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| 1 | Characterization of microRNAs in serum: a novel class of biomarkers for diagnosis of cancer and other diseases显示文摘在各种各样的纸巾的 microRNAs (miRNAs ) 的 Dysregulated 表示与许多疾病被联系了,包括癌症。这里,我们证明 miRNAs 在象老鼠,老鼠,牛的胎儿,小牛,和马那样的人和另外的动物的浆液和血浆是在场的。在浆液的 miRNAs 的层次在一样的种类的个人之中稳定、可再现、一致。采用 Solexa,我们定序健康中国题目的所有浆液 miRNAs 并且分别地在男、女的题目发现超过 100 和 91 浆液 miRNAs。我们也为肺癌症, colorectal 癌症,和糖尿病识别了浆液 miRNAs 的特定的表示模式,提供证据那浆液 miRNAs 为各种各样的疾病包含指纹。癌症特定的浆液 miRNAs 由 Solexa 获得了的二个非小的房间肺进一步在 75 个健康施主和 152 个癌症病人的独立审判被验证,用量的反向的抄写聚合酶链反应试金。通过这些分析,我们断定浆液 miRNAs 能为各种各样的癌症和另外的疾病的察觉用作潜在的 biomarkers。 | Xi Chen Yi Ba Lijia Ma Xing Cai Yuan Yin Kehui Wang Jig ang Guo Yujing Zhang Jiangning Chen Xing Guo Qibin Li Xiaoying Li Wenjing Wang Yan Zhang Jin Wang Xueyuan Jiang Yang Xiang Chen Xu Pingping Zheng Juanbin Zhang Ruiqiang Li Hongjie Zhang Xiaobin Shang Ting Gong Guang Ning Jun Wang Ke Zen Junfeng Zhang Chen-Yu Zhang | 2008 | Cell Research2008，18，10： | 975 |
| 2 | Protolith ages and deformation mechanism of metamorphic rocks in the Zhangbaling uplift segment of the Tan-Lu Fault Zone显示文摘Protolith ages and Indosinian deformation mechanism of metamorphic rocks in the Zhangbaling uplift segment of the Tan-Lu Fault Zone are important, unsolved problems. Our LA-ICP-MS zircon dating work indicates that protolith ages of the greenschist-facies Zhangbaling Group are 754–753 Ma, and those of the amphibolite-facies Feidong Complex are 800–745 Ma. These rocks belong to the earliest cover of the Yangtze Plate. Their ages and metamorphic features suggest that the rocks did not come from the Dabie Orogen. The Indosinian structures in the Zhangbaling Group and lower Sinian strata formed in a flatlying ductile detachment zone with a shear sense of top-to-the-SSW whereas those in the underlying Feidong Complex are characterized by ENE-WSW inclined folds developed under a ductile regime. It is suggested therefore that the sinistral Tan-Lu Fault Zone of the Indosinian period is buried under the Hefei Basin west of the Zhangbaling uplift segment and the uplift segment is a displaced block neighboring the fault zone. Detachment deformation between the upper rigid and lower ductile crust during displacement of the Zhangbaling uplift segment resulted in the formation of the flat-lying ductile detachment zone and its underlying drag fold zone of a ductile regime. The protolith ages and deformation mechanism in the Zhangbaling uplift segment further prove sinistral origination of the Tan-Lu Fault Zone during the continent-continent collision of the North China and Yangtze plates and support the indentation model for the two-plate collision that considers the Tan-Lu Fault Zone as an oblique convergence boundary. | ZHAO Tian ZHU Guang LIN ShaoZe YAN LeJia JIANG QinQin | 2014 | Science China Earth Sciences2014，57，11： | 25 |
| 3 | Acute kidney injury in acute-on-chronic liver failure is different from in decompensated cirrhosis显示文摘AIM To evaluate the differences in acute kidney injury(AKI) between acute-on-chronic liver failure(ACLF) and decompensated cirrhosis(DC) patients. METHODS During the period from December 2015 to July 2017, 280 patients with hepatitis B virus(HBV)-related ACLF(HBV-ACLF) and 132 patients with HBV-related DC(HBV-DC) who were admitted to our center were recruited consecutively into an observational study. Urine specimens were collected from all subjects and the levels of five urinary tubular injury biomarkers were detected,including neutrophil gelatinase-associated lipocalin(NGAL), interleukin-18(IL-18), liver-type fatty acid binding protein(L-FABP), cystatin C(CysC), and kidney injury molecule-1(KIM-1). Simultaneously, the patient demographics, occurrence and progression of AKI, and response to terlipressin therapy were recorded. All patients were followed up for 3 mo or until death after enrollment. RESULTS AKI occurred in 71 and 28 of HBV-ACLF and HBV-DC patients, respectively(25.4% vs 21.2%, P = 0.358). Among all patients, the levels of four urinary biomarkers(NGAL, CysC, L-FABP, IL-18) were significantly elevated in patients with HBV-ACLF and AKI(ACLF-AKI), compared with that in patients with HBV-DC and AKI(DC-AKI) or those without AKI. There was a higher proportion of patients with AKI progression in ACLF-AKI patients than in DC-AKI patients(49.3% vs 17.9%, P = 0.013). Fortythree patients with ACLF-AKI and 19 patients with DC-AKI were treated with terlipressin. The response rate of ACLFAKI patients was significantly lower than that of patients with DC-AKI(32.6% vs 57.9%, P = 0.018). Furthermore, patients with ACLF-AKI had the lowest 90 d survival rates among all groups(P < 0.001).CONCLUSION AKI in ACLF patients is more likely associated with structural kidney injury, and is more progressive, with a poorer response to terlipressin treatment and a worse prognosis than that in DC patients. | Qun-Qun Jiang Mei-Fang Han Ke Ma Guang Chen Xiao-Yang Wan Semvua Bukheti Kilonzo Wen-Yu Wu Yong-Li Wang Jie You Qin Ning | 2018 | World Journal of Gastroenterology2018，24，21： | 25 |
| 4 | Constraints of (U-Th)/He ages on early Paleozoic tectonothermal evolution of the Tarim Basin,China显示文摘The thermal evolution of source rocks in the Paleozoic stratigraphic sequences has been an outstanding problem for petroleum exploration in the Tarim Basin, as the thermal history of the Paleozoic could not be reconstructed objectively due to the lack of effective thermal indicators in the early Paleozoic carbonate successions. The (U-Th)/He thermochronometry of apatite and zircon has recently been used as an effective tool to study the structural uplift and thermal history of sedimentary basins. The Paleozoic tectonothermal histories of two typical wells in the Tarim Basin were modeled using the thermal indicators of (U-Th)/He, apatite fission track (AFT), and vitrinite reflectance (Ro) data in this paper. The Paleozoic strata in the two wells were shallow due to persistent uplift and significant erosion during the Hercynian tectonic events (from Devonian to Triassic). Therefore, the paleothermal indicators in the Paleozoic strata may retain the original thermal evolution and can be used to re- construct the Paleozoic thermal history of the Tarim Basin. The apatite and zircon helium ages from core and cuttings samples were analyzed and the Paleozoic thermal histories of wells KQ1 and T1 were modeled by combining helium ages, AFT, and equivalence vitrinite reflectance (VRo) data. The modeling results show that the geothermal gradient evolution is different in the Kongquehe Slop and Bachu Uplift of Tarim Basin during the Paleozoic. The thermal gradient in Well T1 on the Bachu Up- lift was only 28–30°C/km in Cambrian, and it increased to 30–33°C/km in Ordovician and 31–34°C/km during the Silurian and Devonian. The thermal gradient of Ordovician in Well KQ1 on the Kongquehe Slope was 35°C/km and decreased to 32–35°C/km during the Silurian and Devonian. Therefore, the combined use of (U-Th)/He ages and other thermal indicators appears to be useful in reconstructing the basin thermal history and provides new insight into the understanding of the early Paleozoic thermal history of the Tarim Basin. | QIU NanSheng WANG JiYang MEI QingHua JIANG Guang TAO Cheng | 2010 | Science China Earth Sciences2010，53，7： | 22 |
| 5 | Expression of regulating apoptosis gene and apoptosis index in primary liver cancer显示文摘INTRODUCTIONProgramed cell death plays an important role in thegenesis of cancer.Certain cancer genes canregulate apoptosis.Recently,several proteins thatare structurally related to Bcl-2,an inhibitor ofapoptosis,have been identified.Therefore,novel strategies and agents that target specificmolecular pathways,as well as triggering a | Hong Yu Xu You Lin Yang Xi Li Guan Guang Song Ai Min Jiang Li Jun Shi | 2000 | World Journal of Gastroenterology2000，6，5： | 21 |
| 6 | BE-PLUS: a new base editing tool with broadened editing window and enhanced fidelity显示文摘基础编辑() ,包含 cytidine 脱氨基酶和催化地有缺点的 Cas9,广泛地被用来执行基础编辑。然而,狭窄的编辑窗口是限制它的实用程序。这里,我们开发了依照到由熔化 10 的 U (T) 范围(加) 的更大的 C 为招募 GCN4 肽拷贝到 nCas9 (D10A ) 的编程作为基础编辑命名的一种新编辑技术 scFv-APOBEC-UGI-GB1 到目标地点。新系统完成与一扇拓宽的窗户的基础编辑,导致一个增加的指向染色体的范围。有趣地,新系统很产出更少讨厌的 indels 和 non-C-to-T 变换。我们也通过站 codons (iSTOP ) 的正式就职越过整个染色体在基因混乱表明了它的潜在的使用。一起拿,加系统与编辑窗口和提高的忠实增加提供一个新编辑工具。 | Wen Jiang Songjie Feng Shisheng Huang Wenxia Yu Guanglei Li Guang Yang Yajing Liu Yu Zhang Lei Zhang Yu Hou Jia Chen Jieping Chen Xingxu Huang | 2018 | Cell Research2018，28，8： | 20 |
| 7 | Lentivirus-mediated shRNA interference targeting STAT3 inhibits human pancreatic cancer cell invasion显示文摘AIM: To investigate RNA interference targeting signal transducer and activator of transcription-3 (STAT3) on invasion of human pancreatic cancer cells. METHODS: We constructed three plasmids of RNA interference targeting the STAT3 gene. After LV (lentivirus)-STAT3siRNA (STAT3 small interfering RNA) the vector was transfected into the human pancreatic cell line, SW1990 and cell proliferation was measured by the MTT assay. Flow cytometry was used to assess cell cycle. Vascular endothelial growth factor (VEGF) and matrix metalloproteinase-2 (MMP-2) mRNA and protein expression were examined by quantitative PCR and western blotting, respectively. The invasion ability of SW1990 cells was determined by cell invasion assay. RESULTS: We successfully constructed the LVSTAT3siRNA lentivirus vector and proved that it can suppress expression of STAT3 gene in SW1990 cells. RNA interference of STAT3 by the LV-STAT3siRNA construct signifi cantly inhibited the growth of SW1990 cells, in addition to signifi cantly decreasing both VEGF and MMP-2 mRNA and protein expression. Moreover, suppression of STAT3 by LV-STAT3siRNA decreased the invasion ability of SW1990 cells.CONCLUSION: The STAT3 signaling pathway may provide a novel therapeutic target for the treatment of pancreatic cancer since it inhibits the invasion ability of pancreatic cancer cells. | Guang Yan Chen Huang Jun Cao Ke-Jian Huang Tao Jiang Zheng-Jun Qiu | 2009 | World Journal of Gastroenterology2009，15，30： | 19 |
| 8 | Exploring an Integrative Therapy for Treating COVID-19:A Randomized Controlled Trial显示文摘Objectives:To develop a new Chinese medicine(CM)-based drug and to evaluate its safety and effect for suppressing acute respiratory distress syndrome(ARDS)in COVID-19 patients.Methods:A putative ARDS-suppressing drug Keguan-1 was first developed and then evaluated by a randomized,controlled two-arm trial.The two arms of the trial consist of a control therapy(alpha interferon inhalation,50(x g twice daily;and lopinavir/ritonavir,400 and 100 mg twice daily,respectively)and a testing therapy(control therapy plus Keguan-119.4 g twice daily)by random number table at 1:1 ratio with 24 cases each group.After 2-week treatment,adverse events,time to fever resolution,ARDS development,and lung injury on newly diagnosed COVID-19 patients were assessed.Results:An analysis of the data from the first 30 participants showed that the control arm and the testing arm did not exhibit any significant differences in terms of adverse events.Based on this result,the study was expanded to include a total of 48 participants(24 cases each arm).The results show that compared with the control arm,the testing arm exhibited a significant improvement in time to fever resolution(P=0.035),and a significant reduction in the development of ARDS(P=0.048).Conclusions:Keguan-1-based integrative therapy was safe and superior to the standard therapy in suppressing the development of ARDS in COVID-19 patients.(Trial registration No.NCT 04251871 at www.clinicaltrials.gov). | WANG Jia-bo WANG Zhong-xia JING Jing ZHAO Peng DONG Jing-hui ZHOU Yong-feng YANG Guang NIU Ming ZHAO Xu JIANG Tian-jun Bl Jing-feng XU Zhe ZHANG Ping WU Dan BAI Zhao-fang GUO Yu-ming YU Si-miao SUN Yong-qiang ZHANG Zi-teng ZHAN Xiao-yan LI Peng-yan DING Jin-biao ZHAO Peng-fei SONG Xue-ai TANG Jian-yuan HE Dong-chu CHEN Zhu QIN En-qiang WANG Rui-lin XIAO Xiao-he | 2020 | Chinese Journal of Integrative Medicine2020，26，9： | 18 |
| 9 | Spatial patterns of ecosystem vulnerability changes during 2001–2011 in the three-river source region of the Qinghai-Tibetan Plateau, China显示文摘The three-river source region(TRSR, including Yangtze, Yellow and Lancang rivers), located in the Qinghai-Tibetan Plateau, China, is a typical alpine zone with apparent ecosystem vulnerability and sensitivity. In this paper, we introduced many interdisciplinary factors, such as landscape pattern indices(Shannon diversity index and Shannon evenness index) and extreme climate factors(number of extreme high temperature days, number of extreme low temperature days, and number of extreme precipitation days), to establish a new model for evaluating the spatial patterns of ecosystem vulnerability changes in the TRSR. The change intensity(CI) of ecosystem vulnerability was also analyzed. The results showed that the established evaluation model was effective and the ecosystem vulnerability in the whole study area was intensive. During the study period of 2001–2011, there was a slight degradation in the eco-environmental quality. The Yellow River source region had the best eco-environmental quality, while the Yangtze River source region had the worst one. In addition, the zones dominated by deserts were the most severely deteriorated areas and the eco-environmental quality of the zones occupied by evergreen coniferous forests showed a better change. Furthermore, the larger the change rates of the climate factors(accumulative temperature of ≥10°C and annual average precipitation) are, the more intensive the CI of ecosystem vulnerability is. This study would provide a scientific basis for the eco-environmental protection and restoration in the TRSR. | GUO Bing ZHOU Yi ZHU Jinfeng LIU Wenliang WANG Futao WANG Litao YAN Fuli WANG Feng YANG Guang LUO Wei JIANG Lin | 2016 | Journal of Arid Land2016，8，1： | 16 |
| 10 | Relationship Between Serum DNA Replication, Clinicopathological Characteristics and Prognosis of Hepatitis B Virus-associated Glomerulonephritis with Severe Proteinuria by Lamivudine Plus Adefovir Dipivoxil Combination Therapy显示文摘Objective To explore the relationship between HBV DNA and the clinical manifestations, pathological types, injury severity, and prognosis with HBV-GN. Methods 102 patients with HBV-GN were divided into 3 groups, according to the serum titer of the HBV DNA. 24-h urine protein excretion, and other parameters were measured. Renal biopsy were performed. The association between HBV DNA and the pathological stage of membranous nephropathy was analyzed in 78 patients with HBV-MN. 24-h urine protein excretion was used for the evaluation of the prognosis, and the relationship between HBV DNA and prognosis were analyzed. Results Several findings were demonstrated with the increase of serum HBV DNA: 24-h urine protein excretion, plasma cholesterol, and triglycerides increased significantly(P<0.05), while the plasma level of albumin decreased significantly(P<0.05); The changes of serum creatinine, C3 and C4 were found but no statistical significance. Glomerular deposition of HBVAg increased, and the pathological injury was more severe. The clinical remission rate was lower in the high replication group after treatment as compared with the low replication group(P<0.01). Conclusion With the increase of serum HBV DNA, the urine protein excretion and the kidney injury were more severe, and the clinical remission rate was decreased. | JIANG Wei LIU Tuo DONG Hui XU Yan LIU Li Qiu GUAN Guang Ju LIU Xiang Chun | 2015 | Biomedical and Environmental Sciences2015，28，3： | 13 |
| 11 | Molecular Typing of Leptospira interrogans Strains Isolated from Rattus tanezumi in Guizhou Province,Southwest of China显示文摘Objective To identify and type three leptospires isolated from Rattus tanezumi in Guizhou Province by using three molecular techniques (PFGE, MLVA, and MLST), reveal the molecular characteristic of causative agents of local leptospirosis and evaluate these three molecular methods based on their detection resolution and efficiency. Methods Three Leptospira strains were isolated from the kidney of Rattus tanezumi and cultured with EMJH medium. PFGE, MLVA, and MLST assays were applied to type the three strains isolated from Rattus tanezumi in Guizhou Province. Results PFGE, MLVA, and MLST typing showed that the three leptospiral isolates matched with leptospiral serogroup Icterohaemorrhagiae serovar Lai. The findings of the genotyping methods were consistent. MLVA and MLST defined genotypes, whereas PFGE allowed the recognition of additional subgroups within the genotypes, and the findings of molecular typing were also consistent with those of traditional techniques. Conclusion Three leptospiral isolates from Guizhou Province matched with leptospiral serogroup Icterohaemorrhagiae serovar Lai, and PFGE, MLVA, and MLST, as reliable molecular techniques for identifying and typing of Leptospira interrogans, would contribute to the active surveillance, outbreak investigation and source tracking for leptospirosis in Guizhou Province. | LI Shi Jun ZHANG Cui Cai LI Xiu Wen TIAN Ke Cheng TANG Guang Peng WANG Ding Ming LIU Ying NIE Yi Xin JIANG Xiu Gao | 2012 | Biomedical and Environmental Sciences2012，25，5： | 12 |
| 12 | Preoperative inflammation-based markers predict early and late recurrence of hepatocellular carcinoma after curative hepatectomy显示文摘BACKGROUND:Recurrence of hepatocellular carcinoma(HCC) after curative resection remains a major cause of treatment failure and tumor-related death.Patterns of HCC recurrence can be categorized into early recurrence and late recurrence which have different underlying mechanisms.In this study,we investigated if simple inflammation-based clinical markers can distinguish patterns of recurrence after curative resection of HCC.METHODS:A retrospective analysis of 223 patients who underwent curative hepatectomy for HCC was performed.Preoperative inflammation-based factors including neutrophil/lymphocyte ratio(NLR),platelet/lymphocyte ratio,γ-glutamyl transferase/alanine aminotransferase ratio,aspartate aminotransferase/platelet ratio index(APRI) and prognostic nutritional index together with other clinicopathologic parameters were evaluated by univariate analysis and multivariate analysis to identify independent prognostic factors.By combining risk factors,predictive models were established to distinguish populations at high risk of early or late recurrence.RESULTS:Age ≤50 years,resection margin ≤1 cm,TNM stage III-IV,NLR>2.75,APRI>0.23 and positive alpha-fetoprotein were independent adverse prognostic factors for early recurrence.Patients with three or more risk factors were at significant higher risk of early recurrence.APRI>0.23 and positive hepatitis B e antigen(HBe Ag) were independent risk factors of late recurrence,the coexistence of high APRI and positive HBe Ag increased the risk of late recurrence.CONCLUSIONS:Preoperative inflammation-based prognostic factors predict early and late recurrence of HCC after curative resection.Different prognostic factor combinations distinguish high-risk populations of early or late HCC recurrence. | Yue Liu Zhong-Xia Wang Yin Cao Guang Zhang Wei-Bo Chen Chun-Ping Jiang | 2016 | Hepatobiliary & Pancreatic Diseases International2016，15，3： | 12 |
| 13 | Deformation characteristics and formation mechanism of the Yunmengshan metamorphic core complex显示文摘The Yunmengshan metamorphic core complex in the middle part of the Yanshan Fold and Thrust Belt records crust extension processes of the eastern North China Craton during its peak destruction.Development of the metamorphic core complex was controlled by the generally NNE-striking Dashuiyu Shear Zone.The shear zone dips SE and becomes shallower NE-wards,leading to exposures of a ductile shear zone in the southern and middle parts and brittle faults in the northern part.Exposure structures,microstructures,and quartz C-axis fabrics indicate that the ductile shear zone belongs to an extensional shear zone with a top-to-the-SE shear sense.Deformation temperatures of 300–520°C suggest a midcrustal origin for the ductile shear zone.A ductile deformation belt in the footwall of the shear zone is only as wide as 1–3 km,indicating no widespread mid-crustal ductile flow in the region during the deformation.Zircon U–Pb dating of dykes and plutons as well as hornblende and biotite40Ar/39Ar dating demonstrate that the metamorphic core complex originated at 135 Ma and experienced intense shearing of the Dashuiyu Shear Zone,development of the supradetachment basins,and synkinematic intrusion during 135–125 Ma.The metamorphic core complex was subjected to rapid exhumation during 125–114 Ma when the Dashuiyu Shear Zone suffered continuous activity and passive doming.The shear zone and its hanging wall were cut or replaced by a series of brittle faults when they wereuplifted to a brittle regime,showing that exhumation took place in continuous extensional activities.The metamorphic core complex turned into slow exhumation in an extensional regime in the following latest Early Cretaceous.The evolution history suggests that the Yunmengshan metamorphic core complex was developed by the rolling-hinge model,a common formation mechanism for intraplate metamorphic core complexes in the North China Craton,under the continuous NW–SE extension during the Early Cretaceous(135–100 Ma). | Yin Chen Guang Zhu Dazhi Jiang Shaoze Lin | 2014 | Chinese Science Bulletin2014，59，20： | 10 |
| 14 | Establishment of transgenic mouse harboring hepatitis B virus (adr subtype) genomes显示文摘INTRODUCTIONHepatitis B virus (HBV) belongs to the group ofhepatovirus, a major pathogen of human acute andchronic hepatitis B[1 4], which has a very closeassociation with human hepatocellular carcinoma(HCC)[5-8], For example, a statistical data from ahospital in Shanghai showed that 80% of HCCpatients were positive for HBsAg ( personalcommunication). | Yi Ping Hu1 Wei Jiang Hu1 Wen Chao Zheng2 Jian Xiu Li1 De Shun Dai1 Xin Min Wang1 Shu Zhong Zhang1 Hong Yu Yu3 Wei Sun4 Guang Rong Hao4 1Department of Cell Biology, Second Military Medical University, Shanghai 200433, China2University of Wisconsin, Madison, WI 53705, USA3Department of Pathology, Second Military Medical University, Shanghai 200433, China4Center of laboratory Animals, Second Military Medical University, Shanghai 200433, China | 2001 | World Journal of Gastroenterology2001，7，1： | 9 |
| 15 | Simple preparation and catalytic properties of ZnO for ozonation degradation of phenol in water显示文摘ZnO 粒子大约 200 nm 通过一个灵巧的热水的方法被准备。与单个 ozonation 相比,酚的降级效率增加了大约 23.7% ,中介的降级效率在 298 K 面对 ZnO 改善了大约四次。另外,催化剂在 ozonation 过程有好稳定性。温度的影响被调查,更好的催化作用效率能在更低的温度被获得,这被发现。 | Yu Ming Dong Guang Li Wang Ping Ping Jiang Ai Min Zhang Lin Yue Xiao Ming Zhang | 2011 | Chinese Chemical Letters2011，22，2： | 9 |
| 16 | Visible calculation of mining index based on stope 3D surveying and block modeling显示文摘Aimed at the CMS laser scanning theory and characteristic, a combined actual situation of stope N4-5 of Fankou Lead-Zinc Mine and complementary monitoring of the stope were carried out by carefully choos- ing two measuring points. The cavity 3D visible model was created by large-scale mining industry soft- ware Surpac after changing the measured data. The stope mine design model, bottom structural model and backfill model of the south and north sides of the stope N4-5 were established according to the stope design data. On this basis, the stope block model was established, and then block attribute was estimated. The amount the ore remains, mullock, backfill and total mined ore were calculated through the solid model restrains. Finally, the stope mining dilution rate and loss rate reached 8.2% and 1.47%, respectively. The practice indicates that the mining index visible calculation method based on cavity 3D monitoring and stope block modeling can make up the deficiency of adopting the solid model to directly carry out the Boolean operation. The stope mining indexes obtained by this method are accurate and reliable, and can be used to guide the actual production management and estimate the mining quality. | Liu Xiaoming Luo Zhouquan Yang Biao Lu Guang Cao Shengxiang Jiang Xinjian | 2012 | International Journal of Mining Science and Technology2012，22，2： | 7 |
| 17 | Oxyphyllones A and B,novel sesquiterpenes with an unusual 4,5-secoeudesmane skeleton from Alpinia oxyphylla显示文摘二新奇 4,5-secoeudesmane sesquiterpenoids, oxyphyllones A (1 ) 和 B (2 ) 从 Alpinia oxyphylla 的水果被孤立。他们的结构被包括 1D 和 2D NMR 系列的分光镜的方法建立。这二混合物是有在 Zingiberaceae 的家庭的一架 4,5-secoeudesmane 骨骼的自然地发生的 sesquiterpenoids 的第一个例子, oxyphyllone A (1 ) 是 13-norsesquiterpenoid 的第一种 4,5-secoeudesmane 类型。1 和 2 展出了的混合物对三个癌症房间的 cytotoxicities 都不在 10 μ 排队; g/mL。 | Jun Ju Xu Ning Hua Tan Jiang Xiong Abiodun Humphrey Adebayo Hong Jin Han Guang Zhi Zeng Chang Jiu Ji Yu Mei Zhang Mei Ju Zhu | 2009 | Chinese Chemical Letters2009，20，8： | 7 |
| 18 | Characteristics of ectopic adrenocorticotropic hormone syndrome due to thymic carcinoid and analysis of the molecular mechanism显示文摘 | BI Yu-fang YE Lei CHEN Yu-hong NING Guang SUN Shou-yue JIANG Lei ZHU Na ZHOU Wei-wei WANG Wei-qing | 2008 | Chinese Medical Journal2008，，7： | 7 |
| 19 | Preoperative serum liver enzyme markers for predicting early recurrence after curative resection of hepatocellular carcinoma显示文摘BACKGROUND:Early recurrence of hepatocellular carcinoma(HCC)is associated with worse prognosis after liver resection This study aimed to investigate the prognostic value of com mon liver enzyme markers in HCC early recurrence after cu rative hepatectomy and to establish a simple predictive model for HCC early recurrence. | Zhong-Xia Wang Chun-Ping Jiang Yin Cao Guang Zhang Wei-Bo Chen Yi-Tao Ding | 2015 | Hepatobiliary & Pancreatic Diseases International2015，14，2： | 7 |
| 20 | Molecular Characterization and Drug-resistance of Mycobacterium tuberculosis Strains in Xuzhou, China显示文摘To understand the genetic diversity and drug resistance status of Mycobacterium tuberculosis(M tuberculosis)circulating in Xuzhou of China,the spacer-oligonucleotide typing(Spoligotyping)and multi-loci VNTRs(variable number tandem repeats)analysis(MLVA)were utilized for the genotyping of the isolates.Drug susceptibility test(DST) | PANG Hui TONG Jing LIU Hai Can DU Yang Guang ZHAO Xiu Qin JIANG Yi WU Xiao Cui YANG Jin Chuan WAN Kang Lin | 2014 | Biomedical and Environmental Sciences2014，27，12： | 7 |
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