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| 1 | Highly accurate colorectal cancer prediction model based on Raman spectroscopy using patient serum显示文摘BACKGROUND Colorectal cancer(CRC) is an important disease worldwide, accounting for the second highest number of cancer-related deaths and the third highest number of new cancer cases. The blood test is a simple and minimally invasive diagnostic test. However, there is currently no blood test that can accurately diagnose CRC.AIM To develop a comprehensive, spontaneous, minimally invasive, label-free, bloodbased CRC screening technique based on Raman spectroscopy.METHODS We used Raman spectra recorded using 184 serum samples obtained from patients undergoing colonoscopies. Patients with malignant tumor histories as well as those with cancers in organs other than the large intestine were excluded. Consequently, the specific diseases of 184 patients were CRC(12), rectal neuroendocrine tumor(2), colorectal adenoma(68), colorectal hyperplastic polyp(18), and others(84). We used the 1064-nm wavelength laser for excitation. The power of the laser was set to 200 mW.RESULTS Use of the recorded Raman spectra as training data allowed the construction of a boosted tree CRC prediction model based on machine learning. Therefore, the generalized R^2 values for CRC, adenomas, hyperplastic polyps, and neuroendocrine tumors were 0.9982, 0.9630, 0.9962, and 0.9986, respectively.CONCLUSION For machine learning using Raman spectral data, a highly accurate CRC prediction model with a high R^2 value was constructed. We are currently planning studies to demonstrate the accuracy of this model with a large amount of additional data. | Hiroaki Ito Naoyuki Uragami Tomokazu Miyazaki William Yang Kenji Issha Kai Matsuo Satoshi Kimura Yuji Arai Hiromasa Tokunaga Saiko Okada Machiko Kawamura Noboru Yokoyama Miki Kushima Haruhiro Inoue Takashi Fukagai Yumi Kamijo | 2020 | World Journal of Gastrointestinal Oncology2020，12，11： | 2 |
| 2 | Identification of genes specifically methylated in E pstein– B arr virus‐associated gastric carcinomas显示文摘 | Toshiyuki Okada Munetaka Nakamura Jun Nishikawa Kouhei Sakai Yibo Zhang Mari Saito Akihiro Morishige Atsunori Oga Kosuke Sasaki Yutaka Suehiro Yuji Hinoda Isao Sakaida | 2013 | Cancer Sci2013，，10： | 2 |
| 3 | Serum biomarkers as predictors of lung function decline in chronic obstructive pulmonary disease显示文摘 | Yuji Higashimoto Takuya Iwata e Morihiro Okada | 2009 | Respir Med2009，103，： | 1 |
| 4 | SSJD14101300049070显示文摘 | Ken-ichi Okada Manabu Kawai Masaji Tani Seiko Hirono Motoki Miyazawa Atsushi Shimizu Yuji Kitahata Hiroki Yamaue | 2014 | World Journal of Surgery2014，，11： | 1 |
| 5 | Role of DNA methylation in the development of Epstein–Barr virus‐associated gastric carcinoma显示文摘 | Mari Saito Jun Nishikawa Toshiyuki Okada Akihiro Morishige Kouhei Sakai Munetaka Nakamura Shu Kiyotoki Kouichi Hamabe Takeshi Okamoto Atsunori Oga Kohsuke Sasaki Yutaka Suehiro Yuji Hinoda Isao Sakaida | 2012 | J Med Virol2012，，1： | 1 |
| 6 | Temperature- and pH-responsive aminopropyl-silica ion- exchange columns grafted with copolymers of Nisopropylacrylamide显示文摘 | Sakamoto C Okada Yuji Kanazawa H | 2004 | Journal of Chromatography2004，1030，12： | 1 |
| 7 | The Carcinoembryonic Antigen Level in Pancreatic Juice and Mural Nodule Size Are Predictors of Malignancy for Branch Duct Type Intraductal Papillary Mucinous Neoplasms of the Pancreas显示文摘 | Seiko Hirono Masaji Tani Manabu Kawai Ken-ichi Okada Motoki Miyazawa Atsushi Shimizu Yuji Kitahata Hiroki Yamaue | 2012 | Annals of Surgery2012，，3： | 1 |
| 8 | Transbronchial human interleukin-10 gene transfer reduces acute inflammation associated with allograft rejection and intragraft interleukin-2 and tumor necrosis factor-α gene expression in a rat model of lung transplantation显示文摘 | Hisashi Oishi Yoshinori Okada Toshiaki Kikuchi Yasushi Hoshikawa Tetsu Sado Masafumi Noda Chiaki Endo Akira Sakurada Yuji Matsumura Takashi Kondo | 2010 | Journal of Heart and Lung Transplantation2010，，3： | 1 |
| 9 | Role of free radicals in the development of severe acute pancreatitis显示文摘 | TADAO M YUJI Okada | 2004 | Nihon Rinsho Japanese Journal of Clinical Medicine2004，62，11： | 1 |
| 10 | Preoperative estimation of asialoglycoprotein receptor expression in the remnant liver from CT/99mTc-GSA SPECT fusion images correlates well with postoperative liver function parameters显示文摘 | Yuji Iimuro Toru Kashiwagi Junichi Yamanaka Tadamichi Hirano Shinichi Saito Takaaki Sugimoto Shinichiro Watanabe Nobukazu Kuroda Toshihiro Okada Yasukane Asano Naoki Uyama Jiro Fujimoto | 2010 | Journal of Hepato - Biliary - Pancreatic Sciences2010，，5： | 1 |
| 11 | Effect of Helicobacter bilis Infection on Human Bile Duct Cancer Cells显示文摘 | Satoru Takayama Hiroki Takahashi Yoichi Matsuo Yuji Okada Hiromitsu Takeyama | 2010 | Digestive Diseases and Sciences2010，，7： | 1 |
| 12 | Expression and Prognostic Roles of Integrins and Interleukin-1 Receptor Type I in Patients with Ductal Adenocarcinoma of the Pancreas显示文摘 | Hirozumi Sawai Hitoshi Funahashi Yoichi Matsuo Minoru Yamamoto Yuji Okada Tetsushi Hayakawa Tadao Manabe | 2003 | Digestive Diseases and Sciences2003，，7： | 1 |
| 13 | 8-O-Cinnamoylneoline, A New Alkaloid from the Flower Buds of Aconitum carmichaeli and its Toxic and Analgesic Activities显示文摘 | Masanori Taki Kazuaki Niitu Yuji Omiya Masamichi Noguchi Mikio Fukuchi Masaki Aburada Minoru Okada | 2003 | Planta Med2003，，09： | 1 |
| 14 | Nerve growth factor stimulates MMP-2 expression and activity and increases invasion by human pancreatic cancer cells显示文摘 | Yuji Okada Guido Eibl Sushovan Guha John P. Duffy Howard A. Reber Oscar J. Hines | 2004 | Clinical and Experimental Metastasis2004，，4： | 1 |
| 15 | Importance of luminal membrane mesothelin expression in intraductalpapillary mucinous neoplasms显示文摘 | Takahiro Einama Hirofumi Kamachi Hiroshi Nishihara Shigenori Homma Hiromi Kanno Marin Ishikawa Futoshi Kawamata Yuji Konishi Masanori Sato Munenori Tahara Kuniaki Okada Shunji Muraoka Toshiya Kamiyama Akinobu Taketomi Yoshihiro Matsuno Hiroyuki Furukawa S | 2015 | Oncology Letters2015，，： | 1 |
| 16 | Immunohistochemical analysis of invasive micropapillary carcinoma pattern in four cases of gastric cancer显示文摘 | Yuji Ohtsuki Naoto Kuroda Shigeru Yunoki Shinzo Murakami Yuji Mizukami Yuhei Okada Mitsuko Iguchi Gang-Hong Lee Mutsuo Furihata | 2013 | Medical Molecular Morphology2013，，2： | 1 |
| 17 | Preoperative cholangitis during biliary drainage increases the incidence of postoperative severe complications after pancreaticoduodenectomy显示文摘 | Yuji Kitahata Manabu Kawai Masaji Tani Seiko Hirono Ken-ichi Okada Motoki Miyazawa Atsushi Shimizu Hiroki Yamaue | 2013 | The American Journal of Surgery2013，，： | 1 |
| 18 | Modic changes of the cervical spine in patients with whiplash injury: A prospective 11-year follow-up study显示文摘 | Morio Matsumoto Daisuke Ichihara Eijiro Okada Yoshiaki Toyama Hirokazu Fujiwara Suketaka Momoshima Yuji Nishiwaki Takeshi Takahata | 2013 | Injury2013，，6： | 1 |
| 19 | The mixture state of individual aerosol particles in the 1997 Indonesian haze episode显示文摘 | Kikuo Okada Miwako Ikegami Yuji Zaizen Yukio Makino Jorgen B. Jensen John L. Gras | 2001 | Journal of Aerosol Science2001，，： | 1 |
| 20 | Dominant-Negative Hypoxia-Inducible Factor-1α Reduces Tumorigenicity of Pancreatic Cancer Cells through the Suppression of Glucose Metabolism显示文摘 | Jian Chen Songji Zhao Kunihiro Nakada Yuji Kuge Nagara Tamaki Futoshi Okada Jingxin Wang Masanobu Shindo Fumihiro Higashino Kohji Takeda Masahiro Asaka Hiroyuki Katoh Toshio Sugiyama Masuo Hosokawa Masanobu Kobayashi | 2003 | The American Journal of Pathology2003，，4： | 1 |
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