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| 1 | Interface engineering of high efficiency perovskite solar cells based on ZnO nanorods using atomic layer deposition显示文摘尽管有无机器官的金属混血儿 perovskite 太阳能电池(PSC ) 的更加改进的效率,电子运输仍然是一个挑战性的问题。在这份报纸,我们报导 ZnO nanorods 的使用准备了由热水象在 perovskite 的电子运输层自己组装太阳能电池。perovskite 太阳能电池的效率被使钝化显著地提高经由艾尔 2 ZnO nanorods 上的 O 3 单层。由采用艾尔 2 O 3 单层, methylammonium 铅碘化物 PSC 的平均力量变换效率从 10.33% ~ 15.06% 被增加,并且获得的最高的效率是 16.08% 。我们建议用单层的原子层免职的缺点的钝化可能为 PSC 的所有类型的改进提供一条新小径…… | Shibin Li Peng Zhang Yafei Wang Hojjatollah Sarvari Detao Liu Jiang Wu Yajie Yang Zhiming Wang Zhi David Chen | 2017 | Nano Research2017，10，3： | 6 |
| 2 | Mouse knockout models reveal largely dispensable but context-dependent functions of IncRNAs during development显示文摘 | Xue Han Sai Luo Guangdun Peng Yuyang Lu Guizhong Cui Lichao Liu Pixi Yan Yafei Yin Wei Liu Ran Wang Jiejie Zhang Shanshan Ai Zai Chang Jie Na Aibin He Naihe Jing Xiaohua Shen | 2018 | Journal of Molecular Cell Biology2018，10，2： | 3 |
| 3 | A strategy for enhancing anaerobic digestion of waste activated sludge: Driving anodic oxidation by adding nitrate into microbial electrolysis cell显示文摘Cathodic reduction of CO_2 and anodic oxidation of organic matters are crucial to methaneproducing microbial electrolysis cell(MEC) applied in anaerobic digestion of waste activated sludge. However, cathodic CO_2 reduction is usually restrained by slow metabolism rates of H_2-utilizing methanogens and low electron-capturing capacity of CO_2, which consequently slows down the anodic oxidation that participates to sludge disintegration. Herein, a strategy with adding nitrate as electron acceptor to foster electronic transfer between the anode and cathode was proposed to improve anodic oxidation. Results showed that the average efficiency of anodic oxidation in the nitrate-added MEC increased by 55.9%. Accordingly,volatile suspended solid removal efficiency in the nitrate-added MEC was 21.9% higher than that of control MEC. Although the initial cumulative methane production in the nitrateadded MEC was lower than that of control MEC, the cumulative methane production in 24 days was 8.9% higher. Fourier transform infrared spectroscopy analysis indicated that anodic oxidation of MEC with nitrate accelerated the disintegration of sludge flocs and cell walls. Calculation on current signal further revealed that anodic oxidation driven by cathodic nitrate reduction was the main mechanism responsible for the improved sludge digestion. | Hong Peng Zhiqiang Zhao Hong Xiao Yafei Yang Huimin Zhao Yaobin Zhang | 2019 | Journal of Environmental Sciences2019，31，7： | 2 |
| 4 | Risks of maternal prepregnancy overweight/obesity, excessive gestational weight gain, and bottle-feeding in infancy rapid weight gain: evidence from a cohort study in China显示文摘Rapid weight gain(RWG) in infants is associated with numerous health problems, and its risk factors are still unclear. We assessed 98,097 maternal-infant pairs from a population-based cohort study and followed up with them until the infants were6 months old. We assessed the associations between maternal prepregnancy weight status;gestational weight gain;feeding pattern;and infants’ RWG at 0–1, 0–3, 1–3, and 3–6 months using multivariate unconditional logistic regression models, with controlled confounders. We found that maternal prepregnancy weight status, gestational weight gain, and feeding pattern at the1 st, 3 rd, and 6 th months had significant impacts on the infants’ RWG at each time period(P<0.05). Infants with overweight/obese mothers had a higher risk of RWG after birth, whereas those of mothers who experienced excessive gestational weight gain had higher risks of RWG from birth than the other groups(P<0.01). Infants who were formula-fed had a higher risk of RWG than breastfed infants at the same time point(P<0.01). In conclusion, maternal prepregnancy obesity, excessive gestational weight gain, and formula-feeding were risk factors for infants’ RWG during the first 6 months of life. | Shaoping Yang Hong Mei Hui Mei Yan Yang Na Li Yafei Tan Yiming Zhang Dan Zhang Yan Zhang An’na Peng Bin Zhang | 2019 | Science China(Life Sciences)2019，62，12： | 2 |
| 5 | Targeting lactate dehydrogenase A (LDHA) exerts antileukemic effects on T-cell acute lymphoblastic leukemia显示文摘Background:T-cell acute lymphoblastic leukemia(T-ALL)is an uncommon and aggressive subtype of acute lymphoblastic leukemia(ALL).In the serum of T-ALL patients,the activity of lactate dehydrogenase A(LDHA)is increased.We proposed that targeting LDHA may be a potential strategy to improve T-ALL outcomes.The current study was conducted to investigate the antileukemic effect of LDHA gene-targeting treatment on T-ALL and the underlying molecular mechanism.Methods:Primary T-ALL cell lines Jurkat and DU528 were treated with the LDH inhibitor oxamate.MTT,colony formation,apoptosis,and cell cycle assays were performed to investigate the effects of oxamate on T-ALL cells.Quantitative real-time PCR(qPCR)and Western blotting analyses were applied to determine the related signaling pathways.A mitochondrial reactive oxygen species(ROS)assay was performed to evaluate ROS production after T-ALL cells were treated with oxamate.A T-ALL transgenic zebrafish model with LDHA gene knockdown was established using CRISPR/Cas9 gene-editing technology,and then TUNEL,Western blotting,and T-ALL tumor progression analyses were conducted to investigate the effects of LDHA gene knockdown on T-ALL transgenic zebrafish.Results:Oxamate significantly inhibited proliferation and induced apoptosis of Jurkat and DU528 cells.It also arrested Jurkat and DU528 cells in G0/G1 phase and stimulated ROS production(all P<0.001).Blocking LDHA significantly decreased the gene and protein expression of c-Myc,as well as the levels of phosphorylated serine/threonine kinase(AKT)and glycogen synthase kinase 3 beta(GSK-3β)in the phosphatidylinositol 3′-kinase(PI3K)signaling pathway.LDHA gene knockdown delayed disease progression and down-regulated c-Myc mRNA and protein expression in T-ALL transgenic zebrafish.Conclusion:Targeting LDHA exerted an antileukemic effect on T-ALL,representing a potential strategy for T-ALL treatment. | Haizhi Yu Yafei Yin Yifang Yi Zhao Cheng Wenyong Kuang Ruijuan Li Haiying Zhong Yajuan Cui Lingli Yuan Fanjie Gong Zhihua Wang Heng Li Hongling Peng Guangsen Zhang | 2020 | Cancer Communications2020，40，10： | 2 |
| 6 | Study on the interaction mechanism between laser and rock during perforation显示文摘 | Fei Yan Yafei Gu Yajun Wang Chunming Wang Xiyuan Hu Hanxiu Peng Zhiliang Yao Zheng Wang Yi Shen | 2013 | Optics and Laser Technology2013，，： | 1 |
| 7 | NiCo_(2)S_(4)/N microspheres grown on N,S co-doped reduced graphene oxide as an efficient bifunctional electrocatalyst for overall water splitting in alkaline and neutral pH显示文摘It is of vital importance to design efficient and low-cost bifunctional catalysts for the electrochemical water splitting under alkaline and neutral pH conditions.In this work,we report an efficient and stable NiCo_(2)S_(4)/N,S co-doped reduced graphene oxide(NCS/NS-rGO)electrocatalyst for water splitting,in which NCS microspheres are composed of one-dimentional(1D)nanorods grown homogeneously on the surface of NS-rGOs).The synergetic effect,abundant active sites,and hybridization of NCS/NS-rGO endow their outstanding electrocatalytic performance for hydrogen evolution reaction(HER)and oxygen evolution reaction(OER)in both alkaline and neutral conditions.Furthermore,NCS/NS-rGO employed as both anode and cathode in a two-electrode alkaline and neutral system electrolyzers deliver 10 mA/cm^(2) with the low cell voltage of 1.58 V in alkaline and 1.91 V in neutral condition.These results illustrate the rational design of carbon-supported nickel-cobalt based bifunctional materials for practical water splitting over a wide pH range. | Haoquan Li Long Chen Pengfei Jin Yafei Li Jianxiang Pang Juan Hou Shanglong Peng Gang Wang Yulin Shi | 2022 | Nano Research2022，15，2： | 1 |
| 8 | Amiodaron and digitalis of injection were compared with the treatment of atrial fibrillation and atrial flutter显示文摘 | Peng Yafei Zhong Ling Wang Yibo | 2001 | Chinese Journal Of Cardiology2001，29，： | 1 |
| 9 | Removal of methylene blue from aqueous solutions by adsorption onto chemically activated halloysite nanotubes 显示文摘 | Luo Peng Zhang Bing Zhao Yafei | 2011 | korean Journal of Chemical Engineering2011，28，3： | 1 |
| 10 | Removal of methylene blue from aqueous solutions by adsorption onto chemically activated halloysite nanotubes 显示文摘 | Luo Peng Zlumg Bing Zhao Yafei | 2011 | Korean Journal of Chemical Engineering2011，28，3： | 1 |
| 11 | The histone methyltransferase SUVR2 promotes DSB repair via chromatin remodeling and liquidliquid phase separation显示文摘Maintaining genomic integrity and stability is particularly important for stem cells,which are at the top of the cell lineage origin.Here,we discovered that the plant-specific histone methyltransferase SUVR2 maintains the genome integrity of the root tip stem cells through chromatin remodeling and liquid-liquid phase separation(LLPS)when facing DNA double-strand breaks(DSBs).The histone methyltransferase SUVR2(MtSUVR2)has histone methyltransferase activity and catalyzes the conversion of histone H3 lysine 9 monomethylation(H3K9me1)to H3K9me2/3 in vitro and in Medicago truncatula.Under DNA damage,the proportion of heterochromatin decreased and the level of DSB damage marker y-H2AX increased in suvr2 mutants,indicating that MtSUVR2 promotes the compaction of the chromatin structure through H3K9 methylation modification to protect DNA from damage.Interestingly,MtSUVR2 was induced by DSBs to phase separate and form droplets to localize at the damage sites,and this was confirmed by immunofluorescence and fluorescence recovery after photobleaching experiments.The IDR1 and lowcomplexity domain regions of MtSUVR2 determined its phase separation in the nucleus,whereas the IDR2 region determined the interaction with the homologous recombinase MtRAD51.Furthermore,we found that MtSUVR2 drove the phase separation of MtRAD51 to form'DNA repair bodies,'which could enhance the stability of MtRAD51 proteins to facilitate error-free homologous recombination repair of stem cells.Taken together,our study reveals that chromatin remodeling-associated proteins participate in DNA repair through LLPS. | Qianwen Liu Peng Liu Tuo Ji Lihua Zheng Chen Shen Shasha Ran Jinling Liu Yafei Zhao Yiding Niu Tao Wang Jiangli Dong | 2022 | Molecular Plant2022，15，7： | 1 |
| 12 | Boosting Efficient Ammonia Synthesis over Atomically Dispersed Co-Based Catalyst via the Modulation of Geometric and Electronic Structures显示文摘Ammonia(NH_(3))synthesis at mild conditions is of great significance,while the significant bottleneck of this process is the activation of N_(2) to realize the desired NH_(3) synthesis performance,which requires deep insight and rational design of active sites at the atomic level.Here,were synthesized atomically dispersed Co-based catalysts with different Co-N coordination numbers(CNs)to explore the coordination-sensitive NH_(3) synthesis reaction for the first time.Our studies showed that Co-based catalysts increased the NH_(3) synthesis rate gradually with a decrease in CN.The Co-N_(2) catalyst exhibited the highest NH_(3) synthesis rate of 85.3 mmol gCo^(−1) h^(−1) at 300℃ and 1 MPa,which outperformed most of the previously reported Co-based catalysts.Various characterizations and theoretical calculations demonstrated that atomically dispersed Co catalyst with low CN could generate more unoccupied Co 3d charges and tetrahedral cobalt(Ⅱ)sites.The unoccupied Co 3d charge,in turn,promoted the electron donation from the Co active center to the antibonding π-orbital(π*)of N_(2) and expedites N_(2) hydrogenation.Furthermore,the Co-N_(2) catalyst with more tetrahedral cobalt(II)sites could effectively facilitate the desorption of N-containing intermediate species(such as*NH_(3) and*N_(2)H_(4))to obtain a high NH_(3) synthesis rate. | Yanliang Zhou Congying Wang Xuanbei Peng Tianhua Zhang Xiuyun Wang Yafei Jiang Haifeng Qi Lirong Zheng Jianxin Lin Lilong Jiang | 2022 | CCS Chemistry2022，4，5： | 1 |
| 13 | Homotypic clustering of L1 and B1/Alu repeats compartmentalizes the 3D genome显示文摘Organization of the genome into euchromatin and heterochromatin appears to be evolutionarily conserved and relatively stable during lineage differentiation.In an effort to unravel the basic principle underlying genome folding,here we focus on the genome itself and report a fundamental role for L1(LINE1 or LINE-1)and B1/Alu retrotransposons,the most abundant subclasses of repetitive sequences,in chromatin compartmentalization.We find that homotypic clustering of L1 and B1/Alu demarcates the genome into grossly exclusive domains,and characterizes and predicts Hi-C compartments.Spatial segregation of L1-rich sequences in the nuclear and nucleolar peripheries and B1/Alu-rich sequences in the nuclear interior is conserved in mouse and human cells and occurs dynamically during the cell cycle.In addition,de novo establishment of L1 and B1 nuclear segregation is coincident with the formation of higher-order chromatin structures during early embryogenesis and appears to be critically regulated by L1 and B1 transcripts.Importantly,depletion of L1 transcripts in embryonic stem cells drastically weakens homotypic repeat contacts and compartmental strength,and disrupts the nuclear segregation of L1-or B1-rich chromosomal sequences at genome-wide and individual sites.Mechanistically,nuclear co-localization and liquid droplet formation of L1 repeat DNA and RNA with heterochromatin protein HP1αsuggest a phase-separation mechanism by which L1 promotes heterochromatin compartmentalization.Taken together,we propose a genetically encoded model in which L1 and B1/Alu repeats blueprint chromatin macrostructure.Our model explains the robustness of genome folding into a common conserved core,on which dynamic gene regulation is overlaid across cells. | J.Yuyang Lu Lei Chang Tong Li Ting Wang Yafei Yin Ge Zhan Xue Han Ke Zhang Yibing Tao Michelle Percharde Liang Wang Qi Peng Pixi Yan Hui Zhang Xianju Bi Wen Shao Yantao Hong Zhongyang Wu Runze Ma Peizhe Wang Wenzhi Li Jing Zhang Zai Chang Yingping Hou Bing Zhu Miguel Ramalho-Santos Pilong Li Wei Xie Jie Na Yujie Sun Xiaohua Shen | 2021 | Cell Research2021，31，6： | 1 |
| 14 | A multiple user sharing behaviors based approach for fake file detection in P2P environments显示文摘File pollution is a problem that is threatening security and availability in peer-to-peer environments, and could eventually be fatal to the survival of these systems. Current methods of fake file detection, which are based on trust mechanisms or file characteristics, do not consider the problems such as interference of multiple user sharing behaviors, the difficulty in obtaining large amounts of raw data, and malicious fraud immediately after version publication. This is the first time that differences in the sharing habits of users and particularly long retention time for individual files have been detected, which impact fake file detection. This paper proposes a pollution prevention model based on multiple user sharing behaviors, which reduces interference in multiple user sharing behaviors and malicious fraud immediately after version publication. It designs a low-cost implementation mechanism for use in structured peer-to-peer networks, which automatically collects a large amount of user file-sharing information and alleviates difficulties in obtaining large quantities of raw data. A parameter configuration is also given in this paper. Simulation experiments use realistic system logs and prove that this approach detects fake files accurately and quickly, thus decreasing download times of fake files, effectively guaranteeing almost 100% real file downloads and resisting file pollution. | JIANG Jing, LI YongJun, FENG QinYuan, HUANG Peng & DAI YaFei Department of Computer Science and Technology, Peking University, Beijing 100871, China | 2010 | Science China(Information Sciences)2010，53，11： | 1 |
| 15 | Study on the adsorption of Neutral Red from aqueous solution onto halloysite nanotubes显示文摘 | Peng Luo Yafei Zhao Bing Zhang Jindun Liu Yong Yang Junfang Liu | 2009 | Water Research2009，，： | 1 |
| 16 | Protective effects of lycopene against H2O2-induced oxidative injury and apoptosis in human endothelial cells显示文摘 | TANG Xiangyu YANG Xiangdong PENG Yafei | 2009 | Cardiovascular Drugs and Therapy2009，23，6： | 1 |
| 17 | Novel Microglia-based Therapeutic Approaches to Neurodegenerative Disorders显示文摘prominent immune cells in the central nervous system,microglia constantly monitor the environment and provide neuronal protection,which are important functions for maintaining brain homeostasis.In the diseased brain,microglia are crucial mediators of neuroinflammation that regulates a broad spectrum of cellular responses.In this review,we summarize current knowledge on the multifunctional contributions of microglia to homeostasis and their involvement in neurodegeneration.We further provide a comprehensive overview of therapeutic interventions targeting microglia in neurodegenerative diseases.Notably,we propose microglial depletion and subsequent repopulation as promising replacement therapy.Although microglial replacement therapy is still in its infancy,it will likely be a trend in the development of treatments for neurodegenerative diseases due to its versatility and selectivity. | Lijuan Zhang Yafei Wang Taohui Liu Ying Mao Bo Peng | 2023 | Neuroscience Bulletin2023，39，3： | 1 |
| 18 | Novel cyclometalated platinum (II) complex containing alkyl-trifluorene picolinic acid as emitter for single-layer white PLEDs显示文摘 | Yafei Wang Yu Liu Xiaoshuang Li Hongrui Qi Meixiang Zhu Lei Wang Gangtie Lei Qiliang Wei Weiguo Zhu Junbiao Peng Yong Cao | 2010 | Organic Electronics2010，，12： | 1 |
| 19 | Synthesis and photovoltaic performance of N-dioctylmethyl- 2,7-carbazole-alt-5,7-bis(thiophen-2-yl)-2,3-biphenylthieno[3,4-b] pyrazine copolymeric derivatives appending various donor units in phenyl moieties显示文摘A series of N-dioctylmethyl-2,7-carbazole-alt-5,7-bis(thiophen-2-yl)-2,3-biphenylthieno[3,4-b]pyrazine(PCz-3Th Pz-Ph)copolymeric derivatives appending various donor units in two phenyl rings,namely,PCz-3Th Pz-Ph Th,PCz-3Th Pz-Ph Fl,PCz-3Th Pz-Ph Cz,and PCz-3Th Pz-Ph Tpa were synthesized and characterized.The effect of these appending donor units,e.g.,thiophene(Th),fluorene(Fl),carbazole(Cz),and triarylamine(Tpa),was investigated on dispersible,optical,electrochemical,and photovoltaic properties for their polymers.The copolymers of PCz-3Th Pz-Ph Cz and PCz-3Th Pz-Ph Tpa containing Cz or Tpa units exhibited higher short-circuit current density(Jsc)and power conversion efficiency(PCE)in their bulk heterojunction polymeric solar cells.The highest PCE of 1.66%and Jsc of 7.16 m A cm 2 were obtained in a device with the PCz-3Th Pz-Ph Cz/PC61BM blend under AM 1.5 G irradiation(100 m W cm 2);these values are 1.78 and 1.59 times higher than the corresponding values for the PCz-3Th Pz-Ph-based device.When PC61BM was placed by PC71BM,the PCz-3Th Pz-Ph Cz-based device displayed an enhanced PCE of 2.98%and a Jsc of 10.88 m A cm 2.This work demonstrated that appending additional hole-transporting units of Cz and Tpa into the side-chain of a polymer with a D-A backbone can significantly enhance the photovoltaic performance of their resultant polymers. | Jianmin Li Hua Tan Fanyuan Meng Wenhong Peng Yafei Wang Yu Liu Weiguo Zhu | 2015 | Science China Chemistry2015，58，2： | 1 |
| 20 | Synergistic integration of metal nanoclusters and biomolecules as hybrid systems for therapeutic applications显示文摘Therapeutic nanoparticles are designed to enhance efficacy,real-time monitoring,targeting accuracy,biocompatibility,biodegradability,safety,and the synergy of diagnosis and treatment of diseases by leveraging the unique physicochemical and biological properties of well-developed bio-nanomaterials.Recently,bio-inspired metal nanoclusters(NCs)consisting of several to roughly dozens of atoms(<2 nm)have attracted increasing research interest,owing to their ultrafine size,tunable fluorescent capability,good biocompatibility,variable metallic composition,and extensive surface bio-functionalization.Hybrid coreeshell nanostructures that effectively incorporate unique fluorescent inorganic moieties with various biomolecules,such as proteins(enzymes,antigens,and antibodies),DNA,and specific cells,create fluorescently visualized molecular nanoparticle.The resultant nanoparticles possess combinatorial properties and synergistic efficacy,such as simplicity,active bio-responsiveness,improved applicability,and low cost,for combination therapy,such as accurate targeting,bioimaging,and enhanced therapeutic and biocatalytic effects.In contrast to larger nanoparticles,bio-inspired metal NCs allow rapid renal clearance and better pharmacokinetics in biological systems.Notably,advances in nanoscience,interfacial chemistry,and biotechnologies have further spurred researchers to explore bio-inspired metal NCs for therapeutic purposes.The current review presents a comprehensive and timely overview of various metal NCs for various therapeutic applications,with a special emphasis on the design rationale behind the use of biomolecules/cells as the main scaffolds.In the different hybrid platform,we summarize the current challenges and emerging perspectives,which are expected to offer in-depth insight into the rational design of bio-inspired metal NCs for personalized treatment and clinical translation. | Peng Gao Xin Chang Dagan Zhang Yafei Cai Gen Chen Hao Wang Tianfu Wang | 2021 | Acta Pharmaceutica Sinica B2021，11，5： | 0 |
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