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| 1 | Global correlation for strontium isotope curve in the Late Cretaceous of Tibet and dating marine sediments显示文摘87Sr/86Sr ratios of marine carbonate samples collected from a sedimentary section of the Late Cretaceous in the south of Tibet were measured. Based on the absence of cathodoluminescence and a very low Mn/Sr ratio (average 0.06) of the samples, it is thought that they contain information on the original seawater strontium isotope composition. The strontium isotope evolution curve of the Late Cretaceous in Tibet we established here, is consistent with other coeval curves from Europe, North America and Antarctica, supports the notion that the strontium isotope composition of seawater is governed by global events, which provides a new approach for the inter-continental and inter-basinal correlations of Late Cretaceous in the area and is a complementarity for biostratigraphy. In addition, we attempt to determine the age of the boundaries for Campanian/Santonian and Maastrichtian/Campanian by 87Sr/86Sr ratios for Gamba section in southern Tibet. The two boundaries are located in the thickness of 217 m (83.5 Ma) and 291 m (71.3 Ma), respectively. | HUANG Sijing SHI He SHEN Licheng ZHANG Meng WU Wenhui | 2005 | Science China Earth Sciences2005，48，2： | 11 |
| 2 | High-Resolution Genome-wide Association Study Identifies Genomic Regions and Candidate Genes for Important Agronomic Traits in Wheat显示文摘Wheat(Triticum aestivum)is a major staple food crop worldwide.Genetic dissection of important agronomic traits is essential for continuous improvement of wheat yield to meet the demand of the world's growing population.We conducted a large-scale genome-wide association study(GWAS)using a panel of 768 wheat cultivars that were genotyped with 327609 single-nucleotide polymorphisms generated by genotyping-by-sequencing and detected 395 quantitative trait loci(QTLs)for 12 traits under 7 environments.Among them,273 QTLs were delimited to≤1.0-Mb intervals and 7 of them are either known genes(Rht-D,Vrn-B1,and Vrn-D1)that have been cloned or known QTLs(TaGA2ox8,APO1,TaSus1-7B,and Rht12)that were previously mapped.Eight putative candidate genes were identified for three QTLs that enhance spike seed setting and grain size using gene expression data and were validated in three bi-parental populations.Protein sequence analysis identified 33 putative wheat orthologs that have high identity with rice genes in QTLs affecting similar traits.Large r^2 values for additive effects observed among the QTLs for most traits indicated that the phenotypes of these identified QTLs were highly predictable.Results from this study demonstrated that significantly increasing GWAS population size and marker density greatly improves detection and identification of candidate genes underlying a QTL,solidifying the foundation for large-scale QTL fine mapping,candidate gene validation,and developing functional markers for genomics-based breeding in wheat. | Yunlong Pang Chunxia Liu Danfeng Wang Paul St.Amand Amy Bernardo Wenhui Li Fang He Linzhi Li Liming Wang Xiufang Yuan Lei Dong Yu Su Huirui Zhang Meng Zhao Yunlong Liangi Hongze Jia Xitong Shen Yue Lu Hongming Jiang Yuye Wu Anfei Li Honggang Wang Lingrang Kong Guihua Bai Shubing Liu | 2020 | Molecular Plant2020，13，9： | 8 |
| 3 | Defects as a factor limiting carrier mobility in WSe2: A spectroscopic investigation显示文摘二维的转变金属 dichalcogenides (TMD ) 的电的表演被结构的缺点的数字强烈影响。在这个工作,我们提供一条光分光镜的描述途径相关结构的缺点的数字和 WSe 2 设备的电的表演。electron-beam-lithographyprocessed WSe 2 的低温度的光致发光(PL ) 系列由于缺点一定的激子展出清楚的导致缺点的 PL 排出物,它将强烈降级电的表演。由采用一种 electron-beam-free 转移电极技术,我们成功地准备了包含缺点的有限数量的一台 backgated WSe 2 设备。约 200 厘米 2 | Zhangting Wu Zhongzhong Luo Yuting Shen Weiwei Zhao Wenhui Wang Haiyan Nan Xitao Guo Litao Sun Xinran Wang Yumeng You Zhenhua Ni | 2016 | Nano Research2016，9，12： | 8 |
| 4 | Isotopic composition charac-teristics and identification of immature and low-mature oils显示文摘Isotopic composition characteristics and the significance of immature and low-mature oils are first systematically discussed. The carbon isotopes of the whole oil can be divided into two groups, one has δ13C main peak values ranging from -30‰ to -29 and the other from -27‰ to -25‰, they are related to lacustrine and salt-lake facies or swamp facies, respectively. The carbon isotopic fractionation among different group components is relatively small, usually less than 2‰ and the biggest difference in fractionation often occurs between saturated and aromatic fractions. Their δD values vary between -180‰ and -130‰. The main peak of their δD values concentrates between -170‰ and -150‰, suggesting a domination of lacustrine facies. However, the secondary peak ranges from -160‰ to -150‰, showing a frequent salinization of paleo-water bodies. The average δ13C values of the methane vary between -50‰ and -52‰, about 10‰ lighter than those of mature oils. There is a relatively good | XU Yongchang SHEN Ping LIU Wenhui GUAN Ping HUANG Difan | 2001 | Chinese Science Bulletin2001，46，22： | 6 |
| 5 | Optical super-resolution microscopy and its applications in nano-catalysis显示文摘常规光显微镜学的分辨率仅仅是 200 nm,它为许多应用程序正在变得越来越不足够。为了超过衍射,限制了分辨率,超级决定的显微镜学(SRM ) 被开发了完成一~十纳米的高分辨率。涉及 SRM 的技术能被分配进二个宽广范畴,也就是真的超级决定的技术和功能的超级决定的技术。在功能的超级决定的技术,随机的超级决定的显微镜学(SSRM ) 广泛地由于它的低开销,简单操作,和高分辨率被使用。在 SSRM 的原则进程是积累许多衍射有限 emitters 的坐标(例如,单个荧光灯分子) 在由本地化点的矩心的对象上散布函数(PSF ) ,然后重建用这些的对象的图象协调。什么时候衍射有限 emitters 由 nanoparticles 参加关于催化作用的催化反应,活动分发和运动信息能被 SSRM 获得。SSRM 被使用了并且在催化作用的几块地里展出了突出的优点,例如金属 nanoparticle 催化作用,分子的筛催化作用,和光催化。因为 SSRM 能在一 nanoparticle 以内解决催化活动,它答应加速新、更好的催化剂的发展和发现。这评论将在 nano 催化作用介绍简短介绍给 SRM,和对 SSRM 和它的应用的详细描述。 | Wenhui Wang Junnan Gu Ting He Yangbin Shen Shaobo Xi Lei Tian Feifei Li Haoyuan Li Liuming Yan Xiaochun Zhou | 2015 | Nano Research2015，8，2： | 3 |
| 6 | A breakthrough of researching reservoir adsorption gas and its significance显示文摘GC-C-MS on linear isotope analysis equipment makes it possible to measure the hydrocarbon gases at the level of 10 -3-10 -2 μL- By applying this technique the carbon isotopes of C1-C3 of the adsorbed gas from the Triassic oil sand bed of the Aican-l Well in the Turpan-Hami basin were analysed. The δ13C values of C1-C3, are -55.1‰, -38.6‰ and -35.0‰ respectively. In terms of geochemical characteristics of natural gases and crude oils, in combination with basinal geological backgrounds, it is considered that the reservoir adsorbed gas was formed by crude-oil biodegradation, absorbed by reservoir rocks and its oil-gas source is related with the Permain (perhaps including the Carboniferous). The adsorbed gas is obviously different from the Jurassic coal-generated oil and gas. | Yongchang Xu Xiaobao Zhang Ping Shen Wenhui Liu | 1999 | Chinese Science Bulletin1999，44，8： | 3 |
| 7 | Crucial function of histone lysine methylation in plant reproduction显示文摘Unlike animals, plants do not set aside germ cells early in development. In angiosperm species, reproduction occurs in the adult plant upon flowering. The multicellular male and female gametophytes differentiate from meiotic products within reproductive floral organs. Double fertilization is another remarkable feature of most angiosperm species. The zygote derived from fertilization of the egg cell by one of the sperm cells and the endosperm from fertilization of the central cell by the second sperm cell develop in a coordinated manner together and enclosed in the sporophytic maternal integuments, forming the seed. Understanding plant reproduction is biologically pertinent and agronomically and ecologically important. Here, we describe the known functions of histone lysine methylations in various steps of reproduction in the reference plant Arabidopsis thaliana. It is emerging that histone lysine methylation is key for understanding epigenetic regulation networks of genome function. | YAO XiaoZhen SHEN WenHui | 2011 | Chinese Science Bulletin2011，56，33： | 2 |
| 8 | Natural gas geochemistry of low evolutionary stage of mediumand small-sized basins in Yunnan Province, southwestern China显示文摘The biogenic gas and premature-low mature associated gases in some medium and small-sized basins of Yannan Province, such as Luliang, Yanglin, Baoshan and Jinggu basins, have beed researched. The results show that the biogenic-gas consists mainly of methane which is more than 99% in gasous hydrocarbons and of lighter carbon isotopic composition with δ13C1 values from -60.0‰ to - 75.4‰. The methane carbon isotopic compositions in the Baoshan Basin is relatively heavy (δ13C1, - 60‰-- 65‰), but those in Luliang and | Yongchang Xu Ping Shen Jiangjing Zhen Wenhui Liu Ping Guan | 1999 | Chinese Science Bulletin1999，44，18： | 2 |
| 9 | Effect of Zibushenjing Fang on skeletal development and brain tissue antioxidation in mice with kidney essence insufficiency: a mechanistic study显示文摘OBJECTIVE: To investigate the effects of Zibushenjing Fang (formula for tonifying the kidney essence) on skeletal development and brain tissue antioxidation in mice with kidney essence insufficiency. METHODS: Fifty male Kunming mice were randomly divided into five groups: normal group, model group, Jinkuishenqi Wan group, Zibushenjing Fang high dose group, and Zibushenjing Fang low dose group, with 10 mice in each group. The model of kidney essence insufficiency syndrome was established in all the mice except the normal group by using a cat to threaten the mice and by swimming until exhaustion daily which lasted about 21 days. Mice in the model group were administered 20 mL/ kg -1 · d -1 of normal saline intragastrically. The Jinkuishenqi Wan group was given 2.7 g/kg-1 · d-1 ofa solution of Jinkuishenqi Wan. The Zibushenjing Fang high dose group was given 20 g/kg -1 · d -1 and the Zibushenjing Fang low dose group was given 10 g/kg -1 · d -1 of a solution of Zibushenjing Fang.The general condition of all the groups was observed, including the quantity of food and water intake, swimming time, length of femur, and weight of the femur and musculus quadriceps femoris. The total superoxide dismutase (T-SOD), glutathione peroxi- dase (GSH-Px), and methane dicarboxylic aldehyde (MDA) activities in the brain tissues were detected. RESULTS: Zibushenjing Fang could improve the manifestation of kidney essence insufficiency, increase the quantity of food and water intake, swimming time, femur length, and femur and musculus quadriceps femoris weight. It could also regulate the activities of T-SOD, GSH-Px, and MDA in brain tissue. CONCLUSION: Zibushenjing Fang may play an important role in treating kidney essence insufficiency syndrome by promoting body development and improving brain tissue antioxidation. | Yuezhen He Junxiao Yao Shilin Shen Xiaojun Su Yuping Wang Li Li Wenhui Wang Jiping Shi | 2013 | Journal of Traditional Chinese Medicine2013，33，3： | 2 |
| 10 | Geochemistry on mantle-derived volatiles in natural gases from eastern China oil/gas provinces (II)显示文摘 | Yongchang Xu Ping Shen Mingxin Tao Wenhui Liu | 1997 | Science in China Series D: Earth Sciences1997，，3： | 1 |
| 11 | Geochemistry on mantle-derived volatiles in natural gases from eastern China oil/gas provinces (I)显示文摘 | Yongchang Xu Ping Shen Mingxin Tao Wenhui Liu | 1997 | Science in China Series D: Earth Sciences1997，，2： | 1 |
| 12 | Ultra-wide-band antenna design using FDTD and double populationgenetic algorithm 显示文摘 | Zhao Guohua Shen Wenhui Wu Mingliang | 2009 | Microwave and Optical TechnologyLetters2009，51，2： | 1 |
| 13 | Immune escape by SARS-CoV-2 Omicron variant and structural basis of its effective neutralization by a broad neutralizing human antibody VacW-209显示文摘Dear Editor,Coronavirus disease 2019(COVID-19)caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)and its variants is still a pandemic raging across the world(Supplementary information,Fig.S1a,b).A new variant,Omicron,was first detected in South Africa and got dominant in many regions.1 Omicron has been classified as a variant of concern by the World Health Organization(WHO),whose spike carried more than 30 mutations(Supplementary information,Fig.S1c).1,2 To make a comprehensive evaluation of the susceptibility of Omicron,we summarized plasma samples from 19 convalescent individuals infected with the wild-type(WT)virus,and measured their neutralizing activities against the WT,Beta,Delta,Mu,C.1.2,and Omicron(Supplementary information,Figs.S1d and S2).The Omicron showed more serious resistance to neutralizing antibodies(nAbs)than other variants including Beta and Mu(45.6-fold,9.6-fold,and 15.4-fold,respectively,compared with that against the WT)。 | Bin Ju Qingbing Zheng Huimin Guo Qing Fan Tingting Li Shuo Song Hui Sun Senlin Shen Xinrong Zhou Wenhui Xue Lingyan Cui Bing Zhou Shaowei Li Ningshao Xia Zheng Zhang | 2022 | Cell Research2022，32，5： | 1 |
| 14 | Induction of Pluripotency in Mouse Somatic Cells with Lineage Specifiers显示文摘 | Jian Shu Chen Wu Yetao Wu Zhiyuan Li Sida Shao Wenhui Zhao Xing Tang Huan Yang Lijun Shen Xiaohan Zuo Weifeng Yang Yan Shi Xiaochun Chi Hongquan Zhang Ge Gao Youmin Shu Kehu Yuan Weiwu He Chao Tang Yang Zhao Hongkui Deng | 2013 | Cell2013，，5： | 1 |
| 15 | Gut microbisal methionine impacts circadian clock gene expression and reactive oxygen species level in host gastrointestinal tract显示文摘Dear Editor,Circadian rhythms are the periodic turmover of biological behaviors and physiological functions of many organisms(Allada and Bass,2021).In mammals,circadian rhythms are maintained by the clock system,involving central clock in suprachiasmatic nucleus and peripheral clock in organs like intestine;and at cellular level a cell-autonomous transcriptional and translational feedback loop involving clock genes like BMAL1(brain and muscle ARNT-Like 1,also known as ARNTL),CLOCK(clock circadian regulator),PER1/2/3(period circadian regulator 1/2/3)and CRY1/2(cryptochrome circadian regulator 1/2)(Allada and Bass,2021). | Xiaolin Liu Yue Ma Ying Yu Wenhui Zhang ingjing Shi Xuan Zhang Min Dai Yuhan Wang Hao Zhang Jiahe Zhang Jianghua Shen Faming Zhang Moshi Song Jun Wang | 2023 | Protein & Cell2023，14，4： | 1 |
| 16 | Super enhancers targeting ZBTB16 in osteogenesis protect against osteoporosis显示文摘As the major cell precursors in osteogenesis, mesenchymal stem cells(MSCs) are indispensable for bone homeostasis and development. However, the primary mechanisms regulating osteogenic differentiation are controversial. Composed of multiple constituent enhancers, super enhancers(SEs) are powerful cis-regulatory elements that identify genes that ensure sequential differentiation. The present study demonstrated that SEs were indispensable for MSC osteogenesis and involved in osteoporosis development. Through integrated analysis, we identified the most common SE-targeted and osteoporosis-related osteogenic gene,ZBTB16. ZBTB16, positively regulated by SEs, promoted MSC osteogenesis but was expressed at lower levels in osteoporosis.Mechanistically, SEs recruited bromodomain containing 4(BRD4) at the site of ZBTB16, which then bound to RNA polymerase IIassociated protein 2(RPAP2) that transported RNA polymerase Ⅱ(POL Ⅱ) into the nucleus. The subsequent synergistic regulation of POL Ⅱ carboxyterminal domain(CTD) phosphorylation by BRD4 and RPAP2 initiated ZBTB16 transcriptional elongation, which facilitated MSC osteogenesis via the key osteogenic transcription factor SP7. Bone-targeting ZBTB16 overexpression had a therapeutic effect on the decreased bone density and remodeling capacity of Brd4^(fl/fl)Prx1-cre mice and osteoporosis(OP) models.Therefore, our study shows that SEs orchestrate the osteogenesis of MSCs by targeting ZBTB16 expression, which provides an attractive focus and therapeutic target for osteoporosis. | Wenhui Yu Zhongyu Xie Jinteng Li Jiajie Lin Zepeng Su Yunshu Che Feng Ye Zhaoqiang Zhang Peitao Xu Yipeng Zeng Xiaojun Xu Zhikun Li Pei Feng Rujia Mi Yanfeng Wu Huiyong Shen | 2023 | Bone Research2023，11，3： | 1 |
| 17 | Pressure-induced Lifshitz transition in the type Ⅱ Dirac semimetal PtTe_2显示文摘Numerous exotic properties have been discovered in Dirac Semimetals(DSMs) and Weyl Semimetals(WSMs). In a given DSM/WSM, the Dirac/Weyl nodes usually coexist with other bulk states, making their respective contribution elusive. In this work, we distinguish the role of bulk states from the tilted Dirac nodes on the transport properties in DSMs. Specifically, we applied pressure to a type-II DSM material, PtTe2, and studied its pressure modified electronic and lattice structure systematically by using in situ transport measurements and X-ray diffraction(XRD). A pressure-induced transition at about 20 GPa is revealed in the transport properties, while the layered lattice structure is robust against pressure as illustrated in XRD measurement results.Density functional theory(DFT) calculations suggest that this is originated from the Lifshitz transition in the bulk states. Our findings provide evidence to identify the bulk states' influence on transport from the topologically-protected DSM states in the DSM material. | FengLiang Liu JiaHeng Li KeNan Zhang Shang Peng HuaQing Huang MingZhe Yan NaNa Li Qian Zhang SongHao Guo XuJie Lü Peng Cai LiFeng Yin ShuYun Zhou WenHui Duan Jian Shen WenGe Yang | 2019 | Science China(Physics,Mechanics & Astronomy)2019，62，4： | 1 |
| 18 | Osteoking downregulates Mgp in an osteoporotic fracture rat model显示文摘OBJECTIVE: To investigate the effectiveness of osteoking, a Traditional Chinese Medicine originating from Yi nationality, against osteoporosis(OP) and osteoporotic fracture(OPF), and to elucidate its mechanism of action.METHODS: An osteoporotic fracture rat model was established;animals were divided into three treatment groups: parathyroid hormone, osteoking and0.9%NaCl. After 4, 8 and 12 weeks of treatment, serum and bone tissues were collected. Enzyme-linked immuno sorbent assay, x-ray, histopathological evaluation and proteomics were used.Proteomics and GO annotation were performed based on identified peptides. The relative network was obtained from the STRING database and verified by polymerase chain reaction and Western blotting.RESULTS: After osteoking treatment, the bone mineral density(BMD) increased with time in the osteoking group. At week 12, the BMD and bone mineral salt content of the osteoking group were 4.5%and 20.6% higher than those of the negative control group, respectively. Furthermore, the body weight followed the order of positive control group > osteoking group > negative control group,with significant differences among the groups(P <0.05). Micro-CT analysis of femur sections revealed that the bone surface/volume ratio was significantly higher in the osteoking group than that in the negative control group. X-ray images demonstrated that the osteoking group showed clear callus.Moreover, high-voltage micro-CT demonstrated a massive cortical bone accumulation in the osteoking group. The gray values of callus in the osteoking group were higher than those in the negative group. From week 4 to 12, the serum bone alkaline phosphatase level increased by 49.6% in the osteoking group and the serum propeptide of type procollagen level decreased by 80.6%. Alizarin reⅠd staining demonstrated that the calcium deposition in the osteoking group was higher than that in the negative control group. Notably, the expression of Mgp, a key osteogenesis inhibitor, was lower in the osteoking group compared with the negative control group. Moreover, Sparc, bone morphogenetic protein-2 and Bglap expression was higher in the osteoking group through activation of the transforming growth factor-receptor activator of nuclear factor κB Ligand pathway.CONCLUSION: Osteoking treatment increased bone quality and promoted calcium deposition.The results suggest that osteoking inhibits Mgp through the TGF-β/RANKL pathway to improve OP/OPF. | Sun Yan Wang Xiaoqi Chen Ran Zhu Di Shen Zhiqiang Zhao Hongbin Lee Wenhui | 2020 | Journal of Traditional Chinese Medicine2020，40，3： | 1 |
| 19 | Growth of large scale PtTe,PtTe_(2) and PtSe_(2) films on a wide range of substrates显示文摘1T phase of transition metal dichalcogenides(TMDCs)formed by group 10 transition metals(e.g.Pt,Pd)have attracted increasing interests due to their novel properties and potential device applications.Synthesis of large scale thin films with controlled phase is critical especially considering that these materials have relatively strong interlayer interaction and are difficult to exfoliate.Here we report the growth of centimeter-scale PtTe,1T-PtTe2 and 1T-PtSe2 films via direct deposition of Pt metals followed by tellurization or selenization.We find that by controlling the Te flux,a hitherto-unexplored PtTe phase can also be obtained,which can be further tuned into PtTe2 by high temperature annealing under Te flux.These films with different thickness can be grown on a wide range of substrates,including NaCl which can be further dissolved to obtain free-standing PtTe2 or PtSe2 films.Moreover,a systematic thickness dependent resistivity and Hall conductivity measurements show that distinguished from the semiconducting PtSe2 with hole carriers,PtTe2 and PtTe films are metallic.Our work opens new opportunities for investigating the physical properties and potential applications of group 10 TMDC films and the new monochalcogenide PtTe film. | Kenan Zhang Meng Wang Xue Zhou Yuan Wang Shengchun Shen Ke Deng Huining Peng Jiaheng Li Xubo Lai Liuwan Zhang Yang Wu Wenhui Duan Pu Yu Shuyun Zhou | 2021 | Nano Research2021，14，6： | 1 |
| 20 | Characterization of uncommon portosystemic collateral circulations inpatients with hepatic cirrhosis显示文摘 | Qin Wu Lijun Shen Jindong Chu Xuemei Ma Bo Jin Fanping Meng Jinpin Chen Yanling Wang Libing Wu Jun Han Wenhui Zhang Wei Ma Huaming Wang Hanwei Li | 2015 | Oncology Letters2015，，1： | 1 |
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