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| 1 | Spatio-temporal Changes of ≥10℃ Accumulated Temperature in Northeastern China since 1961显示文摘The objective of this study was to provide reliable basis for decision making for national food security and layout and structure adjustment of grain production in the northeastern China. The data of mean daily air temperature of 1961-2009 from 106 meteorological stations in the northeastern China were chosen in this study. Using statistical methods and isoline method, the spatio-temporal changes of various decadal ≥ 10℃ accumulated temperature and the climatic means of ≥ 10℃ accumulated temperature were studied in this paper. The results showed that 1) The geo-graphical distribution of ≥ 10℃ accumulated temperature in the northeastern China could be influenced directly by the latitude, longitude and altitude. If latitude moved one degree northward, the average decrease amplitude of the climatic means was 101.9℃ in the study area. 2) The means of decadal ≥ 10℃ accumulated temperature rose since the 1980s, and their increase amplitudes became larger in the 1990s and the 2010s obviously. Compared with those of the 1980s, ≥ 10℃ accumulated temperature increased by about 100℃ in the mountainous and plain areas in the 1990s; compared with those of the 1990s, ≥ 10℃ accumulated temperature increased by about 200℃ in the Hulun Buir High Plain and the Songnen Plain, and 100℃ in the Sanjiang Plain and the Liaohe Plain in the 2010s. 3) The means of the decadal ≥ 10℃ accumulated temperature for 106 meteorological stations in the northeastern China increased with the rate of 145.57℃/10yr in 1961-2009. 4) The climatic means of ≥ 10℃ accumulated temperature increased from 1961-1990 to 1971-2000 and 1981-2009. Compared with the climatic mean of 1971-2000, that of 1981-2009 had increased by above 50℃ in most of the study area, even up to 156℃. Compared with the climatic mean of 1961-1990, that of 1981-2009 increased by above 100℃ in most parts of the study area, even up to 200℃. 5) The maximum northward shift, eastward and westward extension amplitudes of 3100℃, 3300℃ and 3500℃ isolines were larger among all isoli-nes for the climatic means of the three phases. Compared with the positions of the isolines of 1961-1990, those ampli-tudes of 3100℃ isoline of 1981-2009 were 145 km, 109 km and 64 km, respectively; those of 3300℃ isoline were 154 km, 54 km and 64 km, respectively; and the maximum northward shift of 3500℃ isoline was about 100 km. | YAN Minhua LIU Xingtu ZHANG Wei LI Xiujun LIU Shi | 2011 | Chinese Geographical Science2011，21，1： | 21 |
| 2 | The Notch signaling pathway in retinal dysplasia and retina vascular homeostasis显示文摘The retina is one of the most essential elements of vision pathway in vertebrate. The dysplasia of retina cause congenital blindness or vision disability in individuals, and the misbalance in adult retinal vascular homeostasis leads to neovascularization-associated diseases in adults, such as diabetic retinopathy or age-related macular degeneration. Many developmental signaling pathways are involved in the process of retinal development and vascular homeostasis. Among them, Notch signaling pathway has long been studied, and Notch signaling-interfered mouse models show both neural retina dysplasia and vascular abnormality. In this review, we discuss the roles of Notch signaling in the maintenance of retinal progenitor cells, specification of retinal neurons and glial cells, and the sustaining of retina vascular homeostasis, especially from the aspects of conditional knockout mouse models. The potential of Notch signal manipulation may provide a powerful cell fate- and neovascularization-controlling tool that could have important applications in treatment of retinal diseases. | Minhua Zheng Zifeng Zhang Xingcheng Zhao Yuqiang Ding Hua Han | 2010 | Journal of Genetics and Genomics2010，37，9： | 13 |
| 3 | Research progress in the SO2 resistance of the catalysts for selective catalytic reduction of NOx显示文摘The selective catalytic reduction(SCR) of NO_x with NH_3 has been proven to be an efficient technology for NO_x conversion to N_2. However, the catalysts used for SCR usually suffer from the problem of sulfur poisoning which seriously limits their practical application. This review summarized sulfur poisoning mechanisms of various SCR de NO_x catalysts and strategies to reduce deactivation caused by SO_2 such as doping metals, controlling the structures and morphologies of the catalysts, and selecting appropriate supports. The methods and procedures of catalysts preparation and the reaction conditions also have effect on SO_2-resistance of the catalysts.Several novel catalyst systems that exhibited good SO_2 resistance are also introduced. This paper could provide guidance for the development of highly efficient sulfur-tolerant de NO_x catalysts. | Minhua Zhang Baojuan Huang Haoxi Jiang Yifei Chen | 2017 | Chinese Journal of Chemical Engineering2017，25，12： | 8 |
| 4 | Black phosphorus-based photothermal therapy with aCD47-mediated immune checkpoint blockade for enhanced cancer immunotherapy显示文摘Here,we describe a combination strategy of black phosphorus(BP)-based photothermal therapy together with anti-CD47 antibody(aCD47)-based immunotherapy to synergistically enhance cancer treatment.Tumour resistance to immune checkpoint blockades in most cancers due to immune escape from host surveillance,along with the initiation of metastasis through immunosuppressive cells in the tumour microenvironment,remains a significant challenge for cancer immunotherapy.aCD47,an agent for CD47/SIRPαaxis blockade,induces modest phagocytic activity and a low response rate for monotherapy,resulting in failures in clinical trials.We showed that BP-mediated ablation of tumours through photothermal effects could serve as an effective strategy for specific immunological stimulation,improving the inherently poor immunogenicity of tumours,which is particularly useful for enhancing cancer immunotherapy.BP in combination with aCD47 blockade activates both innate and adaptive immunities and promotes local and systemic anticancer immune responses,thus offering a synergistically enhanced effect in suppression of tumour progression and in inducing abscopal effects for inhibition of metastatic cancers.Our combination strategy provides a promising platform in which photothermal agents could help to enhance the therapeutic efficacy of immunotherapy. | Zhongjian Xie Minhua Peng Ruitao Lu Xiangying Meng Weiyuan Liang Zhongjun Li Meng Qiu Bin Zhang Guohui Nie Ni Xie Han Zhang Paras N.Prasad | 2020 | Light(Science & Applications)2020，9，1： | 3 |
| 5 | Crystal structure of plant PLDα1 reveals catalytic and regulatory mechanisms of eukaryotic phospholipase D显示文摘Phospholipase D(PLD)hydrolyzes the phosphodiester bond of glycerophospholipids and produces phosphatidic acid(PA),which acts as a second messenger in many living organisms.A large number of PLDs have been identified in eukaryotes,and are viewed as promising targets for drug design because these enzymes are known to be tightly regulated and to function in the pathophysiology of many human diseases.However,the underlying molecular mechanisms of catalysis and regulation of eukaryotic PLD remain elusive.Here,we determined the crystal structure of full-length plant PLDα1 in the apo state and in complex with PA.The structure shows that the N-terminal C2 domain hydrophobically interacts with the C-terminal catalytic domain that features two HKD motifs.Our analysis reveals the catalytic site,substrate-binding mechanism,and a new Ca2+-binding site that is required for the activation of PLD.In addition,we tested several efficient small-molecule inhibitors against PLDα1,and suggested a possible competitive inhibition mechanism according to structure-based docking analysis.This study explains many long-standing questions about PLDs and provides structural insights into PLD-targeted inhibitor/drug design. | Jianxu Li Fang Yu Hui Guo Renxue Xiong Wenjing Zhang Fangyuan He Minhua Zhang Peng Zhang | 2020 | Cell Research2020，30，1： | 3 |
| 6 | Optimization of a synthetic medium for ethanol production by xylose-fermenting Zymomonas mobilis using response surface methodology显示文摘A synthetic medium for ethanol production by recombinant xylose-fermenting Zymomonas mobilis was optimized using Plackett-Burman(PB) design and response surface methodology(RSM).The effects of 19 medium components were investigated by PB design.Eight of these components were determined to have significant effects on ethanol production.The statistical model was constructed via central composite design(CCD) using five selected variables,including xylose,trisodium citrate,choline chloride,pyridoxine,and thiamine.The validity of the developed model was verified.The ethanol concentration in the optimized medium was 6.7% higher than in the RM medium.The optimized medium was then simplified to give the final synthetic medium(S2),in which the ethanol concentration was 20.7% higher than in the RM medium.Xylose and trisodium citrate were the key medium components influencing ethanol production,while calcium pantothenate was the only growth factor required by recombinant Z.mobilis.Ethanol production and growth response were directly proportional to the logarithm of the concentration of trisodium citrate in the range of 0.1-1.6 g/L. | DONG HuiNa ZHAO XueMing MA YuanYuan ZHANG MinHua | 2012 | Chinese Science Bulletin2012，57，28： | 3 |
| 7 | CFD simulation on shell-and-tube heat exchangers with small-angle helical baffles显示文摘Shell-and-tube 热 exchanger 与螺旋状困惑比那优异与部分在减少压力落下,消除死了的地区并且降低试管捆的颤动的风险困惑。这份报纸集中了于小角度螺旋状困惑那仅仅在开的文学被报导了。这些困惑是间断的螺旋状与 10 晦敬 s 慲的一个螺旋角度困惑?? | Minhua ZHANG | 2015 | Frontiers of Chemical Science and Engineering2015，9，2： | 3 |
| 8 | 对比经肛全直肠系膜切除术与腹腔镜全直肠系膜切除术:一项多中心III期随机临床试验(TaLaR试验)方案显示文摘背景:全直肠系膜切除术是直肠癌治疗的标准手术方法。经肛全直肠系膜切除术(taTME)是治疗低位直肠癌的新术式。既往研究表明,与腹腔镜全直肠系膜切除术(lapTME)相比,taTME应用于低位直肠癌患者可提供更高质量的手术标本,但其长期肿瘤学结果仍需进一步观察。因此,我们设计了这个非劣效性临床试验(TaLaR试验),比较taTME与lapTME治疗直肠癌的短期和长期结果。方法/设计:TaLaR试验是一项多中心III期随机对照试验。研究对象为经磁共振成像、直肠指检或结肠镜检查被诊断为位于腹膜反折以下的直肠癌,若肿瘤分期≤cT3N2直接手术,若>cT3N2则先行新辅助治疗。通过计算,本研究需纳入1,114例患者(每组557例)。纳入病例随机分配到taTME或lapTME组。本研究的主要终点是3年无病生存率(DFS)和5年总生存率(OS)。次要终点包括手术标本质量、围手术期结果、骨盆和肛门功能以及生活质量。讨论:我们认为,TaLaR试验将阐明taTME是否可以达到与lapTME相似的肿瘤学结果,以及是否可改善直肠癌患者的手术标本质量及恢复情况。 | Liang Kang Ziwei Zeng Shuangling Luo Hong Zhang Quan Wang Mingyang Ren Miao Wu Weidong Tong Qing Xu Yi Xiao Aiwen Wu Yuan-Guang Chen Bo Feng Zhanlong Shen Liang Huang Xingwei Zhang Minhua Zheng Jian-Ping Wang | 2021 | Gastroenterology Report2021，9，1： | 2 |
| 9 | Different roles of galectin-9 isoforms in modulating E-selectin expression and adhesion function in LoVo colon carcinoma cells显示文摘 | Feng Zhang Minhua Zheng Ying Qu Jianfang Li Jun Ji Bo Feng Aiguo Lu Jianwen Li Mingliang Wang Bingya Liu | 2009 | Molecular Biology Reports2009，，5： | 1 |
| 10 | The improvement of TCP performance in bandwidth asymmetric network显示文摘 | Liu Yu Ye Minhua Zhang Huimin | 2003 | Personal Indoor and Mobile Radio Communications Proceedings2003，1，： | 1 |
| 11 | Serum thymidine kinase 1 correlates to clinical stages and clinical reactions and monitors the outcome of therapy of 1,247 cancer patients in routine clinical settings显示文摘 | Yan Chen Mingang Ying YanSong Chen Minhua Hu Yingying Lin Dedong Chen Xiaoli Li Ming Zhang Xia Yun Ji Zhou Ellen He Sven Skog | 2010 | International Journal of Clinical Oncology2010，，4： | 1 |
| 12 | Second harmonic generation and self-frequency doubling performance in Nd:GdCa4O(BO3)3 crystal显示文摘 | Lu Junhua Li Guangming Liu Junhai Zhang Shujun Chen Huanchu Jiang Minhua Shao Zongshu | 1999 | Optics Communications1999，168，56： | 1 |
| 13 | Electrochemical impedance spectroscopy study of Ni/MH batteries 显示文摘 | Cheng Shaoan Zhang Jianqing Zhao Minhua | 1999 | Journal of Alloys and Compounds1999，293，295： | 1 |
| 14 | The ABCC4 gene is a promising target for pancreatic cancer therapy显示文摘 | Zhuo Zhang Jiancheng Wang Baiyong Shen Chenghong Peng Minhua Zheng | 2011 | Gene2011，，2： | 1 |
| 15 | Mussel-inspired fabrication of structurally stable chitosan/polyaerylonitrile composite membrane for pervaporation dehydration显示文摘 | Ma Jing Zhang Minhua Wu Hong Yin Xin Chen Jing Jiong Zhongyi | 2010 | Journal of Membrane Science2010，348，： | 1 |
| 16 | Electrochemical impedance spectroscopy study of MH/Ni batteries显示文摘 | Zhang Jianqing Zhao Minhua | 1999 | Journal of Alloys and Compounds1999，293，： | 1 |
| 17 | Surfaceenhanced Raman scattering-active substrates of electrospun polyvinyl alcohol/gold-silver nanofibers显示文摘 | LI Xiaofei CAO Minhua ZHANG Han | 2012 | Journal of Colloid and Interface Science2012，382，1： | 1 |
| 18 | Investigationon Process Mechanism on Cu-Cr Catalysts for Ethanol Dehy-drogenation to Ethyl Acetate 显示文摘 | Zhang Minhua Li Guiming Jiang Haoxi | 2011 | Catal Lett2011，141，8： | 1 |
| 19 | Serum thymidine kinase 1 correlates to clinical stages and clinical reactions and monitors the outcome of therapy of 1,247 cancer patients in routine clinical settings显示文摘 | Yan Chen Mingang Ying YanSong Chen Minhua Hu Yingying Lin Dedong Chen Xiaoli Li Ming Zhang Xia Yun Ji Zhou Ellen He Sven Skog | 2010 | International Journal of Clinical Oncology2010，，4： | 1 |
| 20 | Distribution of aluminum and its influence on the acid strength of Y zeolite显示文摘 | Wang Na Zhang Minhua Yu Yingzhe | 2013 | Microporous and Mesoporous Materials2013，，169： | 1 |
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