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| 1 | Causal role of Helicobacter pylori infection and eradication therapy in gastric carcinogenesis显示文摘许多流行病学的报告显示感染玩的那 Helicobacter pylori (H pylori ) 在胃的致癌作用的一个重要角色。几基因、渐成说的改变以一种多步方式贡献癌症房间的开始,提升,和前进。H pylori 被知道在胃粘膜导致慢性炎。包括超级氧化物,它的产品参予开始跟随的 DNA 损坏,并且导出发炎的 cytokines 和生长因素贡献胃的致癌作用的提升。由根除 H pylori,胃的发炎能被治好;治疗减少不仅煽动性的房间渗入,而且 atrophy/intestinal 组织变形的层次部分地。使随机化的控制试用表明根除治疗减少了在没有癌症前期的条件的情况中的胃的癌症流行。另外,从日本组的最近的流行病学的研究证明特别肠的类型,胃的癌症的发展被成功的根除治疗减少,尽管这些以一种非使随机化的方式被设计。然而,内视镜的察觉是评估胃的致癌作用的度的唯一的方法,这应该被提及。我们报导了内视镜、组织学的形态学能被根除治疗修改,它可能贡献胃的癌症开发的流行。就癌症房间增长的生物性质而言,足够地长期的后续将是必要的讨论根除治疗的反癌症效果,这被考虑。 | Masanori Ito Shinji Tanaka Tomoari Kamada Ken Haruma Kazuaki Chayama | 2006 | World Journal of Gastroenterology2006，12，1： | 7 |
| 2 | Japanese Society for Cancer of the Colon and Rectum (JSCCR) guidelines 2010 for the treatment of colorectal cancer显示文摘 | Toshiaki Watanabe Michio Itabashi Yasuhiro Shimada Shinji Tanaka Yoshinori Ito Yoichi Ajioka Tetsuya Hamaguchi Ichinosuke Hyodo Masahiro Igarashi Hideyuki Ishida Megumi Ishiguro Yukihide Kanemitsu Norihiro Kokudo Kei Muro Atsushi Ochiai Masahiko Oguchi Ya | 2012 | International Journal of Clinical Oncology2012，，1： | 5 |
| 3 | Serum Mac-2 binding protein is a novel biomarker for chronic pancreatitis显示文摘AIM: To determine the efficacy of Mac-2 binding protein(Mac-2bp) for diagnosis of chronic pancreatitis.METHODS: Fifty-nine healthy volunteers(HV), 162 patients with chronic pancreatitis(CP), and 94 patients with pancreatic ductal adenocarcinoma(PDAC) were enrolled in this study. We measured serum Mac-2bp using our developed enzyme-linked immunosorbent assay kit. Additional biochemical variables were measured using an automated analyzer(including aminotransferase, alanine aminotransferase, γ-glutamyltransferase, alkaline phosphatase, triglyceride, C-reactive protein, and amylase levels) or chemiluminescent enzyme immunoassay(carbohydrate antigen 19-9 and carcinoembryonic antigen). The ability of Mac-2bp to predict CP diagnosis accurately was assessed using receiver operating characteristic(ROC) analyses.RESULTS: Serum Mac-2bp levels were significantly increased in CP patients compared to HV(P < 0.0001) and PDAC patients(P < 0.0001). Area under the ROC curve values of Mac-2bp for the discrimination of CP from HV and PDAC were 0.727 and 0.784, respectively. Multivariate analyses demonstrated that serum Mac-2bp levels were independent determinants for CP diagnosis from HV and PDAC patients. Immunohistological staining showed that Mac-2bp was expressed faintly in the pancreas tissues of both CP and PDAC patients. Serum aspartate aminotransferase, alanine aminotransferase, γ-glutamyltransferase, alkaline phosphatase, and triglyceride levels were significantly higher in patients with CP or PDAC. Serum Mac-2bp levels were highly correlated with protein levels of alanine aminotransferase, γ-glutamyltransferase, and C-reactive protein, but not amylase, suggesting that the damaged liver produces Mac-2bp. CONCLUSION: Measurement of serum Mac-2bp may be a novel and useful biomarker for CP diagnosis as well as liver fibrosis in the general population. | Tomohiro Maekawa Yoshihiro Kamada Yusuke Ebisutani Makiko Ueda Tomoki Hata Koichi Kawamoto Shinji Takamatsu Kayo Mizutani Mayuka Shimomura Tomoaki Sobajima Hironobu Fujii Kotarosumitomo Nakayama Kimihiro Nishino Makoto Yamada Takashi Kumada Toshifumi Ito Hidetoshi Eguchi Hiroaki Nagano Eiji Miyoshi | 2016 | World Journal of Gastroenterology2016，22，17： | 3 |
| 4 | Usefulness of Kyoto criteria as expanded selection criteria for liver transplantation for hepatocellular carcinoma显示文摘 | Toshimi Kaido Kohei Ogawa Akira Mori Yasuhiro Fujimoto Takashi Ito Koji Tomiyama Yasutsugu Takada Shinji Uemoto | 2013 | Surgery2013，，： | 3 |
| 5 | Characteristics of Metachronous Gastric Tumors after Endoscopic Submucosal Dissection for Gastric Intraepithelial Neoplasms显示文摘 | Tomoyuki Boda Masanori Ito Shiro Oka Yoko Kitamura Norifumi Numata Yoji Sanomura Taiji Matsuo Shinji Tanaka Masaharu Yoshihara Koji Arihiro Kazuaki Chayama Sergio Morini | 2014 | Gastroenterology Research and Practice2014，，： | 2 |
| 6 | Prognostic Implication of Para-aortic Lymph Node Metastasis in Resectable Pancreatic Cancer显示文摘 | Ryuichiro Doi Kazuhiro Kami Daisuke Ito Koji Fujimoto Yoshiya Kawaguchi Michihiko Wada Masafumi Kogire Ryo Hosotani Masayuki Imamura Shinji Uemoto | 2007 | World Journal of Surgery2007，，： | 2 |
| 7 | Reduction in gastric cancer mortality by screening based on serum pepsinogen concentration: A case-control study显示文摘 | Masaharu Yoshihara Toru Hiyama Shigeto Yoshida Masanori Ito Shinji Tanaka Yoshiyuki Watanabe Ken Haruma | 2007 | Scandinavian Journal of Gastroenterology2007，，6： | 2 |
| 8 | Prognostic Implication of Para-aortic Lymph Node Metastasis in Resectable Pancreatic Cancer显示文摘 | Ryuichiro Doi MD Kazuhiro Kami MD Daisuke Ito MD Koji Fujimoto MD Yoshiya Kawaguchi MD Michihiko Wada MD Masafumi Kogire MD Ryo Hosotani MD Masayuki Imamura MD Shinji Uemoto MD | 2007 | World Journal of Surgery2007，，1： | 2 |
| 9 | Mycophenolate Mofetil Is Effective and Well Tolerated in the Treatment of Refractory Acute and Chronic Graft-versus-Host Disease显示文摘 | Akiyoshi Takami Kanako Mochizuki Hirokazu Okumura Hirohito Yamazaki Masahide Yamazaki Yukio Kondo Hidesaku Asakura Shinji Nakao Satsuki Ito Yukio Suga | 2006 | International Journal of Hematology2006，，1： | 1 |
| 10 | Characterization of the glutamatergic system for induction and maintenance of allodynia显示文摘 | Toshiaki Minami Shinji Matsumura Emiko Okuda-Ashitaka Keiko Shimamoto Kenji Sakimura Masayoshi Mishina Hidemaro Mori Seiji Ito | 2001 | Brain Research2001，，1： | 1 |
| 11 | Expansion of selection criteria for patients with hepatocellular carcinoma in living donor liver transplantation显示文摘 | Takashi Ito Yasutsugu Takada Mikiko Ueda Hironori Haga Yoji Maetani Fumitaka Oike Kohei Ogawa Seisuke Sakamoto Yasuhiro Ogura Hiroto Egawa Koichi Tanaka Shinji Uemoto | 2007 | Liver Transpl2007，，12： | 1 |
| 12 | Reducing Peg-IFN doses causes later virologic response or no response in HCV genotype 1 patients treated with Peg-IFN alfa-2b plus ribavirin显示文摘 | Tsugiko Oze Naoki Hiramatsu Changho Song Takayuki Yakushijin Sadaharu Iio Yoshinobu Doi Masahide Oshita Hideki Hagiwara Eiji Mita Toshifumi Ito Yoshiaki Inui Taizo Hijioka Shinji Tamura Harumasa Yoshihara Atsuo Inoue Yasuharu Imai Eijiro Hayashi Michio Ka | 2012 | Journal of Gastroenterology2012，，3： | 1 |
| 13 | Intraductal Papillary Mucinous Neoplasms of the Pancreas: Clinicopathologic Characteristics and Long-Term Follow-Up After Resection显示文摘 | Kazuyuki Nagai Ryuichiro Doi Atsushi Kida Kazuhiro Kami Yoshiya Kawaguchi Tatsuo Ito Takaki Sakurai Shinji Uemoto | 2008 | World Journal of Surgery2008，，2： | 1 |
| 14 | Japanese Society for Cancer of the Colon and Rectum (JSCCR) guidelines 2010 for the treatment of colorectal cancer显示文摘 | Toshiaki Watanabe Michio Itabashi Yasuhiro Shimada Shinji Tanaka Yoshinori Ito Yoichi Ajioka Tetsuya Hamaguchi Ichinosuke Hyodo Masahiro Igarashi Hideyuki Ishida Megumi Ishiguro Yukihide Kanemitsu Norihiro Kokudo Kei Muro Atsushi Ochiai Masahiko Oguchi Ya | 2012 | International Journal of Clinical Oncology2012，，1： | 1 |
| 15 | Clinicopathologic Features and Endoscopic Resection of Early Primary Nonampullary Duodenal Carcinoma显示文摘 | Shiro Oka Shinji Tanaka Shinji Nagata Toru Hiyama Masanori Ito Yasuhiko Kitadai Masaharu Yoshihara Ken Haruma Kazuaki Chayama | 2003 | Journal of Clinical Gastroenterology2003，，5： | 1 |
| 16 | Relation between histologic gastritis and gastric motility in Japanese patients with functional dyspepsia: evaluation by transabdominal ultrasonography显示文摘 | Yoshiaki Matsumoto Masanori Ito Daisuke Kamino Shinji Tanaka Ken Haruma Kazuaki Chayama | 2008 | Journal of Gastroenterology2008，，5： | 1 |
| 17 | Expression of ephrin-B1 in hepatocellular carcinoma: possible involvement in neovascularization显示文摘 | Yoshiyuki Sawai Shinji Tamura Koji Fukui Nobuyuki Ito Kazuho Imanaka Ayuko Saeki Shigeru Sakuda Shinichi Kiso Yuji Matsuzawa | 2003 | Journal of Hepatology2003，，6： | 1 |
| 18 | Immunohistochemical expression of geminin in colorectal cancer: Implicationof prognostic significance显示文摘 | Keisuke Nishihara Kohei Shomori Takayuki Tamura Shinji Fujioka Toshihide Ogawa Hisao Ito | 2009 | Oncology Reports2009，，5： | 1 |
| 19 | Biological Het- erogeneity, Including Systemic Replication in Mice, of HSN1 Influenza A Virus Isolates from Humans in Hang Kong 显示文摘 | Peng Gao Shinji Watanabe Toshihiro Ito | 1999 | American Society for Microbiology1999，73，4： | 1 |
| 20 | Hypoxia-Inducible Factor Augments Experimental Colitis Through an MIF–Dependent Inflammatory Signaling Cascade显示文摘 | Yatrik M. Shah Shinji Ito Keiichirou Morimura Chi Chen Sun–Hee Yim Volker H. Haase Frank J. Gonzalez | 2008 | Gastroenterology2008，，7： | 1 |
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