,我们发现 1 M ATO 主要通过 p21 支持了 MSC 老朽,尽管它没在这剂量在 apoptosis 上有效果。而且, ATO 支持了 adipogenic 区别,但是在 MSC 禁止了 osteogenic 区别。我们的学习也显示出那 CCAAT/enhancer-binding 蛋白质 alpha C/EBP 和 peroxisome 激活 proliferator 的受体 gamma PPAR 可能涉及 ATO 导致的 adipogenic 和 osteogenic 区别的规定。我们的结果显示 ATO 可以由影响骨头髓微型环境施加反肿瘤效果。而且,它可以调整 MSC 的 adipogenic 和 osteogenic 区别。 | Huanchen Cheng Lin Qiu Hao Zhang Mei Cheng Wei Li Xuefei Zhao Keyu Liu Lei Lei Jun Ma | 2011 | Acta Biochimica et Biophysica Sinica2011，43，3： | 8 |
| 18 | Self-assembled multifunctional DNA nanoflowers for the circumvention of multidrug resistance in targeted anticancer drug delivery显示文摘癌症化疗被它的副作用和 multidrug 抵抗(MDR ) 限制了。因此,指向了能围绕 MDR 的药交货系统被需要。这里,我们向 chemosensitive 和在白血病和乳癌房间模型围绕了 MDR 的 MDR 癌症房间为指向的药交货汇报多功能的 DNA nanoflowers (NF ) 。NF 经由卷圆复制, NF 为特定的癌症房间识别,为 bioimaging 的 fluorophores,和 doxorubicin (纪录影片) 用 aptamers 在期间被合并产生的 DNA 和镁焦磷酸盐的潜在的一起沉淀是自我装配的为药交货的有约束力的 DNA。NF 尺寸是悦耳的(在直径击倒 nm 到 200 ) ,并且浓密地包装的药绑定主题和多孔的 intrastructures 赋予 NF 以一个高装载药的能力(71.4% , wt/wt ) 。尽管 Doxloaded NF (NF 纪录影片) 在生理的 pH 是稳定的,药版本在酸或基本的条件下面被便于。NF 交付纪录影片进目标 chemosensitive 和 MDR 癌症房间,阻止药流出并且提高在 MDR 房间的药保留。NF 纪录影片在两个目标 chemosensitive 房间和 MDR 房间,然而并非在 nontarget 房间导致有势力 cytotoxicity,并发地因此围绕 MDR 并且减少副作用。总的来说,这些 NF 为在指向的癌症治疗围绕 MDR 正在答应工具。 | Lei Mei Guizhi Zhu Liping Qiu Cuichen Wu Huapei Chen Hao Liang Sena Cansiz Yifan Lv Xiaobing Zhang Weihong Tan | 2015 | Nano Research2015，8，11： | 8 |
| 19 | Association of Overlapped and Un-overlapped Comorbidities with COVID-19 Severity and Treatment Outcomes: A Retrospective Cohort Study from Nine Provinces in China显示文摘Objective Several COVID-19 patients have overlapping comorbidities. The independent role of each component contributing to the risk of COVID-19 is unknown, and how some non-cardiometabolic comorbidities affect the risk of COVID-19 remains unclear.Methods A retrospective follow-up design was adopted. A total of 1,160 laboratory-confirmed patients were enrolled from nine provinces in China. Data on comorbidities were obtained from the patients’ medical records. Multivariable logistic regression models were used to estimate the odds ratio(OR) and 95% confidence interval(95% CI) of the associations between comorbidities(cardiometabolic or non-cardiometabolic diseases), clinical severity, and treatment outcomes of COVID-19.Results Overall, 158(13.6%) patients were diagnosed with severe illness and 32(2.7%) had unfavorable outcomes. Hypertension(2.87, 1.30–6.32), type 2 diabetes(T2 DM)(3.57, 2.32–5.49),cardiovascular disease(CVD)(3.78, 1.81–7.89), fatty liver disease(7.53, 1.96–28.96), hyperlipidemia(2.15, 1.26–3.67), other lung diseases(6.00, 3.01–11.96), and electrolyte imbalance(10.40, 3.00–26.10)were independently linked to increased odds of being severely ill. T2 DM(6.07, 2.89–12.75), CVD(8.47,6.03–11.89), and electrolyte imbalance(19.44, 11.47–32.96) were also strong predictors of unfavorable outcomes. Women with comorbidities were more likely to have severe disease on admission(5.46,3.25–9.19), while men with comorbidities were more likely to have unfavorable treatment outcomes(6.58, 1.46–29.64) within two weeks.Conclusion Besides hypertension, diabetes, and CVD, fatty liver disease, hyperlipidemia, other lung diseases, and electrolyte imbalance were independent risk factors for COVID-19 severity and poor treatment outcome. Women with comorbidities were more likely to have severe disease, while men with comorbidities were more likely to have unfavorable treatment outcomes. | MA Yan ZHU Dong Shan CHEN Ren Bo SHI Nan Nan LIU Si Hong FAN Yi Pin WU Gui Hui YANG Pu Ye BAI Jiang Feng CHEN Hong CHEN Li Ying FENG Qiao GUO Tuan Mao HOU Yong HU Gui Fen HU Xiao Mei HU Yun Hong HUANG Jin HUANG Qiu Hua HUANG Shao Zhen JI Liang JIN Hai Hao LEI Xiao LI Chun Yan LI Min Qing LI Qun Tang LI Xian Yong LIU Hong De LIU Jin Ping LIU Zhang MA Yu Ting MAO Ya MO Liu Fen NA Hui WANG Jing Wei SONG Fang Li SUN Sheng WANG Dong Ting WANG Ming Xuan WANG Xiao Yan WANG Yin Zhen WANG Yu Dong WU Wei WU Lan Ping XIAO Yan Hua XIE Hai Jun XU Hong Ming XU Shou Fang XUE Rui Xia YANG Chun YANG Kai Jun YUAN Sheng Li ZHANG Gong Qi ZHANG Jin Bo ZHANG Lin Song ZHAO Shu Sen ZHAO Wan Ying ZHENG Kai ZHOU Ying Chun ZHU Jun Teng ZHU Tian Qing ZHANG Hua Min WANG Yan Ping WANG Yong Yan 无 | 2020 | Biomedical and Environmental Sciences2020，33，12： | 8 |
| 20 | Role of activating transcription factor 3 (ATF3) in sublytic C5b-9-induced glomerular mesangial cell apoptosis显示文摘 | Xiaoming Jiang Jing Zhang Mei Xia Wen Qiu Hui Wang Dan Zhao Yingwei Wang | 2010 | Cellular & Molecular Immunology2010，7，2： | 7 |
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