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| 1 | A two-step lineage reprogramming strategy to generate functionally competent human hepatocytes from fibroblasts显示文摘Terminally differentiated cells can be generated by lineage reprogramming,which is,however,hindered by incomplete conversion with residual initial cell identity and partial functionality. Here, we demonstrate a new reprogramming strategy by mimicking the natural regeneration route, which permits generating expandable hepatic progenitor cells and functionally competent human hepatocytes. Fibroblasts were first induced into human hepatic progenitor-like cells (hHPLCs), which could robustly expand in vitro and efficiently engraft in vivo. Moreover, hHPLCs could be efficiently induced into mature human hepatocytes (hiHeps) in vitro, whose molecular identity highly resembles primary human hepatocytes (PHHs). Most importantly, hiHeps could be generated in large quantity and were functionally competent to replace PHHs for drug-metabolism estimation, toxicity prediction and hepatitis B virus infection modeling. Our results highlight the advantages of the progenitor stage for successful lineage reprogramming. This strategy is promising for generating other mature human cell types by lineage reprogramming. | Bingqing Xie Da Sun Yuanyuan Du Jun Jia Shicheng Sun Jun Xu Yifang Liu Chengang Xiang Sitong Chen Huangfan Xie Qiming Wang Guangya Li Xuehui LYU Hui Shen Shiyu Li Min Wu Xiaonan Zhang Yue Pu Kuanhui Xiang Weifeng Lai Peng Du Zhenghong Yuan Cheng Li Yan Shi Shichun Lu Hongkui Deng | 2019 | Cell Research2019，29，9： | 9 |
| 2 | Research of Electrochemical Noise Technology on Corrosion Resistance显示文摘This paper is focus on the corrosion resistance property analysis on three electric blasting of the coating-FeAl,FeCrAl,FeCrAlRE by electrochemical noise technology,acceleration of copper acetate salt spray accelerated corrosion test.According to a comparative analysis of three tests coated by the Impedance curve,FeCrAlRE coating power spectral density(SPD)curve and Power curve,FeAl,FeCrAlRE coating has two more notable for the corrosion resistance properties than FeAl,FeCrAl coatings. | Wei Shicheng Yi, Liang Yi, Liu Wang Yujing Xu Binshi | 2012 | 稀有金属材料与工程2012，41，S1： | 2 |
| 3 | Fluorination of ZnWO4 photocatalyst and influence on the degradation mechanism for 4-chlorophenol显示文摘 | Huang Guangli Zhang Shicheng Xu Tongguang et aI | 2008 | Eviron Sci Technol2008，42，： | 1 |
| 4 | Effect of heat treatment on microwave absorption properties of Ni-Zn-Mg-La ferrite nanopmlicles 显示文摘 | Yi Liu Shicheng Wei Binshi Xu | 2013 | Journal of Magnetism and Magnetic Materials2013，349，2014： | 1 |
| 5 | Fertilizer recommendation for maize in China based on yield response and agronomic efficiency显示文摘 | Xinpeng Xu Ping He Mirasol F. Pampolino Adrian M. Johnston Shaojun Qiu Shicheng Zhao Limin Chuan Wei Zhou | 2014 | Field Crops Research2014，，： | 1 |
| 6 | Nutrient requirements for maize in China based on QUEFTS analysis显示文摘 | Xinpeng Xu Ping He Mirasol F. Pampolino Limin Chuan Adrian M. Johnston Shaojun Qiu Shicheng Zhao Wei Zhou | 2013 | Field Crops Research2013，，： | 1 |
| 7 | Estimating nutrient uptake requirements for wheat in China显示文摘 | Limin Chuan Ping He Jiyun Jin Shutian Li Cynthia Grant Xinpeng Xu Shaojun Qiu Shicheng Zhao Wei Zhou | 2013 | Field Crops Research2013，，： | 1 |
| 8 | Puerarin blocks the signaling transmission mediated by P2X 3 in SG and DRG to relieve myocardial ischemic damage显示文摘 | Shuangmei Liu Chunping Zhang Qingming Shi Guilin Li Miaomiao Song Yun Gao Changshui Xu Hong Xu Bo Fan Shicheng Yu Chaoran Zheng Qicheng Zhu Bing Wu Lichao Peng Huangui Xiong Qin Wu Shangdong Liang | 2014 | Brain Research Bulletin2014，，： | 1 |
| 9 | Fabrication and photoelectrochemical properties of porous ZnWO 4 film显示文摘 | Xu Zhao Wenqing Yao Yan Wu Shicheng Zhang Haipeng Yang Yongfa Zhu | 2006 | Journal of Solid State Chemistry2006，，8： | 1 |
| 10 | Elec- trochemical tuning of vertically aligned MoS2 nanofilms and its application in improving hydrogen evolution re- action显示文摘 | WANG Haotian LU Zhiyi XU Shicheng | 2013 | PANS2013，110，19： | 1 |
| 11 | Fretting Corrosion Behavior of Zn-Al-Mg-RE Coating under Dry Friction and NaCl Solution显示文摘The fretting behavior of Zn-Al-Mg-RE coating prepared by high velocity arc spraying was studied for the first time in this paper.All specimens were fretted in air and 3.5%NaCl solution independently.The worn surfaces of the coating were investigated by scanning electron microscopy and X-ray energy dispersive spectroscopy.Fretting tests have shown that friction coefficient in 3.5%NaCl solution was similar to dry condition for Zn-Al-Mg-RE coating.Study of worn surfaces revealed the main mechanism in dry friction was the oxidative wear;while in 3.5%NaCl solution,the main mechanisms were delamination process and abrasive wear. | Yi, Liu Xu Binshi Wei Shicheng Wang Yujiang Yi, Liang | 2012 | 稀有金属材料与工程2012，41，S1： | 1 |
| 12 | Nutrient requirements for maize in China based on QUEFTS analysis显示文摘 | Xinpeng Xu Ping He Mirasol F. Pampolino Limin Chuan Adrian M. Johnston Shaojun Qiu Shicheng Zhao Wei Zhou | 2013 | Field Crops Research2013，，： | 1 |
| 13 | Estimating nutrient uptake requirements for wheat in China显示文摘 | Limin Chuan Ping He Jiyun Jin Shutian Li Cynthia Grant Xinpeng Xu Shaojun Qiu Shicheng Zhao Wei Zhou | 2013 | Field Crops Research2013，，： | 1 |
| 14 | Catalytic Performance of Manganese Cobalt Oxides on Methane Combustion at Low Temperature显示文摘 | Li Junhua Liang Xing Xu Shicheng | 2009 | Appl Catal B2009，90，12： | 1 |
| 15 | Comparison on performance of electro-thermal explosion plasma spraying FeAl-based coatings 显示文摘 | Wei Shicheng Xu Binshi Wang Haidou | 2007 | Surface and Coatings Technology2007，210，911： | 1 |
| 16 | Effects of support acidity on the reaction mechanisms of selective catalytic reduction of NO by CH_(4) in excess oxygen显示文摘The reaction mechanisms of selective catalytic reduction(SCR)of nitric oxide(NO)by methane(CH4)over solid superacid-based catalysts were proposed and testified by DRIFTS studies on transient reaction as well as by kinetic models.Catalysts derived from different supports would lead to different reaction pathways,and the acidity of solid superacid played an important role in determining the reaction mechanisms and the catalytic activities.Higher ratios of BrØnsted acid sites to Lewis acid sites would lead to stronger oxidation of methane and then could facilitate the step of methane activation.Strong BrØnsted acid sites would not necessarily lead to better catalytic performance,however,since the active surface NO_(y) species and the corresponding reaction routes were determined by the overall acidity strength of the support.The reaction routes where NO_(2)moiety was engaged as an important intermediate involved moderate oxidation of methane,the rate of which could determine the overall activity.The reaction involving NO moiety was likely to be determined by the step of reduction of NO.Therefore,to enhance the SCR activity of solid superacid catalysts,reactions between appropriate couples of active NO_(y)species and activated hydrocarbon intermediates should be realized by modification of the support acidity. | Shicheng XU Junhua LI Dong YANG Jiming HAO | 2009 | Frontiers of Environmental Science & Engineering2009，3，2： | 1 |
| 17 | Non-small molecule PROTACs(NSM-PROTACs):Protein degradation kaleidoscope显示文摘The proteolysis targeting chimeras(PROTACs)technology has been rapidly developed since its birth in 2001,attracting rapidly growing attention of scientific institutes and pharmaceutical companies.At present,a variety of small molecule PROTACs have entered the clinical trial.However,as small molecule PROTACs flourish,non-small molecule PROTACs(NSM-PROTACs)such as peptide PROTACs,nucleic acid PROTACs and antibody PROTACs have also advanced considerably over recent years,exhibiting the unique characters beyond the small molecule PROTACs.Here,we briefly introduce the types of NSM-PROTACs,describe the advantages of NSM-PROTACs,and summarize the development of NSM-PROTACs so far in detail.We hope this article could not only provide useful insights into NSM-PROTACs,but also expand the research interest of NSM-PROTACs. | Sinan Ma Jianai Ji Yuanyuan Tong Yuxuan Zhu Junwei Dou Xian Zhang Shicheng Xu Tianbao Zhu Xiaoli Xu Qidong You Zhengyu Jiang | 2022 | Acta Pharmaceutica Sinica B2022，12，7： | 1 |
| 18 | Novel role of LINC01013/miR-6795-5p/FMNL3 axis in the regulation of hepatocellular carcinoma stem cell features显示文摘Cancer stem cells(CSCs)are major contributors to tumor initiation,recurrence,and metastasis of hepatocellular carcinoma(HCC).Some long non-coding RNAs have been reported as modulators of stem-like properties in cancer cells.However,the role of LINC01013 in liver CSCs has not yet been clarified.In this study,we aimed to elucidate the expression pattern and functions of LINC01013 in HCC.HCC tissues and normal controls were collected,and the expression pattern of LINC01013 and miR-6795-5p was identified by quick real-time polymerase chain reaction.Cell counting kit-8 assay,colony formation,and spheroid formation were performed to measure cell viability,proliferation,and self-renewal of HCC cell lines.The expression of stem markers was detected by western blot analysis.The effect of LINC01013 on viability,proliferation,and stem-like properties was detected through gain-of-function and loss-of-function experiments.The direct interaction among LINC01013,miR-6795-5p,and FMNL3 was testified by dual-luciferase reporter gene assay.Tumor-bearing mice were constructed to ascertain the functions of LINC01013 in vivo.HCC tissues showed increased LINC01013 and FMNL3 expression,while it showed a decreased miR-6795-5p expression as compared to the relative controls.Moreover,the high level of LINC01013 was closely related to the poor prognosis of HCC patients.LINC01013 directly binds to miR-6795-5p and subsequently relieves FMNL3.Silencing LINC01013,FMNL3,or overexpression of miR-6795-5p could suppress spheroid and colony formation,proliferation,as well as expression of stemness markers in HepG2 and SNU-182 cells.LINC01013 knockdown suppressed growth and stem-like traits of HCC cells in vivo by reducing FMNL3 expression.LINC01013/miR-6795-5p/FMNL3 axis may be a novel therapeutic target for HCC. | Wanli Wang Shicheng Xu Ying Di Zhiyong Zhang Qingshan Li Kun Guo Yi Lv Bo Wang | 2021 | Acta Biochimica et Biophysica Sinica2021，53，6： | 1 |
| 19 | Studies on the micellization and intermicellar interaction of CTAB in dilute solution显示文摘 | Haiyang Yang Shicheng Zhang He Liu Xiaoyun Xu Jing Zhang Pingsheng He | 2005 | Journal of Materials Science2005，，17： | 1 |
| 20 | Computer-Based Medical Systems显示文摘 | Wang Kuanquan Zhang Shicheng | 2002 | Proceedings of the 15th IEEE Symposium on Volume2002，，202： | 1 |
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