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| 1 | Numerical study of the effects of local atmospheric circulations on a pollution event over Beijing–Tianjin–Hebei, China显示文摘Currently, the Chinese central government is considering plans to build a trilateral economic sphere in the Bohai Bay area, including Beijing, Tianjin and Hebei(BTH), where haze pollution frequently occurs. To achieve sustainable development, it is necessary to understand the physical mechanism of the haze pollution there. Therefore, the pollutant transport mechanisms of a haze event over the BTH region from 23 to 24 September 2011 were studied using the Weather Research and Forecasting model and the FLEXible-PARTicle dispersion model to understand the effects of the local atmospheric circulations and atmospheric boundary layer structure. Results suggested that the penetration by sea-breeze could strengthen the vertical dispersion by lifting up the planetary boundary layer height(PBLH) and carry the local pollutants to the downstream areas; in the early night, two elevated pollution layers(EPLs) may be generated over the mountain areas: the pollutants in the upper EPL at the altitude of 2–2.5 km were favored to disperse by long-range transport, while the lower EPL at the altitude of 1 km may serve as a reservoir, and the pollutants there could be transported downward and contribute to the surface air pollution.The intensity of the sea–land and mountain–valley breeze circulations played an important role in the vertical transport and distribution of pollutants. It was also found that the diurnal evolution of the PBLH is important for the vertical dispersion of the pollutants,which is strongly affected by the local atmospheric circulations and the distribution of urban areas. | Yucong Miao Shuhua Liu Yijia Zheng Shu Wang Bicheng Chen Hui Zheng Jingchuan Zhao | 2015 | Journal of Environmental Sciences2015，27，4： | 14 |
| 2 | NEW TECHNOLOGY FOR FAULT DIAGNOSIS BASED ON WAVELET DENOISING AND MODIFIED EXPONENTIAL TIME-FREQUENCY DISTRIBUTION显示文摘Fast wavelet multi-resolution analysis (wavelet MRA) provides a effective tool for analyzing and canceling disturbing components in original signal. Because of its exponential frequency axis, this method isn’t suitable for extracting harmonic components. The modified exponential time-frequency distribution ( MED) overcomes the problems of Wigner distribution( WD) ,can suppress cross-terms and cancel noise further more. MED provides high resolution in both time and frequency domains, so it can make out weak period impulse components fmm signal with mighty harmonic components. According to the 'time' behavior, together with 'frequency' behavior in one figure,the essential structure of a signal is revealed clearly. According to the analysis of algorithm and fault diagnosis example, the joint of wavelet MRA and MED is a powerful tool for fault diagnosis. | Wang Xinqing,Wang Yaohua,Qian Shuhua,Chen Liuhai (Engineering College of PLA University of Science and Technology) Xu Yanshen,Zhao Xiangsong (Tianjin University) | 2001 | Chinese Journal of Mechanical Engineering2001，14，3： | 13 |
| 3 | The transcription factor ICE1 functions in cold stress response by binding to the promoters of CBF and COR genes显示文摘A recent paper by Kidokoro et al.(2020)in The Plant Cell reported a transgene-dependent transcriptional silencing phenomenon in the dominant ice1-1 Arabidopsis mutant containing the CBF3-LUC reporter,and questioned whether ICE1 may regulate CBF genes and may be involved in plant cold response.Here,we evaluate available evidence supporting the involvement of ICE1 in plant cold response,and provide ChIP-seq data showing ICE1 binding to the promoters of CBF genes and other regulatory genes known to be critical for cold response as well as to the promoters of some COR genes. | Kai Tang Lun Zhao Yuying Ren Shuhua Yang Jian-Kang Zhu Chunzhao Zhao | 2020 | Journal of Integrative Plant Biology2020，62，3： | 13 |
| 4 | Recent advances in the improvement of g-C_(3)N_(4) based photocatalytic materials显示文摘g-C_(3)N_(4) have been widely used in the fields of photocatalytic hydrogen production,photocatalytic degradation of dyes and oxidative degradation of toxic gases due to their excellent performance.It has attracted extensive attention in recent years due to its highly efficient photocatalytic capacity of hydrogen generation,water oxidation,carbon dioxide reduction and degradation of organic pollutants.Because of the abundant carbon and nitrogen composition of the earth,large-scale production and industrial applications of this material are possible.The modification of this material makes its performance more excellent so that this new material can obtain a steady stream of vitality.These outstanding works have become important materials and milestones on the road to mankind's photocatalytic hydrogen production.This review will begin with the basic idea of designing,synthesizing and improving g-C_(3)N_(4) based photocatalytic materials,and introduce the latest development of g-C_(3)N_(4) photocatalysts in hydrogen production from four aspects of controlling the carbon/nitrogen ratio,morphology,element doping and heterojunction structure of g-C_(3)N_(4) materials. | Yupeng Xing Xiaoke Wang Shuhua Hao Xueli Zhang Xiao Wang Wenxuan Ma Gang Zhao Xijin Xu | 2021 | Chinese Chemical Letters2021，32，1： | 10 |
| 5 | Chromosome-Level Reference Genome and Population Genomic Analysis Provide Insights into the Evolution and Improvement of Domesticated Mulberry (Morns alba)显示文摘Mulberry(Morns spp.)is the sole plant consumed by the domesticated silkworm.However,the genome of domesticated mulberry has not yet been sequenced,and the ploidy level of this species remains unclear.Here,we report a high-quality,chromosome-level domesticated mulberry(Morus alba)genome.Analysis of genomic data and karyotype analyses confirmed that M.alba is a diploid with 28 chromosomes(2/7=2x=28).Population genomic analysis based on resequencing of 134 mulberry accessions classified domesticated mulberry into three geographical groups,namely,Taihu Basin of southeastern China(Hu mulberry),northern and southwestern China,and Japan.Hu mulberry had the lowest nucleotide diversity among these accessions and demonstrated obvious signatures of selection associated with environmental adaptation.Further phylogenetic analysis supports a previous proposal that multiple domesticated mulberry accessions previously classified as different species actually belong to one species.This study expands our understanding of genome evolution of the genus Morus and population structure of domesticated mulberry,which would facilitate mulberry breeding and improvement. | Feng Jiao Rongsong Luo Xuelei Dai Hui Liu Gang Yu Shuhua Han Xin Lu Chao Su Qi Chen Qinxia Song Caiting Meng Fanghong Li Hongmei Sun Rui Zhang Tian Hui Yonghua Qian Aichun Zhao Yu Jiang | 2020 | Molecular Plant2020，13，7： | 10 |
| 6 | Understanding the impact of mountain landscapes on water balance in the upper Heihe River watershed in northwestern China显示文摘Estimating the impact of mountain landscape on hydrology or water balance is essential for the sustainable development strategies of water resources.Specifically,understanding how the change of each landscape influences hydrological components will greatly improve the predictability of hydrological responses to mountain landscape changes and thus can help the government make sounder decisions.In the paper,we used the VIC(Variable Infiltration Capacity)model to conduct hydrological modeling in the upper Heihe River watershed,along with a frozen-soil module and a glacier melting module to improve the simulation.The improved model performed satisfactorily.We concluded that there are differences in the runoff generation of mountain landscape both in space and time.About 50% of the total runoff at the catchment outlet were generated in mid-mountain zone(2,900-4,000 m asl),and water was mainly consumed in low mountain region(1,700-2,900 m asl)because of the higher requirements of trees and grasses.The runoff coefficient was 0.37 in the upper Heihe River watershed.Barren landscape produced the largest runoff yields(52.46% of the total runoff)in the upper Heihe River watershed,followed by grassland(34.15%),shrub(9.02%),glacier(3.57%),and forest(0.49%).In order to simulate the impact of landscape change on hydrological components,three landscape change scenarios were designed in the study.Scenario 1,2 and 3 were to convert all shady slope landscapes at 2,000-3,300 m,2,000-3,700 m,and 2,000-4,000 m asl respectively to forest lands,with forest coverage rate increased to 12.4%,28.5% and 42.0%,respectively.The runoff at the catchment outlet correspondingly declined by 3.5%,13.1% and 24.2% under the three scenarios.The forest landscape is very important in water conservation as it reduced the flood peak and increased the base flow.The mountains as 'water towers' play important roles in water resources generation and the impact of mountain landscapes on hydrology is significant. | Jia QIN YongJian DING JinKui WU MingJie GAO ShuHua YI ChuanCheng ZHAO BaiSheng YE Man LI ShengXia WANG | 2013 | Journal of Arid Land2013，5，3： | 6 |
| 7 | Accelerated Ageing Tests for Evaluations of a Durability Performance of Glass-fiber Reinforcement Polyester Composites显示文摘The paper presented accelerated ageing test results of a durability study on ortho-phthalic anhydride-type unsaturated polyester resin(191#) and its glass-fiber reinforcement polyester composites(GFRPC).The samples were exposed in an artificial xenon arc lamp ageing cell or a thermo-oxidative ageing cell.Morphology and gloss of the specimens were investigated by using a microscope and a gloss-meter,respectively.The tensile strength,bending strength and inter-laminar shear strength(ILSS) of GFRPC were tested before and after exposure,and were considered to evaluate the durability performance of this material.The polyester resin was analyzed by fourier transform infrared(FT-IR) spectroscopy.The results showed that the glossiness of the specimens got worse and some cracks appeared on their surface during the course of ageing,the tensile strength and bending strengths of the specimens first increased and then decreased.The ILSS of the composites decreased after they were aged in the xenon arc lamp cell,but increased while they were aged in the thermo-oxidative cell.The changes of these trends become more obvious during ageing in the xenon arc lamp cell,so the main influencing factor leading to the failure of this material is UV irradiation. | Yunying Wang Jiangyan Meng Qing Zhao Shuhua Qi | 2010 | Journal of Materials Science & Technology2010，26，6： | 6 |
| 8 | Bevacizumab biosimilar LY01008 compared with bevacizumab(Avastin)as first-line treatment for Chinese patients with unresectable,metastatic,or recurrent non-squamous non-small-cell lung cancer:A multicenter,randomized,double-blinded,phase Ⅲ trial显示文摘Background:Previous studies have demonstrated the preclinical pharmacological and toxicological consistency,and clinical pharmacokinetic equivalence of bevacizumab biosimilar LY01008 with reference bevacizumab(Avastin).This randomized controlled trial aimed to compare the efficacy and safety of LY01008 with Avastin in first-line treatment of Chinese patients with advanced or recurrent non-squamous non-small cell lung cancer(NSCLC).Methods:StageⅢB-ⅣNSCLC patients with evaluable lesions,good physical status,and adequate organ functions from 67 centers across China were randomized in a ratio of 1:1 to receive LY01008 or Avastin 15 mg/kg intravenously in combination with paclitaxel/carboplatin(combined treatment)for 4-6 cycles,followed by maintenance monotherapy with LY01008 until disease progression,intolerable toxicity,or death.The primary endpoint was objective response rate(ORR)in accordance with Response Evaluation Criteria in Solid Tumors(RECIST)version 1.1 confirmed by independent radiological review committees(IRRC).Secondary endpoints included disease control rate(DCR),duration of response(DoR),progression-free survival(PFS),overall survival(OS),and safety.This study was registered in Clinical Trials.gov(NCT03533127).Results:Between December 15^(th),2017,and May 15^(th),2019,a total of 649 patients were randomized to the LY01008(n=324)or Avastin(n=325)group.As of September 25th,2019 for primary endpoint analysis,589 patients received ORR evaluation,with a median number of combined treatment cycles of 5(range 1-6)andmedian duration of treatment of 3.0(range 0.0-5.1)months.ORRof responseevaluable patients in the LY01008 and Avastin groups were 48.5% and 53.0%,respectively.The stratified ORR ratio was 0.91(90%CI 0.80-1.04,within the prespecified equivalence margin of 0.75-1.33).Up to May 15^(th),2020,with a median follow-up of 13.6(range 0.8-28.4)months,no notable differences in DCR,median DoR,median PFS,median OS,and 1-year OS rate were observed between the LY01008 and Avastin groups.There were no clinically meaningful differences in safety and immunogenicity across treatment groups.Conclusions:LY01008 demonstrated similarity to Avastin in terms of efficacy and safety in Chinese patients with advanced or recurrent non-squamous NSCLC.LY01008 combined with paclitaxel/carboplatin is expected to become a new treatment option for unresectable,metastatic,LY01008 and Avastin groups.There were no clinically meaningful differences in safety and immunogenicity across treatment groups.Conclusions:LY01008 demonstrated similarity to Avastin in terms of efficacy and safety in Chinese patients with advanced or recurrent non-squamous NSCLC.LY01008 combined with paclitaxel/carboplatin is expected to become a new treatment option for unresectable,metastatic,or recurrent non-squamous NSCLC patients in the first-line setting. | Yuankai Shi Kaijian Lei Yuming Jia Bingqiang Ni Zhiyong He Minghong Bi Xicheng Wang Jianhua Shi Ming Zhou Qian Sun Guolei Wang Dongji Chen Yongqian Shu Lianke Liu Zhongliang Guo Yong Liu Junquan Yang Ke Wang Ke Xiao LinWu Tienan Yi Debin Sun Mafei Kang Tianjiang Ma Yimin Mao Jinsheng Shi Tiegang Tang Yan Wang Puyuan Xing Dongqing Lv Wangjun Liao Zhiguo Luo Bin Wang Xiaohong Wu Xiaoli Zhu Shuhua Han Qisen Guo Rongyu Liu Zhiwei Lu Jianyong Zhang Jian Fang Changlu Hu Yinghua Ji Guolong Liu Hong Lu Dedong Wu Junhong Zhang Shuyang Zhu Zheng Liu Wensheng Qiu Feng Ye Yan Yu Yanqiu Zhao Qinhong Zheng Jun Chen Zhanyu Pan Yiping Zhang Wenjuan Lian Bo Jiang Bo Qiu Guojun Zhang Hua Zhang Yanju Chen Yuan Chen Hongbing Duan Manxiang Li Shengming Liu Lijun Ma Hongming Pan Xia Yuan Xueli Yuan Yulong Zheng Emei Gao Li Zhao Shumin Wang Can Wu | 2021 | Cancer Communications2021，41，9： | 5 |
| 9 | Integrated transcriptomics and metabolomics analyses provide insights into cold stress response in wheat显示文摘Cold tolerance of crop plants influences survival and productivity under low-temperature conditions. Elucidation of molecular mechanisms underlying low temperature tolerance could be helpful in breeding. In this study, we used integrated transcriptomics and metabolomics analyses to investigate changes in gene/metabolite activity in a winter-hardy wheat cultivar of(cv. Jing 411) when subjected to sold stress. The 223 metabolites mainly enriched during cold acclimation included carbohydrates, flavonoids, and amino acids.Eight common metabolites had altered abundance following freezing treatment;six increased and two decreased. Transcriptome analysis revealed that 29,066 genes were differentially expressed in wheat crowns after cold acclimation compared to the nonacclimated control. Among them, 745 genes were up-regulated following freezing treatment, suggesting substantial change in expression of a large quantity of genes upon cold acclimation and freezing treatment, which impacts on the modified metabolites.Integrated analysis of gene expression and metabolite profiles revealed that the abscisic acid(ABA)/jasmonic acid(JA) phytohormone signaling and proline biosynthesis pathways were significantly modulated under cold acclimation and freezing treatments. Our results indicated that low-temperature stress induced substantial changes in both transcriptomes and metabolomes. Critical pathways associated with ABA/JA signaling and proline biosynthesis played important roles in regulating cold tolerance in wheat. | Yong Zhao Meng Zhou Ke Xu Jiahao Li Shanshan Li Shuhua Zhang Xueju Yang | 2019 | The Crop Journal2019，7，6： | 4 |
| 10 | Study on Regeneration of MDEA Solution Using Membrane Distillation显示文摘对待 MDEA 在天然气包含的酸气体是 MDEA 答案的新生的效率限制了的使用的 widely.But 最佳的温度是的这 technology.An 的发展为用实验结果显示出的膜 distillation.The 的 MDEA 答案的新生必要 MDEA 的新生率与率增加了的增加的 temperature.But 升起了在新生温度到达了某个 value.This 以后,慢慢地,学习能证实 M | Cai Pei Wang Shuli Zhao Shuhua | 2008 | China Petroleum Processing & Petrochemical Technology2008，10，4： | 3 |
| 11 | Why the hydrothermal fluorinated method can improve photocatalytic activity of carbon nitride显示文摘Carbon nitride(CN) photocatalysts have attracted much attention due to their excellent photocatalytic properties.And hydrothermal fluorination is a common method to improve the photocatalytic effect of CN photocatalyst.Here,the influence of the band gap was first revealed of fluorination and hydroxylation of CN photocatalyst based on the first theoretical principle.Here,the effect of fluorination and hydroxylation on the CN band gap was discussed for the first time using the first theoretical principle.With F atoms and OH doping,the band gap of CN was significantly improved,conduction band and valence band moved up.Then,F-CN photocatalyst with F atoms and OH was successfully synthesized by a hydrothermal fluorinated method.Next,the reasons why F-CN photocatalyst was more effective than that of traditional CN photocatalyst were fully discussed.From the photocatalytic effect of photocatalyst(12,593.2 μmolg^(-1) h^(-1)to the morphology(super-small nanosheets),structure(homojunctions),composition(metal-free),specific surface area(54.1 m^(2)/g),visible light absorption response(AQE is10.9% at 420 nm) and photo-induced carrier life(14.13 ns).Therefore,this work has a great guiding effect on the development of CN photocatalyst. | Gang Zhao Yupeng Xing Shuhua Hao Xijin Xu Wenxuan Ma Jinghua Guo | 2021 | Chinese Chemical Letters2021，32，1： | 1 |
| 12 | Precision Medicine:What Challenges Are We Facing?显示文摘Following the publication of the US National Research Council(NRC)report‘‘Toward Precision Medicine:Building a Knowledge Network for Biomedical Research and a New Taxonomy of Diseases'in 2011[1],several nations have announced that their national research programs would definitely head toward this direction.Now,precision medicine(PM)became a banner for many large-scale | Yu Xue Eric-Wubbo Lameijer Kai Ye Kunlin Zhang Suhua Chang Xiaoyue Wang Jianmin Wu Ge Gao Fangqing Zhao Jian Li Chunsheng Han Shuhua Xu Jingfa Xiao Xuerui Yang Xiaomin Ying Xuegong Zhang Wei-Hua Chen Yun Liu Zhang Zhang Kun Huang Jun Yu | 2016 | Genomics, Proteomics & Bioinformatics2016，14，5： | 1 |
| 13 | Investigation of oil vapor emission and its evaluation methods显示文摘 | HUANG Weiqiu BAI Juan ZHAO Shuhua | 2011 | Journal of Loss Prevention in the Process Industries2011，24，2： | 1 |
| 14 | Investigation of oil vapor emission and its evaluation methods显示文摘 | Huang Weiqiu Bai Juan Zhao Shuhua | 2011 | J Loss Prevent Process Ind2011，24，2： | 1 |
| 15 | Investigation of oil vapor emission and its evaluation methods显示文摘 | Huang Weiqiu Bai Juan Zhao Shuhua | 2011 | Journal of Loss Prevention in the Process Industries2011，24，2： | 1 |
| 16 | The Surface Energy Budget and Its Impact on the Freeze-thaw Processes of Active Layer in Permafrost Regions of the Qinghai-Tibetan Plateau显示文摘The surface energy budget is closely related to freeze-thaw processes and is also a key issue for land surface process research in permafrost regions.In this study,in situ data collected from 2005 to 2015 at the Tanggula site were used to analyze surface energy regimes,the interaction between surface energy budget and freeze-thaw processes.The results confirmed that surface energy flux in the permafrost region of the Qinghai-Tibetan Plateau exhibited obvious seasonal variations.Annual average net radiation(R_(n))for 2010 was 86.5 W m^(-2),with the largest being in July and smallest in November.Surface soil heat flux(G_(0))was positive during warm seasons but negative in cold seasons with annual average value of 2.7 W m^(-2).Variations in R_(n) and G_(0) were closely related to freeze-thaw processes.Sensible heat flux(H)was the main energy budget component during cold seasons,whereas latent heat flux(LE)dominated surface energy distribution in warm seasons.Freeze-thaw processes,snow cover,precipitation,and surface conditions were important influence factors for surface energy flux.Albedo was strongly dependent on soil moisture content and ground surface state,increasing significantly when land surface was covered with deep snow,and exhibited negative correlation with surface soil moisture content.Energy variation was significantly related to active layer thaw depth.Soil heat balance coefficient K was>1 during the investigation time period,indicating the permafrost in the Tanggula area tended to degrade. | Junjie MA Ren LI Hongchao LIU Zhongwei HUANG Tonghua WU Guojie HU Yao XIAO Lin ZHAO Yizhen DU Shuhua YANG | 2022 | Advances in Atmospheric Sciences2022，39，1： | 1 |
| 17 | Si nanowire Bio-FET for electrical and label-free detection of cancer cell-derived exosomes显示文摘Exosomes are highly important in clinical diagnosis due to their high homology with their parental cells.However,conventional exosome detection methods still face the challenges of expensive equipment,low sensitivity,and complex procedures.Field effect transistors(FETs)are not only the most essential electronic component in the modern microelectronics industry but also show great potential for biomolecule detection owing to the advantages of rapid response,high sensitivity,and label-free detection.In this study,we proposed a Si nanowire field-effect transistor(Si-NW Bio-FET)device chemically modified with specific antibodies for the electrical and label-free detection of exosomes.The Si-NW FETs were fabricated by standard microelectronic processes with 45 nm width nanowires and packaged in a polydimethylsiloxane(PDMS)microfluidic channel.The nanowires were further modified with the specific CD63 antibody to form a Si-NW Bio-FET.The use of the developed Si-NW Bio-FET for the electrical and labelfree detection of exosomes was successfully demonstrated with a limit of detection(LOD)of 2159 particles/mL.In contrast to other technologies,in this study,Si-NW Bio-FET provides a unique strategy for directly quantifying and realtime detecting exosomes without labeling,indicating its potential as a tool for the early diagnosis of cancer. | Wenjie Zhao Jiawei Hu Jinlong Liu Xin Li Sheng Sun Xiaofeng Luan Yang Zhao Shuhua Wei Mingxiao Li Qingzhu Zhang Chengjun Huang | 2022 | Microsystems & Nanoengineering2022，8，3： | 1 |
| 18 | The effect of connective tissue growth factor on renal fibrosis and podocyte injury in hypertensive rats显示文摘 | Wen Lu Shuhua Liu Zhiming Zhao Yipeng Liu Ting Li | 2014 | Renal Failure2014，，： | 1 |
| 19 | Hot deformation behavior of a Nb-containing 316LN stainless steel显示文摘 | Zhang Wenhui Sun Shuhua Zhao Deli Wang Baozhong Wang Zhenhua Fu Wantang | 2011 | Materials and Design2011，，8： | 1 |
| 20 | Genomic diversity and post-admixture adaptation in the Uyghurs显示文摘Population admixture results in genome-wide combinations of genetic variants derived from different ancestral populations of distinct ancestry, thus providing a unique opportunity for understanding the genetic determinants of phenotypic variation in humans. Here, we used whole-genome sequencing of 92 individuals with high coverage(30–60×) to systematically investigate genomic diversity in the Uyghurs living in Xinjiang, China(XJU), an admixed population of both European-like and East-Asian-like ancestry.The XJU population shows greater genetic diversity, especially a higher proportion of rare variants,compared with their ancestral source populations, corresponding to greater phenotypic diversity of XJU.Admixture-induced functional variants in EDAR were associated with the diversity of facial morphology in XJU. Interestingly, the interaction of functional variants between SLC24A5 and OCA2 likely influences the diversity of skin pigmentation. Notably, selection has seemingly been relaxed or canceled in several genes with significantly biased ancestry, such as HERC2–OCA2. Moreover, signatures of post-admixture adaptation in XJU were identified, including genes related to metabolism(e.g. CYP2D6), digestion(e.g.COL11A1), olfactory perception(e.g. ANO2) and immunity(e.g. HLA). Our results demonstrated population admixture as a driving force, locally or globally, in shaping human genetic and phenotypic diversity as well as in adaptive evolution. | Yuwen Pan Chao Zhang Yan Lu Zhilin Ning Dongsheng Lu Yang Gao Xiaohan Zhao Yajun Yang Yaqun Guan Dolikun Mamatyusupu Shuhua Xu | 2022 | National Science Review2022，9，3： | 1 |
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