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| 1 | 2018加拿大心境障碍与焦虑障碍治疗协作组/国际双相障碍学会指南:双相障碍的管理显示文摘加拿大心境障碍与焦虑障碍治疗协作组(Canadian Network for Mood and Anxiety Treatments,CANMAT)曾于2005年发布了第1版双相障碍管理指南,并分别于2007、2009和2013年对该指南进行了更新,其中最近的2次更新是与国际双相障碍学会(International Society for Bipolar Disorders,ISBD)合作完成。2018版CANMAT/ISBD双相障碍治疗指南(以下简称指南)反映了自2005年首版指南发表以来本领域取得的重大进展,包括疾病诊断与疾病管理的更新以及药物治疗与心理治疗的近期研究进展。这些前沿进展中综合考虑了循证证据的级别,并基于治疗疗效、临床实践经验、安全性、耐受性和药物导致的转相风险等,对一线、二线及三线治疗方案进行了简明而清晰的推荐。本指南中新增内容涵盖了双相Ⅰ型障碍(BD-Ⅰ)的躁狂发作急性期、抑郁发作急性期和双相障碍维持期的一线及二线治疗推荐等级划分。这种对治疗推荐等级的划分综合考虑了治疗方法对双相障碍不同时相的影响,将进一步帮助临床医生做出基于循证证据的治疗决策。锂盐、喹硫平、双丙戊酸盐、阿塞那平、阿立哌唑、帕利哌酮、利培酮和卡利拉嗪单药或联合使用被推荐为躁狂发作急性期的一线治疗选择。BD-Ⅰ抑郁期的一线治疗选择包括喹硫平、鲁拉西酮、锂盐、拉莫三嗪单药,鲁拉西酮联合锂盐或双丙戊酸盐或拉莫三嗪辅助治疗。尽管急性期治疗有效的药物通常应继续用于BD-Ⅰ的维持期治疗,但也存在一些特殊情况(例如抗抑郁药)。现有数据表明,锂盐、喹硫平、双丙戊酸盐、拉莫三嗪、阿塞那平和阿立哌唑单药或联合治疗应被视为维持治疗的初始或更换治疗方案时的一线选择。除了探讨BD-Ⅰ的相关问题外,本指南中还对双相Ⅱ型障碍(BD-Ⅱ)的临床管理进行了系统回顾并给予治疗推荐,同时针对特殊人群也有相关推荐,如处于各个生殖周期的女性、儿童、青少年和老年人。此外,本指南中还讨论了特定精神疾病及共病(如物质滥用、焦虑障碍和代谢性疾病)的影响。最后,本指南中概述了安全性和药物监测的相关问题。CANMAT/ISBD工作组希望本指南能够成为全球临床医生的实用工具。 | Lakshmi N Yatham Sidney H Kennedy Sagar V Parikh Ayal Sehaffer David J Bond Benicio N Frey Verinder Sharma Benjamin I Goldstein Soham Rej Serge Beaulieu Martin Alda Glenda MaeQueen Roumen V Milev Arun Ravindran Claire O'Donovan Diane Mclntosh Raymond W Lam Gustavo Vazquez Flavio Kapczinski Roger S Melntyre Jan Kozicky Shigenobu Kanba Beny Lafer Trisha Suppes Joseph R Calabrese Eduard Vieta Gin Malhi Robert M Post Michael Berk 胡晨(译) 王刚(译) | 2019 | 中华精神科杂志2019，52，1： | 25 |
| 2 | Multipurpose use of the over-the-scope-clip system(“Bear claw”) in the gastrointestinal tract:Swiss experience in a tertiary center显示文摘AIM:To evaluate the outcome of over-the-scope-clip system(OTSC)for endoscopic treatment of various indications in daily clinical practice in Switzerland.METHODS:This prospective,consecutive case series was conducted at a tertiary care hospital from September 2010 to January 2014.Indications for OTSC application were fistulae,anastomotic leakage,perforation,unroofed submucosal lesion for biopsy,refractory bleeding,and stent fixation in the gastrointestinal(GI)tract.Primary technical success was defined as the adequate deployment of the OTSC on the target lesion.Clinical success was defined as resolution of the problem;for instance,no requirement for surgery or further endoscopic intervention.In cases of recurrence,retreatment of a lesion with a second intervention was possible.Complications were classified into those related to sedation,endoscopy,or deployment of the clip.RESULTS:A total of 28 OTSC system applications werecarried out in 21 patients[median age 64 years(range42-85),33%females].The main indications were fistulae(52%),mostly after percutaneous endoscopic gastrostomy tube removal,and anastomotic leakage after GI surgery(29%).Further indications were unroofed submucosal lesions after biopsy,upper gastrointestinal bleeding,or esophageal stent fixation.The OTSC treatments were applied either in the upper(48%)or lower(52%)GI tract.The mean lesion size was 8 mm(range:2-20 mm).Primary technical success and clinical success rates were 85%and 67%,respectively.In53%of cases,the suction method was used without accessories(e.g.,twin grasper or tissue anchor).No endoscopy-related or OTSC-related complications were observed.CONCLUSION:OTSC is a useful tool for endoscopic closure of various GI lesions,including fistulae and leakages.Future randomized prospective multicenter trials are warranted. | Michael Christian Sulz Reto Bertolini Remus Frei Gian-Marco Semadeni Jan Borovicka Christa Meyenberger | 2014 | World Journal of Gastroenterology2014，20，43： | 17 |
| 3 | From Wisdom of the Crowd to Crowdfunding显示文摘 | Clemens Bechter Stefan Jentzsch Michael Frey | 2011 | 通讯和计算机(中英文版)2011，8，11： | 10 |
| 4 | Late biliary complications in human alveolar echinococcosis are associated with high mortality显示文摘AIM:To evaluate the incidence of late biliary complications in non-resectable alveolar echinococcosis(AE)under long-term chemotherapy with benzimidazoles.METHODS:Retrospective analysis of AE patients with biliary complications occurring more than three years after the diagnosis of AE.We compared characteristics of patients with and without biliary complications,analyzed potential risk factor for biliary complications and performed survival analyses.RESULTS:Ninety four of 148 patients with AE in Zurich had non-resectable AE requiring long-term benzimidazole chemotherapy,of which 26(28%)patients developed late biliary complications.These patients had a median age of 55.5(35.5-65)years at diagnosis of AE and developed biliary complications after 15(8.25-19)years of chemotherapy.The most common biliary complications during long-term chemotherapy were late-onset cholangitis(n=14),sclerosing cholangitis-like lesions(n=8),hepatolithiasis(n=5),affection of the common bile duct(n=7)and secondary biliary cirrhosis(n=7).Thirteen of the 26 patients had undergone surgery(including 12 resections)before chemotherapy.Previous surgery was a risk factor for late biliary complications in linear regression analysis(P=0.012).CONCLUSION:Late biliary complications can be observed in nearly one third of patients with non-resectable AE,with previous surgery being a potential risk factor.After the occurrence of late biliary complications,the median survival is only 3 years,suggesting that late biliary complications indicate a poor prognostic outcome. | Pascal Frei Benjamin Misselwitz Meher K Prakash Alain M Schoepfer Bettina M Prinz Vavricka Beat Müllhaupt Michael Fried Kuno Lehmann Rudolf W Ammann Stephan R Vavricka | 2014 | World Journal of Gastroenterology2014，20，19： | 5 |
| 5 | Maize HapMap2 identifies extant variation from a genome in flux 显示文摘 | Jer-Ming Chia Chi Song Peter J Bradbury Denise Cos- tich Natalia de Leon John Doebley Robert J Elshire Brandon Gaut Laura Geller Jeffrey C Glaubitz Michael Gore Kate E Guill Jim Holland Matthew B Hufford Jinsheng Lai Meng Li Xin Liu Yanli Lu Richard Mc- Combie Rebecca Nelson Jesse Poland Boddupalli M Prasanna Tanja Pyhajarvi Tingzhao Rong Rajandeep S Sekhon Qi Sun Maud I Tenaillon Feng Tian Jun Wang Xun Xu Zhiwu Zhang Shawn M Kaeppler Jef- frey Ross-lbarra Michael D McMullen Edward S Buck- ler Gengyun Zhang Yunbi Xu Doreen Ware | 2012 | Nat Genet2012，，44： | 1 |
| 6 | The effects of a subanesthetic dose of ketamine on verbal memory in normal volunteers显示文摘 | Arti Parwani Martin A. Weiler Teresa A. Blaxton Dale Warfel Michael Hardin Kristin Frey Adrienne C. Lahti | 2005 | Psychopharmacology2005，，3： | 1 |
| 7 | Abciximab Improves Both Epicardial Flow and Myocardial Reperfusion in ST-Elevation Myocardial Infarction: Observations from the TIMI 14 Trial显示文摘 | James A. de Lemos Elliott M. Antman C. Michael Gibson Carolyn H. McCabe Robert P. Giugliano Sabina A. Murphy Stephanie A. Coulter Keaven Anderson Joel Scherer Martin J. Frey R. Van der Wieken Frans Van de Werf Eugene Braunwald | 2000 | Circulation: Journal of the American Heart Association2000，，3： | 1 |
| 8 | Clinical impact of programmed cell death ligand 1 expression in colorectal cancer显示文摘 | Raoul A. Droeser Christian Hirt Carsten T. Viehl Daniel M. Frey Christian Nebiker Xaver Huber Inti Zlobec Serenella Eppenberger-Castori Alexander Tzankov Raffaele Rosso Markus Zuber Manuele Giuseppe Muraro Francesca Amicarella Eleonora Cremonesi Michael H | 2013 | European Journal of Cancer2013，，9： | 1 |
| 9 | Endoscopy for repeatedly ingested sharp foreign bodies in patients with borderline personality disorder: an international survey显示文摘 | Cornelia M. Frei-Lanter Stephan R. Vavricka Tillmann H.C. Kruger Radu Tutuian Andreas Geier Peter Bauerfeind Tanja Krones Michael Fried Pascal Frei | 2012 | European Journal of Gastroenterology & Hepatology2012，，7： | 1 |
| 10 | The impact of atmospheric CO 2 concentration enrichment on rice quality – A research review显示文摘 | Yunxia Wang Michael Frei Qiling Song Lianxin Yang | 2011 | Acta Ecologica Sinica2011，，6： | 1 |
| 11 | Pyrazole diaminopyrimidines as dual inhibitors of KDR and Aurora B kinases显示文摘 | Michael L. Curtin H. Robin Heyman Robin R. Frey Patrick A. Marcotte Keith B. Glaser James R. Jankowski Terrance J. Magoc Daniel H. Albert Amanda M. Olson David R. Reuter Jennifer J. Bouska Debra A. Montgomery Joann P. Palma Cherrie K. Donawho Kent D. Stew | 2012 | Bioorganic & Medicinal Chemistry Letters2012，，14： | 1 |
| 12 | Constraints on mantle source compositions imposed by phosphorus and the rare-earth elements显示文摘 | Fred A. Frey Michael F. Roden Alan Zindler | 1980 | Contributions to Mineralogy and Petrology1980，，2： | 1 |
| 13 | Microbial activity and community structure of a soil after heavy metal contamination in a model forest ecosystem显示文摘 | MICHAEL STEMMEK FRANCO WIDMEK | 2006 | Soft Biology and Biochem istry2006，38，7： | 1 |
| 14 | Learning from the crowd:Road infrastructure monitoring system显示文摘The condition of the road infrastructure has severe impacts on the road safety, driving comfort, and on the rolling resistance. Therefore, the road infrastructure must be monitored comprehensively and in regular intervals to identify damaged road segments and road hazards.Methods have been developed to comprehensively and automatically digitize the road infrastructure and estimate the road quality, which are based on vehicle sensors and a supervised machine learning classification. Since different types of vehicles have various suspension systems with different response functions, one classifier cannot be taken over to other vehicles. Usually, a high amount of time is needed to acquire training data for each individual vehicle and classifier.To address this problem, the methods to collect training data automatically for new vehicles based on the comparison of trajectories of untrained and trained vehicles have been developed. The results show that the method based on a k-dimensional tree and Euclidean distance performs best and is robust in transferring the information of the road surface from one vehicle to another. Furthermore, this method offers the possibility to merge the output and road infrastructure information from multiple vehicles to enable a more robust and precise prediction of the ground truth. | Johannes Masino Jakob Thumm Michael Frey Frank Gauterin | 2017 | Journal of Traffic and Transportation Engineering(English Edition)2017，4，5： | 1 |
| 15 | Su1261 Expression of Interleukins 22 and 33, Matrix Metalloproteinases 9 and 13, Mast Cell Markers and Hypoxia-Inducible Factor 1α in Crohn’s Disease Associated Fistulae显示文摘 | Sandra M. Frei Silvia Lang Ekkehard C. Jehle Michael Fried Gerhard Rogler Michael Scharl | 2013 | Gastroenterology2013，，5： | 1 |
| 16 | Periodontitis and Gingivitis in Inflammatory Bowel Disease: A Case–Control Study显示文摘 | Stephan R. Vavricka Christine N. Manser Sebastian Hediger Marius V?gelin Michael Scharl Luc Biedermann Sebastian Rogler Frank Seibold René Sanderink Thomas Attin Alain Schoepfer Michael Fried Gerhard Rogler Pascal Frei | 2013 | Inflammatory Bowel Diseases2013，，13： | 1 |
| 17 | Routine use of Hemospray for gastrointestinal bleeding: prospective two-center experience in Switzerland显示文摘 | Michael Sulz Remus Frei Christa Meyenberger Peter Bauerfeind Gian-Marco Semadeni Christoph Gubler | 2014 | Endoscopy2014，，： | 1 |
| 18 | Insertion/deletion polymor- phism in the promoter of NFKBI iinfluences severity but not mortality of acute respiratory distress syndrome 显示文摘 | Michael A Ulrich H Frey KR | 2009 | Intensive Care Meal2009，33，1： | 1 |
| 19 | Olfactory training is helpful in postinfectious olfactory loss: A randomized, controlled, multicenter study显示文摘 | Michael Damm Louisa K. Pikart Heike Reimann Silke Burkert ?nder G?ktas Boris Haxel Sabine Frey Ioannis Charalampakis Achim Beule Berthold Renner Thomas Hummel Karl‐Bernd Hüttenbrink | 2014 | The Laryngoscope2014，，4： | 1 |
| 20 | Binding of α-dihydrotetrabenazine to the vesicular monoamine transporter is stereospecific显示文摘 | Michael Kilbourn Lihsueh Lee Thierry Vander Borght Douglas Jewett Kirk Frey | 1995 | European Journal of Pharmacology1995，，3： | 1 |
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