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| 1 | Combination of graphene oxide and platelet-rich plasma improves tendon-bone healing in a rabbit model of supraspinatus tendon reconstruction显示文摘The treatment of rotator cuff tear is one of the major challenges for orthopedic surgeons.The key to treatment is the reconstruction of the tendon-bone interface(TBI).Autologous platelet-rich plasma(PRP)is used as a therapeutic agent to accelerate the healing of tendons,as it contains a variety of growth factors and is easy to prepare.Graphene oxide(GO)is known to improve the physical properties of biomaterials and promote tissue repair.In this study,PRP gels containing various concentrations of GO were prepared to promote TBI healing and supraspinatus tendon reconstruction in a rabbit model.The incorporation of GO improved the ultrastructure and mechanical properties of the PRP gels.The gels containing 0.5 mg/ml GO(0.5 GO/PRP)continuously released transforming growth factor-b1(TGF-b1)and platelet-derived growth factor(PDGF)-AB,and the released TGF-b1 and PDGF-AB were still at high concentrations,1063.451 pg/ml and814.217 pg/ml,respectively,on the 14th day.In vitro assays showed that the 0.5 GO/PRP gels had good biocompatibility and promoted bone marrow mesenchymal stem cells proliferation and osteogenic and chondrogenic differentiation.After 12 weeks of implantation,the magnetic resonance imaging,microcomputed tomography and histological results indicated that the newly regenerated tendons in the 0.5 GO/PRP group had a similar structure to natural tendons.Moreover,the biomechanical results showed that the newly formed tendons in the 0.5 GO/PRP group had better biomechanical properties compared to those in the other groups,and had more stable TBI tissue.Therefore,the combination of PRP and GO has the potential to be a powerful advancement in the treatment of rotator cuff injuries. | Dingsu Bao Jiacheng Sun Min Gong Jie Shi Bo Qin Kai Deng Gang Liu Shengqiang Zeng Zhou Xiang Shijie Fu | 2021 | Regenerative Biomaterials2021，8，6： | 4 |
| 2 | CO flux of soil respiration in natural recovering karst abandoned farmland in Southwest China显示文摘To estimate carbon sequestration potential in the karst area,soil respiration in a natural recovering karst abandoned farmland in Shawan,Puding,Guizhou,southwest China was continuously and automatically monitored for more than two years.The results show that the CO2flux of soil respiration(2.63±1.89 lmol m^-2s-^1)is higher in the karst area than in non-karst areas under similar conditions but that regional value(1.32 lmol m-2s-1)is lower because of larger rock fragment coverage(~50%).A the same time,the temperature sensitivity of soil respiration(Q10)in this study area is significantly higher than that of non-karst areas under similar conditions.Soil respiration has an obvious temporal variation,which is reflected in a significant exponential relationship between soil respiration and soil temperature,but the relationship between soil respiration and soil moisture is very complex.Especially soil respiration has an obvious spatial variation,which is likely affected by different diffusion or water-rock reaction processes. | Yanwei Wang Weijun Luo Guangneng Zeng Hanling Yang Meifang Wang Yina Lyu Anyun Cheng Lin Zhang Xianli Cai Jia Chen Shijie Wang | 2020 | Acta Geochimica2020，39，4： | 2 |
| 3 | Effects of oxygen and moisture on the I-V characteristics of TiO_(2) thin films显示文摘Current-voltage(I-V)characteristics well reveal the resistive switching performance of materials promising for the next-generation memory-resistance random access memory(ReRAM).It has been observed that the atmospheric environment can affect the resistive switching performance,but the origin of this effect is still under debate.Conductive Atomic Force Microscopy(c-AFM)is widely used to study the resistive switching performance because of its capability to realize the resistive switching at the nanoscale that is becoming attractive as the miniaturization of memory devices.This study therefore aims to understand the effects of oxygen and moisture on the I-V characteristics of the TiO_(2)thin film by performing c-AFM measurements in ambient air,synthetic air,and argon gas.It is found that the oxygen in the environment can reduce the set and the reset voltages for the resistive switching,and it can also reduce the resistance at the low resistance state(LRS).Where the moisture in the environment can increase the set and reset voltages,and increase the resistance at LRS.These effects of oxygen and moisture in the environment can be attributed to the modification of the effective electric field during the resistive switching processes,which have been further confirmed by Kelvin Probe Force Microscopy(KPFM)measurements.In addition,it is found that the local ionic dynamics of TiO_(2)during the resistive switching are strongly dependent of the environments by performing the FORC-IV(First Order Reversal Curve-Current-Voltage)measurements in the three gas environments.Results in this work can provide a new perspective on the effect of environments on the resistive switching of materials,that is,the modulation of the effective electric field due to the adsorption of oxygen and moisture under the c-AFM tip. | Wanheng Lu Lai-Mun Wong Shijie Wang Kaiyang Zeng | 2018 | Journal of Materiomics2018，4，3： | 2 |
| 4 | Embedded BCI Rehabilitation System for Stroke显示文摘In stroke rehabilitation,rehabilitation equipments can help with the training.But traditional equipments are not convenient to carry,which limits patients to use related rehabilitation techniques.To solve this kind of problem,a new embedded rehabilitation system based on brain computer interface(BCI)is proposed in this paper.The system is based on motor imagery(MI)therapy,in which electroencephalogram(EEG)is evoked by grasping motor imageries of left and right hands,then collected by a wearable device.The EEG is transmitted to a Raspberry Pie processing unit through Bluetooth and decoded as the instructions to control the equipment extension.Users experience the limb movement through the visual feedback so as to achieve active rehabilitation.A pilot study shows that the user can control the movement of the rehabilitation equipment through his mind,and the equipment is convenient to carry.The study provides a new way to stroke rehabilitation. | Wanzeng Kong Siman Fu Bin Deng Hong Zeng Jianhai Zhang Shijie Guo | 2019 | Journal of Beijing Institute of Technology2019，28，1： | 2 |
| 5 | Seismic experimental study on a concrete pylon from a typical medium span cable-stayed bridge显示文摘 | Yan XU Shijie ZENG Xinzhi DUAN Dongbing JI | 2018 | Frontiers of Structural and Civil Engineering2018，12，3： | 2 |
| 6 | Local phenomena at grain boundaries:An alternative approach to grasp the role of oxygen vacancies in metallization of VO_(2)显示文摘Vanadium dioxide(VO_(2))undergoes an insulator to metal transition(MIT)and an accompanied phase transition from a monoclinic(M)structure to rutile(R)structure near room temperature,forming the basis for many VO_(2)-based functional devices.The MIT transition of VO_(2)and the functionality of VO_(2)-based devices can be controlled by a variety of chemical and physical stimuli.With these external stimuli,defects,such as oxygen vacancies,are often inevitably introduced.However,due to the VeO systeminduced challenge to synthesize stable VO_(2)with different oxygen vacancy concentrations,the impact of oxygen vacancies on the resistance and transition of the VO_(2)is not fully understood.Oxygen vacancy,as one of the typical defects in VO_(2),is expected to concentrate at grain boundaries,and hence a concentration gradient of oxygen vacancies may exist between the grains interior and the boundaries,and this suggests a possibility to study the effects of oxygen vacancies on the transition of VO_(2)by probing local phenomena at the grain boundaries.For investigating local phenomena at the grain boundaries,Scanning Probe Microscopy(SPM)techniques are effective,which allows probing the structure and various properties at the nanoscale.In this work,a series of SPM techniques,including Atomic Force Microscopy(AFM),conductive-AFM(c-AFM),Electrochemical Strain Microscopy(ESM),and Kelvin Probe Force Microscopy(KPFM),are employed to measure variations of the surface structure,the resistance,the oxygen vacancy concentration,and the work function between the grain interior and the grain boundary.It has been demonstrated that,for most cases,both the resistance and the work function are lower at the grain boundaries as a result of the accumulation of oxygen vacancies at those positions.In addition,the resistance change induced by the electric field has been observed in the deposited VO_(2)thin films,which may be associated with the generation/annihilation of the oxygen vacancies,rather than charge injection.This work has demonstrated the effects of oxygen vacancies in the transition of VO_(2)by probing the local phenomena at grain boundaries,also provided a new insight into the resistance change of VO_(2)under an electric field. | Wanheng Lu Lai-Mun Wong Shijie Wang Kaiyang Zeng | 2018 | Journal of Materiomics2018，4，4： | 2 |
| 7 | Effect of different land use/land cover on karst hydrogeochemistry: A paired catchment study of Chenqi and Dengzhanhe, Puding, Guizhou, SW China显示文摘 | Min Zhao Cheng Zeng Zaihua Liu Shijie Wang | 2010 | Journal of Hydrology2010，，1： | 1 |
| 8 | A new π-conjugated star-shaped polymer comprising of full fluorene units: An efficient blue emitter without reduction of color purity undergoing an annealing显示文摘 | Shijie Ren Jiangong Cheng Danli Zeng Wenqing Zhu Jing Sun Junping Du Erjian Xu Hongliang Zhong Yingchun Liu Qiang Fang | 2008 | Synthetic Metals2008，，1： | 1 |
| 9 | Dual-Functional Organotelluride Additive for Highly Efficient Sulfur Redox Kinetics and Lithium Regulation in Lithium–Sulfur Batteries显示文摘High energy density and low cost made lithium–sulfur(Li–S)batteries appealing for the next-generation energy storage devices.However,their commercial viability is seriously challenged by serious polysulfide shuttle effect,sluggish sulfur kinetics,and uncontrollable dendritic Li growth.Herein,a dual-functional electrolyte additive,diphenyl ditelluride(DPDTe)is reported for Li–S battery.For sulfur cathodes,DPDTe works as a redox mediator to accelerate redox kinetics of sulfur,in which Te radical-mediated catalytic cycle at the solid–liquid interface contributes significantly to the whole process.For lithium anodes,DPDTe can react with lithium metal to form a smooth and stable organic–inorganic hybrid solid-electrolyte interphase(SEI),enabling homogeneous lithium deposition for suppressing dendrite growth.Consequently,the Li–S battery with DPDTe exhibits remarkable cycling stability and superb rate capability,with a high capacity up to 1227.3 mAh g^(-1)and stable cycling over 300 cycles.Moreover,a Li–S pouch cell with DPDTe is evaluated as the proof of concept.This work demonstrates that organotelluride compounds can be used as functional electrolyte additives and offers new insights and opportunities for practical Li–S batteries. | Wei Zhang Fenfen Ma Qiang Wu Ziqi Zeng Wei Zhong Shijie Cheng Xin Chen Jia Xie | 2023 | Energy & Environmental Materials2023，6，3： | 1 |
| 10 | 1,3,5-Trifluorobenzene endorsed EC-free electrolyte for high-voltage and wide-temperature lithium-ion batteries显示文摘Ethylene carbonate(EC)is susceptible to the aggressive chemistry of nickel-rich cathodes,making it undesirable for high-voltage lithium-ion batteries(LIBs).The arbitrary elimination of EC leads to better oxidative tolerance but always incurs interfacial degradation and electrolyte decomposition.Herein,an EC-free electrolyte is deliberately developed based on gradient solvation by pairing solvation-protection agent(1,3,5-trifluorobenzene,F_(3)B)with propylene carbonate(PC)/methyl ethyl carbonate(EMC)formulation.F_(3)B keeps out of inner coordination shell but decomposes preferentially to construct robust interphase,inhibiting solvent decomposition and electrode corrosion.Thereby,the optimized electrolyte(1.1 M)with wide liquid range(-70–77℃)conveys decent interfacial compatibility and high-voltage stability(4.6 V for LiNi_(0.6)Mn_(0.2)Co_(0.2)O_(2),NCM622),qualifying reliable operation of practical NCM/graphite pouch cell(81.1%capacity retention over 600 cycles at 0.5 C).The solvation preservation and interface protection from F_(3)B blaze a new avenue for developing high-voltage electrolytes in next-generation LIBs. | Mingsheng Qin Ziqi Zeng Qiang Wu Xiaowei Liu Qijun Liu Shijie Cheng Jia Xie | 2023 | Journal of Energy Chemistry2023，，10： | 1 |
| 11 | A New Sen- sor for Copper ( II ) Ion Based on Carboxyl Acid Groups Substituted Polyfluoreneethynylene 显示文摘 | Zeng Danli Cheng Jiangong Shijie Ren | 2008 | Reactive & Func- tional Polymers2008，68，： | 1 |
| 12 | Intelligent Predetermination of Generator Tripping Scheme: Knowledge Fusion-based Deep Reinforcement Learning Framework显示文摘Generator tripping scheme(GTS)is the most commonly used scheme to prevent power systems from losing safety and stability.Usually,GTS is composed of offline predetermination and real-time scenario match.However,it is extremely time-consuming and labor-intensive for manual predetermination for a large-scale modern power system.To improve efficiency of predetermination,this paper proposes a framework of knowledge fusion-based deep reinforcement learning(KF-DRL)for intelligent predetermination of GTS.First,the Markov Decision Process(MDP)for GTS problem is formulated based on transient instability events.Then,linear action space is developed to reduce dimensionality of action space for multiple controllable generators.Especially,KF-DRL leverages domain knowledge about GTS to mask invalid actions during the decision-making process.This can enhance the efficiency and learning process.Moreover,the graph convolutional network(GCN)is introduced to the policy network for enhanced learning ability.Numerical simulation results obtained on New England power system demonstrate superiority of the proposed KF-DRL framework for GTS over the purely data-driven DRL method. | Lingkang Zeng Wei Yao Ze Hu Hang Shuai Zhouping Li Jinyu Wen Shijie Cheng | 2024 | CSEE Journal of Power and Energy Systems2024，10，1： | 0 |
| 13 | BASIN-RANGE SYSTEM EVOLUTION OF QINLING-DABIE OROGENIC BELT AND ITS IMPACT ON REGIONAL ENVIRONMENT显示文摘As the structural body related to temporal-spatial evolution and tectonic dynamic system, the orogenic belt and basin are not only dependent on each other in space but also closely related with each other in terms of infrastructure, matter transference and dynamic mechanisms. By using apatite fission-track method, the authors firstly analyze the uplift and denudation ratios of the Qinling-Dabie orogenic belt, and by using tectonically deformed combination analysis and tectonic-thermal simulation the main geological occurrences are also illustrated. It is found that there must have had multi-phase differential uplift and denudation phenomena in the Qinling-Dabie orogenic belt during the Mesozoic-Cenozoic. Then, the regional evolution pattern of qualitative and quantitative denudation process is obtained during the post-orogenic period. On the basis of summarizing evolution process of the basin-range system in the Qinling-Dabie orogenic belt during the Mesozoic-Cenozoic and its effects on regional environment, the influence of evolution process on geomorphologic landscapes change, water system vicissitude, eco-environment succession and drainage basin system evolution is discussed. | HU Baoqing ZENG Qiaosong LIU Shunsheng WANG Shijie | 2004 | Geotectonica et Metallogenia2004，28，1： | 0 |
| 14 | Challenges and strategies of formulating low-temperature electrolytes in lithium-ion batteries显示文摘Lithium-ion batteries(LIBs)have monopolized energy storage markets in modern society.The reliable operation of LIBs at cold condition(<0°C),nevertheless,is inevitably hampered by the sluggish kinetics and parasite reactions,which falls behind the increasing demands for portable electronics and electric vehicles.The electrolyte controls both Li+transport and interfacial reaction,dictating the low-temperature performance substantially.Therefore,the rational formulation of electrolytes is significant for realizing superior lowtemperature performance and broadening application niches of LIBs.Herein,we first discuss the kinetic limitations of low-temperature LIBs,highlighting the importance of electrolyte structure and interfacial chemistry.Then,the advancements for formulating subzero-temperature electrolyte are summarized with in-depth discussions about electrolyte formulation,solvation structure,interfacial chemistry,and low-temperature behaviors.Moreover,some opportunities for lithium metal batteries and the corresponding lowtemperature electrolyte are covered.Finally,the major challenges and future perspectives are outlined for low-temperature LIBs. | Mingsheng Qin Ziqi Zeng Shijie Cheng Jia Xie | 2023 | Interdisciplinary Materials2023，2，2： | 0 |
| 15 | Loosely coordinating diluted highly concentrated electrolyte toward -60℃ Li metal batteries显示文摘Lithium metal batteries(LMBs) promise energy density over 400 Wh kg^(-1).However,they suffer severe electrochemical performance deterioration at sub-zero temperatures.Such failure behavior highly correlates to inferior lithium metal anode(LMA) compatibility and sluggish Li^(+) desolvation.Here,we demonstrate that cyclopentylmethyl ether(CPME) based diluted high-concentration electrolyte(DHCE)enables-60℃ LMBs operation.By leveraging the loose coordination between Li^(+) and CPME,such developed electrolyte boosts the formation of ion clusters to derive anion-dominant interfacial chemistry for enhancing LMA compatibility and greatly accelerates Li^(+) desolvation kinetics.The resulting electrolyte demonstrates high Coulombic efficiencies(CE),providing over 99.5%,99.1%,98.5% and 95% at 25,-20,-40,and-60℃respectively.The assembled Li-S battery exhibits remarkable cyclic stability in-20,and-40℃ at 0.2 C charging and 0.5 C discharging.Even at-60℃,Li-S cell with this designed electrolyte retains> 70% of the initial capacity over 170 cycles.Besides,lithium metal coin cell and pouch cell with10 mg cm^(-2) high S cathode loading exhibit cycling stability at-20℃.This work offers an opportunity for rational designing electrolytes toward low temperature LMBs. | Han Zhang Ziqi Zeng Qiang Wu Xinlan Wang Mingsheng Qin Sheng Lei Shijie Cheng Jia Xie | 2024 | Journal of Energy Chemistry2024，90，3： | 0 |
| 16 | A Novel Method for the Prenatal Diagnosis of Cleft Palate Based on Amniotic Fluid Metabolites显示文摘Background and purpose The prenatal diagnosis of cleft palate is an important component of sequential therapy,but the relevant diagnostic methods are still limited.We aimed here,to explore the possibility of an early prenatal diagnosis of cleft palate by assessing metabolites in pregnant mice.Methods Twenty-four inseminated females were randomly divided into retinoic acid(RA)-treated(treated with retinoic acid at 10.5 gestation days)and control groups.The metabolites of the embryonic palatal tissue,maternal amniotic fluid,and serum were characterized using 9.4T magnetic resonance spectroscopy in vitro.Then,a predictive model was established through the principal component analysis(PCA),and the correlations between the metabolites of amniotic fluid and palatal tissue were explored using orthogonal-2 partial least squares(O2-PLS).Results The incidences of cleft palate were 100%and 0%in the RA-treated and control groups,respectively.A predictive PCA model with a high specificity and sensitivity was established for the early prenatal diagnosis of isolated cleft palate using amniotic fluid metabolic data.Between RA-treated and control mice,we found that two metabolites in the amniotic fluid and palatal tissue were correlated.Creatinine showed the same trend in the palatal tissue and amniotic fluid,while choline showed opposite trends in the two tissues.However,the data for serum metabolites could not be used to establish a prediction model.Conclusion This study indicates that assessing the metabolites of amniotic fluid is a potential approach for the prenatal diagnosis of isolated cleft palate. | Wancong ZHANG Lewen JIANG Zhiwei SHEN Jiasheng CHEN Xiaoping ZHONG Weiping ZENG Jianda ZHOU Zhihao HE Shijie TANG | 2020 | Chinese Journal Of Plastic and Reconstructive Surgery2020，2，2： | 0 |
| 17 | High-safety and high-voltage lithium metal batteries enabled by nonflammable diluted highly concentrated electrolyte显示文摘Lithium metal batteries(LMBs)show great promise for achieving energy densities over 400 Wh·kg^(-1).However,highly flammable organic electrolytes are a long-lasting problem that triggers safety hazards and hinders the commercial application of LMBs.Here,a nonflammable diluted highly concentrated electrolyte(DHCE)with ethoxy(pentafluoro)cyclotriphosphazene(PFPN)as a diluent is developed to simultaneously achieve high safety and cycling stability of high-voltage LMBs.The optimal DHCE not only ensures reversible Li deposition/dissolution behavior with a superior average Coulombic efficiency(CE)over 99.1%on lithium metal anode(LMA),but also suppresses side reactions and stress crack on the LiCoO_(2)(LCO)under high cut-off voltage.The newly developed DHCE exhibits high thermal stability,showing complete nonflammability and reduced heat generation between the electrolyte and delithiated LCO/cycled LMA.This work offers an opportunity for rational designing nonflammable electrolytes toward high-voltage and safe LMBs. | Han Zhang Ziqi Zeng Shuping Wang Yuanke Wu Changhao Li Mengchuang Liu Xinlan Wang Shijie Cheng Jia Xie | 2024 | Nano Research2024，17，4： | 0 |
| 18 | A model cathode for mechanistic study of organosulfide electrochemistry in Li-organosulfide batteries显示文摘Organosulfides offer new opportunities for high performance lithium-sulfur(Li-S)batteries because of materials abundance,versatile structures and unique properties.Yet,their redox kinetics as well as cycling performance need to be further improved.Employing redox mediators is a highly effective strategy to address above challenges.However,the underlying mechanism in this chemistry is so far insufficiently explored.Here,phenyl disulfide(Ph S–SPh)and phenyl diselenide(Ph Se–Se Ph)are used as a model system for mechanistic understanding of organosulfide electrochemistry,particularly the rate acceleration.Profiling the reaction thermodynamics and charge-discharge process reveals redox of both S–S and C–S bonds,as well as that the coupling between radical exchange and electrochemical redox is the key to enhance the sulfur kinetics.This study not only establishes a basic understanding of orgaonsulfide electrochemistry in Li-S batteries,but also points out a general strategy for enhancing the kinetics of sulfur electrodes in electrochemical devices. | Wei Zhang Fenfen Ma Sibei Guo Xin Chen Ziqi Zeng Qiang Wu Shuping Li Shijie Cheng Jia Xie | 2022 | Journal of Energy Chemistry2022，31，3： | 0 |
| 19 | Detrital Zircon U-Pb Dating of Nanshuangyashan Formation in the Jiamusi Massif, NE China and its Tectonic Implications显示文摘A suite of the fossil-rich marine-land interbedded strata(Nanshuangyashan Formation) is distributed at the eastern margin of the Jiamusi massif in the eastern Heilongjiang Province, NE China. The authors had recently discovered a suite of arkose beneath the marine-land interbedded strata, which overlays unconformably on the Permain granite in the eastern margin of the Jiamusi massif. The LA-ICP-MS zircon U-Pb dating indicate that all detrital zircons from the analysed four arkose samples show the four population ages of >800 Ma, 538-481 Ma, 269-250 Ma and 223-215 Ma. The former three population ages are widely recorded in the Jiamusi-Khanka massif and the Songnen massif. The later group is the minimal age population in the analyzed samples, limiting the sedimentation time of the arkoses occurred after the Late Triassic. At present, the minimal age population is not recorded in the Jiamusi massif, but the granites with the ages of 228-210 Ma are widely distributed in the Songnen-Zhangguangcai Range massif and the Khanka massif. The predominantly Permian zircons are characterized by oscillatory zoning and euhedral shapes, with variable zircon εHf(t) values(-5.5 to +11.2), indicating that they were derived from mixture sources, possibly mixed with components of the Songnen-Zhangguangcai Range massif and the Jiamusi-Khanka massif. These results, combined with regional analyses, indicate that the closing of Mudanjiang ocean and Panthalassa ocean possibly existed from Early Permian to Late Triassic. | CUI Weilong ZENG Zhen ZHANG Xingzhou LIU Zhenghong WANG Shijie PU Jianbin FU Qiulin GUO Ye | 2019 | Acta Geologica Sinica(English Edition)2019，93，5： | 0 |
| 20 | Chemokine Ligand 13 Expression is Abundant in the Tumor Microenvironment and Indicates Poor Prognosis of Kidney Clear Cell Carcinoma显示文摘The chemokine ligand 13-chemokine receptor 5(CXCL13-CXCR5)axis has been characterized as a critical tumor-promoting signaling pathway in the tumor microenvironment(TME)in multiple types of solid tumors.In this study,we analyzed the expression profile of CXCL13 in kidney clear cell carcinoma(KIRC)and its correlation with tumor-infiltrating immune cells(TIICs).A monoclonal antibody against CXCL13 with high affinity and purity was generated in our lab for western blot and immunohistochemistry(IHC).Bioinformatic analysis was performed based on bulk-seq data from the Cancer Genome Atlas(TCGA)-KIRC and single-cell RNA-seq data from scRNASeqDB and PanglaoDB.Results showed that high CXCL13 expression in TME was associated with shorter progression-free survival(PFS),disease-specific survival(DSS),and overall survival(OS).KIRC cell lines,as well as several other cancer cell lines,had negative CXCL13 expression.IHC staining from the Human Protein Atlas(HPA)and our tissue array indicated that CXCL13 might be mainly expressed by TIICs,but not KIRC tumor cells.CXCL13 expression was strongly and positively correlated withγδT cell abundance in TME.Besides,γδT cell infiltration was associated with poor survival of KIRC.Methylation 450k array data showed that CXCL13 promoter hypomethylation was common in TIICs.The methylation level of cg16361705 within the CXCL13 promoter might play an important role in modulating CXCL13 transcription.In conclusion,our study revealed that CXCL13 expression andγδT cell infiltration in TME is associated with unfavorable survival of KIRC.TIICs,most possiblyγδT cells,are the dominant source of CXCL13 in KIRC TME. | MENGDAN WU MENGYAO SUN QINHUAI LAI YIN LU YUYIN FU YUJIA PENG WEIRONG LAI LISHI ZENG SHENGYAN ZHAO YUYAN LI ZHIXIONG ZHANG XIAOFENG CHEN FAN QIAO YIWEN ZHANG SHIJIE ZHOU LANTU GOU JINLIANG YANG | 2021 | BIOCELL2021，45，3： | 0 |
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