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| 1 | Cytoplasmic m6A reader YTHDF3 promotes mRNA translation显示文摘 | Ang Li Yu-Sheng Chen Xiao-Li Ping Xin Yang Wen Xiao Ying Yang Hui-Ying Sun Qin Zhu Poonam Baidya Xing Wang Devi Prasad Bhattarai Yong-Liang Zhao Bao-Fa Sun Yun-Gui Yang | 2017 | Cell Research2017，27，3： | 82 |
| 2 | 2018 Chinese Pediatric Cardiology Society(CPCS) guideline for diagnosis and treatment of syncope in children and adolescents显示文摘Syncope belongs to the transient loss of consciousness(TLOC), characterized by a rapid onset, short duration, and spontaneous complete recovery. It is common in children and adolescents, accounting for 1% to 2% of emergency department visits.Recurrent syncope can seriously affect children's physical and mental health, learning ability and quality of life and sometimes cardiac syncope even poses a risk of sudden death. The present guideline for the diagnosis and treatment of syncope in children and adolescents was developed for guiding a better clinical management of pediatric syncope. Based on the globally recent development and the evidence-based data in China, 2018 Chinese Pediatric Cardiology Society(CPCS) guideline for diagnosis and treatment of syncope in children and adolescents was jointly prepared by the Pediatric Cardiology Society, Chinese Pediatric Society, Chinese Medical Association(CMA)/Committee on Pediatric Syncope, Pediatricians Branch, Chinese Medical Doctor Association(CMDA)/Committee on Pediatric Cardiology, Chinese College of Cardiovascular Physicians, Chinese Medical Doctor Association(CMDA)/Pediatric Cardiology Society, Beijing Pediatric Society, Beijing Medical Association(BMA). The present guideline includes the underlying diseases of syncope in children and adolescents, the diagnostic procedures, methodology and clinical significance of standing test and headup tilt test, the clinical diagnosis vasovagal syncope, postural orthostatic tachycardia syndrome, orthostatic hypotension and orthostatic hypertension, and the treatment of syncope as well as follow-up. | Cheng Wang Yaqi Li Ying Liao Hong Tian Min Huang Xiangyu Dong Lin Shi Jinghui Sun Hongfang Jin Junbao Du Jindou An Jie Chen Mingwu Chen Qi Chen Sun Chen Yonghong Chen Zhi Chen Adolphus Kai-tung Chau Junbao Du Zhongdong Du Junkai Duan Hongyu Duan Xiangyu Dong Lin Feng Lijun Fu Fangqi Gong Yonghao Gui Ling Han Zhenhui Han Bing He Zhixu He Xiufen Hu Yimin Hua Guoying Huang Min Huang Ping Huang Yujuan Huang Hongfang Jin Mei Jin Bo Li Fen Li Tao Li Xiaohui Li Xiaoyan Liu Yan Li Haitao Lv Tiewei Lv Zipu Li Luyi Ma Silin Pan Yusheng Pang Hua Peng Yuming Qin Jie Shen Lin Shi Kun Sun Jinghui Sun Hong Tian Jie Tian Cheng Wang Hong Wang Lei Wang Jinju Wang Wendi Wang Yuli Wang Rongzhou Wu Tianhe Xia Yanyan Xiao Chunhong Xie Yanlin Xing Zhenyu Xiong Baoyuan Xu Yi Xu Hui Yan Shiwei Yang Qijian Yi Xia Yu Xianyi Yu Yue Yuan Hongyan Zhang Huili Zhang Li Zhang Qingyou Zhang Xi Zhang Yanmin Zhang Zhiwei Zhang Cuifen Zhao Bin Zhou Hua Zhu | 2018 | Science Bulletin2018，63，23： | 54 |
| 3 | Evidence chain-based causality identification in herb-induced liver injury: exemplification of a well-known liver-restorative herb Polygonum multiflorum显示文摘草药的药最近在美国作为导致药的肝损害(DILI ) 的第二个很普通的原因被认出了。然而,识别一些植物的 DILI 诱发性的可靠方法例如 Heshouwu (蓼 multiflorum 的弄干的根) ,留下缺乏。在这研究,有肝机能障碍和 Heshouwu DILI 的 147 个报导文学的案例的 12 307 个住院病人的一个总数被屏蔽。一个一般算法仅仅显示了那 22.5%(9/40 ) 并且(45/147 ) 分别地, 30.6% 所有住院和文学案例报告表明 Heshouwu 的 DILI 诱发性的高概率。由对比,(19/20 )95% 生药学,植物化学,和 metabolomic 有希望地调查的所有情况测试展出高度可能的诱发性,包括不正确地以前被归因的一个病人和从由 pharmacognostic 证据的 Heshouwu 诱发性被排除的一个案例。污染也是的毒素(重金属,杀虫剂,和 mycotoxins ) 从 Heshouwu DILI 诱发性排除了。为 Heshouwu DILI 诊断地址安全的这些屏蔽方法的客观性担心考虑包含芪的草药的药和饮食的补充。 | Jiabo Wang Zhijie Ma Ming Niu Yun Zhu Qingsheng Liang Yanling Zhao Jingyuan Song Zhaofang Bai Yaming Zhang Ping Zhang Na Li Yakun Meng Qi Li Lushan Qin Guangju Teng Junling Cao Baosen Li Shilin Chen Yonggang Li Zhengsheng Zou Honghao Zhou Xiaohe Xiao | 2015 | Frontiers of Medicine2015，9，4： | 47 |
| 4 | 中国大学生抑郁症和自杀行为的研究进展显示文摘 | 周鄂生 Qin Ping 杨旭 曹毅 王昆 周砚青 | 2007 | 公共卫生与预防医学2007，18，2： | 40 |
| 5 | 42,573 cases of hepatectomy in China: a multicenter retrospective investigation显示文摘Hepatectomy is currently routinely performed in most hospitals in China. China owns the largest population of liver diseases and the biggest number of liver resection cases. A nationwide multicenter retrospective investigation involving 112 hospitals was performed, and focused on liver resection for patients with hepatocellular carcinoma(HCC). 42,573 cases of hepatectomy were enrolled, and 18,275 valid cases of liver resection for HCC patients were selected for statistical analysis. The epidemiology of HCC, distribution of hepatectomy, postoperative complications and prognosis were finally analyzed. In the 18,275 HCC patients,81% had hepatitis B virus infection and 10% had hepatitis C virus infection. 38% of the HCC patients had normal Alphafetoprotein(AFP) level, and other 35% had an AFP level lower than 400 ng mL^(-1). In the study period, 97% of the hepatectomy for HCC were treated with open surgery, and 23.81% had vascular exclusion techniques. The operation time was(191.7±105.6) min,the blood loss was(546.0±562.8) m L, and blood transfusion was(543.0±1,035.2) m L. The median survival for HCC patients was 631 days, with 1-, 3-, and 5-year overall survival of 73.2%, 28.8% and 19.6%, respectively. Liver cirrhosis, multiple nodules,tumor thrombosis and high AFP level were risk factors that affect postoperative survival. | Binhao Zhang Bixiang Zhang Zhiwei Zhang Zhiyong Huang Yifa Chen Minshan Chen Ping Bie Baogang Peng Liqun Wu Zhiming Wang Bo Li Jia Fan Lunxiu Qin Ping Chen Jingfeng Liu Zhe Tang Jun Niu Xinmin Yin Deyu Li Songqing He Bin Jiang Yilei Mao Weiping Zhou Xiaoping Chen | 2018 | Science China(Life Sciences)2018，61，6： | 39 |
| 6 | Chinese medicine CGA formula ameliorates DMN- induced liver fibrosis in rats via inhibiting MMP2/9, TIMP1/2 and the TGF-β/Smad signaling pathways显示文摘 | Xue-mei LI Jing-hua PENG Zhao-lin SUN Hua-jie TIAN Xiao-hua DUAN Lin LIU Xin MA Qin FENG Ping LIU Yi-yang HU | 2016 | Acta Pharmacologica Sinica2016，37，6： | 34 |
| 7 | Toward Wisdom-Evolutionary and Primitive-Concise 6G:A New Paradigm of Semantic Communication Networks显示文摘The sixth generation(6G)mobile networks will reshape the world by offering instant,efficient,and intelligent hyper-connectivity,as envisioned by the previously proposed Ubiquitous-X 6G networks.Such hyper-massive and global connectivity will introduce tremendous challenges into the operation and management of 6G networks,calling for revolutionary theories and technological innovations.To this end,we propose a new route to boost network capabilities toward a wisdom-evolutionary and primitive-concise network(WePCN)vision for the Ubiquitous-X 6G network.In particular,we aim to concretize the evolution path toward the WePCN by first conceiving a new semantic representation framework,namely semantic base,and then establishing an intelligent and efficient semantic communication(IE-SC)network architecture.In the IE-SC architecture,a semantic intelligence plane is employed to interconnect the semantic-empowered physical-bearing layer,network protocol layer,and application-intent layer via semantic information flows.The proposed architecture integrates artificial intelligence and network technologies to enable intelligent interactions among various communication objects in 6G.It features a lower bandwidth requirement,less redundancy,and more accurate intent identification.We also present a brief review of recent advances in semantic communications and highlight potential use cases,complemented by a range of open challenges for 6G. | Ping Zhang Wenjun Xu Hui Gao Kai Niu Xiaodong Xu Xiaoqi Qin Caixia Yuan Zhijin Qin Haitao Zhao Jibo Wei Fangwei Zhang | 2022 | Engineering2022，8，1： | 28 |
| 8 | Intranasal recombinant human erythropoietin protects rats against focal cerebral ischemia显示文摘 | Yue - Ping Yu Qiu - Qin Xu Qi Zhang Wei - Ping Zhang Li - Hui Zhang Er - Qing Wei | 2005 | 中国药理通讯2005，22，4： | 20 |
| 9 | Simvastatin inhibited cardiac hypertrophy and fibrosis in apolipoprotein E-deficient mice fed a "Western-style diet" by increasing PPAR a and ~ expression and reducing TC, MMP-9, and Cat S levels显示文摘 | Yan-wen QIN Ping YE Ji-qiang HE Li SHENG Lu-ya WANG Jie DU | 2010 | Acta Pharmacologica Sinica2010，31，10： | 19 |
| 10 | Gene therapy for human colorectal carcinoma using human CEA promoter controlled bacterial ADP-ribosylating toxin genes:PEA and DTA gene transfer显示文摘INTRODUCTIONAmajorrequirementforinvivogenetherapyforcanceristotargetthetherapeuticgeneexpresiontomalignanttissuesbyselectingp... | CAO Guang Wen 1, QI Zhong Tian 1, PAN Xin 1, ZHANG Xiao Qin 1, MIAO Xiao Hui 1, FENG Yan 1, LU Xin Hua 1, Shigeki Kuriyama 2 and DU Ping 1 | 1998 | World Journal of Gastroenterology1998，4，5： | 18 |
| 11 | Exploring an Integrative Therapy for Treating COVID-19:A Randomized Controlled Trial显示文摘Objectives:To develop a new Chinese medicine(CM)-based drug and to evaluate its safety and effect for suppressing acute respiratory distress syndrome(ARDS)in COVID-19 patients.Methods:A putative ARDS-suppressing drug Keguan-1 was first developed and then evaluated by a randomized,controlled two-arm trial.The two arms of the trial consist of a control therapy(alpha interferon inhalation,50(x g twice daily;and lopinavir/ritonavir,400 and 100 mg twice daily,respectively)and a testing therapy(control therapy plus Keguan-119.4 g twice daily)by random number table at 1:1 ratio with 24 cases each group.After 2-week treatment,adverse events,time to fever resolution,ARDS development,and lung injury on newly diagnosed COVID-19 patients were assessed.Results:An analysis of the data from the first 30 participants showed that the control arm and the testing arm did not exhibit any significant differences in terms of adverse events.Based on this result,the study was expanded to include a total of 48 participants(24 cases each arm).The results show that compared with the control arm,the testing arm exhibited a significant improvement in time to fever resolution(P=0.035),and a significant reduction in the development of ARDS(P=0.048).Conclusions:Keguan-1-based integrative therapy was safe and superior to the standard therapy in suppressing the development of ARDS in COVID-19 patients.(Trial registration No.NCT 04251871 at www.clinicaltrials.gov). | WANG Jia-bo WANG Zhong-xia JING Jing ZHAO Peng DONG Jing-hui ZHOU Yong-feng YANG Guang NIU Ming ZHAO Xu JIANG Tian-jun Bl Jing-feng XU Zhe ZHANG Ping WU Dan BAI Zhao-fang GUO Yu-ming YU Si-miao SUN Yong-qiang ZHANG Zi-teng ZHAN Xiao-yan LI Peng-yan DING Jin-biao ZHAO Peng-fei SONG Xue-ai TANG Jian-yuan HE Dong-chu CHEN Zhu QIN En-qiang WANG Rui-lin XIAO Xiao-he | 2020 | Chinese Journal of Integrative Medicine2020，26，9： | 18 |
| 12 | Prenatal diagnosis of methylmalonic aciduria by analysis of organic acids and total homocysteine in amniotic fluid显示文摘背景:Methylmalonic 酸尿(MMA ) 是在中国的器官的酸尿的最经常的疾病。各种各样的生物化学的策略为 MMA 的出生前的诊断被跟随。然而,后来, MMA 影响的胎儿减少了 methylmalonic 酸的排泄,出生前的生物化学的诊断的困难是明显的。煤气的层析团分光术(GC/MS ) 和双人脚踏车团分光术(ESI/MS/MS ) 允许我们在影响胎儿识别疾病。这研究的目的是在 MMA 的出生前的诊断在羊膜的液体决定有机酸和全部的人半胱氨酸的分析的价值。方法:临床诊断并且有 MMA 的九个职业人员乐队的结果并且出生前在风险基于九个胎儿的生物化学的分析诊断因为 MMA 被调查。从在为 MMA 的风险的怀孕和新陈代谢的联盟者正常怀孕的羊膜的液体样品在 16 点被获得 - 24 星期怀孕期。Methylmalonic 酸和甲基枸橼酸被 GC/MS 测量, propionylcarnitine 被 ESI/MS/MS 分析,并且全部的人半胱氨酸由荧光极化免疫分析是坚定的。结果:在二怀孕, methylmalonic 酸的高水平,甲基枸橼酸, propionylcarnitine,和总数,人半胱氨酸在胎儿显示了联合 MMA 和 homocysteinemia。继续的怀孕和收到的维生素 B12 作为出生前的处理,和其它补充的母亲之一终止了她的怀孕。在一个,怀孕, methylmalonic 酸的显著地提高的层次,甲基枸橼酸,和 propionylcarnitine,和正常全部的人半胱氨酸铺平被发现在胎儿显示孤立的 MMA;流产在这个案例上被执行。在另外的六怀孕,上述提及的代谢物的所有层次是正常的建议胎儿没被 MMA 影响。diagnoses 被严峻的尿有机酸和血浆总数人半胱氨酸在交货以后证实。结论:MMA 的新陈代谢的畸形在怀孕期早发生。在羊膜的液体的全部的人半胱氨酸的水平可以是胎儿的联合 MMA 和 homocysteinemia 的另外的指示物。在羊膜的液体的全部的人半胱氨酸水平的决心可以为疾病的出生前的诊断成为一个方便、可靠的方法。 | ZHANG Yao YANG Yan-ling HASEGAWA Yuki YAMAGUCHI Seiji SHI Chun-yan SONG Jin-qing SAYAMI Sujan LIU Ping YAN Rong DONG Jin-hua QIN Jiong | 2008 | Chinese Medical Journal2008，，3： | 18 |
| 13 | Impact of Heat Wave in 2005 on Mortality in Guangzhou, China显示文摘Objective To assess the impact of the heat wave in 2005 on mortality among the residents in Guangzhou and to identify susceptible subpopulations in Guangzhou, China. Methods The data of daily number of deaths and meteorological measures from 2003 to 2006 in Guangzhou were used in this study. Heat wave was defined as ≥7 consecutive days with daily maximum temperature above 35.0 ℃ and daily mean temperature above the 97th percentile during the study period. The excess deaths and rate ratio (RR) of mortality in the case period compared with the reference period in the same summer were calculated. Results During the study period, only one heat wave in 2005 was identified and the total number of excess deaths was 145 with an average of 12 deaths per day. The effect of the heat wave on non-accidental mortality (RR=1.23, 95% CI: 1.11-1.37) was found with statistically significant difference. Also, greater effects were observed for cardiovascular mortality (RR=1.34, 95% CI: 1.13-1.59) and respiratory mortality (RR=1.31, 95% CI: 1.02-1.69). Females, the elderly and people with lower socioeconomic status were at significantly higher risk of heat wave-associatedmortality. Conclusion The 2005 heat wave had a substantial impact on mortality among the residents in Guangzhou, particularly among some susceptible subpopulations. The findings from the present study may provide scientific evidences to develop relevant public health policies and prevention measures aimed at reduction of preventable mortality from heat waves. | YANG Jun LIU Hua Zhang OU Chun Quan LIN Guo Zhen DING Yan ZHOU Qin SHEN Ji Chuan CHEN Ping Yan | 2013 | Biomedical and Environmental Sciences2013，26，8： | 16 |
| 14 | Effect of β2-adrenergic agonist clenbuterol on ischemia/reperfusion injury in isolated rat hearts and cardiomyocyte apoptosis induced by hydrogen peroxide显示文摘目的: 在 ischemia/reperfusion (I/R ) 上观察贝它 2-adrenergic 收缩筋 cienbuterol 的效果在孤立的老鼠心和过氧化氢(H2O2 ) 的损害 -in-duced cardiomyocyte apoptosis.Methods : 孤立的老鼠心受到 30 min 一台 Langendorff 仪器上的全球局部缺血和 60 min 灌注。心脏的功能被心搏率,左室的结束心脏舒张的压力(LVEDP ) ,左室的收缩压,左心室压(+dp/dt_( 最大)) 的最大的上升率和冠的自河(CF ) 评估。在冠的自河, malondialdehyde (MDA ) ,超级氧化物歧化酶(草皮) ,和在心脏的织物的 Ca^(2+)-ATPase 活动的 Lactate 脱氢酶(LDH ) 用商业工具包被测量。 apoptotic cardiomyocyte 被终端 deoxynucleotidyl 检测标记的 调停transferase 的 digoxigenin-dUTP 刻痕结束( TUNEL ) assay.Bax/Bcl-2 mRNA 层次和 caspase-3 的表达式被 RT-PCR 并且免疫弄污检测, respectively.Cultured 新生儿老鼠 cardiomyocytes 与 cienbuterol 被预先孵化,并且氧化压力损害被 H2O2.Cell 生存能力导致, cardiomyocyte apoptosis 被流动血细胞计数( FCM )评估 .Results :在在 I/R 损害以后的孤立的老鼠心, cienbuterol 显著地改进了心脏舒张的功能( LVEDP 和 CF )和Ca^(2+) -ATPase 活动。有 cienbuterol 的处理增加了草皮活动并且减少 MDA 水平和 LDH 与 I/R 组(P<0.05 ) 相比释放。而且, cienbuterol 减少了 apoptosis ,它在TUNEL积极的房间, Bax/Bcl-2 mRNA ,和 caspase-3 expres-sion.In 与减小被联系 导致H2O2 的 cardiomyocyte 损害, cienbuterol 增加了房间生存能力并且与 ICI118551 (选择贝它 2-adrenergic 对手)稀释了 cardiomyocyte apoptosis.Pre处理减少这些与 对待clenbuterol 的组( P<0.05 )相比完成 .Conclusion : Cienbuterol 改善了室的心脏舒张的功能由在 haning Ca^(2+) -ATPase 活动和减少的氧化应力和心脏的肌细胞,在一只试验性的老鼠的 apoptosis 当模特儿心肌层 I/R.It , H2O2 在 vitro.It 导致的减少的 cardiomyocyte apoptosis 对心肌层 I/R 损害在心脏的保护起一个关键作用。 | Ping LIU Ji-zhou XIANG Lei ZHAO Lei YANG Ben-rong HU Qin FU | 2008 | Acta Pharmacologica Sinica2008，29，6： | 14 |
| 15 | Genotypic Characterization of Methicillin-resistant Staphylococcus aureus Isolated from Pigs and Retail Foods in China显示文摘Objective To investigate the genotypic diversity of Methicillin-resistant Staphylococcus aureus(MRSA) isolated from pigs and retail foods from different geographical areas in China and further to study the routes and rates of transmission of this pathogen from animals to food. Methods Seventy-one MRSA isolates were obtained from pigs and retail foods and then characterized by multi-locus sequencing typing(MLST), spa typing, multiple-locus variable number of tandem repeat analysis(MLVA), pulsed-field gel electrophoresis(PFGE), and antimicrobial susceptibility testing. Results All isolated MRSA exhibited multi-drug resistance(MDR). Greater diversity was found in food-associated MRSA(7 STs, 8 spa types, and 10 MLVA patterns) compared to pig-associated MRSA(3 STs, 1 spa type, and 6 MLVA patterns). PFGE patterns were more diverse for pig-associated MRSA than those of food-associated isolates(40 vs. 11 pulse types). Among the pig-associated isolates, CC9-ST9-t899-MC2236 was the most prevalent clone(96.4%), and CC9-ST9-t437-MC621(20.0%) was the predominant clone among the food-associated isolates. The CC9-ST9 isolates showed significantly higher antimicrobial resistance than other clones. Interestingly, CC398-ST398-t034 clone was identified from both pig-and food-associated isolates. Of note, some community-and hospital-associated MRSA strains(t030, t172, t1244, and t4549) were also identified as food-associated isolates. Conclusion CC9-ST9-t899-MC2236-MDR was the most predominant clone in pigs, but significant genetic diversity was observed in food-associated MRSA. Our results demonstrate the great need for improved surveillance of MRSA in livestock and food and effective prevention strategies to limit MDR-MRSA infections in China. | WANG Wei LIU Feng ZULQARNAIN Baloch ZHANG Cun Shan MA Ke PENG Zi Xin YAN Shao Fei HU Yu Jie GAN Xin DONG Yin Ping BAI Yao LI Feng Qin YAN Xiao Mei MA Ai Guo XU Jin | 2017 | Biomedical and Environmental Sciences2017，30，8： | 13 |
| 16 | NGX6 inhibits cell invasion and adhesion through suppression of Wnt/β-catenin signal pathway in colon cancer显示文摘结肠癌是与增加的病态和死亡被联系的一个普通恶意的肿瘤。鼻咽的联系癌的基因(NGX6 ) 6 是肿瘤转移的新奇候选人 suppressor 基因,它在结肠癌是下面调整的。这研究被设计在人的结肠癌房间线的生长和侵略上调查 NGX6 的角色,并且阐明, HT-29 他们的行动的分子的机制。结果证明 NGX6 能禁止侵略和 HT-29 房间的细胞外的矩阵粘附并且恢复差距 junctional 房间的细胞间的通讯。而且, NGX6 能从原子核和细胞质压制 -catenin 的 translocation 到血浆膜,禁止 TCF4 抄本因素,和下面调整的活动 Wnt-direct-targeted 基因 c-myc, cyclin D1 和 COX-2 的表示。我们建议 NGX6 在结肠癌通过 Wnt 信号小径的抑制禁止房间侵略和粘附。 | Qin Guo Shourong Shen Mantian Liao Ping Lian Xiaoyan Wang | 2010 | Acta Biochimica et Biophysica Sinica2010，42，7： | 13 |
| 17 | Role of Fas/FasL Pathway-mediated Alveolar Macrophages Releasing Inflammatory Cytokines in Human Silicosis显示文摘The role of Fas/Fas ligand (FasL) in mediating alveolar macrophage (AM)-derived inflammatory cytokines in 29 human lung silicosis patients and 6 controls was studied.It showed that the serum levels of IL-1β,TNF-α,IL-8,MIP-1α,MCP-1,and TGF-β1were higher in silicosis patients than in controls,and increased with the progression of silicosis except TGF-β1 and IL-8.TGF-β1,IL-8,MCP-1,MIP-1αwere efficiently down-regulated by anti-FasL antibody or caspase-8 inhibitor,indicating that Fas/FasL signaling promotes the | YAO San Qiao HE Qin Cheng YUAN Ju Xiang CHEN Jie CHEN Gang LU Yao BAI Yu Ping ZHANG Chun Min YUAN Yang XU Ying Jun | 2013 | Biomedical and Environmental Sciences2013，26，11： | 13 |
| 18 | Dihydrotanshinone I inhibits angiogenesis both in vitro and in vivo显示文摘Dihydrotanshinone 我(DI ) ,从鼠尾草植物 miltiorrhiza Bunge 提取的自然地发生的混合物,被报导了有 cytotoxicity 到许多肿瘤房间。在这研究,我们在人的脐的静脉 endothelial 房间调查了它的 anti-angiogenic 能力。DI 导致了有势力 cytotoxicity 到人的脐的静脉 endothelial 房间,与约 1.28 亩 g/ml 的 IC50 价值。在 0.25-1 亩 g/ml, DI dose-dependently 压制了分别地愈合弯屈, Transwell 侵略和 Matrigel 试管形成试金检测的人的脐的静脉 endothelial 房间移植,侵略,和试管形成。而且,在在小鸡胚胎 chorioallantoic 的 vivo anti-angiogenic 活动重要的显示出的 DI 膜试金。DI 在 0.2 亩 g/egg 导致了微容器密度的 61.1% 禁止的率。总起来说,我们的结果证明 DI 能通过压制 endothelial 房间增长,移植,侵略和试管形成禁止 angio 开始,显示 DI 有一个潜力作为一个新奇 anti-angiogenic 代理人被发展。 | Weipeng Bian Fei Chen Ling Bai Ping Zhang Wenxin Qin | 2008 | Acta Biochimica et Biophysica Sinica2008，40，1： | 13 |
| 19 | Provision of Residential Solid Waste Management Service in Rural China显示文摘在越过中国盖住很多随机取样的村庄的数据集上绘画,现在的纸在农村中国检验居住稳固的浪费管理服务预备的问题。用一个逻辑模型,我们关于居住稳固的废物处理在村庄水平在服务预备上评估不同因素的影响。这些因素包括居住稳固的废物产生,村民的委员会的金融能力,村庄选举和村庄头的单个特征引起的环境压力。我们发现那生活密度,人均的收入,灌溉土地的比率,和人均的利润由村庄企业提交了到村民的委员会的村庄都在服务预备上有积极影响。而且,被村民流行地选的村庄头是更可能的提供满足选民的要求的服务。 | Chunhui Ye Ping Qin | 2008 | China & World Economy2008，16，5： | 12 |
| 20 | Influences of dietary protein sources and crude protein levels on intracellular free amino acid profile in the longissimus dorsi muscle of finishing gilts显示文摘Background: The current study was carried out to determine effects of dietary protein source and crude protein(CP)level on carcass characteristics, meat quality, and muscle amino acid(AA) profile in finishing gilts. The experiment was designed as a 2 × 2 factorial arrangement with two sources of dietary proteins(cottonseed meal, CSM vs. soybean meal, SBM) and two levels of CP(12 % vs. 14 %, as-fed basis). Seventy-two crossbred gilts(89.5 ± 0.9 kg) were allotted to one of four dietary treatments in a randomized complete block design for a period of 28 d. All diets were formulated to be isoenergetic and similar concentrations of standardized ileal digestible essential AA covering the nutrient requirements of pigs.Results: Growth, carcass characteristics and meat quality were not affected by dietary protein source nor crude protein level(P > 0.10) except that average daily feed intake was increased by CSM diets(P = 0.03). Gilts offered reduced protein diets had lower muscle p H45min(P < 0.05). Neither dietary protein source nor crude protein level influenced N deposition. However, reduced protein diets decreased N intake, N excretion, and serum urea nitrogen content, whilst improved N efficiency(P < 0.01). CSM diets increased N intake(P = 0.04),but did not depress N efficiency. The concentrations of phenylalanine, tryptophan, cysteine and tyrosine(P < 0.05) of the longissimus muscle were decreased when gilts offered CSM diets, while muscle intracellular free valine concentration was increased(P = 0.03). The gilts offered reduced protein diets had greater intracellular concentrations of free methionine, lysine, and total AA in muscle(P < 0.05).Conclusion: These results suggest that CSM could replace SBM as a primary protein source in finishing pig diets in terms of performance, N efficiency, carcass characteristics, and meat quality, but decrease the concentrations of muscle specific AA. Furthermore, the reduced protein diet played an important role in increasing muscle intracellular concentrations of specific free amino acids(FAA), and in reducing the relative ratios of specific FAA to lysine in longissimus dorsi muscle of pig, whose biological meaning needs further studies. | Chunfu Qin Ping Huang Kai Qiu Wenjuan Sun Ling Xu Xin Zhang Jingdong Yin | 2016 | Journal of Animal Science and Biotechnology2016，7，2： | 11 |
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