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| 1 | Long-term survival after intraluminal brachytherapy for inoperable hilar cholangiocarcinoma: A case report显示文摘Surgical resection with a tumor-free margin is the onlycurative treatment for hilar cholangiocarcinoma (Klatskin tumor). However, over half of the patients present late with unresectable tumors. Radiotherapy using external beamirradiation or intraluminal brachytherapy (ILBT) has been used to treat unresectable hilar cholangiocarcinoma with satisfactory outcome. We reported a patient with unresectable hilar cholangiocarcinoma surviving more than 6 years after combined external beam irradiation and ILBT. | Siu-Yin Chan Ronnie T. Poon Kelvin K. Ng Chi-Leung Liu Raymond T. Chan Sheung-Tat Fan | 2005 | World Journal of Gastroenterology2005，11，20： | 7 |
| 2 | Primal-dual algorithms for total variation based image restoration under Poisson noise Dedicated to Professor Lin Qun on the Occasion of his 80th Birthday显示文摘We consider the problem of restoring images corrupted by Poisson noise. Under the framework of maximum a posteriori estimator, the problem can be converted into a minimization problem where the objective function is composed of a Kullback-Leibler(KL)-divergence term for the Poisson noise and a total variation(TV) regularization term. Due to the logarithm function in the KL-divergence term, the non-differentiability of TV term and the positivity constraint on the images, it is not easy to design stable and efficiency algorithm for the problem. Recently, many researchers proposed to solve the problem by alternating direction method of multipliers(ADMM). Since the approach introduces some auxiliary variables and requires the solution of some linear systems, the iterative procedure can be complicated. Here we formulate the problem as two new constrained minimax problems and solve them by Chambolle-Pock's first order primal-dual approach. The convergence of our approach is guaranteed by their theory. Comparing with ADMM approaches, our approach requires about half of the auxiliary variables and is matrix-inversion free. Numerical results show that our proposed algorithms are efficient and outperform the ADMM approach. | WEN YouWei CHAN Raymond Honfu ZENG TieYong | 2016 | Science China Mathematics2016，59，1： | 5 |
| 3 | 精神分裂症患者的情感体验和表达(英文)显示文摘背景:精神分裂症存在情感体验和表达障碍。然而,大多数以往研究往往只局限于情感体验(尤其是快感缺乏)或只针对表达。较少有同时研究精神分裂症患者情感体验和表达。目的 :本研究旨在考察精神分裂症患者的快感体验和情感表达。尤其是,特别关注精神分裂症患者的情感障碍(包括快感体验和表达)和阴性症状之间的关系。方法 :150例患者完成了愉快情绪体验量表(Temporal Experience of Pleasure Scale)和情感表达量表(Emotional Expressivity Scale)的评估。结果 :精神分裂症患者表现出快感缺乏,但情感表达的能力完整。以阴性症状为主的精神分裂症患者在期待性愉快体验,尤其是抽象性期待愉快体验上的缺损更为明显结论:研究结果表明,精神分裂症患者存在出快感缺乏,但他们表达情感的能力似乎完好无损。快感缺乏尤以阴性症状为主的精神分裂症患者更为突出。 | Min-yi CHU Xu LI Qin-yu LV Zheng-hui YI Eric F. C. CHEUNG Raymond C. K. CHAN | 2017 | 上海精神医学2017，29，5： | 3 |
| 4 | Consortium for the Human Information and Neurocognitive Endophenotype (CHINE) in China's Mainland: An example from neurological soft signs for neuropsychiatric disorders显示文摘Increasing efforts to identify alternate expressions of neuropsychiatric disorders that are broader than the DSM or ICD diagnostic criteria needed to diagnose them reflects a growing consensus that multidimensional expressions of neuropsychiatric disorders may advance the search for underlying etiological or modulatory factors. Endophenotypic research can be considered to be one of the most promising strategies to bridge the gap between genomic complexity and the phenotypic heterogeneity observed in neuropsychiatric disorders. However, the majority of endophenotype studies were limited to our western counterparts, very little has been done and initiated by scholars in China's Mainland. In this paper, we urge the need to establish a potential central consortium for endophenotypes to study neuropsychiatric disorders in China's Mainland. In particular, we illustrate a potential example of neurological soft signs in following the steps for building the consortium. | CHAN Raymond C K | 2011 | Chinese Science Bulletin2011，56，32： | 3 |
| 5 | Preface显示文摘为“计算数学的杂志”的 2007 年 9 月期的一篇前言被介绍。 | Chan, Raymond Wai-ki Ching Ng, Michael | 2007 | Journal of Computational Mathematics2007，25，5： | 3 |
| 6 | Viral-Human Chimeric Transcript Predisposes Risk to Liver Cancer Development and Progression显示文摘 | Chi-Chiu Lau Tingting Sun Arthur K.K. Ching Mian He Jing-Woei Li Alissa M. Wong Ngai Na Co Anthony W.H. Chan Pik-Shan Li Raymond W.M. Lung Joanna H.M. Tong Paul B.S. Lai Henry L.Y. Chan Ka-Fai To Ting-Fung Chan Nathalie Wong | 2014 | Cancer Cell2014，，3： | 2 |
| 7 | A family study of endophenotypes for psychosis within an early intervention programme in Hong Kong: Rationale and preliminary findings显示文摘The study of endophenotypes may be a viable strategy to tackle the genetic complexity and phenotypic heterogeneity of psychosis, but this research direction is relatively under-developed in China as compared to Western countries. We have recently initiated one of the first family studies of endophenotypes for psychosis in China. Patients entering an established early psychosis intervention service are recruited into this research project for phenotyping, endophenotyping and genotyping. At the endophenotypic level, four domains (neurological soft signs, neurocognition of prospective memory, social cognition of facial emotion recognition, and affective cognition of anticipatory and consummatory pleasure) are studied in the sample of patients with psychosis and their unaffected siblings. This article illustrates the benefit of a research-oriented clinical programme and its findings based on the data collected as of early 2011. | LUI Simon S Y SHAM Pak CHAN Raymond C K CHEUNG Eric F C | 2011 | Chinese Science Bulletin2011，56，32： | 2 |
| 8 | Lack of evidence of active lytic replication of Epstein-Barr and cytomegaloviruses in patients with systemic lupus erythematosus显示文摘LackofevidenceofactivelyticreplicationofEpsteinBarrandcytomegalovirusesinpatientswithsystemiclupuserythematosusLauChakSing,... | Lau Chak Sing, Yuen Yung, Chan Hung and Wong Raymond Woon Sing | 1998 | Chinese Medical Journal1998，，7： | 2 |
| 9 | Is there an anatomical endophenotype for neurodevelopmental disorders? A review of dual disorder anatomical likelihood estimation (ALE) meta-analyses of grey matter volumes显示文摘The term 'neurodevelopmental disorder' broadly encompasses conditions thought to arise early in development and includes schizophrenia, bipolar disorder and autism among others. These conditions share a number of genetic and environmental risk factors postulated to lead to common difficulties in socio-emotional processing, communication and cognitive function. The alternative position is that, while the same traits are affected across these conditions, the nature or direction in which they are modified may be distinct. MRI studies provide a rapidly expanding and rich database which we propose can be used to contribute to this debate. Anatomical likelihood estimation (ALE) is a method of meta-analysis applied to voxel-based MRI studies. We have adapted this method to explore the extent to which schizophrenia and bipolar disorder and schizophrenia and autism share a common brain structural phenotype. We will review this work here and discuss whether there is sufficient other evidence to justify a common framework for further research into the inter-relatedness of such conditions. | MCALONAN Grainne M YU Kevin K CHAN Raymond C K CHUA Siew E CHEUNG Charlton | 2011 | Chinese Science Bulletin2011，56，32： | 2 |
| 10 | Characterization of the Peri-Infarct Zone by Contrast-Enhanced Cardiac Magnetic Resonance Imaging Is a Powerful Predictor of Post–Myocardial Infarction Mortality显示文摘 | Andrew T. Yan Adolphe J. Shayne Kenneth A. Brown Sandeep N. Gupta Carmen W. Chan Tuan M. Luu Marcelo F. Di Carli H Glenn Reynolds William G. Stevenson Raymond Y. Kwong | 2006 | Circulation2006，，1： | 1 |
| 11 | Sine transform based preconditioners for symmetric Toeplitz matrices显示文摘 | Raymond H Chan | 1996 | Linear Algebra Appl1996，232，： | 1 |
| 12 | Modulation of microglia by Wolfberry on the survival of retinal ganglion cells in a rat ocular hypertension model显示文摘 | Kin Chiu Hiu-Chi Chan Sze-Chun Yeung Wai-Hung Yuen Sze-Yong Zee Raymond Chuen-Chung Chang Kwok-Fai So | 2009 | Journal of Ocular Biology Diseases and Informatics2009，，3： | 1 |
| 13 | Localization of cerebral functional deficits in treatment-naive, first-episode schizophrenia using resting-state fMRI显示文摘 | Xiao-Qi Huang Su Lui Wei Deng Raymond C.K. Chan Qi-Zhu Wu Li-Jun Jiang Jun-Ran Zhang Zhi-Yun Jia Xiu-Li Li Fei Li Long Chen Tao Li Qi-Yong Gong | 2009 | Neuroimage2009，，： | 1 |
| 14 | Salt and pepper noise removal by median-type noise detectors and detailpreserving regularization 显示文摘 | Raymond H Chan Chung-Wa Ho Mila Nikolova | 2005 | IEEE Trans2005，14，10： | 1 |
| 15 | A Brokering Protocol for Agent-based E-Commerce 显示文摘 | Kwang Mong Sim Raymond Chan | 2000 | IEEE SMC-part C (S1094-6977)2000，30，4： | 1 |
| 16 | Greenhouse Gas Emissions from Two Soils Receiving Nitrogen Fertilizer and Swine Manure Slurry显示文摘 | Jarecki Marek K Parkin Timothy B Chan Alvarus S K Hatfield Jerry L Jones Raymond | 2008 | Journal of Environmental Quality2008，，4： | 1 |
| 17 | Salt-and-pepper noise removal by median-type noise de- tectors and detail preserving regularization 显示文摘 | Raymond H Chan Chung- Wa Ho and MIlaNikolova | 2005 | IEEE Transactions on image processing2005，14，10： | 1 |
| 18 | A prospective, phase 1/2 study of everolimus and temozolomide in patients with advanced pancreatic neuroendocrine tumor显示文摘 | Jennifer A. Chan Lawrence Blaszkowsky Keith Stuart Andrew X. Zhu Jill Allen Raymond Wadlow David P. Ryan Jeffrey Meyerhardt Marielle Gonzalez Eileen Regan Hui Zheng Matthew H. Kulke | 2013 | Cancer2013，，17： | 1 |
| 19 | Sine transform based preconditioners for symmetric Toeplitz matrices显示文摘 | Raymond H Chan | 1996 | Linear Algebra and Its Application1996，232，： | 1 |
| 20 | Is uric acid protective or deleterious in acute ischemic stroke? A prospective cohort study显示文摘 | Raymond C.S. Seet Katherine Kasiman Jan Gruber Soon-Yew Tang Meng-Cheong Wong Hui-Meng Chang Yiong-Huak Chan Barry Halliwell Christopher P. Chen | 2009 | Atherosclerosis2009，，1： | 1 |
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