|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | N6-Methyladenine DNA Methylation in Japonica and Indica Rice Genomes and Its Association with Gene Expression,Plant Development, and Stress Responses显示文摘N6-Methyladenine (6mA)DNA methylation has recently been implicated as a potential new epigenetic marker in eukaryotes,including the dioot modelArabidopsis thaliana.However,the conservation and divergence of 6mA distribution patterns and functions in plants remain elusive.Here we report high-quality 6mA methylomes at single-nucleotide resolution in rice based on substantially improved genome sequences of two rice cultivars,Nipponbare (Nip;Japonica)and 93-11 (Indica).Analysis of 6mA genomic distribution and its association with transcription suggest that 6mA distribution and function is rather conserved between rice and Arabidopsis.We found that 6mA levels are positively correlated with the expression of key stressrelated genes,which may be responsible for the difference in stress tolerance between Nip and 93-11. Moreover,we showed that mutations in DDM1 cause defects in plant growth and decreased 6mA level. Our results reveal that 6mA is a conserved DNA modification that is positively associated with gene expression and contributes to key agronomic traits in plants. | Qian Zhang Zhe Liang Xuean Cui Changmian Ji Yun Li Pingxian Zhang Jingrong Liu Adeel Riaz Pu Yao Min Liu Yunpeng Wang Tiegang Lu Hao Yu Donglei Yang Hongkun Zheng Xiaofeng Gu | 2018 | Molecular Plant2018，11，12： | 18 |
| 2 | Research Progress in the Application of Chinese Herbal Medicines in Aquaculture: A Review显示文摘 | Hongyu Pu Xiaoyu Li Qingbo Du Hao Cui Yongping Xu | 2017 | Engineering2017，3，5： | 17 |
| 3 | GJB2 mutation spectrum in deaf population in a typical southeastern area of China显示文摘Mutations in GJB2 gene are the most frequently found mutations in patients with nonsyndromic hearing impairment. However, the spectrum and prevalence of mutations in this gene vary among different ethnic groups. In China, 30,000 infants are born with congenital hearing impairment annually. In order to provide appropriate genetic testing and counseling to the families, we investigated the molecular etiology of nonsyndromic deafness in 103 unrelated school children attending Nantong School for the Deaf and Mute in Jiangsu Province, China. The coding exon of the GJB2 gene was PCR amplified and sequenced. Sixty two GJB2 mutant alleles were identified in 35.9% (37/103) of the patients. Twenty five patients carried two pathogenic mutations and 12 patients carried one mutant allele. The 235delC was the most common mutation accounting for 69.4% (43/62) of GJB2 mutant alleles. The GJB2 mutant alleles accounted for 30.1% (62/206) of all chromosomes responsible for nonsyndromic hearing impairment. Testing of the 3 most prevalent deleterious frame shift mutations in this cohort detected 100% of all GJB2 mutant alleles. These results demonstrate that an effective genetic testing of GJB2 gene for patients and families with nonsyndromic hearing impairment is possible. | DAI Pu1*, YOU Yi-wen2*, CUI Jing-hong2*, YU Fei1, HAN Bing 1, KANG Dong-yang1, YUAN Hui-jun1, HAN Dong-yi1, 1. Department of Otolaryngology, PLA General Hospital, Beijing, People’s Republic China, 100853 2. Department of Otolaryngology, Nantong University Affiliated Hospital, Nantong, Jiangsu Province, People’s Republic China, 226001 *Pu Dai, Yiwen You, Jinghong Cui contribute equally to this paper | 2006 | Journal of Otology2006，1，2： | 10 |
| 4 | Comorbidity Burden of Dementia:A Hospital-Based Retrospective Study from 2003 to 2012 in Seven Cities in China显示文摘Dementia is increasing dramatically and imposes a huge burden on society. To date, there is a lack of data on the health status of patients with dementia in China. In an attempt to investigate the comorbidity burden of dementia patients in China at the national level, we enrolled 2,938 patients with Alzheimer's disease(AD), vascular dementia(Va D), or other types of dementia, who were admitted to tertiary hospitals in seven regions of China from January2003 to December 2012. The Charlson Comorbidity Index(CCI) was used to evaluate the comorbidity burden of the patients with dementia. Among these patients, 53.4% had AD, 26.3% had Va D, and 20.3% had other types of dementia. The CCI was 3.0 ± 1.9 for all patients,3.4 ± 1.8 for those with Va D, and 3.0 ± 2.1 for those with AD. The CCI increased with age in all patients, andthe length of hospital stay and daily expenses rose with age and CCI. Males had a higher CCI and a longer stay than females. Moreover, patients admitted in the last 5 years of the study had a higher CCI than those admitted in the first 5 years. We found that the comorbidity burden of patients with dementia is heavy. These findings provide a better understanding of the overall health status of dementia patients, and help to increase the awareness of clinicians and policy-makers to improve medical care for patients. | Qing-Hua Wang Xin Wang Xian-Le Bu Yan Lian Yang Xiang Hong-Bo Luo Hai-Qiang Zou Jie Pu Zhong-He Zhou Xiao-Ping Cui Qing-Song Wang Xiang-Qun Shi Wei Han Qiang Wu Hui-Sheng Chen Hang Lin Chang-Yue Gao Li-Li Zhang Zhi-Qiang Xu Meng Zhang Hua-Dong Zhou Yan-Jiang Wang | 2017 | Neuroscience Bulletin2017，33，6： | 10 |
| 5 | Immobilization of functional nano-objects in living engineered bacterial biofilms for catalytic applications显示文摘Nanoscale objects feature very large surface-area-to-volume ratios and are now understood as powerful tools for catalysis,but their nature as nanomaterials brings challenges including toxicity and nanomaterial pollution.Immobilization is considered a feasible strategy for addressing these limitations.Here,as a proof-of-concept for the immobilization of nanoscale catalysts in the extracellular matrix of bacterial biofilms,we genetically engineered amyloid monomers of the Escherichia coli curli nanofiber system that are secreted and can self-assemble and anchor nano-objects in a spatially precise manner.We demonstrated three scalable,tunable and reusable catalysis systems:biofilm-anchored gold nanoparticles to reduce nitro aromatic compounds such as the pollutant p-nitrophenol,biofilm-anchored hybrid Cd0.9Zn0.1S quantum dots and gold nanoparticles to degrade organic dyes and biofilm-anchored CdSeS@ZnS quantum dots in a semi-artificial photosynthesis system for hydrogen production.Our work demonstrates how the ability of biofilms to grow in scalable and complex spatial arrangements can be exploited for catalytic applications and clearly illustrates the design utility of segregating high-energy nano-objects from injury-prone cellular components by engineering anchoring points in an extracellular matrix. | Xinyu Wang Jiahua Pu Yi Liu Fang Ba Mengkui Cui Ke Li Yu Xie Yan Nie Qixi Mi Tao Li Lingli Liu Manzhou Zhu Chao Zhong | 2019 | National Science Review2019，6，5： | 9 |
| 6 | Numerical study on the bubble dynamics in a broken confined domain显示文摘In this paper,the dynamic characteristics of the bubble in a broken confined domain are studied.The broken confined domain is composed of a solid wall and a plate that has a hole.The axisymmetric numerical model is established by combining the Eulerian finite-element method with volume of fluid(VOF)method,and is validated by comparing the results with those from an experiment.Then the influences of the wall distance,plate distance and size of the hole are analyzed.The results show that cavity-attraction jet caused by the hole and annular jet caused by the upper solid wall compete with each other to dominate the bubble dynamics.The cavity-attraction jet develops earlier,but slower.Thus,jet load in the bubble stage is mainly generated by the annular jet with a higher impact speed.Within a certain range,the closer the hole is to the bubble or the smaller the hole,the longer the pulsation period of the bubble will be. | Hao Tang Yun-Long Liu Pu Cui A-Man Zhang | 2020 | Journal of Hydrodynamics2020，32，6： | 7 |
| 7 | Protonation induced high-T_c phases in iron-based superconductors evidenced by NMR and magnetization measurements显示文摘Chemical substitution during growth is a well-established method to manipulate electronic states of quantum materials, and leads to rich spectra of phase diagrams in cuprate and iron-based superconductors. Here we report a novel and generic strategy to achieve nonvolatile electron doping in series of(i.e.11 and 122 structures) Fe-based superconductors by ionic liquid gating induced protonation at room temperature. Accumulation of protons in bulk compounds induces superconductivity in the parent compounds, and enhances the Tclargely in some superconducting ones. Furthermore, the existence of proton in the lattice enables the first proton nuclear magnetic resonance(NMR) study to probe directly superconductivity. Using Fe S as a model system, our NMR study reveals an emergent high-Tcphase with no coherence peak which is hard to measure by NMR with other isotopes. This novel electric-fieldinduced proton evolution opens up an avenue for manipulation of competing electronic states(e.g.Mott insulators), and may provide an innovative way for a broad perspective of NMR measurements with greatly enhanced detecting resolution. | Yi Cui Gehui Zhang Haobo Li Hai Lin Xiyu Zhu Hai-Hu Wen Guoqing Wang Jinzhao Sun Mingwei Ma Yuan Li Dongliang Gong Tao Xie Yanhong Gu Shiliang Lie Huiqian Luo Pu Yu Weiqiang Yu | 2018 | Science Bulletin2018，63，1： | 7 |
| 8 | In vivo evaluation of urokinase-loaded hollow nanogels for sonothrombolysis on suture embolization-induced acute ischemic stroke rat model显示文摘The urokinase-type plasminogen activator(uPA)loaded hollow nanogels(nUK)were synthesized by a one-step reaction of glycol chitosan and aldehyde capped poly(ethylene oxide).The resultant formulation is sensitive to diagnostic ultrasound(US)of 2 MHz.Herein,we evaluated the in vivo sonothrombolysis performance of the nUK on acute ischemic stroke rat model which was established by suture embolization of middle cerebral artery(MCA).Via intravenous(i.v.)administration,the experimental data prove a controlled release of the therapeutic protein around the clots under ultrasound stimulation,leading to enhanced thrombolysis efficiency of the nUK,evidenced from smaller infarct volume and better clinical scores when compared to the i.v.dose of free uPA no matter with or without US intervention.Meanwhile,the preservation ability of the nanogels not only prolonged the circulation duration of the protein,but also resulted in the better blood-brain barrier protection of the nUK formulation,showing no increased risk on the hemorrhagic transformation than the controls.This work suggests that the nUK is a safe sonothrombolytic formulation for the treatment of acute ischemic stroke. | Yuming Teng Haiqiang Jin Ding Nan Mengnan Li Chenghe Fan Yuanyuan Liu Pu Lv Wei Cui Yongan Sun Hongjun Hao Xiaozhong Qu Zhenzhong Yang Yining Huang | 2018 | Bioactive Materials2018，3，1： | 7 |
| 9 | Assessment of a five-color flow cytometric assay for verifying automated white blood cell differentials显示文摘 | HUANG Chun-mei YU Lian-hui PU Cheng-wei WANG Xin WANG Geng SHEN Li-song WANG Jian-zhong CUI Wei | 2013 | Chinese Medical Journal2013，，4： | 6 |
| 10 | Application of the revised Tumour Node Metastasis (TNM) staging system of clear cell renal cell carcinoma in eastern China: advantages and limitations显示文摘这研究被设计评估是否修订了阶段系统能导致的 2010 瘤节点转移(TNM ) 肾的房间癌(RCC ) 的预后的更精确的预言病人。从 2003 ~ 2011 为 RCC 经历了激进的肾切除术或部分肾切除术的 1216 个病人的一个总数被注册。所有病理地病人证实了清楚的房间 RCC (ccRCC ) 。所有情况被 2002 和 2010 个 TNM 阶段系统在病理学的评论,和幸存以后上演数据被收集。Univariate 和 multivariate 考克斯回归模型被用来在外科以后评估癌症特定的幸存(CSS ) 和没有前进的幸存(PFS ) 。连续变量例如年龄和瘤直径,作为吝啬的价值和标准差(s.d ) 或作为中部的价值被计算。幸存被 Kaplan-Meier 方法计算,并且木头等级测试估计了组之间的差别。在 CSS 和 PFS 的统计上重要的差别在 T3 亚群在病人之中被注意用新 2010 阶段系统。因此,修订了阶段系统能导致的 2010 TNM ccRCC 病人的预后的更精确的预言。不管多么当使用时修订了 2010 阶段系统,我们发现那超过 92 %有 T3 的病人(288/313 ) ,瘤在 T3a 亚群被上演,并且他们的幸存数据不与有 T2b 瘤的病人的那些显著地不同。另外, T2 subclassification 没能独立地在 RCC 病人预言幸存。 | Chao Qin Li-Jiang Sun Li Cui Qiang Cao Jian Zhu Pu Li Gui-Ming Zhang Xin Mao Peng-Fei Shao Mei-Lin Wang Zheng-Dong Zhang Min Gu Wei Zhang Chang-Jun Yin | 2013 | Asian Journal of Andrology2013，15，4： | 3 |
| 11 | An insight into failure mechanism of NASICON-structured Na3V2(PO4)3 in hybrid aqueous rechargeable battery显示文摘NASICON (Na-super-ionic-conductors)-structured materials have attracted extensive research interest due to their great application potential in secondary batteries. However, the mechanism of capacity fading for NASICON-structured electrode materials has been rarely studied. In this paper, we synthesized the NASICON-structured Na3V2(PO4)3/C composite by simple sol-gel and high-temperature solid-phase method and investigated its electrochemical performance in Na-Zn hybrid aqueous rechargeable batteries. After characterizing the structure, morphology and composition variations as well as the interfacial resistance changes of Na3V2(PO4)3/C cathode during cycling, we propose a mechanical and interfacial degradation mechanism for capacity fading of NASICON-structured Na3V2(PO4)3/C in Na-Zn hybrid aqueous rechargeable batteries. This work will shed light on enhancing the mechanical and in terfacial stability of NASICON-structured Na3V2(PO4)3/C in Na-Zn hybrid aqueous rechargeable batteries. | Xinxin Zhang Jun Ma Pu Hu Bingbing Chen Chenglong Lu Xinhong Zhou Pengxian Han Lihua Chen Guanglei Cui | 2019 | Journal of Energy Chemistry2019，28，5： | 3 |
| 12 | Generation of Gene-Modified Cynomolgus Monkey via Cas9/RNA-Mediated Gene Targeting in One-Cell Embryos显示文摘 | Yuyu Niu Bin Shen Yiqiang Cui Yongchang Chen Jianying Wang Lei Wang Yu Kang Xiaoyang Zhao Wei Si Wei Li Andy Peng Xiang Jiankui Zhou Xuejiang Guo Ye Bi Chenyang Si Bian Hu Guoying Dong Hong Wang Zuomin Zhou Tianqing Li Tao Tan Xiuqiong Pu Fang Wang Shaohu | 2014 | Cell2014，，： | 3 |
| 13 | Theoretical study on bubble dynamics under hybrid-boundary and multi-bubble conditions using the unified equation显示文摘This paper aims to use the unified bubble dynamics equation to investigate bubble behavior in complex scenarios involving hybrid free surface/wall boundaries and interactions between multiple bubbles.The effect of singularity movement on the unified equation’s form is analyzed after deriving the bubble pulsation equation using a moving point source and a dipole,followed by discussions on the effect of migration compressibility-related terms on the bubble dynamics.In addition,the present study accounts for the impact of hybrid boundaries,including crossed and parallel boundaries,by introducing a finite number of mirror bubbles for the former and an infinite number of mirror bubbles for the latter.Spark bubble experiments and numerical simulation are conducted to validate the present theory.The application of the unified equation in multi-bubble interactions is exemplified by computing a spherical bubble array containing more than 100 uniformly distributed cavitation bubbles under different boundary conditions.The bubble cluster-induced pressure peak can reach nearly two times or even higher than that of an individual bubble,highlighting the damage potential caused by cavitation bubble clusters. | A-Man Zhang Shi-Min Li Pu Cui Shuai Li Yun-Long Liu | 2023 | Science China(Physics,Mechanics & Astronomy)2023，66，12： | 2 |
| 14 | Environment-friendly surface cleaning using micro-nano bubbles显示文摘Cleaning a surface using a solution containing a large number of micro to nano scale bubbles has significant advantage regarding environmental protection.This review first briefly introduces the cleaning mechanism of micro-nano bubbles(MNBs),including physical and chemical effects.Then the applications of MNBs in cleaning of metal parts,precision parts,cultural relics or food are introduced.After that,coupled cleaning method of ultrasound and bubbles is introduced.Finally,the characterization methods for the cleaning effect are introduced,which mainly focuses on the changes of physico-chemical properties(mass or cleaning area,infiltration,colony number and light scattering intensity)of the cleaned parts or that(like conductivity)of the solvent.It is believed that MNBs technology will be applied in a broader range of surface cleaning applications. | Nuo Jin Fenghua Zhang Yan Cui Le Sun Haoxiang Gao Ziang Pu Weimin Yang | 2022 | Particuology2022，20，7： | 2 |
| 15 | Studies on the binding of vinpocetine to human serum albumin by molecular spectroscopy and modeling显示文摘在 vinpocetine (VPC ) 和在生理的缓冲区的人的浆液白朊(HSA ) 之间的相互作用(pH 7.40 ) 被荧光,英尺红外, UVvis 吸收并且分子的建模调查。VPC 有效地经由静态的熄灭熄灭了 HSA 的内在的荧光。在不同温度的有约束力的地点数字 n 和明显的有约束力的经常的 Ka,相应热力学的参数 G, H 和 S 是计算的。同步荧光和英尺红外系列被用来与 VPC 的增加调查 HSA 分子的结构的变化。分子的建模显示 VPC 能绑在这个地点我 HSA 和恐水病的相互作用,专业正在扮演力量,它与有约束力的模式学习一致。 | Hua Jiang Rong Rong Chen Hong Cui Wang Han Lin Pu | 2012 | Chinese Chemical Letters2012，23，5： | 2 |
| 16 | GOLM1 restricts colitis and colon tumorigenesis by ensuring Notch signaling equilibrium in intestinal homeostasis显示文摘Intestinal epithelium serves as the first barrier against the infections and injuries that mediate colonic inflammation.Colorectal cancer is often accompanied with chronic inflammation.Differed from its well-known oncogenic role in many malignancies,we present here that Golgi membrane protein 1(G0LM1,also referred to as GP73)suppresses colorectal tumorigenesis via maintenance of intestinal epithelial barrier.G0LM1 deficiency in mice conferred susceptibility to mucosal inflammation and colitis-induced epithelial damage,which consequently promoted colon cancer.Mechanistically,depletion of G0LM1 in intestinal epithelial cells(lECs)led to aberrant Notch activation that interfered with IEC differentiation,maturation,and lineage commitment in mice.Pharmacological inhibition of Notch pathway alleviated epithelial lesions and restrained pro-tumorigenic inflammation in G0LM1-deficient mice.Therefore,G0LM1 maintains IEC homeostasis and protects against colitis and colon tumorigenesis by modulating the equilibrium of Notch signaling pathway. | Yang Pu Ya Song Mengdi Zhang Caifeng Long Jie Li Yanan Wang Yinzhe Xu Fei Pan Na Zhao Xinyu Zhang Yanan Xu Jianxin Cui Hongying Wang Yan Li Yong Zhao Di Jin Hongbing Zhang | 2021 | Signal Transduction and Targeted Therapy2021，6，5： | 2 |
| 17 | Effects of sleep deprivation on polysomnography and executive function in patients with depression显示文摘 | Lu Yingzhi Ren Qingtao Zong Li Wu Yingli Zhang Qinfeng Ma Xiuqing Pu Jinyu Dong Hanzhen Liu Qingqing Tang Yunxiang Song Lisheng Chen Xingshi Pan Xiao Cui Yi | 2014 | Chinese Medical Journal2014，，18： | 2 |
| 18 | An efficient papaya leaf distortion mosaic potyvirus vector for virus-induced gene silencing in papaya显示文摘Papaya(Carica papaya L.)is regarded as an excellent model for genomic studies of tropical trees because of its short generation time and its small genome that has been sequenced.However,functional genomic studies in papaya depend on laborious genetic transformations because no rapid tools exist for this species.Here,we developed a highly efficient virus-induced gene silencing(VIGS)vector for use in papaya by modifying an artificially attenuated infectious clone of papaya leaf distortion mosaic virus(PLDMV;genus:Potyvirus),PLDMV-E,into a stable Nimble Cloning(NC)-based PLDMV vector,pPLDMV-NC,in Escherichia coli.The target fragments for gene silencing can easily be cloned into pPLDMV-NC without multiple digestion and ligation steps.Using this PLDMV VIGS system,we silenced and characterized five endogenous genes in papaya,including two common VIGS marker genes,namely,phytoene desaturase,Mg-chelatase H subunit,putative GIBBERELLIN(GA)-INSENSITIVE DWARF1A and 1B encoding GA receptors;and the cytochrome P450 gene CYP83B1,which encodes a key enzyme involved in benzylglucosinolate biosynthesis.The results demonstrate that our newly developed PLDMV VIGS vector is a rapid and convenient tool for functional genomic studies in papaya. | Decai Tuo Pu Yan Guangyuan Zhao Hongguang Cui Guopeng Zhu Yang Liu Xiukun Yang He Wang Xiaoying Li Wentao Shen Peng Zhou | 2021 | Horticulture Research2021，8，1： | 2 |
| 19 | RHOBTB3 promotes proteasomal degradation of HIFa through facilitating hydroxylation and suppresses the Warburg effect显示文摘 | Chen-Song Zhang Qi Liu Mengqi Li Shu-Yong Lin Yongying Peng Di Wu Terytty Yang Li Qiang Fu Weiping Jia Xinjun Wang Teng Ma Yue Zong Jiwen Cui Chengfei Pu Guili Lian Huiling Guo Zhiyun Ye Sheng-Cai Lin | 2015 | Cell Research2015，25，9： | 2 |
| 20 | Experimental and Numerical Study on the Bubble Dynamics near Two-Connected Walls with An Obtuse Angle显示文摘This study is concerned with the dynamic characteristics of bubbles near two connected walls(one horizontal and the other inclined with an obtuse angle from the horizontal one). In this study, we set up an experiment system to conduct typical cases, and the boundary element method is employed to explain the bubble behavior and study the effect of relative parameters. Comparing the two mutually perpendicular walls, we find that the liquid jet deviates from the horizontal direction within a much shorter range. On the intersection of the two walls, the motions of bubbles have similar trends. The relatively low pressure between the bubble and walls causes the transition of the bubble, and a local high-pressure zone leads to the formation of a liquid jet. Moreover, there are moments when the two walls are evenly stressed in the first bubble cycle. Through parameter analysis, we find that the jet directions of bubbles perform interesting discrepancies for different buoyancy and distances to walls. Some instructive conclusions are given to serve practical applications. | LI Shi-min CUI Pu ZHANG Shuai LIU Wen-tao PENG Yu-xiang | 2020 | China Ocean Engineering2020，34，6： | 2 |
您所在的机构暂未开通此部分的功能，请联系管理员