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| 1 | A Chromosome-Level Genome Assembly of Garlic (Allium sativum) Provides Insights into Genome Evolution and Allicin Biosynthesis显示文摘Garlic,an economically important vegetable,spice,and medicinal crop,produces highly enlarged bulbs and unique organosulfur compounds.Here,we report a chromosome-level genome assembly for garlic,with a total size of approximately 16.24 Gb,as well as the annotation of 57561 predicted protein-coding genes,making garlic the first Allium species with a sequenced genome.Analysis of this garlic genome assembly reveals a recent burst of transposable elements,explaining the substantial expansion of the garlic genome.We examined the evolution of certain genes associated with the biosynthesis of allicin and inulin neoseries-type fructans,and provided new insights into the biosynthesis of these two compounds.Furthermore,a large-scale transcriptome was produced to characterize the expression patterns of garlic genes in different tissues and at various growth stages of enlarged bulbs.The reference genome and large-scale transcriptome data generated in this study provide valuable new resources for research on garlic biology and breeding. | Xiudong Sun Siyuan Zhu Ningyang Li Yi Cheng Jing Zhao Xuguang Qiao Li Lu Shiqi Liu Yanzhou Wang Chan Liu Benping Li Wu Guo Shuang Gao Zemao Yang Fu Li Zheng Zeng Qing Tang Yupeng Pan Mengjiao Guan Jian Zhao Xiaomi ng Lu Huanwe n Meng Zhenlin Han Chun she ng Gao Wenkai Jiang Xing Zhao Shilin Tian Jianguang Su Zhihui Cheng Touming Liu | 2020 | Molecular Plant2020，13，9： | 14 |
| 2 | Additive manufacturing of high-strength CrMnFeCoNi high-entropy alloys-based composites with WC addition显示文摘Laser melting deposition with WC addition has been developed to fabricate high-strength CrMnFeCoNibased high-entropy alloys-based composites.By this technique,a microstructure of compact refined equiaxed grains can be achieved,and the tensile strength can be remarkably improved.The sample with 5 wt%WC addition shows a promising mechanical performance with a tensile strength of 800 MPa and an elongation of 37%.The improvement in mechanical property may be attributed to the formation of Cr(23)C6 reinforcement precipitates,which could promote the heterogeneous nucleation of grains and hinder the propagation of slip bands. | Jinfeng Li Shuo Xiang Hengwei Luan Abdukadir Amar Xue Liu Siyuan Lu Yangyang Zeng Guomin Le Xiaoying Wang Fengsheng Qu Chunli Jiang Guannan Yang | 2019 | Journal of Materials Science & Technology2019，35，11： | 13 |
| 3 | 紫杉醇脂质体与紫杉醇联合铂类同步放化疗治疗宫颈癌的随机对照研究(英文)显示文摘Objective:The aim of the study was to compare the efficacy,side effect and influence on the survival rate of two chemotherapy regimens,paclitaxel liposome combined with platinum and paclitaxel combined with platinum,in concurrent chemoradiotherapy for cervical carcinoma.Methods:The 162 cases with primary cervical carcinoma diagnosed between January 2008 and November 2009 in Jiangxi Maternal and Child Health Hospital(China) were enrolled in this randomized controlled trial.Seventy-one cases were included in paclitaxel group and 91 in paclitaxel liposome group.And the chemotherapy doses were as follows:paclitaxel liposome and paclitaxel 135 mg/m2;cisplatin 80 mg/m2 or carboplatin AUC 4-6;then repeated every 21 days for two or three times.Radical radiotherapy was given to both groups at the same time.Efficacy was evaluated according to the tumor regression six months later and follow-up was done consistently.Results:The overall response rates of paclitaxel group and paclitaxel liposome group were 90.1% and 89 % respectively(P > 0.05).The one year cumulative survival was 91.4% for paclitaxel group and 89.2% for paclitaxel liposome group(P > 0.05).The incidence rates of adverse effects such as rash,gastrointestinal toxicity,bone marrow suppression and muscle/joint pain in paclitaxel liposome group were much lower than those in paclitaxel group(P < 0.05),while there was no difference regarding hair loss,hepatic function damage,peripheral neuritis and other aspects(P > 0.05).Conclusion:Paclitaxel liposome plus platinum is a safe and effective method for staging IIa-IV cervical carcinomas.While the long-term efficacy should be further observed. | Siyuan Zeng Ling Li Meiling Zhong Wei Jiang Yun Xiao | 2012 | The Chinese-German Journal of Clinical Oncology2012，11，2： | 3 |
| 4 | Mineralogical Characteristics and in-situ Sulfur Isotopic Analysis of Gold-Bearing Sulfides from the Qilishan Gold Deposit in the Jiaodong Peninsula,China显示文摘Large-scale gold mineralization during the Early Cretaceous is identified in the Jiao-dong Peninsula of China.Sources of ore-forming fluids remain debated.We study the Qilishan gold deposit in the northwestern Jiaodong Peninsula with detailed mineralogical observation and in-situ sulfur isotope analyses,in order to reveal the gold occurrence and the origin of ore-forming fluids.The Qilishan gold deposit is mainly clastic altered rock-type in mineralization,and ore minerals are visible native gold,electrum,pyrite,chalcopyrite and galena,gangue minerals as quartz,sericite and calcite.The gold occurrence includes inclusion and intergranular types,formed within pyrites and chalcopy-rites and along their fissures.In-situ sulfur isotope analysis of gold-bearing sulfides suggests that the Qilishan deposit is enriched in heavy sulfur,withδ34S values mainly from+8.0‰to+12.0‰.δ34S val-ues increase gradually with the fluid evolution from the early to late stages,which is interpreted to be related to the loss of sulfur via sulfide precipitation.The crystallization of sulfides from hydrothermal fluids may have triggered the instability of Au(HS)2,and finally led to gold precipitation.Combined with sulfur isotope compositions of other gold deposits(n=43)and wall-rocks in the Jiaodong Peninsu-la,it is proposed that the ore-forming fluids were probably not directly originated from metamorphic wall-rocks(e.g.,Jiaodong Group).Moreover,the relatively long time interval rules out the possibility that the gold mineralization(ca.120 Ma)was associated with granitic magma activities(mostly 160-150 Ma).Possible ore genesis scenario is that,long-term subduction of slabs(e.g.,the Paleo-Pacific)with gold-enriched pyritic materials and crustal sedimentary rocks resulted in both high Au contents and positiveδ34S values of sulfur in the lithospheric mantle below the North China Craton.Subse-quently,devolatilization of the metasomatized mantle produced auriferous fluids that migrated up-ward along translithospheric fault systems,and gold finally precipitated in favorable structural posi-tions,generating the world-class Jiaodong deposits in the Early Cretaceous. | Xinghua Ma Qingwen Zeng Siyuan Tao Rui Cao Zhenhua Zhou | 2021 | Journal of Earth Science2021，32，1： | 3 |
| 5 | Heterogeneity in endothelial cells and widespread venous arterialization during early vascular development in mammals显示文摘Arteriogenesis rather than unspecialized capillary expansion is critical for restoring effective circulation to compromised tissues in patients.Deciphering the origin and specification of arterial endothelial cells during embryonic development will shed light on the understanding of adult arteriogenesis.However,during early embryonic angiogenesis,the process of endothelial diversification and molecular events underlying arteriovenous fate settling remain largely unresolved in mammals.Here,we constructed the single-cell transcriptomic Iandscape of vascular endothelial cells(VECs)during the time window for the occurrenee of key vasculogenic and angiogenic events in both mouse and human embryos.We uncovered two distinct arterial VEC types,the major artery VECs and arterial plexus VECs,and un expectedly diverge nt arteriove nous characteristics among VECs that are located in morphologically undistinguishable vascular plexus intra-embryonically.Using computational prediction and further lineage tracing of venous-featured VECs with a newly developed Nr2f2^(CrexER) | Siyuan Hou Zongcheng Li Ji Dong Yun Gao Zhilin Chang Xiaochen Ding Shuaili Li Yunqiao Li Yang Zeng Qian Xin Baihan Wang Yanli Ni Xiaowei Ning Yuqiong Hu Xiaoying Fan Yu Hou Xianlong Li Lu Wen Bin Zhou Bing Liu Fuchou Tang Yu Lan | 2022 | Cell Research2022，32，4： | 2 |
| 6 | Histones released by NETosis enhance the infectivity of SARS-CoV-2 by bridging the spike protein subunit 2 and sialic acid on host cells显示文摘Neutrophil extracellular traps(NETs)can capture and kill viruses,such as influenza viruses,human immunodeficiency virus(HIV),and respiratory syncytial virus(RSV),thus contributing to host defense.Contrary to our expectation,we show here that the histones released by NETosis enhance the infectivity of SARS-CoV-2,as found by using live SARS-CoV-2 and two pseudovirus systems as well as a mouse model.The histone H3 or H4 selectively binds to subunit 2 of the spike(S)protein,as shown by a biochemical binding assay,surface plasmon resonance and binding energy calculation as well as the construction of a mutant S protein by replacing four acidic amino acids.Sialic acid on the host cell surface is the key molecule to which histones bridge subunit 2 of the S protein.Moreover,histones enhance cell-cell fusion.Finally,treatment with an inhibitor of NETosis,histone H3 or H4,or sialic acid notably affected the levels of sgRNA copies and the number of apoptotic cells in a mouse model.These findings suggest that SARS-CoV-2 could hijack histones from neutrophil NETosis to promote its host cell attachment and entry process and may be important in exploring pathogenesis and possible strategies to develop new effective therapies for COVID-19. | Weiqi Hong Jingyun Yang Jun Zou Zhenfei Bi Cai He Hong Lei Xuemei He Xue Li Aqu Alu Wenyan Ren Zeng Wang Xiaohua Jiang Kunhong Zhong Guowen Jia Yun Yang Wenhai Yu Qing Huang Mengli Yang Yanan Zhou Yuan Zhao Dexuan Kuang Junbin Wang Haixuan Wang Siyuan Chen Min Luo Ziqi Zhang Tiangi Lu Li Chen Haiying Que Zhiyao He Qiu Sun Wei Wang Guobo Shen Guangwen Lu Zhiwei Zhao Li Yang Jinliang Yang Zhenling Wang Jiong Li Xiangrong Song Lunzhi Dai Chong Chen Jia Geng Maling Gou Lu Chen Haohao Dong Yong Peng Canhua Huang Zhiyong Qian Wei Cheng Changfa Fan Yuquan Wei Zhaoming Su Aiping Tong Shuaiyao Lu Xiaozhong Peng Xiawei Wei | 2022 | Cellular & Molecular Immunology2022，19，5： | 2 |
| 7 | Tectonic Dynamic Metallization of Silver-GoldHydrothermal Fluids in Proterozoic GneissTerrene Shear Zones, Suichang, Zhejiang, China显示文摘The Suichang mine is the largest silicified vein-type silver-gold mineralization system in Southeast China, whose ore bodies are controlled by shear zones developing in Lower Proterozoic gneiss terrene with initial migmatization, which is covered by Upper Jurassic and Lower Cretaceous volcanic rock system and cut by acidic igneous veins of Jurassic and Cretaceous. The conclusions are as follows: (1) The ore-forming fluid is defined as superhigh tectonic-metamorphic fluid on the base of : 1 (D)-(18O) values 2 fluid inclusions;3 trace elements of pyrite from ores. (2) The shear zone silicified orebod-ies occurred in proterozoic, Jurassic and Cretaceous, which have been transforms in part by ore-bearing comb quartz vein of volcanism. | Wang Siyuan Xiao Qibing Zeng Jianguo Faculty of Earth Resources, China University of Geosciences, Wuhan 430074 | 2001 | Journal of China University of Geosciences2001，12，1： | 1 |
| 8 | Layout design and application of 4D-printing bio-inspired structures with programmable actuators显示文摘Four-dimensional(4D)printing is an advanced form of three-dimensional(3D)printing with controllable and programmable shape transformation over time.Actuators are used as a controlling factor with multi-stage shape recovery,with emerging opportunities to customize the mechanical properties of bio-inspired structures.The print pattern of shape memory polymer(SMP)fbers strongly afects the achievable resolution,and consequently infuences several other physical and mechanical properties of fabricated actuators.However,the deformations of bio-inspired structures due to actuator layout are more complex because of the presence of the coupling of multi-directional strain.In this study,the initial structure was designed from closed-shell behavior and divided into a general unit and actuator unit,the latter responsible for driving the transformation.Mutual stress confrontation between the actuator and the general unit was considered in the layout thermodynamic model,in order to eliminate the transformation produced by the uncontrolled shape memory behavior of the general unit.Three critical and efective strategies for the layout design of actuators were proposed and then applied to achieve the desired accurate deformation of 3D-printed bilayer structures.Finally,the proposed approach was validated and adopted for fabricating a complex shell-like gripper structure. | Siyuan Zeng Yixiong Feng Yicong Gao Hao Zheng Jianrong Tan | 2022 | Bio-Design and Manufacturing2022，5，1： | 1 |
| 9 | A Client Selection Method Based on Loss Function Optimization for Federated Learning显示文摘Federated learning is a distributedmachine learningmethod that can solve the increasingly serious problemof data islands and user data privacy,as it allows training data to be kept locally and not shared with other users.It trains a globalmodel by aggregating locally-computedmodels of clients rather than their rawdata.However,the divergence of local models caused by data heterogeneity of different clients may lead to slow convergence of the global model.For this problem,we focus on the client selection with federated learning,which can affect the convergence performance of the global model with the selected local models.We propose FedChoice,a client selection method based on loss function optimization,to select appropriate local models to improve the convergence of the global model.It firstly sets selected probability for clients with the value of loss function,and the client with high loss will be set higher selected probability,which can make them more likely to participate in training.Then,it introduces a local control vector and a global control vector to predict the local gradient direction and global gradient direction,respectively,and calculates the gradient correction vector to correct the gradient direction to reduce the cumulative deviationof the local gradient causedby theNon-IIDdata.Wemake experiments to verify the validity of FedChoice on CIFAR-10,CINIC-10,MNIST,EMNITS,and FEMNIST datasets,and the results show that the convergence of FedChoice is significantly improved,compared with FedAvg,FedProx,and FedNova. | Yan Zeng Siyuan Teng Tian Xiang Jilin Zhang Yuankai Mu Yongjian Ren Jian Wan | 2023 | Computer Modeling in Engineering & Sciences2023，，10： | 0 |
| 10 | Complicated deformation simulating on temperature-driven 4D printed bilayer structures based on reduced bilayer plate model显示文摘The four-dimensional(4D) printing technology, as a combination of additive manufacturing and smart materials, has attracted increasing research interest in recent years. The bilayer structures printed with smart materials using this technology can realize complicated deformation under some special stimuli due to the material properties.The deformation prediction of bilayer structures can make the design process more rapid and thus is of great importance. However, the previous works on deformation prediction of bilayer structures rarely study the complicated deformations or the influence of the printing process on deformation. Thus, this paper proposes a new method to predict the complicated deformations of temperature-sensitive 4D printed bilayer structures,in particular to the bilayer structures based on temperature-driven shape-memory polymers(SMPs) and fabricated using the fused deposition modeling(FDM) technology. The programming process to the material during printing is revealed and considered in the simulation model. Simulation results are compared with experiments to verify the validity of the method. The advantages of this method are stable convergence and high efficiency,as the three-dimensional(3D) problem is converted to a two-dimensional(2D) problem.The simulation parameters in the model can be further associated with the printing parameters, which shows good application prospect in 4D printed bilayer structure design. | Junjie SONG Yixiong FENG Yong WANG Siyuan ZENG Zhaoxi HONG Hao QIU Jianrong TAN | 2021 | Applied Mathematics and Mechanics(English Edition)2021，42，11： | 0 |
| 11 | Distinct durability of IgM/IgG antibody responses in COVID-19 patients with differing severity显示文摘Dear Editor,The coronavirus disease 2019(COVID-19)pandemic is generating a demand for simultaneous vaccine development,which is expected to prevent future outbreaks by eliciting sufficient and protective immunity. | Junyan Han Ning Zhang Danying Chen Yuhuan Gong Guoli Li Yaxian Kong Lin Pu Chen Chen Jingyuan Liu Qi Wang Ju Zhang Xuesen Zhao Juan Du Kai Han Chuan Song Linghang Wang Mingxi Hua Yu Hao Rui Song Yangzi Song Fengting Yu Siyuan Yang Haofeng Xiong Wei Zhang George F.Gao Fujie Zhang Ang Li Hui Zeng Yuhai Bi | 2022 | Science China(Life Sciences)2022，65，1： | 0 |
| 12 | Multi-UAVs Collaborative Path Planning in the Cramped Environment显示文摘Due to its flexibility and complementarity, the multiUAVs system is well adapted to complex and cramped workspaces, with great application potential in the search and rescue(SAR) and indoor goods delivery fields. However, safe and effective path planning of multiple unmanned aerial vehicles(UAVs)in the cramped environment is always challenging: conflicts with each other are frequent because of high-density flight paths, collision probability increases because of space constraints, and the search space increases significantly, including time scale, 3D scale and model scale. Thus, this paper proposes a hierarchical collaborative planning framework with a conflict avoidance module at the high level and a path generation module at the low level. The enhanced conflict-base search(ECBS) in our framework is improved to handle the conflicts in the global path planning and avoid the occurrence of local deadlock. And both the collision and kinematic models of UAVs are considered to improve path smoothness and flight safety. Moreover, we specifically designed and published the cramped environment test set containing various unique obstacles to evaluating our framework performance thoroughly. Experiments are carried out relying on Rviz, with multiple flight missions: random, opposite, and staggered, which showed that the proposed method can generate smooth cooperative paths without conflict for at least 60 UAVs in a few minutes.The benchmark and source code are released in http://gffzz188fe103f8f1460asxckbcbp0k5vo6nfk.ffgz.tsg.suse.edu.cn/inin-xingtian/multi-UAVs-path-planner. | Siyuan Feng Linzhi Zeng Jining Liu Yi Yang Wenjie Song | 2024 | IEEE/CAA Journal of Automatica Sinica2024，11，2： | 0 |
| 13 | Information technology and artificial intelligence support in management experiences of the pediatric designated hospital during the COVID-19 epidemic in 2022 in Shanghai显示文摘Objective:To describe the information technology and artificial intelligence support in management experiences of the pediatric designated hospital in the wave of COVID-19 in Shanghai.Methods:We retrospectively concluded the management experiences at the largest pediatric designated hospital from March 1st to May 11th in 2022 in Shanghai.We summarized the application of Internet hospital,face recognition technology in outpatient department,critical illness warning system and remote consultation system in the ward and the structed electronic medical record in the inpatient system.We illustrated the role of the information system through the number and prognosis of patients treated.Results:The COVID-19 designated hospitals were built particularly for critical patients requiring high-level medical care,responded quickly and scientifically to prevent and control the epidemic situation.From March 1st to May 11th,2022,we received and treated 768 children confirmed by positive RT-PCR and treated at our center.In our management,we use Internet Information on the Internet Hospital,face recognition technology in outpatient department,critical illness warning system and remote consultation system in the ward,structed electronic medical record in the inpatient system.No deaths or nosocomial infections occurred.The number of offline outpatient visits dropped,from March to May 2022,146,106,48,379,57,686 respectively.But the outpatient volume on the internet hospital increased significantly(3,347 in March 2022 vs.372 in March 2021;4,465 in April 2022 vs.409 in April 2021;4,677 in May 2022 vs.538 in May 2021).Conclusions:Information technology and artificial intelligence has provided significant supports in the management.The system might optimize the admission screening process,increases the communication inside and outside the ward,achieves early detection and diagnosis,timely isolates patients,and timely treatment of various types of children. | Yu Shi Jin Fu Mei Zeng Yanling Ge Xiangshi Wang Aimei Xia Weijie Shen Jiali Wang Weiming Chen Siyuan Jiang Xiaowen Zhai | 2023 | Intelligent Medicine2023，3，1： | 0 |
| 14 | Epizootiological surveillance of porcine circoviruses in free-ranging wild boars in China显示文摘Four species of porcine circoviruses(PCV1–4)have been reported to circulate in Chinese domestic pigs,while the epizootiology of these viruses in free-ranging wild boars in China remains unknown.In this study,tissue and serum samples collected from diseased or apparently healthy wild boars between 2018 and 2020 in 19 regions of China were tested for the prevalence of PCV1–4 infections.Positive rates of PCV1,PCV2,and PCV3 DNA in the tissue samples of Chinese wild boars were 1.6%(4/247),58.3%(144/247),and 10.9%(27/247)respectively,with none positive for PCV4.Sequence analysis of viral genome showed that the four PCV1 strains distributed in Hunan and Inner Mongolia shared 97.5%–99.6%sequence identity with global distributed reference strains.Comparison of the ORF2 gene sequences showed that 80 PCV2 strains widely distributed in 18 regions shared 79.5%–100%sequence identity with reference strains from domestic pigs and wild boars,and were grouped into PCV2a(7),PCV2b(31)and PCV2d(42).For PCV3,17 sequenced strains shared 97.2%–100%nucleotide identity at the genomic level and could be divided into PCV3a(3),PCV3b(2)and PCV3c(12)based on the phylogeny of ORF2 gene sequences.Serological data revealed antibody positive rates against PCV1 and PCV2 of 11.4%(19/167)and 53.9%(90/167)respectively.The data obtained in this study improved our understanding about the epidemiological situations of PCVs infection in free-ranging wild boars in China and will be valuable for the prevention and control of diseases caused by PCVs infection. | Wenjie Gong Haiying Du Tong Wang Heting Sun Peng Peng Siyuan Qin Haidong Geng Zheng Zeng Wangwang Liang Hongquan Ling Changchun Tu Zhongzhong Tu | 2023 | Virologica Sinica2023，38，5： | 0 |
| 15 | Blue light-induced phosphorylation of Arabidopsis cryptochrome 1 is essential for its photosensitivity显示文摘Plants possess two cryptochrome photoreceptors,cryptochrome 1(CRY1)and cryptochrome 2(CRY2),that mediate overlapping and distinct physiological responses.Both CRY1 and CRY2 undergo blue light-induced phosphorylation,but the molecular details of CRY1 phosphorylation remain unclear.Here we identify 19 in vivo phosphorylation sites in CRY1 using mass spectrometry and systematically analyze the physiological and photobiochemical activities of CRY1 variants with phosphosite substitutions.We demonstrate that nonphosphorylatable CRY1 variants have impaired phosphorylation,degradation,and physiological functions,whereasphosphomimeticvariants mimic the physiological functions of phosphorylated CRY1 to constitutively inhibit hypocotyl elongation.We further demonstrate that phosphomimetic CRY1 variants exhibit enhanced interaction with the E3 ubiquitin ligase COP1(CONSTITUTIVELY PHOTOMORPHOGENIC 1).This finding is consistent with the hypothesis that phosphorylation of CRY1 is required for COP1-dependent signaling and regulation of CRY1.We also determine that PHOTOREGULATORY PROTEIN KINASEs(PPKs)phosphorylate CRY1 in a blue light-dependent manner and that this phosphorylation is critical for CRY1 signaling and regulation.These results indicate that,similar to CRY2,blue light-dependent phosphorylation of CRY1 determines its photosensitivity. | Lin Gao Qing Liu Ming Zhong Nannan Zeng Weixian Deng Yaxing Li Dong Wang Siyuan Liu Qin Wang | 2022 | Journal of Integrative Plant Biology2022，64，9： | 0 |
| 16 | Reversible grafting of antibiotics onto contact lens mediated by labile chemical bonds for smart prevention and treatment of corneal bacterial infections显示文摘Eye trauma, decreased immunity, and contact lens wear often cause serious bacterial infections and irreversible corneal damage. To realize the responsive release of antibiotics such as gentamicin sulfate(GS), a novel antibacterial contact lens was constructed through self-assembly of antibiotics loaded ADAGS/PEI(polyethyleneimine) multilayer films on the surface. Both in vitro and in vivo antibacterial tests demonstrated high efficient and fast antibacterial property based on the smart responsive to bacterial infections and reversible drug loading and release. | Bailiang Wang Jiahong Zeng Yishun Guo Lin Liang Yingyingjin Siyuan Qian Renjie Miao Liang Hu Fan Lu | 2021 | Journal of Materials Science & Technology2021，，2： | 0 |
| 17 | Optimal Timing of Antiretroviral Therapy Initiation in Acquired Immunodeficiency Syndrome-Associated Toxoplasmic Encephalitis:A Prospective Observational Multicenter Study in China显示文摘Background:Toxoplasmic encephalitis(TE)is the most frequent cause of expansive brain lesions among patients with acquired immunodeficiency syndrome(AIDS).However,the optimal timing of antiretroviral therapy(ART)initiation in these patients remains controversial.This study aims to investigate the differences in outcomes of ART initiation at different times,in order to help clarify the treatment timing of AIDS-associated TE.Methods:This multicenter prospective observational study included 87 patients recruited from 11 research centers in China(from March 2019 to December 2022).Of the patients,38 were assigned to the early ART group(initiating ART within 2 weeks after anti-Toxoplasma treatment initiation),and the remaining 49 patients received deferred ART(initiating ART at least 2 weeks after anti-Toxoplasma treatment initiation).The main outcomes includedmortality and emergence of immune reconstitution inflammatory syndrome(IRIS).Human immunodeficiency virus(HIV)-1 viral load and CD4^(+)T-cell counts at weeks 24 and 48 were observed.Results:The number of deaths(1 vs.5,P=0.225)and incidence of IRIS(2.6%vs.0,P=0.437)were not significantly different between the early and deferred ART groups at week 48.Early ART initiation did not contribute significantly to HIV-1 viral load control(<50 copies/mL,n=8 vs.n=3 at week 24,P=0.142;n=7 vs.n=7 atweek 48,P=1.000).The median CD4^(+)T-cell counts between the two groups were not significantly different,either at week 24(155 vs.91 cells/mm^(3),P=0.837)or atweek 48(181 vs.146 cells/mm^(3),P=0.219).Conclusion:In patients with AIDS-associated TE,early ART initiation was not significantly different from deferred ART initiation in terms of incidence of mortality,IRIS,and HIV virological and immunological outcomes.Trial registration:This study was registered(registration number:ChiCTR1900021195)as one of 12 clinical trials under the title of a general project at the Chinese Clinical Trial Registry(chictr.gov)on February 1,2019.Enrollment for this study began inMarch 2019. | Yao Li Haidong Jiang Yanming Zeng Yanqiu Lu Siyuan Chen Yulin Zhang Zhongsheng Jiang Tongtong Yang Shuiqing Liu Yaokai Chen | 2024 | Infectious Diseases & Immunity2024，4，1： | 0 |
| 18 | Soliton frequency comb generation in CMOS-compatible silicon nitride microresonators显示文摘The monolithic integration of soliton microcomb devices with active photonic components and high-frequency electronics is highly desirable for practical applications. Among many materials, silicon nitride(SiN_(x)) waveguide layers prepared by low-pressure chemical vapor deposition(LPCVD) have been the main platform for on-chip optical frequency comb generation. However, the high temperatures involved in LPCVD render it incompatible as a back-end process with complementary metal oxide semiconductor(CMOS) or active Ⅲ-Ⅴ compound semiconductor fabrication flows. We report the generation of coherent soliton frequency combs in micro-ring resonators fabricated in deuterated silicon nitride(SiN_(x):D) waveguides with a loss of 0.09 d B/cm. Deposited at 270℃ by an inductance-coupled plasma chemical vapor deposition(ICP-CVD) process, the material preparation and fabrication flow are fully CMOS-compatible. These results enable the integration of silicon-nitride-based optical combs and photonic integrated circuits(PICs) on prefabricated CMOS and/or Ⅲ-Ⅴ substrates, therefore marking a major step forward in Si Nxphotonic technologies. | YAOZU XIE JIAQI LI YANFENG ZHANG ZERU WU SHIHAO ZENG SHUQING LIN ZHAOYANG WU WENCHAO ZHOU YUJIE CHEN SIYUAN YU | 2022 | Photonics Research2022，10，5： | 0 |
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