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| 1 | Promoter methylation of Wnt/β-Catenin signal inhibitor TMEM88 is associated with unfavorable prognosis of nonsmall cell lung cancer显示文摘Objective:Recent research has indicated that altered promoter methylation of oncogenes and tumor suppressor genes is an important mechanism in lung cancer development and progression.In this study,we investigated the association between promoter methylation of TMEM88,a possible inhibitor of the Wnt/β-Catenin signaling,and the survival of patients with nonsmall cell lung cancer(NSCLC).Methods:Twelve pairs of tumor and adjacent non-tumor samples were used for microarray analyses of DNA methylation and gene expression.For validation,more than two hundred additional samples were analyzed for methylation using bisulfite pyrosequencing and for gene expression using q RT-PCR.Then the cell function were tested by wound healing,transwell,CCK8 and cell cycle assay.Results:Our analysis of patient specimens showed that TMEM88 methylation was higher in NSCLC tumors(82.2%±10.3,P<0.01)compared with the adjacent normal tissues(65.9%±7.2).The survival analysis revealed that patients with high TMEM88methylation had a shorter overall survival(46 months)compared with patients with low TMEM88 methylation(>56 months;P=0.021).In addition,we found that demethylation treatment could inhibit tumor cell proliferation,migration,and invasion,which was supportive of an association between methylation and survival.Conclusions:Based on these consistent observations,we concluded that TMEM88 may play an important role in NSCLC progression and that promoter methylation of TMEM88 may serve as a biomarker for NSCLC prognosis and treatment. | Rongna Ma Nannan Feng Xiao Yu Hongyan Lin Xiaohong Zhang Oumin Shi Huan Zhang Shuo Zhang Lei Li Min Zheng Ming Gao Herbert Yu Biyun Qian | 2017 | Cancer Biology & Medicine2017，14，4： | 6 |
| 2 | A Simple and Efficient Copper(Ⅱ) Complex as a Catalyst for N-Arylation of Imidazoles显示文摘四便宜并且 air-/moisture-stable pyrrolecarbaldiminato-Cu 建筑群 14 被综合并且评估了是为有芳基卤化物的咪唑的 N-arylation 的催化剂的一个新奇的班。许多芳基碘化物,溴化物和激活的芳基氯化物经历了结合咪唑,由催化剂支持了 4,在里面对没有由惰性的气体的保护的好收益中等。 | Yanli Jiao Nannan Yan Jianwei Xie Xiaowei Ma Ping Liu Bin Dai | 2013 | Chinese Journal of Chemistry2013，31，2： | 3 |
| 3 | Direct conversion of methane to methanol over Cu exchanged mordenite:Effect of counter ions显示文摘Direct conversion of methane(CH4)to methanol(DMTM)is a promising,but very challenging process for the utilization of abundant CH4 as a low carbon resource.In this context,Cu loaded zeolites,mordenite(MOR)in particular,were recognized as the most effective system to perform DMTM.In this work,different Cu salts were used to exchange with MOR,by which the effect of counter ions on the catalytic performance towards DMTM was investigated.The prepared catalysts were characterized and evaluated systematically.It was found that the counter ions affected the speciation of Cu sites,probably due to their capability in extraction of protons from MOR and the influence on the hydrolysis state of the Cu2+in aqueous solution.These behaviors adjusted the association between Cu2+and the exchangeable protons in MOR.As a result,varied DMTM performance was observed.Among the used Cu salts,Cu(CH3COO)2 exchanged MOR showed the highest performance,achieving stable CH3 OH yield of 117±28μmol/g in 5 consecutive cycles,these values are among the highest for Cu loaded MOR zeolites in open publications. | Chuang Ma Xianjun Tan Haijiao Zhang Qun Shen Nannan Sun Wei Wei | 2020 | Chinese Chemical Letters2020，31，1： | 2 |
| 4 | Traditional Chinese Medicine guidelines for coronavirus disease 2019显示文摘OBJECTIVE:To summarize the evidence from Traditional Chinese Medicine(TCM)practice in the treatment of coronavirus disease 2019(COVID-19)and provide timely clinical practice guidance.METHODS:The guidelines were developed in accordance with the World Health Organization rapid guideline process.The evidence on TCM for COVID-19 from published guidelines,direct and indirect published clinical evidence,first hand clinical data,and expert experience and consensus were collected.The grading of recommendations assessment,development and evaluation(GRADE)method was used to grade the evidence and make the recommendations.RESULTS:Based on the available evidence,the guidelines recommended 17 Chinese medicines for COVID-19:2 Chinese herbal granules,7 Chinese patent medicines,and 8 Chinese herbal injections.CONCLUSION:As the literature search was conducted on March,any subsequent versions of these guidelines require an up-to-date literature review.We hope that the evidence summary in these guidelines will be helpful in global efforts to address COVID-19. | Liang Ning Ma Yanfang Wang Jingya Li Huizhen Wang Xiaohui Jiao Liwen Liu Bin Ma Yan Zhao Chen Luo Xufei Zhao Siya Lu Meng Cao Jin Hu Wenpin Zhang Hairong Liu Guoxiu Lu Cheng Liu Mengyu Li Li Han Xuejie Liu Yuqi Wang Liying Zhao Xueyao Wei Dongfeng Bai Jing Sun Mingyu Yang Yong Wu Xiaodan Chen Yaolong Shi Nannan Wang Yanping Wang Yongyan | 2020 | Journal of Traditional Chinese Medicine2020，40，6： | 2 |
| 5 | Multi responsive methylcellulose/Fe-alginate-g-PVA/PVA/Fe3O4 microgels for immobilizing enzyme 显示文摘 | Xiao Congming Ma Peipei Geng Nannan | 2011 | Polymers for Advanced Technologies2011，22，12： | 1 |
| 6 | Study on catalytic mechanisms of Fe_(3)O_(4)-rGO_(x) in three typical advanced oxidation processes for tetracycline hydrochloride degradation显示文摘This study explored the catalytic mechanism and performance impacted by the materials ratio of Fe_(3)O_(4)-GO_(x) composites in three typical advanced oxidation processes(AOPs)of O_(3),peroxodisulfate(PDS)and photo-Fenton processes for tetracycline hydrochloride(TCH)degradation.The ratio of GO in the Fe_(3)O_(4)-GO_(x) composites exhibited different trends of degradation capacity in each AOPs based on different mechanisms.Fe_(3)O_(4)-rGO_(20wt%) exhibited the optimum catalytic performance which enhanced the ozone decomposition efficiency from 33.48%(ozone alone)to 51.83%with the major reactive oxygen species(ROS)of O_(2)·-.In PDS and photo-Fenton processes,Fe_(3)O_(4)-rGO_(5wt%) had the highest catalytic performance in PDS and H_(2)O_(2) decomposition for SO_(4)·–,and·OH generation,respectively.Compared with using PDS alone,PDS decomposition rate and TCH degradation rate could be increased by 5.97 and 1.73 times under Fe_(3)O_(4)-rGO_(5wt%) catalysis.In the photo-Fenton system,Fe_(3)O_(4)-rGO_(5wt%) with the best catalyst performance in H_(2)O_(2) decomposition,and TCH degradation rate increased by 2.02 times compared with blank group.Meantime,the catalytic mechanisms in those systems of that the ROS produced by conversion between Fe^(2+)/Fe^(3+)were also analyzed. | Heshan Zheng Yunying Hou Shuo Li Jun Ma Jun Nan Nannan Wang | 2023 | Chinese Chemical Letters2023，34，1： | 1 |
| 7 | Delay-dependent decentralised control for a class of uncertain similar interconnected systems with state delay and input delay显示文摘 | Ma Yuechao Jin Shujie Gu Nannan | 2015 | International Journal of Systems Science2015，46，16： | 1 |
| 8 | Increased P38-MAPK is responsible for chemotherapy resistance in human gastric cancer cells 显示文摘 | Guo Xianling Ma Nannan Wang Jin | 2008 | BMC Cancer2008，8，： | 1 |
| 9 | Susceptibility of male and female Japanese medaka (Oryzias latipes) to 2,4,6-trichlorophenol-induced micronuclei in peripheral erythrocytes显示文摘2,4,6-trichlorophenol (2,4,6-TCP) is a wide- spread probable human carcinogen and has been proven to have genotoxicity in in vitro assays. However, little genotoxicity information and no micronuclei induction data for 2,4,6-TCP is available from in vivo tests, especially for sex-specific differences. Following a preliminary test, a piscine peripheral erythrocyte micro- nucleus assay was conducted on medaka (Oryzias latipes) after a 28-day exposure to 2,4,6-TCE In the present study, the mean micronuclei (MNC) frequencies of all of the groups increased in a dose-dependent manner, which indicated the potential genotoxicity of 2,4,6-TCE More- over, males were found to be more susceptible compared with females after a 28-day exposure to 2,4,6-TCP in all of the dosed groups above 10 ~tg-L-1. This is the first report on the potential of micronuclei induction and a sex-susceptible effect in the peripheral erythrocytes of mature fish after 2,4,6-TCP in vivo exposure. | Nannan LIU Mei MA Yiping XU Jinmiao ZHA Kaifeng RAO Zijian WANG | 2013 | Frontiers of Environmental Science & Engineering2013，7，1： | 1 |
| 10 | An integrated information fusion approach based on the theory of evidence and group decision-making显示文摘 | Yee Leung Ji Nannan Ma Jianghong | 2012 | Information Fusion2012，23，2： | 1 |
| 11 | Removal of fluoride ions from aqueous solution by the calcination product of Mg-Al-Fe hydrotalcite-like compound显示文摘 | MA Wei ZHAO Nannan YANG Gang | 2011 | Desalination2011，268，： | 1 |
| 12 | Tumor Necrosis Factor-alpha Promotes Tumor Growth by Inducing Vascular Endothelial Growth Factor显示文摘 | Yingying Jing Nannan Ma Tingting Fan Chenyang Wang Xinxin Bu Guocheng Jiang Rong Li Lu Gao Ding Li Mengchao Wu Lixin Wei | 2011 | Cancer Investigation2011，，7： | 1 |
| 13 | A short review of catalysis for CO2conversion显示文摘 | Ma Jun Sun Nannan Sun Yuhan | 2009 | CatalysisToday2009，148，34： | 1 |
| 14 | Correlation between knowledge of prevention COVID-19 and depression of residents in Henan province,China显示文摘Background:Coronavirus disease 2019(COVID-19) has shown explosive growth in cities in central China in recent days.Residents have the depression due to lack of corresponding prevention knowledge.Methods:A cross-sectional study was investigated 385 residents over 18 years of age.Structured questionnaire and DASS-21 scale used to explore the association between knowledge of prevention COVID-19 and depression among residents.Results:73 respondents (20.3%) suffered varying degrees of depression.The knowledge of the behavior of respondents most concerned (AOR 7.45,95%CI,1.87 ~ 29.77),the main symptoms of the COVID-19 (AOR 9.72,95%CI,1.19 ~ 79.12) and using special ambulances to transport patients or suspected patients (AOR 2.22,95%CI,1.07 ~ 4.62) was found to be significant related to depression.Conclusions:Although residents currently have a lower prevalence of depression,but there is a strong correlation between the knowledge and attitude of prevention COVID-19 and depression.Government agencies need to expand ways to spread the knowledge of prevention COVID-19. | Anna Ma Dongyang Wang Nannan Wang ShanShan Zhu Qiong Li Shuangxi Guo | 2020 | 中国研究型医院2020，7，2： | 0 |
| 15 | Analysis of piezoelectric semiconductor fibers under gradient temperature changes显示文摘Piezoelectric semiconductors(PSs)possess both semiconducting properties and piezoelectric coupling effects,making them optimal building blocks for semiconductor devices.PS fiber-like structures have wide applications in multi-functional semiconductor devices.In this paper,a one-dimensional(1D)theoretical model is established to describe the piezotronic responses of a PS fiber under gradient temperature changes.The theoretical model aims to explain the mechanism behind the resistance change caused by such gradient temperature changes.Numerical results demonstrate that a gradient temperature change significantly affects the physical fields within the PS fiber,and can induce changes in its surface resistance.It provides important theoretical guidance on the development of piezotronic devices that are sensitive to temperature effects. | Shuangpeng LI Ruoran CHENG Nannan MA Chunli ZHANG | 2024 | Applied Mathematics and Mechanics(English Edition)2024，45，2： | 0 |
| 16 | OPAQUE3, encoding a transmembrane bZIP transcription factor, regulates endosperm storage protein and starch biosynthesis in rice显示文摘Starch and storage proteins are the main components of rice(Oryza sativa L.)grains.Despite their importance,the molecular regulatory mechanisms of storage protein and starch biosynthesis remain largely elusive.Here,we identified a rice opaque endosperm mutant,opaque3(o3),that overaccumulates 57-kDa proglutelins and has significantly lower protein and starch contents than the wild type.The o3 mutant also has abnormal protein body structures and compound starch grains in its endosperm cells.OPAQUE3(O3)encodes a transmembrane basic leucine zipper(bZIP)transcription factor(OsbZIP60)and is localized in the endoplasmic reticulum(ER)and the nucleus,but it is localized mostly in the nucleus under ER stress.We demonstrated that O3 could activate the expression of several starch synthesis-related genes(GBSSI,AGPL2,SBEI,and ISA2)and storage protein synthesis-related genes(OsGluA2,Prol14,and Glb1).O3 also plays an important role in protein processing and export in the ER by directly binding to the promoters and activating the expression of OsBIP1 and PDIL1-1,two major chaperones that assist with folding of immature secretory proteins in the ER of rice endosperm cells.High-temperature conditions aggravate ER stress and result in more abnormal grain development in o3 mutants.We also revealed that OsbZIP50 can assist O3 in response to ER stress,especially under high-temperature conditions.We thus demonstrate that O3 plays a central role in rice grain development by participating simultaneously in the regulation of storage protein and starch biosynthesis and the maintenance of ER homeostasis in endosperm cells. | Ruijie Cao Shaolu Zhao Guiai Jiao Yingqing Duan Liuyang Ma Nannan Dong Feifei Lu Mingdong Zhu Gaoneng Shao Shikai Hu Zhonghua Sheng Jian Zhang Shaoqing Tang Xiangjin Wei Peisong Hu | 2022 | Plant Communications2022，3，6： | 0 |
| 17 | Diagnostic Value of Neutrophil-Lymphocyte Ratio and Platelet-Lymphocyte Ratio in Patients with Severe COVID-19—7 PLADs,China,January 21–February 10,2020显示文摘Summary What is already known about this topic?Coronavirus disease 2019(COVID-19)causes symptoms ranging from mild to severe.Indicators for identifying severe COVID-19 infection have not been well identified,especially for young patients.What is added by this report?Both neutrophil-lymphocyte ratio(NLR)[area under curve(AUC):0.80;the odds ratios(OR)and 95%confidence intervals(95%CI):1.30(1.13–1.50)]and platelet-lymphocyte ratio(PLR)[AUC:0.87;OR(95%CI):1.05(1.01–1.09)]were determined to be indicators for recognition of patients with severe COVID-19 in young patients less than age 40.What are the implications for public health practice?NLR and PLR are useful indicators for identifying patients with severe COVID-19,especially in young patients less than age 40. | Yan Ma Dongshan Zhu Nannan Shi Lei Zhang Guangkun Chen Youwen Ge Zelei Zhang Renbo Chen Sihong Liu Yipin Fan Huamin Zhang Yanping Wang | 2022 | China CDC weekly2022，4，10： | 0 |
| 18 | Shaggy regulates tissue growth through Hippo pathway in Drosophila显示文摘The evolutionarily conserved Hippo pathway coordinates cell proliferation,differentiation and apoptosis to regulate organ growth and tumorigenesis.Hippo signaling activity is tightly controlled by various upstream signals including growth factors and cell polarity,but the full extent to which the pathway is regulated during development remains to be resolved.Here,we report the identification of Shaggy,the homolog of mammalian Gsk3β,as a novel regulator of the Hippo pathway in Drosophila.Our results show that Shaggy promotes the expression of Hippo target genes in a manner that is dependent on its kinase activity.Loss of Shaggy leads to Yorkie inhibition and downregulation of Hippo pathway target genes.Mechanistically,Shaggy acts upstream of the Hippo pathway and negatively regulates the abundance of the FERM domain containing adaptor protein Expanded.Our results reveal that Shaggy is functionally required for Crumbs/Slmb-mediated downregulation of Expanded in vivo,providing a potential molecular link between cellular architecture and the Hippo signaling pathway. | Honggang Wu Nannan Zhu Jiyong Liu Jun Ma Renjie Jiao | 2022 | Science China(Life Sciences)2022，65，11： | 0 |
| 19 | 高产酒精肺炎克雷伯菌引起的非酒精性脂肪肝病显示文摘文章简介非酒精性脂肪肝(NAFLD)具有进展为肝硬化和肝细胞癌的风险,其潜在病因多种多样,目前认为NAFLD与肠道微生物群的变化有关,然而,它们之间的因果关系尚不清楚。研究团队发现肠道菌群中高产酒精的肺炎克雷伯菌(HiAlc Kpn)可能是NAFLD的一个病因。在NAFLD患者人群中,高达60%的患者肠道菌群中含有HiAlc Kpn。 | 袁静 Chen Chen Jinghua Cui Jing Lu Chao Yan Xiao Wei Xiangna Zhao NanNan Li Shaoli Li Guanhua Xue Weiwei Cheng Boxing Li Huan Li Weishi Lin Changyu Tian Jiangtao Zhao Juqiang Han Daizhi An Qiong Zhang Hong Wei Minghua Zheng Xuejun Ma Wei Li Xiao Chen Zheng Zhang Hui Zeng Sun Ying JianXin Wu Ruifu Yang 刘翟 | 2020 | 科学新闻2020，，2： | 0 |
| 20 | The bacterial effector SidN/Lpg1083 promotes cell death by targeting Lamin-B2显示文摘To facilitate survival,replication,and dissemination,the intracellular pathogen Legionella pneumophila relies on its unique type IVB secretion system(T4SS)to deliver over 330 effectors to hijack host cell pathways in a spatiotemporal manner.The effectors and their host targets are largely unexplored due to their low sequence identity to the known proteins and functional redundancy.The T4SS effector SidN(Lpg1083)is secreted into host cells during the late infection period.However,to the best of our knowledge,the molecular characterization of SidN has not been studied.Herein,we identified SidN as a nuclear envelope-localized effector.Its structure adopts a novel fold,and the N-terminal domain is crucial for its specific subcellular localization.Furthermore,we found that SidN is transported by eukaryotic karyopherin Importin-13 into the nucleus,where it attaches to the N-terminal region of Lamin-B2 to interfere with the integrity of the nuclear envelope,causing nuclear membrane disruption and eventually cell death.Our work provides new insights into the structure and function of an L.pneumophila effector protein,and suggests a potential strategy utilized by the pathogen to promote host cell death and then escape from the host for secondary infection. | Jiajia Gao Wenwen Xu Feng Tang Minrui Xu Qin Zhou Xingyuan Yang Nannan Zhang Jinming Ma Qi Yang Xiaofang Chen Ximing Qin Honghua Ge | 2023 | Journal of Molecular Cell Biology2023，15，5： | 0 |
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