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| 1 | Climate changes in East China since the Late-glacial inferred from high-resolution mountain peat humification records显示文摘High-resolution peat humification records were obtained from Dajiuhu of the Shennongjia Mountains and Qianmutian of the Tianmu Mountains to study climate changes in East China.The analyses of pollen,organic matters,TOC,and Rb/Sr indicate a high degree of peat humification and thus strong decomposition of organic matter when climate was dry.Conversely,when climate was humid,the degree of humification is low because peat was preserved in a waterlogged condition.Peat humification from Dajiuhu occurred not only during the Younger Dryas(about 11.4-12.6 cal ka BP),the Blling-Allerd Warm Period(12.6-15.2 cal ka BP),and the Oldest Dryas(about 15.2-16.0 cal ka BP),but also during the early Holocene(about 11.4-9.4 cal ka BP),the 8.2 cal ka BP cold event,and the Holocene Optimum(about 7.0-4.2 cal ka BP).Both peat humification records since nearly 5 ka BP are consistent,showing that mountain peatland has synchronous responses to the East Asia monsoon-induced precipitation.The LOI data confirm the above observation.The monsoon precipitation since nearly 5 ka BP recorded in these two peat profiles can be divided into three phases.During 4.9-3.5 ka BP,precipitation amount was high but fluctuated greatly.During 3.5-0.9 ka BP,precipitation amount was low.During 0.9-0 ka BP,degree of humification reduced gradually,indicating the increase of monsoon precipitation.Contrast to other high-resolution records from East China monsoon region shows that the monsoon precipitation records of the two peat profiles since nearly 16 ka BP are controlled by a common forcing mechanism of summer solar radicalization in the Northern Hemisphere. | MA ChunMei ZHU Cheng ZHENG ChaoGui YIN Qian ZHAO ZhiPing | 2009 | Science China Earth Sciences2009，52，1： | 22 |
| 2 | Effects of antisense CENP-B on the proliferation of HeLa (Tet-off) cells显示文摘In order to study the change of the expression of centromere protein B (CENP-B) caused by antisense transfection, proto-eukaryotically expressed fused protein GST-CENP-B (65 ku) was injected into mouse, and a peculiar anti-CENP-B serum MaCenpB was collected. A strain of transfected HeLa Tet-off cell HaCb, which contains antisense CENP-B expressing vector pBI-EGFP-as-CenpB, was prepared. Northern blot and Western blot were used to analyze the repression of internal CENP-B in transfected cells. According to the growth curve, the proliferation of HeLa (Tet-off) is repressed by antisense CENP-B, and the multiplication time is prolonged for 32.81 h. The analysis of flow cytometry revealed that, compared with HeLa (Tet-off), the G1 cell population of HaCb is increased (AG1=9%) while S fraction is decreased (AS=11%), but the G2/M phase is nearly unchanged (AG2/M=3%). In the meanwhile, the mi-totic index of HaCb declines greatly compared with that of HeLa (Tet-off). Immunofluorescence showed that the | Qianjin Liang Qian Wang Haiyan Lin Song Luo Chunmei Wang Dacheng He Yongchao Wang | 2002 | Chinese Science Bulletin2002，47，5： | 5 |
| 3 | Animal diversities and characteristics of environmental change revealed by skeletons unearthed at Zhongba Site of Chongqing City,China显示文摘Nearly 200000 animal skeletons are unearthed in the Unit T0202 from Zhongba Site of Zhongxian County.According to the analysis of 129165 specimens,these skeletons may be classified into 5 kinds, namely,Mammalia,Osteichthys,Aves,Amphibian and Reptilia,which belong to 13 orders,28 families and 42 genera.In this paper,based on archeological dating and AMS 14 C data,through statistically analyzing the unearthed skeletons and studying the change of the smallest individual numbers,these research results detected the following:1)In almost all the time of 2370―200 BC,in Zhongba region, some animals distributed widely,such as Muntiacus sp,Elaphodus cephalophus and Muntiacus sp. inhabiting in glade and grassland,Scrofa sp.and Canis familiaris raised by the ancient people,rodentia rabbit and Rattus rattus,which suggested that a fairly good ecological environment of forest and grassland was preserved at that period and the predecessors began to raise domestic animals from 1750 to 1000 BC,which has lasted until today.2)Rhinoceros only lived during 2000―1750 BC,1000― 700 BC and 700―500 BC,which indicates that the ecological environment of grassland and wetland might be better in these phases.3)Macaca sp.and Ursus arctos appeared only after 1750―1000 BC, which may show that the forest condition is better for animals to live during 1750―200 BC.4)The smallest individual numbers of Bublus sp.,bos sp.and otters emerged during about 2370―1750 BC, which perhaps infers that water area during the early period was wider than that of the late period.5) Since skeletons of rhinoceros are discovered in strata of Zhongba Site during 2000―1750 BC and 1000―500 BC,according to the climate and ecology environment which rhinoceros live in now,the average annual temperature and precipitation during 2000―1750 BC and 1000―500 BC are supposed to be probably higher than that of today.Although Zhu Kezhen considered that the first low temperature period in the past 5000 years of China was between 1100 BC and 850 BC,massive pollen of Morus, Ulmus,Fagus,Quercus,Castanea,etc.were found in Dajiuhu peat at that time,which should indicate that the climate was still moderate for living things to live at least in Dajiuhu basin and Zhongba Site.6) Because skeletons of Gervus albirostris were unearthed during 310―200 BC at Zhongba Site,based onthe climate and the ecological environment those animals live in now,the average annual temperature and the average annual precipitation in Zhongba area between 310 BC and 200 BC should be lower than those of today,which is confirmed by the TOC research of Zhongba Site strata. | ZHU Cheng MA ChunMei OUYANG Jie LI ZhongXuan YIN Qian SUN ZhiBin HUANG YunPing R.K.FLAD LI Lan LI YuMei | 2008 | Chinese Science Bulletin2008，53，S1： | 4 |
| 4 | Reconstructing past subsistence patterns on Zhongba Site using stable carbon and oxygen isotopes of fossil tooth enamel显示文摘The oxygen and carbon isotopic ratios in human and animal tooth enamel were measured to reconstruct the subsistence patterns on Zhongba Site between 2400 and 4200 aBP.The results indicate that human consumed chiefly C4 resources,such as millet,and the C3 plants,such as rice and wheat,constituted only a small fraction of the human diets,normally no more than 15%.There are significant differences in food sources between human and pig,and the percentages of C3 plants in pig diets were higher than those in human diets.But theδ13C values of pig partially overlap those of human,demonstrating some similarities in their food sources.The differences in water sources between human and pig are significant.There are significant differences in food and water sources between cattle and deer. This indicates that the two kinds of mammals subsisted in different niches.But theirδ13C values also partially overlap each other,suggesting some similarities in their food sources.There are both signifi- cant differences in meanδ13C andδ18O values between the omnivores,human and pig and the herbi- vores,cattle and deer,implying significant differences in food and water sources between the two categories.During the period the dietary habits of human had not changed,but the pig breeding strategies had changed,from breeding in house to breeding in confinement,and the proportion of C3 plants in pig food increased with time.The scope of human migration had been considerably large by the Warring States because of the development of productive forces. | XiaoSi Tian Cheng Zhu XinWang Xu ChunMei Ma ZhiBin Sun Qian Yin Qing Zhu Wei Shi | 2008 | Chinese Science Bulletin2008，53，S1： | 4 |
| 5 | Precise fabrication of single-atom alloy co-catalyst with optimal charge state for enhanced photocatalysis显示文摘While the surface charge state of co-catalysts plays a critical role for boosting photocatalysis,studies on surface charge regulation via their precise structure control remain extremely rare.Herein,metal-organic framework(MOF)stabilized bimetallic Pd@Pt nanoparticles,which feature adjustable Pt coordination environment and a controlled structure from core-shell to single-atom alloy(SAA),have been fabricated.Significantly,apart from the formation of a Mott-Schottky junction in a conventional way,we elucidate that Pt surface charge regulation can be alternatively achieved by changing its coordination environment and the structure of the Pd@Pt co-catalyst,where the charge between Pd and Pt is redistributed.As a result,the optimized Pd10@Pt1/MOF composite,which involves an unprecedented SAA co-catalyst,exhibits exceptionally high photocatalytic hydrogen production activity,far surpassing its corresponding counterparts. | Yating Pan Yunyang Qian Xusheng Zheng Sheng-Qi Chu Yijun Yang Chunmei Ding Xi Wang Shu-Hong Yu Hai-Long Jiang | 2021 | National Science Review2021，8，1： | 4 |
| 6 | Pyrolysis and co-pyrolysis of lignite and plastic显示文摘The study firstly discusses the pyrolysis characteristics and kinetics by thermogravimetric analysis(TGA),and then investigates the pyrolysis of lignite and co-pyrolysis with plastic(polyethylene or polypropylene)in tube furnace.Meanwhile,the research focuses on the co-pyrolysis products under different mixing ratios as well as pyrolysis products at different testing temperatures and heating rates.The results show that higher final testing temperature and lower heating rate contribute to bond fission in lignite pyrolysis,resulting in less char product.In co-pyrolysis,lignite acts as hydrogen donor,and the yields of char and water rise with increasing amount of plastic in the mixture,while the yields of gas and tar decrease;and a little admixture of plastic will promote the production of gas and tar.Kinetic studies indicate that in temperature range of 530–600°C,activation energies of lignite are higher than those of lignite/plastic blends,and as plastic mass ratio increases from 0%to 10%,samples need less energy to be decomposed during co-pyrolysis. | Qian Chunmei Zhou Min Wei Jianghong Ye Puhai Yang Xu | 2014 | International Journal of Mining Science and Technology2014，24，1： | 4 |
| 7 | Application of Human Adenovirus Genotyping by Phylogenetic Analysis in an Outbreak to Identify Nosocomial Infection显示文摘Nosocomial infections are common in pediatric patients and can be fatal in infants and immunocompromised patients. In September 2018, a high positive rate of human adenovirus HAdV was occurred among hospitalized children in the Children's Hospital Affiliated to the Capital Institute of Paediatrics in Beijing. To investigate whether this outbreak of HAdV was related to nosocomial infections or the result of community infections, we collected respiratory specimens from patients with acute respiratory infections in a respiratory ward during June to December 2018, and screened for respiratory viruses. Among 1,840 cases included, 95(5.2%, 95/1840) were positive for HAdV and 81 were genotyped based on phylogenetic analysis, including seven as HAdV-1(8.6%), 30 HAdV-3(37.0%), two HAdV-6(2.5%), and 42 HAdV-7(51.9%). More HAdV-positive samples were collected in August(4.7%, 12/255), September(15.0%, 41/274) and October(6.9%, 17/247), with a peak in September 2018. By combining the results of HAdV phylogenetic analysis with clinical data of patients, there were 77 cases(4.2%, 77/1840;81.1%, 77/95) excluded from nosocomial infections, eight cases representing possible infections transmitted by visitors or attending parents, three cases without sequences that might have been due to infection transmitted by roommates positive for HAdV, one case of a roommate without an HAdV sequence, and six cases that shared highly homologous sequences with those of their roommates, for which nosocomial infections might be considered. In conclusion, genotyping of HAdVs based on phylogenetic analysis combined with clinical information provides a powerful method to distinguish nosocomial infections from community acquired infection, especially when tracing the origins of nosocomial infections. | Chuanyu Yang Chunmei Zhu Yuan Qian Jie Deng Baoyuan Zhang Runan Zhu Fang Wang Yu Sun Dongmei Chen Qi Guo Yutong Zhou Lei Yu Ling Cao Linqing Zhao | 2021 | Virologica Sinica2021，36，3： | 3 |
| 8 | Quality evaluation of Huaijiao pill by chromatographic fingerprint and simultaneous determination of its major bioactive components显示文摘For quality control purpose,an approach of combining chromatographic fingerprint of Huaijiao pill(HP)and simultaneous determination of its major bioactive components was developed using high performance liquid chromatography coupled with diode array detector(HPLC-DAD).For fingerprint analysis,16 peaks were selected as the characteristic peaks to evaluate the similarities of different samples collected from different batches of three manufacturers.The similarities of 17 Huaijiao pill samples were beyond 0.966,indicating that samples from different batches and manufacturers were,to some extent,consistent.Additionally,simultaneous quantification of seven bioactive markers,namely sophoricoside,baicalin,naringin,genistein,rutin,quercetin and 5-O-methylvisammioside,in HP was performed to interpret the quality consistency.The validation of the proposed approach was acceptable,with the accuracy of 90.2%-106.9%in recovery test.The intra-day and inter-day precisions of the method were evaluated and the RSD values were less than 2.81%.The results from the quantitative data showed that the contents of six marker compounds(except for 5-O-methylvisammioside) were quite consistent between batches produced by one manufacturer and significantly distinctive among different manufacturers.The proposed approach was expected to be developed as a powerful tool for the quality control of HP. | Shuangqin Wang Jingjing Zhang Juan Liu Guangsheng Qian Chunmei Fu | 2016 | Journal of Pharmaceutical Analysis2016，6，4： | 3 |
| 9 | Identification of miRNomes in Human Liver and Hepatocellular Carcinoma Reveals miR-199a/b-3p as Therapeutic Target for Hepatocellular Carcinoma显示文摘 | Jin Hou Li Lin Weiping Zhou Zhengxin Wang Guoshan Ding Qiongzhu Dong Lunxiu Qin Xiaobing Wu Yuanyuan Zheng Yun Yang Wei Tian Qian Zhang Chunmei Wang Qinghua Zhang Shi-Mei Zhuang Limin Zheng Anmin Liang Wenzhao Tao Xuetao Cao | 2011 | Cancer Cell2011，，2： | 3 |
| 10 | Facet Engineering of Advanced Electrocatalysts Toward Hydrogen/Oxygen Evolution Reactions显示文摘The electrocatalytic water splitting technology can generate highpurity hydrogen without emitting carbon dioxide,which is in favor of relieving environmental pollution and energy crisis and achieving carbon neutrality.Electrocatalysts can effectively reduce the reaction energy barrier and increase the reaction efficiency.Facet engineering is considered as a promising strategy in controlling the ratio of desired crystal planes on the surface.Owing to the anisotropy,crystal planes with different orientations usually feature facet-dependent physical and chemical properties,leading to differences in the adsorption energies of oxygen or hydrogen intermediates,and thus exhibit varied electrocatalytic activity toward hydrogen evolution reaction(HER)and oxygen evolution reaction(OER).In this review,a brief introduction of the basic concepts,fundamental understanding of the reaction mechanisms as well as key evaluating parameters for both HER and OER are provided.The formation mechanisms of the crystal facets are comprehensively overviewed aiming to give scientific theory guides to realize dominant crystal planes.Subsequently,three strategies of selective capping agent,selective etching agent,and coordination modulation to tune crystal planes are comprehensively summarized.Then,we present an overview of significant contributions of facet-engineered catalysts toward HER,OER,and overall water splitting.In particular,we highlight that density functional theory calculations play an indispensable role in unveiling the structure–activity correlation between the crystal plane and catalytic activity.Finally,the remaining challenges in facet-engineered catalysts for HER and OER are provided and future prospects for designing advanced facet-engineered electrocatalysts are discussed. | Changshui Wang Qian Zhang Bing Yan Bo You Jiaojiao Zheng Li Feng Chunmei Zhang Shaohua Jiang Wei Chen Shuijian He | 2023 | Nano-Micro Letters2023，15，4： | 2 |
| 11 | Molecular genetic analysis of phosphomannomutase genes in Triticum monococcum显示文摘In higher plants, phosphomannomutase(PMM) is essential for synthesizing the antioxidant ascorbic acid through the Smirnoff–Wheeler pathway. Previously, we characterized six PMM genes(Ta PMM-A1, A2, B1, B2, D1 and D2) in common wheat(Triticum aestivum, AABBDD).Here, we report a molecular genetic analysis of PMM genes in Triticum monococcum(AmAm), a diploid wheat species whose Amgenome is closely related to the A genome of common wheat. Two distinct PMM genes, Tm PMM-1 and Tm PMM-2, were found in T. monococcum. The coding region of Tm PMM-1 was intact and highly conserved. In contrast, two main Tm PMM-2 alleles were identified, with Tm PMM-2a possessing an intact coding sequence and Tm PMM-2b being a pseudogene. The transcript level of Tm PMM-2a was much higher than that of Tm PMM-2b, and a bacterially expressed Tm PMM-2a recombinant protein displayed relatively high PMM activity. In general, the total transcript level of PMM was substantially higher in accessions carrying Tm PMM-1 and Tm PMM-2a than those harboring Tm PMM-1 and Tm PMM-2b. However, total PMM protein and activity levels did not differ drastically between the two genotypes. This work provides new information on PMM genes in T. monococcum and expands our understanding on Triticeae PMM genes, which may aid further functional and applied studies of PMM in crop plants. | Chunmei Yu Xinyan Liu Qian Zhang Xinyu He Wan Huai Baohua Wang Yunying Cao Rong Zhou | 2015 | The Crop Journal2015，3，1： | 1 |
| 12 | Identification of miRNomes in Human Liver and Hepatocellular Carcinoma Reveals miR-199a/b-3p as Therapeutic Target for Hepatocellular Carcinoma显示文摘 | Jin Hou Li Lin Weiping Zhou Zhengxin Wang Guoshan Ding Qiongzhu Dong Lunxiu Qin Xiaobing Wu Yuanyuan Zheng Yun Yang Wei Tian Qian Zhang Chunmei Wang Qinghua Zhang Shi-Mei Zhuang Limin Zheng Anmin Liang Wenzhao Tao Xuetao Cao | 2011 | Cancer Cell2011，，2： | 1 |
| 13 | Overexpression of NYGGF4 (PID1) induces mitochondrial impairment in 3T3-L1 adipocytes显示文摘 | Yaping Zhao Chunmei Zhang Xiaohui Chen Chunlin Gao Chenbo Ji Fukun Chen Chun Zhu Jingai Zhu Jialin Wang Lingmei Qian Xirong Guo | 2010 | Molecular and Cellular Biochemistry (-)2010，，1： | 1 |
| 14 | Zinc Finger Protein 64 Promotes Toll-like Receptor-triggered Proinflammatory and Type I Interferon Production in Macrophages by Enhancing p65 Subunit Activation显示文摘 | Chunmei Wang Xingguang Liu Yin Liu Qian Zhang Zhenyu Yao Bo Huang Peng Zhang Nan Li Xuetao Cao | 2013 | Journal of Biological Chemistry2013，，34： | 1 |
| 15 | α-Lipoic acid ameliorates mitochondrial impairment and reverses apoptosis in FABP3-overexpressing embryonic cancer cells显示文摘 | Lijuan Zhou Jin Jin Guixian Song Hailang Liu Ming Liu Chunmei Shi Lingmei Qian | 2013 | Journal of Bioenergetics and Biomembranes2013，，5： | 1 |
| 16 | Molecular and functional analysis of phosphomannomutase(PMM)from high-er plants and genetic evidence for the involvement of PMM in ascorbic acid biosynthesis in Arabidopsis and Nicotiana ben-thamiana显示文摘 | Qian Weiqiang Yu Chunmei Qin Huanju | | 0，，03： | 1 |
| 17 | Experimental Study on Inert Gas-assisted Laser Cut Veneer Based on LOM显示文摘Based on the LOM(Laminated Object Manufacturing)process,an inert gas-assisted laser method for wood cutting was proposed.The carbonization degree of wood surface was improved by the introduction of helium(He)gas,and the influence of process parameters on the carbonization layer of wood surface was solved,it was significance to reduce the post-processing of LOM and improve the quality of forming workpiece.The cherry wood veneer was used as the experimental material,under the condition of the same process parameters,the wood was cut with or without inert gas-assisted,and the influence factors of kerf quality were studied by variance analysis.The results showed that under the same condition,compared with traditional laser processing,the kerf width was obviously reduced in the inert gas-assisted cutting.Because the He gas had oxygen-isolation and flame retardant effect,which prevented heat accumulation and conduction.The micro morphology of the kerf surface showed that the flatness was better in the inert gas-assisted cutting.As the excess heat was blown out by the cooling and purging of the gas,the phenomenon of oxidation and burning was reduced,the range of HAZ(heat affected zone)was reduced,and the carbonization phenomenon was obviously improved.The surface quality of kerf was improved effectively.According to the analysis of variance,in addition to the effect of laser power,cutting speed and inert gas flow on the cutting width,the interaction between inert gas flow and laser power,laser power and cutting speed were also the main factors which affected the cutting width.The feasibility of the combined inert gas and laser processing to improve wood cutting quality has been verified through experimental research,which provided a certain reference for the followup research on improving the wood processing quality. | Qingwei Liu Chunmei Yang Qian Miao Yifan Liu Jiuqing Liu Wenji Yu | 2020 | Journal of Renewable Materials2020，8，12： | 0 |
| 18 | 核内LC3在自噬体形成中的作用及机制显示文摘细胞出版社《分子细胞》杂志创刊于1997年,每年24期,关注提出最新机理性见解的研究论文和综述。受过专业博士训练的科学编辑与作者、审稿人、科学编委紧密合作,共同确保期刊的高标准性。同时,将最振奋人心、最新的发现带给读者。该杂志2015年公布的影响因子为14.018。 | Rui Huang Yinfeng Xu Wei Wan Xin Shou Jiali Qian Zhiyuan You Bo Liu Chunmei Chang Tianhua Zhou Jennifer Lippincott-Schwartz 刘伟 | 2016 | 科学新闻2016，0，1： | 0 |
| 19 | Identification and profile of phenolamides with anthracnose resistance potential in tea(Camellia sinensis)显示文摘Tea anthracnose is a prevalent disease in China that can lead to reduced tea production and lower quality,yet there is currently a lack of effective means for controlling this disease.In this study,we identified 46 phenolamides(including 27 isomers)in different tissues and organs of tea plants based on a developed workflow,and the secondary mass spectra of all these compounds have been documented.It was revealed that tea plants predominantly accumulate protonated aliphatic phenolamides,rather than aromatic phenolamides.The profile of phenolamides indicate that their buildup in tea plants is specific to certain tissues and acyl-acceptors,and this distribution is associated with the extent of phenolamide acyl-modification.Additionally,it was observed that N-Feruloylputrescine(Fer-Put,a type of phenolamides)was responsive to the stimulated accumulation of the tea anthracnose pathogen.The findings of anti-anthracnose experiments in vitro and on tea leaf demonstrated that Fer-Put was capable of significantly inhibiting the growth of anthracnose pathogen colony,effectively prevented tea leaf disease.Furthermore,it was observed that Fer-Put treatment can enhance the antioxidant enzyme activity of tea leaves.TEA002780.1 and TEA013165.1 gene may be responsible for the biosynthesis of Fer-Put in the disease resistance process in tea plants.Through these studies,the types and distribution of phenolamides in tea plants have been elucidated,and Fer-Put’s ability to resist anthracnose has been established,providing new insights into the resistance of tea anthracnose. | Wenzhao Wang Xingcui Xie Yuanyuan Lv Haonan Guan Lu Liu Qian Huang Yumeng Bao Jie Zhou Lu Bao Chunmei Gong Youben Yu | 2023 | Horticulture Research2023，10，9： | 0 |
| 20 | H3K4me3去甲基化酶KDM5A通过P50靶向抑制SOCS1促进NK细胞活化显示文摘NK细胞数量和功能异常与肿瘤和持续性病毒感染的发生密切相关。目前对于在NK细胞激活过程中,表观遗传机制如何参与调控细胞因子刺激的信号通路仍知之甚少。 | Dezhi Zhao Qian Zhang Yiqi Liu Xia Li Kai Zhao Yuanyuan Ding Zhiqing Li Qicong Shen Chunmei Wang Nan Li 曹雪涛 | 2017 | 科学新闻2017，19，4： | 0 |
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