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| 1 | An updated review of gastric cancer in the next-generation sequencing era:Insights from bench to bedside and vice versa显示文摘Gastric cancer(GC)is one of the most common malignancies and remains the second leading cause of cancer-related death worldwide.There is an increasing understanding of the roles that genetic and epigenetic alterations play in GCs.Recent studies using nextgeneration sequencing(NGS)have revealed a number of potential cancer-driving genes in GC.Whole-exome sequencing of GC has identified recurrent somatic mutations in the chromatin remodeling gene ARID1A and alterations in the cell adhesion gene FAT4,a member of the cadherin gene family.Mutations in chromatin remodeling genes(ARID1A,MLL3 and MLL)have been found in 47%of GCs.Whole-genome sequencing and whole-transcriptome sequencing analyses have also discovered novel alterations in GC.Recent studies of cancer epigenetics have revealed widespread alterations in genes involved in the epigenetic machinery,such as DNA methylation,histone modifications,nucleosome positioning,noncoding RNAs and microRNAs.Recent advances in molecular research on GC have resulted in the introduction of new diagnostic and therapeutic strategies into clinical settings.The antihuman epidermal growth receptor 2(HER2)antibody trastuzumab has led to an era of personalized therapy in GC.In addition,ramucirumab,a monoclonal antibody targeting vascular endothelial growth factor receptor(VEGFR)-2,is the first biological treatment that showed survival benefits as a single-agent therapy in patients with advanced GC who progressed after firstline chemotherapy.Using NGS to systematically identify gene alterations in GC is a promising approach with remarkable potential for investigating the pathogenesis of GC and identifying novel therapeutic targets,as well as useful biomarkers.In this review,we will summarize the recent advances in the understanding of the molecular pathogenesis of GC,focusing on the potential use of these genetic and epigenetic alterations as diagnostic biomarkers and novel therapeutic targets. | Hiroyuki Yamamoto Yoshiyuki Watanabe Tadateru Maehata Ryo Morita Yoshihito Yoshida Ritsuko Oikawa Shinya Ishigooka Shun-ichiro Ozawa Yasumasa Matsuo Kosuke Hosoya Masaki Yamashita Hiroaki Taniguchi Katsuhiko Nosho Hiromu Suzuki Hiroshi Yasuda Yasuhisa Shinomura Fumio Itoh | 2014 | World Journal of Gastroenterology2014，20，14： | 12 |
| 2 | Evaluation of magnifying colonoscopy in the diagnosis of serrated polyps显示文摘AIM:To elucidate the colonoscopic features of serrated lesions of the colorectum using magnifying colonoscopy.METHODS:Broad division of serrated lesions of the colorectum into hyperplastic polyps(HPs),traditional serrated adenomas(TSAs),and sessile serrated adenomas/polyps(SSA/Ps) has been proposed on the basis of recent molecular biological studies.However,few reports have examined the colonoscopic features of these divisions,including magnified colonoscopic findings.This study examined 118 lesions excised in our hospital as suspected serrated lesions after magnified observation between January 2008 and September 2011.Patient characteristics(sex,age),conventional colonoscopic findings(location,size,morphology,color,mucin) and magnified colonoscopic findings(pit pattern diagnosis) were interpreted by five colonoscopists with experience in over 1000 colonoscopies,and were compared with histopathological diagnoses.The pit patterns were categorized according to Kudo's classification,but a more detailed investigation was also performed using the subclassification [type Ⅱ-Open(type Ⅱ-O),type Ⅱ-Long(type Ⅱ-L),or type Ⅳ-Serrated(type Ⅳ-S)] proposed by Kimura T and Yamano H.RESULTS:Lesions comprised 23 HPs(23/118:19.5%),39 TSAs(39/118:33.1%:with cancer in one case),50 SSA/Ps(50/118:42.4%:complicated with cancer in three cases),and six others(6/118:5.1%).We excluded six others,including three regular adenomas,one hamartoma,one inflammatory polyp,and one juvenile polyp for further analysis.Conventional colonoscopy showed that SSA/Ps were characterized as larger in diameter than TSAs and HPs(SSA/P vs HP,13.62 ± 8.62 mm vs 7.74 ± 3.24 mm,P < 0.001;SSA/Ps vs TSA,13.62 ± 8.62 mm vs 9.89 ± 5.73 mm,P < 0.01);common in the right side of the colon [HPs,30.4%(7/23):TSAs,20.5%(8/39):SSA/P,84.0%(42/50),P < 0.001];flat-elevated lesion [HPs,30.4%(7/23):TSAs,5.1%(2/39):SSA/Ps,90.0%(45/50),P < 0.001];normal-colored or pale imucosa [HPs,34.8%(8/23):TSAs,10.3%(4/39):SSA/Ps,80%(40/50),P < 0.001];and with large amounts of mucin [HPs,21.7%(5/23):TSAs,17.9%(7/39):SSA/Ps,72.0%(36/50),P < 0.001].In magnified colonoscopic findings,17 lesions showed either type Ⅱ pit pattern alone or partial type Ⅱ pit pattern as the basic architecture,with 14 HPs(14/17,70.0%) and 3 SSA/Ps.Magnified colonoscopy showed the type Ⅱ-O pit pattern as characteristic of SSA/Ps [sensitivity 83.7%(41/49),specificity 85.7%(54/63)].Cancer was also present in three lesions,in all of which a type Ⅵ pit pattern was also present within the same lesion.There were four HPs and four TSAs each.The type Ⅳ-S pit pattern was characteristic of TSAs [sensitivity 96.7%(30/31),specificity 89.9%(72/81)].Cancer was present in one lesion,in which a type Ⅵ pit pattern was also present within the same lesion.In our study,serrated lesions of the colorectum also possessed the features described in previous reports of conventional colonoscopic findings.The pit pattern diagnosis using magnifying colonoscopy,particularly magnified colonoscopic findings using subclassifications of surface architecture,reflected the pathological characteristics of SSA/Ps and TSAs,and will be useful for colonoscopic diagnosis.CONCLUSION:We suggest that this system could be a good diagnostic tool for SSA/Ps using magnifying colonoscopy. | Shinya Ishigooka Masahito Nomoto Nobuyuki Obinata Yoshichika Oishi Yoshinori Sato Satoko Nakatsu Midori Suzuki Yoshiko Ikeda Tadateru Maehata Tomoaki Kimura Yoshiyuki Watanabe Takashi Nakajima Hiro-o Yamano Hiroshi Yasuda Fumio Itoh | 2012 | World Journal of Gastroenterology2012，18，32： | 11 |
| 3 | 使用ATP酶敏感钾离子通道开放剂——尼可地尔静脉给药用于冠状动脉腔内血管成形术介入治疗的药学证据显示文摘1前言动物实验研究表明,反复短暂的冠脉闭塞导致心脏抗心肌缺血的发作,这种现象被称为缺血性预处理。一些研究表明,这种预处理的效果是由于ATP敏感性钾通道的激活(KATP通道)。人类涉及经皮冠状动脉成形术(PTCA)的临床研究发现KATP通道的关闭与格列本脲防止预处理的效果通常出现在反复球囊扩张期间血管成形术模型中,表明ATP敏感性钾通道在预处理中发挥了核心作用。 | Hitoshi Matsuo Sachiro Watanabe Tomonori Segawa Shinji Yasuda Takeshi Hirose Makoto Iwama Shinichiro Tanaka Takahiko Yamaki Yukihiko Matsuno Masaaki Tomita Shinya Minatoguchi Hisayoshi Fujiwara 魏丽莎 | 2015 | 首都食品与医药2015，0，8： | 3 |
| 4 | Randomized phase II study of gemcitabine and S-1 combination versus gemcitabine alone in the treatment of unresectable advanced pancreatic cancer (Japan Clinical Cancer Research Organization PC-01 study)显示文摘 | Masato Ozaka Yuji Matsumura Hiroshi Ishii Yasushi Omuro Takao Itoi Hisatsugu Mouri Keiji Hanada Yasutoshi Kimura Iruru Maetani Yoshinobu Okabe Masaji Tani Takaaki Ikeda Susumu Hijioka Ryouhei Watanabe Shinya Ohoka Yuki Hirose Masafumi Suyama Naoto Egawa A | 2012 | Cancer Chemotherapy and Pharmacology2012，，5： | 3 |
| 5 | Crk adaptor protein-induced phosphorylation of Gab1 on tyrosine 307 via Src is important for organization of focal adhesions and enhanced cell migration显示文摘在生长因素刺激之上,支架蛋白质, Gab1,是酷氨酸 phosphorylated 并且随后适配器蛋白质, Crk,从 Gab1 播送信号。我们以前证明了没有细胞外的刺激, Crk overexpression,在各种各样的人的癌症可检测,导致 Gab1 的酷氨酸 phosphorylation。在现在的学习,内在的机制进一步被调查。CrkII 的 Mutational 分析证明 SH2 领域,然而并非 SH3 (N) 或 CrkII 的规章的 Y221 残余,为 Gab1-Y307 phosphorylation 的正式就职是批评的。CrkII 的 SH2 变化也减少了和 Gab1 的相互作用。在 GST 下拉试金,而 Crk-SH3 (N) 与 Gab1 异种交往了, Crk-SH2 跳了到野类型的 Gab1,它缺乏聚类的酷氨酸区域(残余 242-410 ) 。Gab1 的酷氨酸 phosphorylation 被表明适配器的所有 Crk 家庭蛋白质,然而并非另外的包含 SH2 导致。Src 家庭 kinase 禁止者, PP2,废除 Gab1 的导致 Crk 的酷氨酸 phosphorylations。Y307 phosphorylation 在缺乏 Src,是,和 Fyn 的成纤维细胞是无法发现的,甚至在 Crk 的 overexpression 之上,而缺乏仅仅是和 Fyn 的房间仍然与 phosphorylated Y307 包含了 Gab1。而且, Crk 导致了 Src-Y416 的 phosphorylation;因此,在 Crk 和 Csk 之间的相互作用被增加。Gab1-Y307F 异种没能近甚至在 HGF 之上本地化血浆膜刺激和减少的房间移植。而且, Gab1-Y307F 扰乱了 Crk, FAK,和 paxillin 的本地化,它是焦点的粘附的典型部件。一起拿,这些结果显示 Crk 通过 Src 便于 Gab1-Y307 的酷氨酸 phosphorylation,贡献焦点的粘附和提高的房间移植的组织,可能从而支持人的癌症开发。 | Takuya Watanabe Masumi Tsuda Yoshinori Makino Tassos Konstantinou Hiroshi Nishihara Tokifumi Majima Akio Minami Stephan M Feller Shinya Tanaka | 2009 | Cell Research2009，19，5： | 2 |
| 6 | Gene expression profiles predicting the response to IFN-β and a combinationof temozolomide and IFN-β in malignant gliomas显示文摘 | Atsuo Yoshino Shinya Tashiro Akiyoshi Ogino Kazunari Yachi Takashi Ohta Takao Fukushima Takao Watanabe Yoichi Katayama Yutaka Okamoto Emiko Sano Kouhei Tsumoto | 2011 | International Journal of Oncology2011，，3： | 1 |
| 7 | Case of acrodermatitis continua of Hallopeau following psoriasis with atypical clinical presentation显示文摘 | Shigeruko Iijima Yukiko Okazaki Shinya Watanabe Yoko Maruyama | 2014 | J Dermatol2014，，11： | 1 |
| 8 | Regression of B-Cell Lymphoma of the Liver with Hepatitis C Virus Infection After Treatment with Pegylated Interferon-α and Ribavirin显示文摘 | Yayoi Oda Tadayuki Kou Masaki Watanabe Yojiro Sakuma Nori Taguchi Yoko Kato Yasushi Kudo Atsushi Yamauchi Yasushi Sugiura Shinya Ohashi Masanori Asada Toyokazu Fukunaga Kiyotaka Kawaguchi Hiroaki Ito Takefumi Nakamura Shujiro Yazumi | 2010 | Digestive Diseases and Sciences2010，，6： | 1 |
| 9 | FDG-PET after radiotherapy is a good prognostic indicator of rectal cancer显示文摘 | Shinya Oku M.D. Keiichi Nakagawa Toshimitsu Momose Yoshitaka Kumakura Atsushi Abe Toshiaki Watanabe Kuni Ohtomo | 2002 | Annals of Nuclear Medicine2002，，6： | 1 |
| 10 | LED Headlamp Development for Mass Production显示文摘 | Tetsuaki Inaba Shinya Watanabe and Yuji Yamada | 2008 | SAE2008，，： | 1 |
| 11 | Adaptation of an H7N7 equine influenza A virus in mice显示文摘 | Shinya K Watanabe S Ito T | 2007 | J Gen Virol2007，88，2： | 1 |
| 12 | Yeasts and lactic acid bacteria mixed-specie biofilm formation is a promising cell immobilization technology for ethanol fermentation显示文摘 | Atsumu Abe Soiehi Furukawa Shinya Watanabe | 2013 | Applied Biochemistry and Biotechnology2013，171，1： | 1 |
| 13 | TRIM29 as a novel prostate basal cell marker for diagnosis of prostate cancer显示文摘 | Yukiko Kanno Masashi Watanabe Taichi Kimura Katsuya Nonomura Shinya Tanaka Shigetsugu Hatakeyama | 2013 | Acta Histochemica2013，，： | 1 |
| 14 | Model incorporating the ITPA genotype identifies patients at high risk of anemia and treatment failure with pegylated‐interferon plus ribavirin therapy for chronic hepatitis C显示文摘 | Masayuki Kurosaki Yasuhito Tanaka Nao Nishida Naoya Sakamoto Nobuyuki Enomoto Kentaro Matsuura Yasuhiro Asahina Mina Nakagawa Mamoru Watanabe Minoru Sakamoto Shinya Maekawa Katsushi Tokunaga Masashi Mizokami Namiki Izumi | 2013 | J Med Virol2013，，3： | 1 |
| 15 | Relation between functional stenosis and tissue characterization of intermediate coronary plaques in patients with stable coronary heart disease显示文摘 | Shinichiro Tanaka Toshiyuki Noda Tomonori Segawa Makoto Iwama Taro Minagawa Sachiro Watanabe Shinya Minatoguchi | 2009 | Journal of Cardiology2009，，3： | 1 |
| 16 | Parallel evolutionary multi-criterion optimization for mobile telecommunication networks optimization显示文摘 | Shinya Watanabe Tomoyuki Hiroyasu Mitsunori Miki | 2002 | Evolutionary Methods for Design Optimizxztion and Control2002，，： | 1 |
| 17 | Yeasts and lactic acid bacteria mixed-specie biofilm formation is a promising cell immobilization technology for ethanol fermentation 显示文摘 | ATSUMU Abe SOICHI Furukawa SHINYA Watanabe | 2013 | Applied Biochemistry and Biotechnology2013，171，1： | 1 |
| 18 | Diagnostic relevance of overexpressed Nanog gene in early lung cancers显示文摘 | Shinya Nirasawa Daisuke Kobayashi Naoki Tsuji Kageaki Kuribayashi Naoki Watanabe | 2009 | Oncology Reports2009，，3： | 1 |
| 19 | Irinotecan plus S-1 (IRIS) versus fluorouracil and folinic acid plus irinotecan (FOLFIRI) as second-line chemotherapy for metastatic colorectal cancer: a randomised phase 2/3 non-inferiority study (FIRIS study)显示文摘 | Kei Muro Narikazu Boku Yasuhiro Shimada Akihito Tsuji Shinichi Sameshima Hideo Baba Taroh Satoh Tadamichi Denda Kenji Ina Tomohiro Nishina Kensei Yamaguchi Hiroya Takiuchi Taito Esaki Shinya Tokunaga Hiroyuki Kuwano Yoshito Komatsu Masahiko Watanabe Ichin | 2010 | Lancet Oncology2010，，9： | 1 |
| 20 | Contrast-enhanced endoscopic ultrasonography in gallbladder diseases显示文摘 | Yoshiki Hirooka Yasuo Naitoh Hidemi Goto Akihiro Ito Shinya Hayakawa Yoshihiro Watanabe Yoshihiro Ishiguro Shinya Kojima Senju Hashimoto Tetsuo Hayakawa | 1998 | Gastrointestinal Endoscopy1998，，4： | 1 |
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