|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | 5-Hydroxymethylcytosine signatures in circulating cell-free DNA as diagnostic biomarkers for human cancers显示文摘象 5-methylcytosine (5mC ) 和 5-hydroxymethylcytosine (5hmC ) 那样的 DNA 修正是知道在哺乳动物影响全球基因表示的 epigenetic 标记。在人的染色体,与基因表示的靠近的关联和高化学的稳定性给他们的流行,这些 DNA epigenetic 标记能为癌症用作理想的 biomarkers 诊断。利用一种高度敏感、选择的化学标记技术,我们这里报导在传播没有房间的 DNA ( cfDNA )并且在从最近与 colorectal 诊断的 260 个病人的一个队收集的配对的肿瘤和邻近的纸巾的 genomic DNA ( gDNA )的 5hmC 的染色体宽的介绍,胃,胰腺,从 90 个健康个人的肝或甲状腺癌症和正常纸巾。5hmC 主要在与开的染色质和容许的 histone 修正重合的 transcriptionally 活跃的区域被散布。柔韧的联系癌症的 5hmC 签名在 cfDNA 被识别为特定的癌症类型是特征的。传播 cfDNA 的 5hmC 底 biomarkers colorectal 和胃的癌症是高度预兆的并且比常规 biomarkers 优异并且比得上从织物活体检视的 5hmC biomarkers。因此,这新策略能从血样品的分析为癌症的诊断和预后导致有效、最低限度地侵略的方法的发展。 | Wenshuai Li Xu Zhang Xingyu Lu Lei You Yanqun Song Zhongguang Luo Jun Zhang Ji Nie Wanwei Zheng Diannan Xu Yaping Wang Yuanqiang Dong Shulin Yu Jun Hong Jianping Shi Hankun Hao Fen Luo Luchun Hua Peng Wang Xiaoping Qian Fang Yuan Lianhuan Wei Ming Cui Taiping Zhang Quan Liao Menghua Dai Ziwen Liu Ge Chen Katherine Meckel Sarbani Adhikari Guifang Jia Marc B Bissonnette Xinxiang Zhang Yupei Zhao Wei Zhang Chuan He Jie Liu | 2017 | Cell Research2017，27，10： | 30 |
| 2 | Chinese Multidisciplinary Expert Consensus on the Diagnosis and Treatment of Hyperuricemia and Related Diseases显示文摘 | Zou, He-Jian Wu, Hu-Sheng Zhou, Jing-Guo Zeng, Xue-Jun Dai, Lie Wu, Hua-Xiang Zhu, Xiao-Xia Mei, Chang-Lin Hao, Chuan-Ming Chen, Nan Liu, Bi-Cheng Chen, Jiang-Hua Yang, Li Nie, Jing Yu, Chen Peng, Ai Yu, Sheng-Qiang Li, Lin Ge, Jun-Bo Huo, Yong Zhang, Shu-Yang Chen, Yun-Dai Dong, Yu-Gang Liang, Chun Dai, Yu-Xiang Gao, Xin Li, Chang-Gui Zhao, Jia-Jun Chen, Hai-Bing Cheng, Zhi-Feng Lin, Huan-Dong Guan, Yang-Tai Wang, Kai Luo, Ben-Yan Dai, Ruo-Lian Jiang, Quan Xue, Luan Liang, Chao-Chao Chen, Ming Fan, Song | 2017 | Chinese Medical Journal2017，，20： | 30 |
| 3 | Identification of the anti-tumor activity and mechanisms of nuciferine through a network pharmacology approach显示文摘瞄准:Nuciferine 是从莲花叶子提取的 aporphine 碱,它是在为重量损失的中国药用的植物的原料。在这研究,我们使用了一条网络药理学途径识别 nuciferine 和内在的 mechanisms.Methods 的反肿瘤活动:nuciferine 的药理学活动和机制通过目标侧面预言被识别,聚类用我们的繁体中文药(TCM ) 的分析和功能的丰富分析网络药理学站台。nuciferine 的反肿瘤活动被验证由在 vitro 并且在 vivo 实验。nuciferine 的反肿瘤机制通过网络目标分析被预言并且验证了由在 vitro experiments.Results:nuciferine 目标侧面与表明小径和生物功能被充实,包括 “脂肪分解酵素 activity” 的规定;, “对 nicotine” 的反应;并且 “房间 proliferation” 的规定;。目标侧面聚类结果建议了那 nuciferine 施加反肿瘤效果。在试验性的确认, nuciferine (0.8 mg/mL ) 显著地在 vitro 禁止了人的 neuroblastoma SY5Y 房间和老鼠 colorectal 癌症 CT26 房间的生存能力,并且 nuciferine (0.05 mg/mL ) 显著地在 vitro 压制了 6 根癌症房间线的侵略。nuciferine 的 Intraperitoneal 注射(9.5 mg/mL, ip,乘为 3 个星期的一个星期的 3 ) 显著地减少了在裸体老鼠的 SY5Y 和 CT26 肿瘤异种皮移植的重量。在 SY5Y 和 CT26 房间的网络目标分析和试验性的确认证明 nuciferine 的反肿瘤效果通过禁止在 SY5Y 和 CT26 cells.Conclusion 表明小径和 IL-1 层次的 PI3K-AKT 被调停:由使用一个 TCM 网络药理学方法, nuciferine 在 vitro 并且在 vivo 对人的 neuroblastoma 和老鼠 colorectal 癌症作为一个反肿瘤代理人被识别,通过禁止表明小径和 IL-1 层次的 PI3K-AKT。 | Quan QI Rui LI Hui-ying LI Yu-bing CAO Ming BAI Xiao-jing FAN Shu-yan WANG Bo ZHANG Shao LI | 2016 | Acta Pharmacologica Sinica2016，37，7： | 23 |
| 4 | A small natural molecule promotes mitochondrial fusion through inhibition of the deubiquitinase USP30显示文摘Mitochondrial 熔化是为正常 mitochondrial 功能和 mitochondrial DNA 继承混合并且统一 mitochondrial 分隔空间的一个高度协调的过程。Dysregulated mitochondrial 熔化原因 mitochondrial 破碎,反常 mitochondrial 生理学和继承,并且有原因地与很多 neuronal 疾病被连接了。这里,我们识别了 potently 导致了 mitochondrial 熔化在在 Mfn1 或 Mfn2 是缺乏的房间恢复 mitochondrial 网络和氧化呼吸的 diterpenoid 衍生物 15-oxospiramilactone (S3 ) 。线粒体局部性的 deubiquitinase USP30 是 S3 的一个目标。由 S3 的 USP30 的抑制导致 Mfn1/2 的 non-degradative ubiquitination 的增加,它提高 Mfn1 和 Mfn2 活动并且支持 mitochondrial 熔化。通过 USP30 的一个禁止者的使用,因此,我们的学习揭开在支持 mitochondrial 的 Mfns 的 non-degradative ubiquitination 的异乎寻常的功能熔化。 | Wen Yue Ziheng Chen HaiYang Li Chen Yan Ming Chen Du Feng Chaojun Yan Hao Wu Lei Du Yueying Wang Jinhua Liu Xiaohu Huang Laixin Xia Lei Liu Xiaohui Wang Haijing Jin Jun Wang Zhiyin Song Xiaojiang Hao Quan Chen | 2014 | Cell Research2014，24，4： | 18 |
| 5 | Sequencing of PCR amplified HBV DNA pre-c and c regions in 2.2.15 cells and antiviral action by targeted antisense oligonucleotide directed against sequence显示文摘INTRODUCTIONManystudieshaveshownthatantisenseoligonucleotides(ASONs)canefficientlyinhibitHBVDNAreplicationandexpresioninvitro... | ZHOUG Sen 1, WEN Shou Ming 2, ZHANG Ding Feng 3, WANG Quan Li 4, WANG Seng Qi 4 and REN Hong 3 | 1998 | World Journal of Gastroenterology1998，4，5： | 16 |
| 6 | Effects of endotoxin on expression of ras, p53 and bcl-2 oncoprotein in hepatocarcinogenesis induced by thioacetamide in rats显示文摘Efectsofendotoxinonexpressionofras,p53andbcl2oncoproteininhepatocarcinogenesisinducedbythioacetamideinratsYANGJinMing1,HAN... | YANG Jin Ming 1, HAN De Wu 1, LIANG Quan Chen 2, ZHAO Jia Li 2, HAO Su Yuan 1, MA Xue Hui 1 and ZHAO Yuan Chang 1 | 1997 | World Journal of Gastroenterology1997，3，4： | 11 |
| 7 | Origin of the unusually high dibenzothiophene concentrations in Lower Ordovician oils from the Tazhong Uplift,Tarim Basin,China显示文摘The origin of the unusually high dibenzothiophene (DBT) concentrations in Lower Ordovician oils from the Tazhong Uplift,Tarim Basin was studied by Fourier transform ion cyclotron resonance mass spectrometry (FT-ICR MS).The most abundant sulfur compounds in the oils are S 1 species with doublebond equivalent (DBE) values of 1-19 and 11-48 carbon atoms.The range of the number of carbon atoms in the sulfur compounds detected by the FT-ICR MS (S 1 species with DBE=9) is about ten times larger than that for sulfur compounds detected by GC/MS (DBTs).This suggests that FT-ICR MS is a much better approach than GC/MS for characterization of DBTs in crude oils.The abundance of S 1 species with DBE=1-8 decreased with increasing thermal maturity,while the abundance of S 1 species with DBE=9 (primarily DBTs) increased.Therefore,thermal maturity is an important factor in the formation of oils with high DBT concentrations.Unusually high abundances of S 1 species with low DBE values (1-8),which include sulfide,thiophene and benzothiophene,were observed in several oils,especially the TZ83 (O 1) oil with high or very high thermal maturity.Thermochemical sulfate reduction (TSR) was thought to be the reason for the high abundance of these low DBE compounds in deep reservoirs,and thermochemical sulfate reduction could affect the distribution and composition of DBTs in the oils.According to the results of FT-ICR MS analysis,there are no signs that TSR is occurring or has occurred recently for most of the Lower Ordovician oils. | Li Sumei Pang Xiongqi Shi Quan Zhang Baoshou Zhang Haizu Pan Na Zhao Ming | 2011 | Petroleum Science2011，8，4： | 9 |
| 8 | Cellular and molecular mechanisms underlying the action of ginsenoside Rg1 against Alzheimer’s disease显示文摘Ginsenoside Rg1 inhibits oxidation, aging and cell apoptosis, and improves cognitive function. In this study, we pretreated rat brain tissue sections with ginsenoside Rg1, and established brain slice models of Alzheimer's disease induced by okadaic acid. The results revealed that ginsenoside Rg1 pretreatment suppressed the increase in phosphorylated Tau protein expression induced by incubation with okadaic acid, and reduced brain-derived neurotrophic factor expression. These results suggest that ginsenoside Rg1 upregulates brain-derived neurotrophic factor expression and inhibits Tau protein phosphorylation in brain slices from a rat model of Alzheimer's disease. | Xi Li Ming Li Yuan Li Qiankun Quan Juan Wang | 2012 | Neural Regeneration Research2012，7，36： | 9 |
| 9 | Evaluation of Vaporized Hydrogen Peroxide Fumigation as a Method for the Bio-decontamination of the High Efficiency Particulate Air Filter Unit显示文摘Objective To evaluate the performance of vaporized hydrogen peroxide (VHP) for the bio-decontamination of the high efficiency particulate air (HEPA) filter unit. Methods Self-made or commercially available bioindicators were placed at designated locations in the HEPA filter unit under VHP fumigation. The spores on coupons were then extracted by 0.5 h submergence in eluent followed by 200-time violent knocks. Results Due to the presence of HEPA filter in the box, spore recovery from coupons placed at the bottom of the filter downstream was significantly higher than that from coupons placed at the other locations. The gap of decontamination efficiency between the top and the bottom of the filter downstream became narrower with the exposure time extended. The decontamination efficiency of the bottom of the filter downstream only improved gently with the injection rate of H2O2 increased and the decontamination efficiency decreased instead when the injection rate exceeded 2.5 g/min. The commercially available bioindicators were competent to indicate the disinfection efficiency of VHP for the HEPA filter unit. Conclusion The HEPA filter unit is more difficult than common enclosure to decontaminate using VHP fumigation. Complete decontamination can be achieved by extending fumigation time. VHP fumigation can be applied for in-situ biodecontamination of the HEPA filter unit as an alternative method to formaldehyde fumigation. | JIA Hai Quan LI Yan Ju SUN Bei ZHAO Si Qing YI Ying ZHAO Ming ZHANG Zong Xing PAN Xin QI Jian Cheng | 2013 | Biomedical and Environmental Sciences2013，26，2： | 8 |
| 10 | Synthesis and application of a hydrophobic hypercrosslinked polymeric resin for removing VOCs from humid gas stream显示文摘恐水病的亢奋的 crosslinked 聚合树脂 LC-1 被准备并且描绘。LC-1 树脂的性质与商业亢奋的 crosslinked 聚合物 NDA-201 树脂的那些相比。另外, trichloroethylene (TCE ) 的动态吸附被调查到在在 303 K 的干燥、潮湿的条件下面的 LC-1 上, LC-1 拥有的结果表演高恐水病的性质和罐头把 TCE 从气体移开没有高湿度的效果,高效地流。 | Peng Liu Chao Long Hong Ming Qian Ying Li Ai Min Li Quan Xing Zhang | 2009 | Chinese Chemical Letters2009，20，4： | 7 |
| 11 | A Novel Ursane Triterpene from Rubus swinhoei显示文摘A novel ursane triterpene, named swinhoeic acid, was isolated from the roots of Rubus swinhoei. Its structure was elucidated as 18, 19-seco, 2(, 3(- dihydroxy- 19 -oxo- urs- 11, 13(18)- dien- 28- oic acid by means of MS, 1DNMR and 2DNMR. | Wei Quan ZHAO1, Li Sheng DING1, Qiang ZHANG2 and Ming Kui WANG1* 1 Chengdu Institute of Biology, Chinese Academy of Sciences, Chengdu 610041 2 West China University of Medical Sciences, Chengdu 610041 | 2001 | Chinese Chemical Letters2001，12，3： | 7 |
| 12 | Preparation of natural isovaleraldehyde by the Maillard reaction显示文摘Isovaleraldehyde possesses malty,fruity,cocoa-like odor and is widely used in fruit,chocolate,coffee flavors.The preparation of natural isovaleraldehyde by the Maillard model reaction was studied in this paper.The effects of the ratio of D-glucose/L-leucine, reaction temperature and pH value on the yield of isovaleraldehyde were explored.The optimum conditions were as follows: n(D-glucose):n(L-leucine)=4,temperature 150℃,reaction time 3 h,pH 5.The highest yield of isovaleraldehyde obtained was about 32%. | Hong Yu Tian Jie Zhang Bao Guo Sun Ming Quan Huang Jian Rong Li Xiao Xiang Han | 2007 | Chinese Chemical Letters2007，18，9： | 5 |
| 13 | Micronuclei and cell survival in human liver cancer cells irradiated by 25MeV/u^(40)Ar^(14+)显示文摘INTRODUCTIONHeavyionswithhighlinearenergytransfer(LET)havethefolowingadvantagesascomparedwiththeconventionalXraysandγraysth... | LI Wen Jian 1, GAO Qing Xiang 2, ZHOU Guang Ming 1 and WEI Zeng Quan 1 | 1999 | World Journal of Gastroenterology1999，5，4： | 5 |
| 14 | Comparison of the personality and other psychological factors of students with internet addiction who do and do not have associated social dysfunction显示文摘 | Qiang CHEN Xing QUAN Huimin LU Pei FEI Ming LI | 2015 | 上海精神医学2015，27，1： | 4 |
| 15 | Transient liquid phase diffusion bonding of copper alloy to stainless steel using CuMn alloys as interlayer显示文摘With CuMn alloy as interlayer, the transient liquid phase (TLP) diffusion bonding of Cu alloys (CuAlBe) to stainless steel (1Cr18Ni9Ti) was studied. The results show that the bonding pressure, time and temperature and the content of Mn in CuMn alloy have great effects on the strength of bonding interface; when they are 1 MPa, 40 min, 1 223 K and 30% respectively, the maximum joint strength of 487 MPa is attained. The fracture occurring at the bonding interface is a plastic one and the effect of Mn has been analyzed. | YU Zhi shui(于治水) WANG Feng jiang(王凤江) LI Xiao quan(李晓泉) WANG Yu(王宇) WU Ming fang(吴铭方) | 2000 | 中国有色金属学会会刊:英文版2000，10，3： | 4 |
| 16 | Extension Protocol for the Investigation on Nutrition Status and Clinical Outcome of Patients with Common Cancers in China(INSCOC)Study:2021 update显示文摘Background Malnutrition is common in patients with cancer,and this adversely affects the survival and quality of life of patients.Chinese Society for Nutritional Oncology issued a multi-center,large-scale,long-term follow-up prospective study,the Investigation on Nutrition Status and Clinical Outcome of Patients with Common Cancers in China(INSCOC study)since 2013.This is an extension to the previous 2013-2020 study protocol.This study still sought to:①address the prognostic impact of nutritional factors and quality of life on cancer patient survival;②describe the overall and cancer-specific incidence and/or distribution of malnutrition and different measurements of patient quality of life.Methods and study design This is an observational,multi-centered,hospital-based prospective cohort study.Data collection will be performed at baseline(within 48 hours after patient admission),during the hospital stay and 30 days after hospital admission.Follow-up will be conducted for 1-20 years after enrollment.The primary outcome will be the all-cause mortality/overall survival,and secondary outcomes will be the length of hospital stay and costs of hospitalization.Study factors will include demographic characteristics,tumor characteristics,information about chronic diseases,hematological measurements(e.g.,red blood cell count,total lymphocyte counts,hemoglobin,albumin,prealbumin,creatinine,C-reactive protein,IL-6),anthropometric measurements(e.g.,height,weight,arm circumference,arm muscle circumference,triceps skinfold thickness,and waist circumference),body composition parameters,PG-SGA scores,quality of life(as indicated by the QLQ-C30 questionnaire),muscle mass(as indicated by the calf circumference),muscle strength(as indicated by the handgrip strength),muscle function(as indicated by the six-meter walking speed test)and physical status assessments(as indicated by the Karnofsky Performance Status scores).This clinical study protocol was approved by local Ethics Committees of all the participating hospitals.Written informed consent is required for each subject included.Discussion This multi-center,large-scale,long-term follow up prospective study will help improve the diagnosis of malnutrition in cancer patients and identify the risk factors associated with adverse clinical outcomes.The anticipated results of this study will highlight the need for a truly scientific appraisal of nutrition therapy in Chinese oncology populations,and finally help treat the potentially reversible elements of malnutrition in cancer patients to improve their clinical outcomes in the future. | Hong Xia Xu Chun Hua Song Liang Yu Yin Chang Wang Zhen Ming Fu Zeng Qing Guo Yuan Lin Ying Ying Shi Wen Hu Yi Ba Su Yi Li Zeng Ning Li Kun Hua Wang Jing Wu Ying He Jia Jun Yang Cong Hua Xie Fu Xiang Zhou Xin Xia Song Gong Yan Chen Wen Jun Ma Su Xia Luo Zi Hua Chen Zhi Kang Chen Ming Hua Cong Hu Ma Chun Ling Zhou Wei Wang Qi Luo Yong Mei Shi Yu Mei Qi Hai Ping Jiang Wen Xian Guan Jun Qiang Chen Xiang Hua Wu Jia Xin Chen Yu Fang Lan Zhou Yong Dong Feng Rong Shao Tan Tao Li Jun Wen Ou Qing Chuan Zhao Jian Xiong Wu Min Weng Qing Hua Yao Ya Yin Yu Quan Jun Lyu Hong Qiu Ming Liu Wei Li Han Ping Shi The Investigation on Nutrition Status and Clinical Outcome of Common Cancers(INSCOC)Group | 2022 | Journal of Nutritional Oncology2022，7，2： | 3 |
| 17 | Integrating morphological spatial pattern analysis and the minimal cumulative resistance model to optimize urban ecological networks: a case study in Shenzhen City, China显示文摘Background:With the increasing fragmentation of landscape induced by rapid urbanization,the construction of ecological networks is of great signifcance to alleviate the degradation of urban habitats and protect natural envi‑ronments.However,there is considerable uncertainty when constructing ecological networks,especially the difer‑ent approaches to selecting ecological sources.We used the southern Chinese city of Shenzhen as a study area to construct and optimize ecological networks using a coupling approach.Ecological source areas were extracted using morphological spatial pattern analysis(MSPA)and the landscape index method.Ecological networks were con‑structed using the minimal cumulative resistance(MCR)model and the gravity model.Stepping stones and ecological fault points were added in corridors to optimize the ecological network.Results:Ten core areas with maximum importance patch values were extracted by the landscape index method as ecological source areas according to MSPA,after which corridors between ecological sources were constructed based on the MCR model.The constructed ecological networks were optimized using 35 stepping stones and 17 ecologi‑cal fault points.The optimized ecological networks included 11 important corridors,34 general corridors,and seven potential corridors.The results of corridor landscape-type analysis showed that a suitable ecological corridor is 60 to 200 m wide.Conclusions:Overall,our results imply that ecological source areas can be identifed virtually,and that ecological networks can be signifcantly optimized by combining MSPA and MCR models.These results provide a methodologi‑cal reference for constructing ecological networks,and they will be useful for urban planning and biodiversity protec‑tion in Shenzhen and other similar regions around the world. | Yang‑Yang Li Yu‑Zhe Zhang Zhi‑Yun Jiang Cheng‑Xuan Guo Ming‑Yue Zhao Zhi‑Guang Yang Ming‑Yan Guo Bing‑Yue Wu Quan‑Ling Chen | 2021 | Ecological Processes2021，10，1： | 3 |
| 18 | Gender associates with both susceptibility to infection and pathogenesis of SARS-CoV-2 in Syrian hamster显示文摘Epidemiological studies of the COVID-19 patients have suggested the male bias in outcomes of lung illness.To experimentally demonstrate the epidemiological results,we performed animal studies to infect male and female Syrian hamsters with SARS-CoV-2.Remarkably,high viral titer in nasal washings was detectable in male hamsters who presented symptoms of weight loss,weakness,piloerection,hunched back and abdominal respiration,as well as severe pneumonia,pulmonary edema,consolidation,and fibrosis.In contrast with the males,the female hamsters showed much lower shedding viral titers,moderate symptoms,and relatively mild lung pathogenesis.The obvious differences in the susceptibility to SARS-CoV-2 and severity of lung pathogenesis between male and female hamsters provided experimental evidence that SARS-CoV-2 infection and the severity of COVID-19 are associated with gender. | Lunzhi Yuan Huachen Zhu Ming Zhou Jian Ma Rirong Chen Yao Chen Liqiang Chen Kun Wu Minping Cai Junping Hong Lifeng Li Che Liu Huan Yu Yali Zhang Jia Wang Tianying Zhang Shengxiang Ge Jun Zhang Quan Yuan Yixin Chen Qiyi Tang Honglin Chen Tong Cheng Yi Guan Ningshao Xia | 2021 | Signal Transduction and Targeted Therapy2021，6，4： | 3 |
| 19 | Effect of Chronic Noise Exposure on Expression of N-Methyl-D-Aspartic Acid Receptor 2B and Tau Phosphorylation in Hippocampus of Rats显示文摘Objective To study the effect of chronic noise exposure on expression of N-methyl-D-aspartic acid receptor 2B (NR2B) and tau phosphorylation in hippocampus of rats. Methods Twenty-four male SD rats were divided in control group and chronic noise exposure group. NR2B expression and tau phosphorylation in hippocampus of rats were detected after chronic noise exposure (100 dB SPL white noise, 4 h/d×30d) and their mechanisms underlying neuronal apoptosis in hippocampus of rats with TUNEL staining. Results The NR2B expression decreased significantly after chronic noise exposure which resulted in tau hyperphosphorylation and neural apoptosis in hippocampus of rats. Immunohistochemistry showed that the tau hyperphosphorylation was most prominent in dentate gyrus (DG) and CA1 region of rat hippocampus. Conclusion The abnormality of neurotransmitter system, especially Glu and NR2B containing NMDA receptor, and tau hyperphosphorylation in hippocampus of rats, may play a role in chronic noise-induced neural apoptosis and cognition impairment. | CUI Bo WU Ming Quan ZHU Li Xing SHE Xiao Jun MA Qiang LIU Hong Tao | 2013 | Biomedical and Environmental Sciences2013，26，3： | 3 |
| 20 | Drag reduction of turbulent channel flows over an anisotropic porous wall with reduced spanwise permeability显示文摘The direct numerical simulation (DNS) is carried out for the incompressible viscous turbulent flows over an anisotropic porous wall. Effects of the anisotropic porous wall on turbulence modifications as well as on the turbulent drag reduction are investigated. The simulation is carried out at a friction Reynolds number of 180, which is based on the averaged friction velocity at the interface between the porous medium and the clear fluid domain. The depth of the porous layer ranges from 0.9 to 54 viscous units. The permeability in the spanwise direction is set to be lower than the other directions in the present simulation. The maximum drag reduction obtained is about 15.3% which occurs for a depth of 9 viscous units. The increasing of drag is addressed when the depth of the porous layer is more than 25 wall units. The thinner porous layer restricts the spanwise extension of the streamwise vortices which suppresses the bursting events near the wall. However, for the thicker porous layer, the wall-normal fluctuations are enhanced due to the weakening of the wall-blocking effect which can trigger strong turbulent structures near the wall. | Qingxiang LI Ming PAN Quan ZHOU Yuhong DONG | 2019 | Applied Mathematics and Mechanics(English Edition)2019，40，7： | 3 |
您所在的机构暂未开通此部分的功能，请联系管理员