|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Auranofin mitigates systemic iron overload and induces ferroptosis via distinct mechanisms显示文摘Iron homeostasis is essential for health;moreover,hepcidin-deficiency results in iron overload in both hereditary hemochromatosis and iron-loading anemia.Here,we identified iron modulators by functionally screening hepcidin agonists using a library of 640 FDA-approved drugs in human hepatic Huh7 cells.We validated the results in C57BL/6J mice and a mouse model of hemochromatosis(Hfe^(−/−)mice).Our screen revealed that the anti-rheumatoid arthritis drug auranofin(AUR)potently upregulates hepcidin expression.Interestingly,we found that canonical signaling pathways that regulate iron,including the Bmp/Smad and IL-6/Jak2/Stat3 pathways,play indispensable roles in mediating AUR’s effects.In addition,AUR induces IL-6 via the NF-κB pathway.In C57BL/6J mice,acute treatment with 5 mg/kg AUR activated hepatic IL-6/hepcidin signaling and decreased serum iron and transferrin saturation.Whereas chronically treating male Hfe^(−/−)mice with 5 mg/kg AUR activated hepatic IL-6/hepcidin signaling,decreasing systemic iron overload,but less effective in females.Further analyses revealed that estrogen reduced the ability of AUR to induce IL-6/hepcidin signaling in Huh7 cells,providing a mechanistic explanation for ineffectiveness of AUR in female Hfe^(−/−)mice.Notably,high-dose AUR(25 mg/kg)induces ferroptosis and causes lipid peroxidation through inhibition of thioredoxin reductase(TXNRD)activity.We demonstrate the ferroptosis inhibitor ferrostatin significantly protects liver toxicity induced by highdose AUR without comprising its beneficial effect on iron metabolism.In conclusion,our findings provide compelling evidence that TXNRD is a key regulator of ferroptosis,and AUR is a novel activator of hepcidin and ferroptosis via distinct mechanisms,suggesting a promising approach for treating hemochromatosis and hepcidin-deficiency related disorders. | Lei Yang Hao Wang Xiang Yang Qian Wu Peng An Xi Jin Weiwei Liu Xin Huang Yuzhu Li Shiyu Yan Shuying Shen Tingbo Liang Junxia Min Fudi Wang | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 5 |
| 2 | Synthesis and gelation behaviors of five new dimeric cholesteryl derivatives显示文摘Five new diacid amides of di-cholesteryl L-glycinates were designed and prepared.The compounds with linkers containing 0,1, 2,3,or 4 methylene units are denoted as 1,2,3,4,and 5,respectively.Their gelation behaviors in 25 solvents were tested as novel low-molecular-mass organic gelators(LMOGs).It was shown that the length of the linker connecting the two-cholesteryl residues in a gelator plays a crucial role in the gelation behavior of the compound.1 gels 11 of the 25 solvents tested at a concentration lower than 1.0%,while 2 gels 17 of the solvents tested.4 and 5,however,gel only 2 and 4 of them,respectively. SEM observation reveals that the lengths of the linkers and the identity of the solvents are the main factors affecting the structures of the aggregates in the gels.Experimentally,a clear linker effect on the microstructures of the gels was observed.As example,the aggregates of 1,2 and 3 in benzene or 1-heptanol adopt structures of thin fibers,rods or lamellas,respectively. Furthermore,it was found that the gelation and aggregation behaviors of 2,3,4,and 5 in DMSO showed an even-odd effect. | LIU KaiQiang PENG JunXia XUE Min YAN Ni LIU Jing FANG Yu | 2011 | Science China Chemistry2011，54，3： | 2 |
| 3 | Proteomics Study of COI1-regulated Proteins in Arabidopsis Flower显示文摘Jasmonates(JAs) are a new class of plant hormone that regulate expression of diverse genes to mediate various plant responses.The Arabidopsis F-box protein COI1 is required for plant defense and male fertility in JA signal pathway.To further investigate the regulatory role of COI1 in male fertility,we compared the proteomics profiles of Arabidopsis wild type(WT) flowers with coi1-1 mutan male-sterile flowers using two-dimensional difference gel electrophoresis coupled with matrix-assisted laser desoption/ionization-time-of-flight mass spectrometry.Sixteen proteins with potential function in specific biological processes such as metabolism processes and defense/stress responses were differentially expressed in WT and coi1-1 mutant flowers.Verification on a phi class glutathione transferase AtGSTF9,one out of these 16 identified proteins,revealed that the expression of AtGSTF9 was severely downregulated in flowers of coi1-1 mutant compared with that of WT.Further function analyses of these genes would provide new insights into the molecular basis of COI1-regulated male fertility. | Lingling Chua Xiaoyi Shan Junxia Wang Wen Peng Guiyou Zhang Daoxin Xie | 2010 | Journal of Integrative Plant Biology2010，52，4： | 1 |
| 4 | CO2 Emission Calculation and Reduction Options in Ceramic Tile Manufacture-The Foshan Case显示文摘 | Junxia Peng Yubo Zhao Lihua Jiao Weimin Zheng Lu Zeng | 2012 | Energy Procedia2012，，： | 1 |
| 5 | Salvianolic Acid B Attenuates Rat Hepatic Fibrosis via Downregulating Angiotensin II Signaling显示文摘 | Shu Li Lina Wang Xiuchuan Yan Qinglan Wang Yanyan Tao Junxia Li Yuan Peng Ping Liu Chenghai Liu Adair Roberto Soares Santos | 2012 | <journal-title>Evidence-Based Complementary and Alternative Medicine2012，，： | 1 |
| 6 | New Dicholesteryl-Based Gelators:Gelling Ability and Selective Gelationof Organic Solvents from Their Mixtures with Water at RoomTemperature显示文摘 | Peng Junxia Liu Kaiqiang Liu Xufei | 2008 | New J Chem2008，32，12： | 1 |
| 7 | Prepara- tion of silver-poly (acrylamide-co-metha-crylic acid ) composite microspheres with patterned surface struc- tures显示文摘 | Xia Huiyun Zhang Ying Peng Junxia | 2006 | Colloid and Polymer Science2006，284，： | 1 |
| 8 | Preparation and fluorescent sensing applications of novel CdSe–chitosan hybrid films显示文摘 | Huiyun Xia Gang He Junxia Peng Weiwei Li Yu Fang | 2010 | Applied Surface Science2010，，23： | 1 |
| 9 | Preparation and fluorescent sensing applications of novel CdSe-Chitosan hybrid films显示文摘 | Xia Huiyun He Gang Peng Junxia | 2010 | Applied Surface Science2010，256，： | 1 |
| 10 | hsa-mir-181a and hsa-mir-181b function as tumor suppressors in human glioma cells显示文摘 | Lei Shi Zihao Cheng Junxia Zhang Rui Li Peng Zhao Zhen Fu Yongping You | 2008 | Brain Research2008，，： | 1 |
| 11 | New dicholesteryl - based gelators : Chirality and spacer length effect 显示文摘 | PENG JUNXIA LIU KAIQIANG LIU JING | 2008 | Langmuir2008，24，： | 1 |
| 12 | Research on the antitumor effect of ginsenoside Rg3 in B16 melanoma cells显示文摘 | Chen Junxia Peng Huimin Ou-yang Xi | 2008 | Melanoma Research2008，18，5： | 1 |
| 13 | A comparative study of alteration in retinal layer segmentation alteration by SD-OCT in neuromyelitis optica spectrum disorders: A systematic review and meta-analysis显示文摘Background:To evaluate the feature of different retinal layer segmentation in neuromyelitis optica spectrum disorders(NMOSD)with spectral-domain optical coherence tomography(SD-OCT)and to compare it with that in multiple sclerosis(MS),healthy controls(HC),and idiopathic optic neuritis(ION).Methods:We retrieved four electronic databases,including Pubmed,Embase,Cochrane Library,and Web of Science from inception to September 1st,2021.A meta-analysis was performed to compare different retinal layer segmentation thicknesses between patients with or without a history of optic neuritis(ON)in NMOSD and the control group,including patients with MS,HC,and ION.Results:Forty-two studies were included and the interval between the last ON onset and examination was greater than 3 months.Compared with that in HC eyes,the loss of retinal nerve fiber layer(RNFL)and macular ganglion cell and inner plexiform layer(GC-IPL)was serious in NMOSD eye especially after ON.Moreover,compared with that in ION eyes or MS-related-ON eyes,the injury to the peripapillary retinal nerve fiber layer(pRNFL)was severe in NMOSD-related-ON eyes.In addition,the correlation coefficient between pRNFL and prognostic visual acuity was 0.43.However,the one-arm study revealed the inner nuclear layer(INL)was thickened in NMOSDrelated-ON eyes compared with HC eyes.Conclusions:Inclusion of the RNFL and macular GC-IPL is recommended for monitoring disease progression and attention should be paid to changes in the INL. | Junxia Fu Shaoying Tan Chunxia Peng Huanfen Zhou Shihui Wei | 2021 | Advances in Ophthalmology Practice and Research2021，1，1： | 1 |
| 14 | Study on the longitudinal capture efficiency of a CW heavy-ion Linac显示文摘Purpose The continuous-wave(CW)linear accelerator,SSC-Linac,has been put into operation successfully as the new injector of Separate Sector Cyclotron(SSC)for Heavy Ion Research Facility in Lanzhou(HIRFL).The SSC-Linac is operated at the frequency of 53.667 MHz,which is the four times of the SSC operating frequency.In order to improve the longitudinal capture efficiency and increase the beam current extracted from the SSC,an independent multi-harmonics buncher(MHB)operating at a fundamental frequency of 13.417 MHz had been designed and manufactured.Method This buncher adopts the dual-gap structure and sawtooth waveform is generated by multi-harmonics synthetized technology.Beam dynamics simulation with MHB was carried out and discussed in this paper.Furthermore,the beam commissioning using 84Kr14+had been performed on SSC-Linac.Results and conclusion The measured maximum capture efficiency 86.5%was obtained,which was well agreed with the simulation results.Due to the successful commissioning of MHB and the outstanding-performance of SSC-Linac,the extracted beam current from SSC has been improved one order of magnitude higher than before. | Qiyu Kong Xuejun Yin Zhongshan Li Peng Jin Heng Du Xiaoni Li Zheng Liu Youjin Yuan Jiawen Xia Jiancheng Yang Weiqing Yang Zhe Xu Junxia Wu Yong Zhang Long Jing | 2022 | Radiation Detection Technology and Methods2022，6，3： | 0 |
| 15 | Apoptosis Induced by Ginsenoside Rg3 in a Human Bladder Carcinoma Cell Line显示文摘OBJECTIVE This study was conducted to explore the effect of Rg3 on inhibition of proliferation and induction of apoptosis in bladder cancer cells. METHODS The EJ bladder cancer cell line was treated with Rg3 at various concentrations. Cell proliferation was measured by the MTT assay. Morphological changes in the cells were observed by fluorescent staining using Hoechst 33258. The cell cycle and apoptotic rate were analyzed by flow cytometry (FCM) and the expression of caspase-3 in cells was detected by immunocytochemistry. DMA ladder analysis was conducted by agarose gel electrophoresis. RESULTS Rg3 inhibited proliferation of EJ cells in a concentration-dependent manner, resulting in an IC50 for Rg3 at 48 h of 125.5μg/ml. When treated with 150μg/ml of Rg3 for 24 h and 48 h, the cells showed apoptotic morphological characteristics including condensed chromatin, nuclear fragmentation, apoptotic bodies and bright fluorescent granules as well as a higher caspase-3 expression. The FCM assay indicated that Rg3 altered the cell cycle and induced apoptosis of the EJ cells, when treated for 24 h and 48 h with 75μg/ml of Rg3 as well as for 48 h with 150μg/ml. The percentages of cells in the S phase and the G2/M transition were increased, whereas the percentages of cells in the G0-G1 transition were decreased. The apoptotic rates were increased from (1.05±0.17)% in the control group cells to (8.41±0.98)%,(18.57±2.20)% and (33.98±1.64)% respectively. Significant changes in the DNA ladders, showed that the effects of Rg3 were displayed in a dose and time dependent manner. CONCLUSION The results suggest that Ginsenoside Rg3 exerts an inhibitory effect on proliferation of EJ cells by inducing apoptosis. | Junxia Chen Huimin Peng Shuping Pu Yuping Guo | 2006 | Chinese Journal of Clinical Oncology2006，3，4： | 0 |
| 16 | LEAF项目建设状态报告显示文摘LEAF or the Low Energy heavy ion Accelerator Facility is a multidiscipline heavy ion research platform under construction at IMP.It is a 5 year National Major Instruments Research Program supported by National Science Foundation of China(NSFC)started in 2015.Oriented to the frontier research in Material Sciences,Astrophysics,Atomic Physics and Highly Charged Ion Physics,LEAF has been designed and constructed with the state of the art technologies for low energy heavy ion acceleration.This facility features a 45 GHz ECR ion source FECR,a heavy ion CW 4-vane radio frequency quadruple accelerator LRFQ,300 kV HV platform,LEBT,MEBT and several dedicated experimental terminals. | Sun Liangting Yang Yao Lu Liang Guo Yuhui Liu Xiaojun Jing Long Li Libin Sun Liepeng Gao Zheng Ma Hongyi Jin Xiaofeng Zhai Yuhan Xu Xianbo Shi Longbo Xing Chaochao Liu Yuting Zhu Tieming Hu Qiang Zhang Peng Zhang Xuezhen Fang Xing Jia Huan Zhang Bin Liu Chaodong Ma Yingming Zhao Bo Wu Beimin Zhu Li Li Jiaqing Lu Wang Guo Junwei Li Chenxing Wang Zhijun Dou Weiping Wu Junxia Zhang Zimin Yao Qinggao Wu Wei Zhou Zhongzu Zhang Junhui Ma Lizhen He Yuan Zhao Hongwei | 2018 | IMP & HIRFL Annual Report2018，，1： | 0 |
| 17 | First Beam Commissioning of SSC-Linac as an Injector of SSC显示文摘The construction of the SSC-Linac has made significant progress in 2019.The first beam commissioning of SSC-Linac as an injector of the Separated Sector Cyclotron(SSC)was performed succssfully with ^(40)Ar^(7+) beam and the particle energy of 5.98 MeV/u was obtained at the exit of SSC on December 17,2019. | Du Heng Yin Xuejun Yang Weiqing Li Zhongshan Kong Qiyu Li Xiaoni Yang Shengli Qian Cheng WangHaoning Cong Yan Jin Peng Zhang Ruifeng Han Xiaodong Fu Xin Wang Kai Jing Long Zhang Yong Li Lili Xie Wenjun Xu Xiaowei Wang Shaoming Chen Wenjun Liu Xiaojun Yue Min An Jingrui Zhang Xiang Yan Huaihai Feng Anhui Zhang Shuai Zhang Yongbo Sun Peng Zhu Tieming Sha Xiaoping Xu Jianye Sun Xiaolong Su Xuemin Li Anping Yan Tailai Meng Jun Zhang Wei Wu Junxia Yao Qinggao Yang Yaqing Xu Zhe Sun Liangting Gao Daqing Yuan Youjin Yang Jiancheng Xia Jiawen | 2019 | IMP & HIRFL Annual Report2019，，1： | 0 |
| 18 | LEAF项目建设状态报告显示文摘LEAF or the Low Energy heavy ion Accelerator Facility is a multidiscipline heavy ion research platform constructing at IMP.It is a 5-year National Major Instruments Research Program supported by National Science Foundation of China(NSFC)started in 2015.Oriented to the frontier research in material sciences,astrophysics,atomic physics and highly charged ion physics,LEAF has been designed and constructed with the state-of-the-art technologies for low energy heavy ion acceleration.This facility features a 45 GHz ECR ion source FECR,a heavy ion CW 4-vane radio frequency quadruple accelerator LRFQ,300 kV HV platform,LEBT,MEBT and several dedicated experimental terminals.The layout of LEAF is given in Fig.1. | Sun Liangting Lu Liang Jia Huan Yang Yao Zhang Bin Guo Yuhui Gao Zheng Ma Hongyi Jin Xiaofeng Zhu Tieming Hu Qiang Zhang Peng Zhang Xuezhen Fang Xing Jing Long Liu Chaodong Ma Yingming Zhao Bo Wu Beimin Liu Xiaojun Li Jiaqing Lu Wang Guo Junwei Yang Long Li Libin Sun Liepeng Shi Longbo Li Chenxing Ma Wei Wang Zhijun Dou Weiping Wu Junxia Zhang Zimin Yao Qinggao Wu Wei Zhou Zhongzu Zhang Junhui Ma Lizhen He Yuan Zhao Hongwei | 2017 | IMP & HIRFL Annual Report2017，，1： | 0 |
| 19 | A Systemic Review and Meta-analysis of the Effect of SARS-CoV-2 Infection on Sperm Parameters显示文摘Objective.Several studies examined the putativefets of SARS-Cov-2infectionon spem parametersHoweve,the resuls remain controversial.In this study,we conducted the most up-to-date systematic review and meta-analysis to investigate the effect of SARS-CoV-2 infection on sperm quality in COVID-19-positive and COVID-19-negative male participants.Method.Seven databases were searched forliterature released through June 10,2022,containing estimates for the outcomes of interest Using a random-fects model(REM)or a fixed-ffects model(FEM),we analyzed the pooled results.The quality of all included studies was asssed by the Newcastle-Ottawa scale In addition,we performed aquanttative and subgroup analysis of semen data across all included studies.Results.Fourteen studies were extracted from 10 publications,involving a total of 1174 participates for meta-analysis.Sperm parameters of 521 COVID-19 male patients and 653 controls were analyzed.In 8 case-control studies,the pooled mean dfference(MD)of total sperm motility was-5.37%(95%confidence interval(CI):-8.47 to-2.28:<0.05),suggesting that total motility was significantly impaired inmale COVID-19 cases.Subgroup analysis showed a significant decreasein semen volume,sperm concentration,and total motility in 238 patients with arecovery timeof less than 90 days.Moreover,in the other 6 included pre-to post-COVID-19 studies,the pooled MDs of sperm concentration,total sperm count,total motility,progressivemotility,and normal morphology were6.54×10^(6)/ml(95%CI:-10.27 to-2.81;p<0.05),38.89×10^(6)(95%CI:-59.20 to-18.58;p<0.05),-7.21%(95%CI:-14.36 to-0.07;p<0.05),-5.12%(95%CI:-8.71 to-1.53;p<0.05),and-1.52%(95%CI:-2.88 to-0.16;p<0.05),respectively,which indicate SARS-CoV-2 infection significantly affected these five sperm parameters.Conclusion.Our results revealed that SARS-CoV-2 infection was significantly correlated with decreased sperm quality.Of six sperm parameters,total motility and sperm concentration were the most significantly decreased parameters.These results suggest a possible negative influence of SARS-CoV-2 infection on testicular function and male fertility.Given the potential detrimental effect of SARS-CoV-2 on semen quality,male reproductive health should be monitored closely in patients with COVID-19.This trial is registered with CRD42021275823. | Xi Chen Jinli Ding Miao Liu Kai Xing Peng Ye Junxia Min Yan Zhang Tailang Yin | 2022 | Research2022，，2： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员