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| 1 | Association of Fusobacterium nucleatum with immunity andmolecular alterations in colorectal cancer显示文摘The human intestinal microbiome plays a major role in human health and diseases, including colorectal cancer. Colorectal carcinogenesis represents a heterogeneous process with a differing set of somatic molecular alterations, influenced by diet, environmental and microbial exposures, and host immunity. Fusobacterium species are part of the human oral and intestinal microbiota. Metagenomic analyses have shown an enrichment of Fusobacterium nucleatum(F. nucleatum) in colorectal carcinoma tissue. Using 511 colorectal carcinomas from Japanese patients, we assessed the presence of F. nucleatum. Our results showed that the frequency of F. nucleatum positivity in the Japanese colorectal cancer was 8.6%(44/511), which was lower than that in United States cohort studies(13%). Similar to the United States studies, F. nucleatum positivityin Japanese colorectal cancers was significantly associated with microsatellite instability(MSI)-high status. Regarding the immune response in colorectal cancer, high levels of infiltrating T-cell subsets(i.e., CD3+, CD8+, CD45RO+, and FOXP3+ cells) have been associated with better patient prognosis. There is also evidence to indicate that molecular features of colorectal cancer, especially MSI, influence T-cell-mediated adaptive immunity. Concerning the association between the gut microbiome and immunity, F. nucleatum has been shown to expand myeloid-derived immune cells, which inhibit T-cell proliferation and induce T-cell apoptosis in colorectal cancer. This finding indicates that F. nucleatum possesses immunosuppressive activities by inhibiting human T-cell responses. Certain micro RNAs are induced during the macrophage inflammatory response and have the ability to regulate host-cell responses to pathogens. Micro RNA-21 increases the levels of IL-10 and prostaglandin E2, which suppress antitumor T-cell-mediated adaptive immunity through the inhibition of the antigen-presenting capacities of dendritic cells and T-cell proliferation in colorectal cancer cells. Thus, emerging evidence may provide insights for strategies to target microbiota, immune cells and tumor molecular alterations for colorectal cancer prevention and treatment. Further investigation is needed to clarify the association of Fusobacterium with T-cells and micro RNA expressions in colorectal cancer. | Katsuhiko Nosho Yasutaka Sukawa Yasushi Adachi Miki Ito Kei Mitsuhashi Hiroyoshi Kurihara Shinichi Kanno Itaru Yamamoto Keisuke Ishigami Hisayoshi Igarashi Reo Maruyama Kohzoh Imai Hiroyuki Yamamoto Yasuhisa Shinomura | 2016 | World Journal of Gastroenterology2016，22，2： | 44 |
| 2 | Hepatitis B virus reactivation with a rituximab-containing regimen显示文摘Rituximab is currently used not only in the treatment of B-cell lymphoma but also for various other diseases, including autoimmune diseases, post-transplant graft vs host disease, and rejection following kidney transplants. Due to rituximab's widespread use, great progress has been made regarding research into complications that arise from its use, one of the most serious being the reactivation of hepatitis B virus(HBV), and efforts continue to establish guidelines for preventive treatment against this occurrence. This report discusses preventive measures against rituximab-induced HBV reactivation and future objectives. | Yutaka Tsutsumi Yoshiya Yamamoto Shinichi Ito Hiroyuki Ohigashi Souichi Shiratori Hirohito Naruse Takanori Teshima | 2015 | World Journal of Hepatology2015，7，21： | 5 |
| 3 | Life prognosis of sentinel node navigation surgery for early-stage gastric cancer:Outcome of lymphatic basin dissection显示文摘BACKGROUND Lymphatic basin dissection is a sentinel node biopsy method that is specific for gastric cancer.In this method,the dyed lymphatic system is dissected en bloc,and sentinel nodes are identified at the back table(ex vivo).Even with lymphatic basin dissection,blood flow to the residual stomach can be preserved,and functionpreserving curative gastrectomy can be performed.The oncological safety of function-preserving curative gastrectomy combined with lymphatic basin dissection has not yet been fully investigated.We hypothesized that the oncological safety of sentinel node navigation surgery(SNNS)is not inferior to that of the guidelines.AIM To investigate the life prognosis of SNNS for gastric cancer in comparison with guidelines surgery.METHODS This was a retrospective cohort study.Patients were selected from gastric cancer patients who underwent sentinel node biopsy from April 1999 to March 2016.Patients from April 1999 to August 2008 were from the Department of Surgery II,Kanazawa University Hospital,and patients from August 2009 to March 2016 were from the Department of Surgical Oncology,Kanazawa Medical University Hospital.Patients who were diagnosed with gastric cancer,which was preoperatively diagnosed as superficial type(type 0),5 cm or less in length,clinical T1-2 and node negative,and underwent various gastrectomies guided by sentinel node navigation were retrospectively collected.The overall survival(OS)and relapsefree survival(RFS)of these patients(SNNS group)were investigated.Patients with gastric cancer of the same stage and who underwent guidelines gastrectomy with standard nodal dissection were also selected as the control group.RESULTS A total of 239 patients in the SNNS group and 423 patients in the control group were included.Pathological nodal metastasis was observed in 10.5%and 10.4%of the SNNS and control groups,respectively.The diagnostic abilities of sentinel node biopsy were 84%and 98.6%for sensitivity and accuracy,respectively.In the SNNS group,81.6%of patients underwent modified gastrectomy or functionpreserving curative gastrectomy with lymphatic basin dissection,in which the extent of nodal dissection was further reduced compared to the guidelines.The OS rate in the SNNS group was 96.8%at 5 years and was significantly better than 91.3%in the control group(P=0.0014).The RFS rates were equal in both groups.After propensity score matching,there were 231 patients in both groups,and the cumulative recurrence rate was 0.43%at 5 years in the SNNS group and 1.30%in the control group,which was not statistically different.CONCLUSION The oncological safety of patients who undergo gastrectomy guided by sentinel node navigation is not inferior to that of the guidelines surgery. | Shinichi Kinami Naohiko Nakamura Tomoharu Miyashita Hidekazu Kitakata Sachio Fushida Takashi Fujimura Yasuo Iida Noriyuki Inaki Toru Ito Hiroyuki Takamura | 2021 | World Journal of Gastroenterology2021，27，46： | 5 |
| 4 | Intraductal Papillary Mucinous Neoplasms of the Pancreas With Distinct Pancreatic Ductal Adenocarcinomas Are Frequently of Gastric Subtype显示文摘 | Noboru Ideno Takao Ohtsuka Hiroshi Kono Kenji Fujiwara Yasunori Oda Shinichi Aishima Tetsuhide Ito Kousei Ishigami Shoji Tokunaga Kenoki Ohuchida Shunichi Takahata Masafumi Nakamura Kazuhiro Mizumoto Masao Tanaka | 2013 | Annals of Surgery2013，，1： | 2 |
| 5 | Intracorporeal circular-stapled esophagojejunostomy using hand-sewn purse-string suture after laparoscopic total gastrectomy显示文摘 | Takahiro Kinoshita Takashi Oshiro Katsuhiko Ito Hidehito Shibasaki Shinichi Okazumi Ryoji Katoh | 2010 | Surgical Endoscopy2010，，11： | 2 |
| 6 | Expression of ephrin-B1 in hepatocellular carcinoma: possible involvement in neovascularization显示文摘 | Yoshiyuki Sawai Shinji Tamura Koji Fukui Nobuyuki Ito Kazuho Imanaka Ayuko Saeki Shigeru Sakuda Shinichi Kiso Yuji Matsuzawa | 2003 | Journal of Hepatology2003，，6： | 1 |
| 7 | Long-Term Outcome After Hernia Repair with the Prolene Hernia System显示文摘 | Shinichi Hasegawa Takaki Yoshikawa Yuji Yamamoto Naoki Ishiwa Souichirou Morinaga Yoshikazu Noguchi Hiroyuki Ito Nobuyuki Wada Kenji Inui Toshio Imada Yasushi Rino Yoshinori Takanashi | 2006 | Surgery Today2006，，12： | 1 |
| 8 | Th1/Th2 cytokine profiles and their relationship to clinical features in patients with chronic hepatitis C virus infection显示文摘 | Satoshi Sobue Tomoyuki Nomura Tetsuya Ishikawa Satomi Ito Katsuhisa Saso Hirotaka Ohara Takashi Joh Makoto Itoh Shinichi Kakumu | 2001 | Journal of Gastroenterology2001，，8： | 1 |
| 9 | Asymmetric Diels-Alder reaction of methacrolein with cyclopentadiene using polymer-supported catalysts: design of highly enantioselective polymeric catalysts显示文摘 | Koichi Kamahori Koichi Ito Shinichi Itsuno | 1996 | J Org Chem1996，61，23： | 1 |
| 10 | Therapeutic endoscopic retrograde cholangiography using a single‐balloon enteroscope in patients with R oux‐en‐ Y anastomosis显示文摘 | Takashi Obana Naotaka Fujita Kei Ito Yutaka Noda Go Kobayashi Jun Horaguchi Shinsuke Koshita Yoshihide Kanno Takahisa Ogawa Shinichi Hashimoto Kaori Masu | 2013 | Digestive Endoscopy2013，，6： | 1 |
| 11 | Th1/Th2 cytokine profiles and their relationship to clinical features in patients with chronic hepatitis C virus infection显示文摘 | Satoshi Sobue Tomoyuki Nomura Tetsuya Ishikawa Satomi Ito Katsuhisa Saso Hirotaka Ohara Takashi Joh Makoto Itoh Shinichi Kakumu | 2001 | Journal of Gastroenterology2001，，8： | 1 |
| 12 | Prognostic utility of T-wave alternans in a real-world population of patients with left ventricular dysfunction: the PREVENT-SCD study显示文摘 | Satoshi Shizuta Kenji Ando Masakiyo Nobuyoshi Takanori Ikeda Hideaki Yoshino Shinichi Hiramatsu Yukio Kazatani Kohei Yamashiro Katsunori Okajima Teishi Kajiya Yoshinori Kobayashi Takao Kato Satoki Fujii Kazuaki Mitsudo Koichi Inoue Hiroshi Ito Yoshisumi H | 2012 | Clinical Research in Cardiology2012，，2： | 1 |
| 13 | Determination of berberine and palmatine in Phellodendri cortex using ion-pair supercritical fluid chromatography on-line coupled with ion-pair supercritical fluid extraction by on-column trapping显示文摘 | Suto Keiichi Kakinuma Shinichi Ito Yuji | 1997 | Journal of Chromatographia A1997，786，2： | 1 |
| 14 | Th1/Th2 cytokine profiles and their relationship to clinical features in patients with chronic hepatitis C virus infection显示文摘 | Satoshi Sobue Tomoyuki Nomura Tetsuya Ishikawa Satomi Ito Katsuhisa Saso Hirotaka Ohara Takashi Joh Makoto Itoh Shinichi Kakumu | 2001 | Journal of Gastroenterology2001，，8： | 1 |
| 15 | Rituximab Administration and Reactivation of HBV显示文摘 | Yutaka Tsutsumi Reiki Ogasawara Yusuke Kamihara Shinichi Ito Yoshiya Yamamoto Junji Tanaka Masahiro Asaka Masahiro Imamura Yoichi Hiasa | 2010 | Hepatitis Research and Treatment2010，，： | 1 |
| 16 | Ultrasonographic diagnosis criteria using scoring for hypertrophic pyloric stenosis 显示文摘 | Shinichi Ito Konoshin Tamura Itsuro Nagae | 2000 | Journal of Pddiatric Surgery2000，35，12： | 1 |
| 17 | Incidence of complications associated with spinal endoscopic surgery: nationwide survey in 2007 by the Committee on Spinal Endoscopic Surgical Skill Qualification of Japanese Orthopaedic Association显示文摘 | Morio Matsumoto Toru Hasegawa Manabu Ito Toshimi Aizawa Shinichi Konno Masatsune Yamagata Sohei Ebara Yudo Hachiya Hiroaki Nakamura Shoji Yagi Kimiaki Sato Akira Dezawa Muneto Yoshida Kenichi Shinomiya Yoshiaki Toyama Katsuji Shimizu Kensei Nagata | 2010 | Journal of Orthopaedic Science2010，，1： | 1 |
| 18 | Association of Fusobacterium nucleatum with clinical and molecular features in colorectal serrated pathway显示文摘 | Miki Ito Shinichi Kanno Katsuhiko Nosho Yasutaka Sukawa Kei Mitsuhashi Hiroyoshi Kurihara Hisayoshi Igarashi Taiga Takahashi Mami Tachibana Hiroaki Takahashi Shinji Yoshii Toshinao Takenouchi Tadashi Hasegawa Kenji Okita Koichi Hirata Reo Maruyama Hiromu | 2015 | Int. J. Cancer2015，，6： | 1 |
| 19 | Incidence of complications associated with spinal endoscopic surgery: nationwide survey in 2007 by the Committee on Spinal Endoscopic Surgical Skill Qualification of Japanese Orthopaedic Association显示文摘 | Morio Matsumoto Toru Hasegawa Manabu Ito Toshimi Aizawa Shinichi Konno Masatsune Yamagata Sohei Ebara Yudo Hachiya Hiroaki Nakamura Shoji Yagi Kimiaki Sato Akira Dezawa Muneto Yoshida Kenichi Shinomiya Yoshiaki Toyama Katsuji Shimizu Kensei Nagata | 2010 | Journal of Orthopaedic Science2010，，1： | 1 |
| 20 | The frequency adjustment method of the quartz crystal resonator using ion beam etching显示文摘 | SHIONO Tadahisa KUBO Shinichi ITO Makoto | 2007 | IEICE Transactions2007，2，2： | 1 |
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