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| 1 | Primary hepatic epithelioid angiomyolipoma: A malignant potential tumor which should be recognized显示文摘AIM: To improve the clinical diagnosis and recognition of hepatic epithelioid angiomyolipoma(HEAML).METHODS: Four cases of primary HEAML were confirmed based on the pathology archive system in our hospital from January 2009 to November 2015. The general state, clinical symptoms, imaging manifestations, histological results and immunohistochemistry of these patients were retrospectively reviewed and analyzed. Studies of HEAML published in the last 15 years were collected from Pub Med and MEDLINE to summarize the clinical symptoms, imaging characteristics, pathological features and management of HEAML.RESULTS: Four cases of primary HEAML were retrieved from our archives. These included three female patients and one male patient, with a mean age of 41.8 ± 11.5 years(ranging from 31 to 56 years). The meantumor size was 7.3 ± 5.5 cm(ranging from 3.0 to 15 cm). In the contrast-enhanced imaging, the tumor was obviously enhanced in the arterial phase, but enhanced continuously or exhibited a slow-density masse during the venous and delayed phases. Histologically, the tumors mainly consisted of epithelioid cells that comprised approximately 95% of the total neoplastic mass. Although no metastases occurred in our patients, pathological studies revealed necrosis, mitotic figures and liver invasion in two patients, which indicates aggressive behavior. Immunohistochemical staining revealed that human melanoma black 45(HMB-45) and Melan-A were positive in 4 cases. We only identified 81 cases with primary HEAML, including our present patients, from 26 articles available from Pub Med and MEDLINE. The majority of the papers were published as case reports. Only 5(5/75, 6%) cases were associated with tuberous sclerosis complex(TSC). More than half(35/66) were discovered incidentally upon physical examination. Approximately 65%(22/34) of the patients were misdiagnosed with HCC or other tumors before surgery. Approximately 10%(8/81) of the patients with HEAML had recurrence or metastasis after surgery, which was a very high and alarming rate.CONCLUSION: HEAML is a very rare primary hepatic tumor that is often misdiagnosed before surgery. Patients should be followed closely after surgery because of its malignant potential. | Jie Liu Cheng-Wu Zhang De-Fei Hong Ran Tao Yuan Chen Min-Jie Shang Yu-Hua Zhang | 2016 | World Journal of Gastroenterology2016，22，20： | 18 |
| 2 | Angiographic prevalence of myocardial bridging in a defined very large number of Chinese patients with chest pain显示文摘背景:心肌内冠的动脉被称为的 epicardial 分割的肌纤维 overlying 心肌的衔接(MB ) 。MB 的可变流行与小、大的样品尺寸研究在尸体和 angiographic 系列被描述了。另外,没有类似的学习在中国人口被报导。这研究的目的是调查 MB 的 angiographic 流行在连续有从我们的中心的胸痛的 37,106 个中国病人。方法:我们进行了观察研究在经历的病人之中与 MB 评估连续案例选择冠的血管造影术,并且在很大的样品尺寸的这研究分析了 angiograhic 流行和 MB 的临床的特征。结果:在有胸痛的 37 105 个病人之中,我们以一种回顾的方式与 1011 MB 发现了 1002 个案例,并且全面流行是 2.70% 。尽管(991/1002 ) 超过 99% 病人有单个桥牌, 8 个案例被发现有超过二 MB (七与二,和一与三) 。没有动脉粥样硬化患者损害,总的来说 54.39% 案例(545/1002 ) 有 MB,并且(973/1011 )96.24% 在左前面的下降冠的动脉(男孩) 衔接定位了,主要在男孩的中间(792/1011, 78.33%) 。根据诺贝尔分类,单个桥(n=991 ) ,阻塞的 <50% 是占优势的(471/991, 47.52%) 。完全, 50%-69% 占了 34.81%(345/991 ) ,阻塞的 >70% 是 17.65%(175/991 ) 。结论:这些数据证明在有胸痛的中国病人的 angiographically 可检测的 MB 的流行类似于以前的研究的那些,与在这种很大的样品尺寸的 2.7% 流行。 | LI Jian-jun SHANG Zheng-lu YAO Min LI Jie YANG Yue-jin CHEN Ji-lin QIAO Shu-bin MA Wei-hua QIN Xue-wen LIU Hai-bo WU Yong-jian YUAN Jin-qing CHEN Jue YOU Shi-jie DAI Jun XU Bo XIA Ran GAO Run-lin | 2008 | Chinese Medical Journal2008，，5： | 17 |
| 3 | Consensus on the application of negative pressure wound therapy of diabetic foot wounds显示文摘Because China is becoming an aging society,the incidence of diabetes and diabetic foot have been increasing.Diabetic foot has become one of the main health-related killers due to its high disability and mortality rates.Negative pressure wound therapy(NPWT)is one of the most effective techniques for the treatment of diabetic foot wounds and great progress,both in terms of research and its clinical application,has been made in the last 20 years of its development.However,due to the complex pathogenesis and management of diabetic foot,irregular application of NPWT often leads to complications,such as infection,bleeding and necrosis,that seriously affect its treatment outcomes.In 2020,under the leadership of Burns,Trauma and Tissue Repair Committee of the Cross-Straits Medicine Exchange Association,the writing group for‘Consensus on the application of negative pressure wound therapy of diabetic foot wounds’was established with the participation of scholars from the specialized areas of burns,endocrinology,vascular surgery,orthopedics and wound repair.Drawing on evidence-based practice suggested by the latest clinical research,this consensus proposes the best clinical practice guidelines for the application and prognostic evaluation of NPWT for diabetic foot.The consensus aims to support the formation of standardized treatment schemes that clinicians can refer to when treating cases of diabetic foot. | Shizhao Ji Xiaobin Liu Jie Huang Junmin Bao Zhaohong Chen Chunmao Han Daifeng Hao Jingsong Hong Dahai Hu Yufeng Jiang Shang Ju Hongye Li Zongyu Li Guangping Liang Yan Liu Gaoxing Luo Guozhong Lv Xingwu Ran Zhongmin Shi Juyu Tang Aiping Wang Guangyi Wang Jiangning Wang Xin Wang Bing Wen Jun Wu Hailin Xu Maojin Xu Xiaofei Ye Liangxi Yuan Yi Zhang Shichu Xiao Zhaofan Xia | 2021 | Burns & Trauma2021，9，1： | 17 |
| 4 | miR-93-5p Transferred by Exosomes Promotes the Proliferation of Esophageal Cancer Cells via Intercellular Communication by Targeting PTEN显示文摘Objective To investigate the relationship between plasma miR-93-5p and the risk of esophageal cancer, as well as the influence of miR-93-5p on the biological function of esophageal cancer cells,exerted through exosomes.Methods The expression of plasma miR-93-5p in esophageal cancer patients and healthy controls was analysed by real-time quantitative PCR. The influence of miR-93-5p on the risk and prognosis of esophageal carcinoma was analyzed by conditional logistic regression and survival analysis. The effect of miR-93-5p on the biological function of recipient cells was investigated by establishing an in vitro donor cell co-culture model. The target gene of miR-93-5p was validated by luciferase reporter assay and Western Blotting.Results Upregulation of plasma miR-93-5p expression significantly increases the risk of esophageal cancer and is associated with poor prognosis. miR-93-5p transferred by exosomes promotes the proliferation of recipient esophageal cancer cells and affects the expression of PTEN and its downstream proteins p21 and cyclin D1.Conclusion Our study provides a reference for the identification of biomarkers for the diagnosis and prognosis of esophageal cancer. | LIU Meng Xin LIAO Juan XIE Ming GAO Zhi Kui WANG Xiang Hu ZHANG Ying SHANG Mu He YIN Li Hong PU Yue Pu LIU Ran | 2018 | Biomedical and Environmental Sciences2018，31，3： | 10 |
| 5 | A cross-sectional study of acute cor pulmonale in acute respiratory distress syndrome patients in China显示文摘Background:Increased right ventricle afterload during acute respiratory distress syndrome(ARDS)may induce acute cor pulmonale(ACP),which is associated with a poor clinical outcome.Echocardiography is now considered as a rapid and non-invasive tool for diagnosis of ACP.The aims of this study were to investigate the morbidity and mortality rates of ACP in ARDS patients in intensive care units(ICUs)across the mainland of China and to determine the severity and prognosis of ACP in ARDS patients through an ultrasound protocol(TRIP).And the association between ACP related factors and the ICU mortality will be revealed.Methods:This study is a multicenter and cross-sectional study in China which will include ICU participants when diagnosed as ARDS.The ultrasound protocol,known as the TRIP,is proposed as severity assessment for ACP,which includes tricuspid regurgitation velocity(T),right ventricular size(R),inferior vena cava diameter fluctuation(I),and pulmonary regurgitation velocity(P).The 28-day mortality,ICU/hospital mortality,the length of stay in ICU,mechanical ventilation days,hemodynamic parameters and lab parameters of liver function and kidney function are all recorded.Discussion:This large-scale study would give a sufficient epidemic investigation of ACP in ARDS patients in China.In addition,with the TRIP protocol,we expect that we could stratify ACP with more echocardiography parameters. | Long-Xiang Su Xiu-Ling Shang Ran Zhu Wei He Pan Pan Hong-Min Zhang Li-Na Zhang Da-Wei Liu Rong-Guo Yu Xiao-Ting Wang 无 | 2019 | Chinese Medical Journal2019，，23： | 6 |
| 6 | Development of the general chapters of the Chinese Pharmacopoeia 2020 edition: A review显示文摘The Chinese Pharmacopoeia 2020 edition was reviewed and approved by the National Medical Products Administration and the National Health Commission of the People’s Republic of China in July 2020.The current edition was officially implemented on December 30,2020.The general chapters of the Chinese Pharmacopoeia discuss the general testing methods and guidelines,which are the common requirements and basis for the implementation of drug standards in the Chinese Pharmacopoeia.Owing to adherence to the principles of scientificity,versatility,operability,and sustainable development,there is an improvement in the general chapters of the 2020 edition over those of the previous editions.Further,the application of advanced and mature analytical techniques has expanded,the development of testing methods for exogenous pollutants in traditional Chinese medicines has been strengthened,and technical requirements are now better harmonized with international standards.The updated edition provides technical and methodological support to ensure safety,effectiveness,and control of pharmaceuticals in China and will play an important and active role in encouraging the application of advanced technologies,improving the quality control of medicines,and strengthening the means of drug regulation in China.This review provides a comprehensive introduction of the main features of and changes to the general chapters in the Chinese Pharmacopoeia 2020 edition and aims to provide reference for its correct understanding and accurate implementation. | Xinyi Xu Huayu Xu Yue Shang Ran Zhu Xiaoxu Hong Zonghua Song Zhaopeng Yang | 2021 | Journal of Pharmaceutical Analysis2021，11，4： | 6 |
| 7 | A Pilot Study of Quantitative Loop-mediated Isothermal Amplification-guided Target Therapies for Hospital-acquired Pneumonia显示文摘 | Fang Wang Ran Li Ying Shang Can Wang Guo-Qing Wang DeXun Zhou Dong-Hong Yang Wen Xi Ke-QiangWang Jing Bao Yu Kang Zhan-Cheng Gao | 2016 | Chinese Medical Journal2016，，2： | 5 |
| 8 | Grain refinement in the coarse-grained region of the heat-affected zone in low-carbon high-strength microalloyed steels显示文摘The microstructural features and grain refinement in the coarse-grained region of the heat-affected zone in low-carbon high-strength microalloyed steels were investigated using optical microscopy, scanning electron microscopy, and electron backscattering diffraction. The coarse-grained region of the heat-affected zone consists of predominantly bainite and a small proportion of acicular ferrite. Bainite packets are separated by high angle boundaries. Acicular ferrite laths or plates in the coarse-grained region of the heat-affected zone formed prior to bainite packets partition austenite grains into many smaller and separate areas, resulting in fine-grained mixed microstructures. Electron backscattering diffraction analysis indicates that the average crystallographic grain size of the coarse-grained region of the heat-affected zone reaches 6-9 μm, much smaller than that of austenite grains. | Ran Wei Cheng-jia Shang Kai-ming Wu | 2010 | International Journal of Minerals,Metallurgy and Materials2010，17，6： | 5 |
| 9 | Ni/MgO catalyst prepared using atmospheric high-frequency discharge plasma for CO_2 reforming of methane显示文摘A new type of Ni/MgO catalyst was prepared using atmospheric high-frequency discharge cold plasma. The influences of conventional method, plasma method, and plasma plus calcination method on the catalytic activity were studied and the CO2 reforming of methane was chosen as the probe reaction. The catalysts were characterized by X-ray diffraction (XRD), transmission electron microscope (TEM), X-ray photoelectron spectroscopy, and CO2 temperature-programmed surface reaction techniques. The results suggested that the nickel-based catalyst prepared by plasma plus calcination method possessed a smaller particle size and a higher dispersion of active component, better low-temperature activity and enhanced anti-coking ability. The conversion of CO2 and CH4 was 90.70% and 89.37%, respectively, and the reaction lasted for 36 h without obvious deactivation under 101.325 kPa and 750°C with CO2/CH4 = 1/1. | Pan Qin Huiyuan Xu Huali Long Yi Ran Shuyong Shang Yongxiang Yin Xiaoyan Dai | 2011 | Journal of Natural Gas Chemistry2011，20，5： | 3 |
| 10 | Standard Protocol Items for Clinical Trials with Traditional Chinese Medicine 2018: Recommendations, Explanation and Elaboration(SPIRIT-TCM Extension 2018)显示文摘Traditional Chinese Medicine(TCM) is one of the oldest systems of medicine. More and more attention has been paid to TCM application, but the variable quality of clinical trials with TCM impedes its widespread acceptance. The Standard Protocol Items: Recommendations for Interventional Trials(SPIRIT) 2013 Statement has established guidelines for designing clinical trials to ensure that the trial results are accurate and reliable. However, there are difficulties when applying SPIRIT 2013 Statement to trials with TCM, due to the unique theory and the characteristic of TCM intervention. An Extension to the original SPIRIT was developed to ensure the quality of trial design with TCM. As Chinese herbal formulae, acupuncture and moxibustion are common and representative interventions in TCM practice, the executive working group determined that the SPIRIT-TCM Extension focus on these three interventions. Extension was developed through initiation, 3 rounds of Delphi consensus survey, and finalizing expert meeting. Seven items from the SPIRIT 2013 Statement were modified, namely, 'title', 'background and rationale', 'objectives', 'eligibility criteria', 'interventions', 'outcomes', and 'data collection methods'. The Extension includes the introduction of the concept of TCM pattern and 3 major TCM interventions, with examples and explanations. The SPIRIT-TCM Extension 2018 provides suggestion for investigators in designing high quality TCM clinical trials. It is expected that wide dissemination and application of this extension ensure continuous improvement of TCM trial quality throughout the world. | DAI Liang CHENG Chung-wah TIAN Ran ZHONG Linda LD LI You-ping LYU Ai-ping CHAN An-wen SHANG Hong-cai BIAN Zhao-xiang | 2019 | Chinese Journal of Integrative Medicine2019，25，1： | 2 |
| 11 | 亚热带森林植物群落沿海拔梯度的分类与系统发育研究显示文摘生物多样性沿海拔梯度的分布格局已受到广泛关注。然而,生物多样性格局沿海拔梯度的变异及其潜在机制尚不清楚。整合生物多样性的多维度信息为理解群落构建机制提供了新思路。本研究在我国东部亚热带森林沿海拔270-1470 m的梯度上设置了17个木本植物固定样地,分析了沿海拔梯度植物群落构建的生态和进化驱动力。基于样地内物种出现(0-1数据)和多度信息,计算群落内被子植物的物种和系统发育alpha和beta多样性、系统发育结构等,并量化多样性指标与微气候和地形之间的关系。研究发现,不论多度加权与否,物种alpha多样性均沿海拔升高而增加,物种和系统发育的相似性随海拔距离的增加而呈衰减趋势。然而,多度加权与否会形成不同的系统发育alpha多样性格局。对于系统发育结构而言,沿海拔增加并无明显趋势。地形和微气候是多样性格局和系统发育结构的主要驱动力。与未考虑物种多度的多样性指标相比,多度加权的指标与坡度和胸高断面积相关性更高。这些结果表明,由局域物种多度介导的确定性过程对沿海拔梯度的植物群落构建具有一定影响。 | Ran Zhang Zhaochen Zhang Kankan Shang Mingshui Zhao Jiaxin Kong Xin Wang Yuzhuo Wang Houjuan Song Oukai Zhang Xuan Lv Jian Zhang | 2021 | Journal of Plant Ecology2021，14，4： | 2 |
| 12 | Protective humoral immunity in SARS-CoV-2 infected pediatric patients显示文摘After the rapid spread of SARS-CoV-2 in Wuhan,China,at the beginning of 2020,about 1.5 million confirmed cases and over 80,000 deaths have been reported around 200 countries and territories all over the world and the number continues to increase.However,we still have limited knowledge of this new coronavirus,especially the interaction between SARS-CoV-2 and our immune system. | Yaguang Zhang Jin Xu Ran Jia Chunyan Yi Wangpeng Gu Pengcheng Liu Xinran Dong Hao Zhou Bo Shang Shipeng Cheng Xiaoyu Sun Jing Ye Xuezhen Li Jia Zhang Zhiyang Ling Liyan Ma Bingbing Wu Mei Zeng Wenhao Zhou Bing Sun | 2020 | Cellular & Molecular Immunology2020，17，7： | 2 |
| 13 | Preparation of carboxylmethylchitosan and alginate blend membrane for diffusion-controlled release of diclofenac diethylamine显示文摘Controlled drug release technology is becoming a commercially sound methodology of administering pharmaceutical therapies,and it is important to predict and control the release kinetics to fully take advantage of this technology.Carboxylmethylchitosan(CMCS)and alginate(SA)blend membranes were successfully prepared by solution casting technique and exposing to acetic acid atmosphere,which induced the protonation of the amino groups of CMCS,and the formation of polyelectrolyte composite hydrogels.By using diclofenac diethylamine as the model drug,the diffusion controlled drug release behaviors of the membranes were studied based on permeation experiment,which indicated that the swelling rates of the membranes could be adjusted by simply changing the weight ratio of CMCS/SA and effectively changed the release rate of the membrane.The study shows that CMCS/SA blend membranes are promising biomaterials used for modulating the permeation behavior and developing advanced drug delivery systems. | Xiaoxue Yuan Ran Liu Wenchang Zhang Xiaoqiang Song Lei Xu Yan Zhao Lei Shang Jingsong Zhang | 2021 | Journal of Materials Science & Technology2021，，4： | 1 |
| 14 | Fiber-optic Vector Vibroscope显示文摘 | Guo T Shang L B Ran Y | 2012 | Optics Letters2012，37，13： | 1 |
| 15 | Pig macrophages with site-specific edited CD163 decrease the susceptibility to infection with porcine reproductive and respiratory syndrome virus显示文摘Porcine reproductive and respiratory syndrome(PRRS)is recognized as one of the most infectious viral diseases of swine.Although Cluster of differentiation 163(CD163)is identified as an essential receptor for mediating PRRS virus(PRRSV)infection,the important residues involved in infection on CD163 are still unclear.Therefore,it is very important to identify these key residues to study the mechanism of PRRSV infection and to generate anti-PRRSV pigs.In this study,we first generated immortalized porcine alveolar macrophage(IPAM)cell lines harboring 40-residues(residues 523-562,including R561(arginine(R)at position 561))deletion of CD163.PRRSV infection experiments showed that these IPAM cell lines were completely resistant to PRRSV infection.We then generated cloned pigs carrying CD163-R561A(an arginine(R)to alanine(A)substitution at position 561 of CD163).PRRSV challenge experiments in porcine alveolar macrophages(PAMs)isolated from the CD163-R561A pigs showed significantly lower susceptibility to PRRSV than that of CD163-R561 PAMs.Through this study,we show that CD163523-562 contains essential residues for mediating PRRSV infection,and that CD163 R561 significantly contributes to PRRSV infection but is not essential for infection.These functional sites can therefore serve as new targets for understanding the mechanism of PRRSV infection.Furthermore,CD163-R561A pigs can be used as an important model for improving pig germplasm with resistance against PRRSV. | XU Kui ZHOU Yan-rong SHANG Hai-tao XU Chang-jiang TAO Ran HAO Wan-jun LIU Sha-sha MU Yu-lian XIAO Shao-bo LI Kui | 2023 | Journal of Integrative Agriculture2023，22，7： | 1 |
| 16 | Effect of the Wenchuan earthquake on habitat use patterns of the giant panda in the Minshan Mountains, southwestern China显示文摘 | Wen Zheng Yu Xu Lihuan Liao Xuyu Yang Xiaodong Gu Tao Shang Jianghong Ran | 2011 | Biological Conservation2011，，1： | 1 |
| 17 | Effects of PAC dosage in a pilot - scale PAC - MBR treating micro - pollu- ted surface water 显示文摘 | Hu Jingyi Shang Ran Deng Huiping | 2014 | Bioresource Technology2014，154，： | 1 |
| 18 | In situ resource utilization of lunar soil for highly efficient extraterrestrial fuel and oxygen supply显示文摘Building up a lunar settlement is the ultimate aim of lunar exploitation.Yet,limited fuel and oxygen supplies restrict human survival on the Moon.Herein,we demonstrate the in situ resource utilization of lunar soil for extraterrestrial fuel and oxygen production,which may power up our solely natural satellite and supply respiratory gas.Specifically,the lunar soil is loaded with Cu species and employed for electro catalytic CO_(2)conversion,demonstrating significant production of methane.In addition,the selected component in lunar soil(i.e.MgSiO_(3))loaded with Cu can reach a CH_(4)F aradaic efficiency of 72.05% with a CH_(4)production rate of 0.8 mL/min at 600 mA/cm^(2).Simultaneously,an O_(2)production rate of 2.3 mL/min can be achieved.Furthermore,we demonstrate that our developed process starting from catalyst preparation to electrocatalytic CO_(2)conversion is so accessible that it can be operated in an unmmaned manner via a robotic system.Such a highly efficient extraterrestrial fuel and oxygen production system is expected to push forward the development of mankind’s civilization toward an extraterrestrial settlement. | Yuan Zhong Jingxiang Low Qing Zhu Yawen Jiang Xiwen Yu Xinyu Wang Fei Zhang Weiwei Shang Ran Long Yingfang Yao Wei Yao Jun Jiang Yi Luo Weihua Wang Jinlong Yang Zhigang Zou Yujie Xiong | 2023 | National Science Review2023，10，2： | 1 |
| 19 | Release and Transformation of Nitrogen from Sediments during In Situ Treatment with Calcium Nitrate Injection for Odor Control显示文摘 | Yu Guang Wei Lin Pei Zhen Chong Yun Xiao Shang Zhong Bin Wei Ran | 2012 | Advanced Materials Research2012，，518： | 1 |
| 20 | Tanshinone II A attenua- tes elastase-induced AAA in rats via inhibition of MyD88-dependent TLR-4 signaling 显示文摘 | Shang T Ran F Qiao Q | 2014 | Vasa-European Journal of Vascular Medicine2014，43，1： | 1 |
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