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| 1 | Biochar-based materials and their applications in removal of organic contaminants from wastewater:state-of-the-art review显示文摘As a class of famous carbon materials,biochars(BCs)and their derivative materials with excellent physicochemical properties and diversified functionalities present great potential in wastewater treatment fields.This review focuses on the latest development in reported biochar-based materials as superior adsorbents or catalysts for removing harmful organic contaminants from wastewater.The construction and properties of biochar-based materials are briefly introduced at the beginning.As one of the major factors affecting the properties of BCs,the wide diversity of feedstocks,such as agricultural and forest residues,industrial by-products as well as municipal wastes,endows BCs different chemical compositions and structures.Woody and herbaceous BCs usually have higher carbon contents,larger surface areas and strong aromaticity,which is in favor of the organic contaminant removal.Driven by the desire of more cost-effective materials,several types of biochar-based hybrid materials,such as magnetic BC composites(MBC),nanometal/nanometallic oxides/hydroxide BC composites and layered nanomaterial-coated BCs,as well as physically/chemically activated BCs,have also been developed.With the help of foreign materials,these types of hybrid BCs have excellent capacities to remove a wide range of organic contaminants,including organic dyestuff,phenols and chemical intermediates,as well as pharmaceutically active compounds,from aquatic solutions.Depending on the different types of biochar-based materials,organic contaminants can be removed by different mechanisms,such as physical adsorption,electrostatic interaction,π-πinteraction and Fenton process,as well as photocatalytic degradation.In summary,the low cost,tunable surface chemistry and excellent physical-chemical properties of BCs allow it to be a potential material in organic contaminant removal.The combination of BCs with foreign materials endows BCs more functionalities and broader development opportunities.Considering the urgent demand of practical wastewater treatment,we hope more researches will focus on the applications and commercialization of biochar-based materials. | Qiang Huang Shuang Song Zhe Chen Baowei Hu Jianrong Chen Xiangke Wang | 2019 | Biochar2019，1，1： | 24 |
| 2 | Exploring an Integrative Therapy for Treating COVID-19:A Randomized Controlled Trial显示文摘Objectives:To develop a new Chinese medicine(CM)-based drug and to evaluate its safety and effect for suppressing acute respiratory distress syndrome(ARDS)in COVID-19 patients.Methods:A putative ARDS-suppressing drug Keguan-1 was first developed and then evaluated by a randomized,controlled two-arm trial.The two arms of the trial consist of a control therapy(alpha interferon inhalation,50(x g twice daily;and lopinavir/ritonavir,400 and 100 mg twice daily,respectively)and a testing therapy(control therapy plus Keguan-119.4 g twice daily)by random number table at 1:1 ratio with 24 cases each group.After 2-week treatment,adverse events,time to fever resolution,ARDS development,and lung injury on newly diagnosed COVID-19 patients were assessed.Results:An analysis of the data from the first 30 participants showed that the control arm and the testing arm did not exhibit any significant differences in terms of adverse events.Based on this result,the study was expanded to include a total of 48 participants(24 cases each arm).The results show that compared with the control arm,the testing arm exhibited a significant improvement in time to fever resolution(P=0.035),and a significant reduction in the development of ARDS(P=0.048).Conclusions:Keguan-1-based integrative therapy was safe and superior to the standard therapy in suppressing the development of ARDS in COVID-19 patients.(Trial registration No.NCT 04251871 at www.clinicaltrials.gov). | WANG Jia-bo WANG Zhong-xia JING Jing ZHAO Peng DONG Jing-hui ZHOU Yong-feng YANG Guang NIU Ming ZHAO Xu JIANG Tian-jun Bl Jing-feng XU Zhe ZHANG Ping WU Dan BAI Zhao-fang GUO Yu-ming YU Si-miao SUN Yong-qiang ZHANG Zi-teng ZHAN Xiao-yan LI Peng-yan DING Jin-biao ZHAO Peng-fei SONG Xue-ai TANG Jian-yuan HE Dong-chu CHEN Zhu QIN En-qiang WANG Rui-lin XIAO Xiao-he | 2020 | Chinese Journal of Integrative Medicine2020，26，9： | 18 |
| 3 | Human umbilical cord-derived mesenchymal stem cell therapy in patients with COVID-19:a phase 1 clinical trial显示文摘No effective drug treatments are available for coronavirus disease 2019(COVID-19).Host-directed therapies targeting the underlying aberrant immune responses leading to pulmonary tissue damage,death,or long-term functional disability in survivors require clinical evaluation.We performed a parallel assigned controlled,non-randomized,phase 1 clinical trial to evaluate the safety of human umbilical cord-derived mesenchymal stem cells(UC-MSCs)infusions in the treatment of patients with moderate and severe COVID-19 pulmonary disease.The study enrolled 18 hospitalized patients with COVID-19(n=9 for each group).The treatment group received three cycles of intravenous infusion of UC-MSCs(3×107 cells per infusion)on days 0,3,and 6.Both groups received standard COVID-treatment regimens.Adverse events,duration of clinical symptoms,laboratory parameters,length of hospitalization,serial chest computed tomography(CT)images,the PaO2/FiO2 ratio,dynamics of cytokines,and IgG and IgM anti-SARS-CoV-2 antibodies were analyzed.No serious UC-MSCs infusion-associated adverse events were observed.Two patients receiving UC-MSCs developed transient facial flushing and fever,and one patient developed transient hypoxia at 12 h post UC-MSCs transfusion.Mechanical ventilation was required in one patient in the treatment group compared with four in the control group.All patients recovered and were discharged.Our data show that intravenous UC-MSCs infusion in patients with moderate and severe COVID-19 is safe and well tolerated.Phase 2/3 randomized,controlled,double-blinded trials with long-term follow-up are needed to evaluate the therapeutic use of UC-MSCs to reduce deaths and improve long-term treatment outcomes in patients with serious COVID-19. | Fanping Meng Ruonan Xu Siyu Wang Zhe Xu Chao Zhang Yuanyuan Li Tao Yang Lei Shi Junliang Fu Tianjun Jiang Lei Huang Peng Zhao Xin Yuan Xing Fan Ji-Yuan Zhang Jinwen Song Dawei Zhang Yanmei Jiao Limin Liu Chunbao Zhou Markus Maeurer Alimuddin Zumla Ming Shi Fu-Sheng Wang | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 16 |
| 4 | Effect of human umbilical cord-derived mesenchymal stem cells on lung damage in severe COVID-19 patients:a randomized,double-blind,placebo-controlled phase 2 trial显示文摘Treatment of severe Coronavirus Disease 2019(COVID-19)is challenging.We performed a phase 2 trial to assess the efficacy andsafety of human umbilical cord-mesenchymal stem cells(UC-MScs)to treat severe coViD-19 patients with lung damage,based onour phase 1 data.In this randomized,double-blind,and placebo-controlled trial,we recruited 101 severe coVID-19 patients withlung damage.They were randomly assigned at a 2:1 ratio to receive either UC-MSCs(4×10^(7)cells per infusion)or placebo on day 0,3,and 6.The primary endpoint was an altered proportion of whole lung lesion volumes from baseline to day 28.Other imagingoutcomes,6-minute walk test(6-MWT),maximum vital capacity,diffusing capacity,and adverse events were recorded and analyzed.In all,100 COVID-19 patients were finally received either UC-MSCs in=65)or placebo(n=35).UC-MSCs administrationexerted numerical improvement in whole lung lesion volume from baseline to day 28 compared with the placebo(the mediandifference was-13.31%,95%Cl-29.14%,2.13%,P=0.08).UC-MSCs significanty reduced the proportions of solid componentlesion volume compared with the placebo(median difference:-15.45%;95%CI-30.82%,-0.39%;P=0.043).The 6-MWT showedan increased distance in patients treated with UC-MSCs(difference:27.00 m;95%CI 0.00,57.00;P=0.057).The incidence of adverseevents was similar in the two groups.These results suggest that UC-MSCs treatment is a safe and potentially effective therapeuticapproach for COVID-19 patients with lung damage.A phase 3 trial is required to evaluate effects on reducing mortality andpreventing long-term pulmonary disability. | Lei Shi Hai Huang Xuechun Lu Xiaoyan Yan Xiaojing Jiang Ruonan Xu Siyu Wang Chao Zhang Xin Yuan Zhe Xu Lei Huang Jun-Liang Fu Yuanyuan Li Yu Zhang Wei-Qi Yao Tianyi Liu Jinwen Song Liangliang Sun Fan Yang Xin Zhang Bo Zhang Ming Shi Fanping Meng Yanning Song Yongpei Yu Jiqiu Wen Qi Li Qing Mao Markus Maeurer Alimuddin Zumla Chen Yao Wei-Fen Xie Fu-Sheng Wang | 2021 | Signal Transduction and Targeted Therapy2021，6，3： | 13 |
| 5 | m^6A-dependent biogenesis of circular RNAs in male germ cells显示文摘The majority of circular RNAs(circRNAs)spliced from coding genes contain open reading frames(ORFs)and thus,have protein coding potential.However,it remains unknown what regulates the biogenesis of these ORF-containing circRNAs,whether they are actually translated into proteins and what functions they play in specific physiological contexts.Here,we report that a large number of circRNAs are synthesized with increasing abundance when late pachytene spermatocytes develop into round and then elongating spermatids during murine spermatogenesis.For a subset of circRNAs,the back splicing appears to occur mostly at m^6A-enriched sites,which are usually located around the start and stop codons in linear mRNAs.Consequently,approximately a half of these male germ cell circRNAs contain large ORFs with m^6A-modified start codons in their junctions,features that have been recently shown to be associated with protein-coding potential.Hundreds of peptides encoded by the junction sequences of these circRNAs were detected using liquid chromatography coupled with mass spectrometry,suggesting that these circRNAs can indeed be translated into proteins in both developing(spermatocytes and spermatids)and mature(spermatozoa)male germ cells.The present study discovered not only a novel role of m^6A in the biogenesis of coding circRNAs,but also a potential mechanism to ensure stable and long-lasting protein production in the absence of linear mRNAs,i.e.,through production of circRNAs containing large ORFs and m^6A-modified start codons in junction sequences. | Chong Tang Yeming Xie Tian Yu Na Liu Zhuqing Wang Rebekah J.Woolsey Yunge Tang Xinzong Zhang Weibing Qin Ying Zhang Ge Song Weiwei Zheng Juan Wang Weitian Chen Xiongyi Wei Zhe Xie Rachel Klukovich Huili Zheng David R.Quilici Wei Yan | 2020 | Cell Research2020，30，3： | 12 |
| 6 | Flexible and transparent graphene/silver-nanowires composite ?lm for high electromagnetic interference shielding effectiveness显示文摘Herein, an efficient approach to prepare flexible, transparent, and lightweight films based on graphene nanosheets(GNS) and silver nanowires(AgNWs) for high electromagnetic interference(EMI) shielding effectiveness(SE) has been explained. High-conductive GNS were fabricated by liquid phase stripping and composited with AgNWs by a two-step spin-coating method. Owing to the high transparency, good conductivity, and homogeneous distribution of both GNS and AgNWs, the obtained GNS/AgNWs film exhibits superb EMI SE and light transmittance, yielding a significantly high EMI SE up to 26 dB in both Ku-band and K-band and light transmittance higher than 78.4%. Moreover, this GNS/AgNWs film shows good flexibility and excellent structural stability. The obtained flexible, light and transparent film could have a great potential for transparent EMI shielding and smart electronics. | Ning Zhang Zhe Wang Rongguo Song Qianlong Wang Hongye Chen Bin Zhang Haifei Lv Zhi Wu Daping He | 2019 | Science Bulletin2019，64，8： | 12 |
| 7 | Therapeutic effect of nerve growth factor on cerebral infarction in dogs using the hemisphere anomalous volume ratio of diffusion-weighted magnetic resonance imaging显示文摘A model of focal cerebral ischemic infarction was established in dogs through middle cerebral artery occlusion of the right side.Thirty minutes after occlusion,models were injected with nerve growth factor adjacent to the infarct locus.The therapeutic effect of nerve growth factor against cerebral infarction was assessed using the hemisphere anomalous volume ratio,a quantitative index of diffusion-weighted MRI.At 6 hours,24 hours,7 days and 3 months after modeling,the hemisphere anomalous volume ratio was significantly reduced after treatment with nerve growth factor. Hematoxylin-eosin staining,immunohistochemistry,electron microscopy and neurological function scores showed that infarct defects were slightly reduced and neurological function significantly improved after nerve growth factor treatment.This result was consistent with diffusion-weighted MRI measurements.Experimental findings indicate that nerve growth factor can protect against cerebral infarction,and that the hemisphere anomalous volume ratio of diffusion-weighted MRI can be used to evaluate the therapeutic effect. | Yong Wang Hui Zhang Zhe Wang Zuojun Geng Huaijun Liu Haiqing Yang Peng Song Qing Liu | 2012 | Neural Regeneration Research2012，7，24： | 9 |
| 8 | Hard X-ray Imager (HXI) onboard the ASO-S mission显示文摘Hard X-ray Imager(HXI)is one of the three scientific instruments onboard the Advanced Spacebased Solar Observatory(ASO-S)mission,which is proposed for the 25th solar maximum by the Chinese solar community.HXI is designed to investigate the non-thermal high-energy electrons accelerated in solar flares by providing images of solar flaring regions in the energy range from 30 keV to 200 keV.The imaging principle of HXI is based on spatially modulated Fourier synthesis and utilizes about 91 sets of bi-grid sub-collimators and corresponding LaBr3 detectors to obtain Fourier components with a spatial resolution of about 3 arcsec and a time resolution better than 0.5 s.An engineering prototype has been developed and tested to verify the feasibility of design.In this paper,we present background,instrument design and the development and test status of the prototype. | Zhe Zhang Deng-Yi Chen Jian Wu Jin Chang Yi-Ming Hu Yang Su Yan Zhang Jian-Ping Wang Yao-Ming Liang Tao Ma Jian-Hua Guo Ming-Sheng Cai Yong-Qiang Zhang Yong-Yi Huang Xiao-Yan Peng Zong-Bin Tang Xuan Zhao Hong-He Zhou Lian-Guo Wang Jing-Xing Song Miao Ma Guang-Zhou Xu Jian-Feng Yang Di Lu Ying-Hong He Jin-You Tao Xiao-Long Ma Bao-Gang Lv Yan-Ping Bai Cai-Xia Cao Yu Huang Wei-Qun Gan | 2019 | Research in Astronomy and Astrophysics2019，19，11： | 9 |
| 9 | Cross electro-nape-acupuncture ameliorates cerebral hemorrhageinduced brain damage by inhibiting necroptosis显示文摘BACKGROUND Receptor interacting protein kinase 1(RIPK1)-mediated cell death,including apoptosis and necroptosis,belongs to programmed cell death.It has been reported that RIPK1-mediated necroptosis exists in lesions of cerebral hemorrhage(CH).Electroacupuncture,a treatment derived from traditional Chinese medicine,could improve neurological impairment in patients with brain injury.AIM To investigate the protective role of cross electro-nape acupuncture(CENA)in CH,and clarify the potential mechanism.METHODS CH rat models were established,and CENA was applied to the experimental rats.Neurological functions and encephaledema were then measured.Necrotic cells in the brain of rats with CH were evaluated by propidium iodide staining.Necroptosis was assessed by immunofluorescence.Activation of the necroptosisrelated pathway was detected by western blot.Extraction of brain tissue,cerebrospinal fluid and serum samples was conducted to measure the expression and secretion of inflammatory cytokines by quantitative real-time polymerase chain reaction and enzyme-linked immunosorbent assay.RESULTS The necroptotic marker p-MLKL was detectable in the brains of rats with CH.Next,we found that CENA could ameliorate neurological functions in rat models of CH.Moreover,the upregulation of RIPK1-mediated necroptosis-related molecules in the brains of rats with CH were inhibited by CENA.Further investigation revealed that CENA partially blocked the interaction between RIPK1 and RIPK3.Finally,in vivo assays showed that CENA decreased the expression of the inflammatory cytokines tumor necrosis factor-α,interleukin-6 and interleukin-8 in CH rat models.CONCLUSION These findings revealed that CENA exerts a protective role in CH models by inhibiting RIPK1-mediated necroptosis. | Guo-Feng Cai Zhong-Ren Sun Zhe Zhuang Hai-Chun Zhou Shan Gao Kai Liu Li-Li Shang Kun-Ping Jia Xiu-Zhen Wang Hui Zhao Guo-Liang Cai Wen-Li Song Sheng-Nan Xu | 2020 | World Journal of Clinical Cases2020，8，10： | 9 |
| 10 | Nitrous oxide emissions following seasonal freeze-thaw events from arable soils in Northeast China显示文摘Seasonal soil freeze-thaw events may enhance soil nitrogen transformation and thus stimulate nitrous oxide(N_2O)emissions in cold regions.However,the mechanisms of soil N_2O emission during the freeze-thaw cycling in the field remain unclear.We evaluated N_2O emissions and soil biotic and abiotic factors in maize and paddy fields over 20 months in Northeast China,and the structural equation model(SEM)was used to determine which factors affected N_2O production during non-growing season.Our results verified that the seasonal freeze-thaw cycles mitigated the available soil nitrogen and carbon limitation during spring thawing period,but simultaneously increased the gaseous N_2O-N losses at the annual time scale under field condition.The N_2O-N cumulative losses during the non-growing season amounted to 0.71 and 0.55 kg N ha^(–1) for the paddy and maize fields,respectively,and contributed to 66 and 18%of the annual total.The highest emission rates(199.2–257.4μg m^(–2) h^(–1))were observed during soil thawing for both fields,but we did not observe an emission peak during soil freezing in early winter.Although the pulses of N_2O emission in spring were short-lived(18 d),it resulted in approximately80%of the non-growing season N_2O-N loss.The N_2O burst during the spring thawing was triggered by the combined impact of high soil moisture,flush available nitrogen and carbon,and rapid recovery of microbial biomass.SEM analysis indicated that the soil moisture,available substrates including NH_4^+and dissolved organic carbon(DOC),and microbial biomass nitrogen(MBN)explained 32,36,16 and 51%of the N_2O flux variation,respectively,during the non-growing season.Our results suggested that N_2O emission during the spring thawing make a vital contribution of the annual nitrogen budget,and the vast seasonally frozen and snow-covered croplands will have high potential to exert a positive feedback on climate change considering the sensitive response of nitrogen biogeochemical cycling to the freeze-thaw disturbance. | CHEN Zhe YANG Shi-qi ZHANG Ai-ping JING Xin SONG Wei-min MI Zhao-rong ZHANG Qing-wen WANG Wen-ying YANG Zheng-li | 2018 | Journal of Integrative Agriculture2018，17，1： | 8 |
| 11 | MicroRNA-638 inhibits cell proliferation by targeting phospholipase D1 in human gastric carcinoma显示文摘MicroRNAs (miRNAs ) 是经常是玩的小非编码的 RNA 的一种类型在 carcinogenesis 的重要角色,而是 miRNAs 的 carcinogenic 机制仍然是不清楚的。这研究将在癌(GC ) 调查功能和 miR-638 的机制。在 GC 和 miR-638 的 DNA 拷贝数字的 miR-638 的表示被即时 PCR 检测。房间增长上的 miR-638 的效果被数 kit-8 试金测量。不同试金,包括生物信息学算法(TargetScan 并且人权保护) ,酶报告试金并且西方的弄污,被用来在 GC 识别 miR-638 的目标基因。在临床的 CRC 纸巾的 miR-638 目标基因的表示被 immunohistochemical 试金也验证。从这研究,我们发现 miR-638 与相应 noncancerous 纸巾(NCT ) 相比是在 GC 纸巾的 downregulated,并且 miR-638 的 DNA 拷贝数字比 NCT 在 GC 是更低的,它可以在 GC 导致 miR-638 的相应 downregulation。miR-638 的宫外的表示在 vitro 禁止了 GC 细胞生长。随后,我们鉴别 PLD1 是在 GC,和 silencing PLD1 表示 phenocopied 的 miR-638 的目标基因 GC 房间增长上的 miR-638 的禁止的效果。而且,我们观察到 PLD1 是在在预言的 GC 的 PLD1 的 GC 纸巾,和高表示的 overexpressed 差的全面幸存。在摘要,我们表明 miR-638 通过禁止 PLD1 在 GC 作为肿瘤 suppressor 工作。 | Jiwei Zhang Zehua Bian Jialiang Zhou Mingxu Song Zhihui Liu Yuyang Feng Li Zhe Binbin Zhang Yuan Yin Zhaohui Huang | 2015 | Protein & Cell2015，6，9： | 8 |
| 12 | Interaction between Schwann cells and other cells during repair of peripheral nerve injury显示文摘Peripheral nerve injury(PNI)is common and,unlike damage to the central nervous system injured nerves can effectively regenerate depending on the location and severity of injury.Peripheral myelinating glia,Schwann cells(SCs),interact with various cells in and around the injury site and are important for debris elimination,repair,and nerve regeneration.Following PNI,Wallerian degeneration of the distal stump is rapidly initiated by degeneration of damaged axons followed by morphologic changes in SCs and the recruitment of circulating macrophages.Interaction with fibroblasts from the injured nerve microenvironment also plays a role in nerve repair.The replication and migration of injury-induced dedifferentiated SCs are also important in repairing the nerve.In particular,SC migration stimulates axonal regeneration and subsequent myelination of regenerated nerve fibers.This mobility increases SC interactions with other cells in the nerve and the exogenous environment,which influence SC behavior post-injury.Following PNI,SCs directly and indirectly interact with other SCs,fibroblasts,and macrophages.In addition,the inter-and intracellular mechanisms that underlie morphological and functional changes in SCs following PNI still require further research to explain known phenomena and less understood cell-specific roles in the repair of the injured peripheral nerve.This review provides a basic assessment of SC function post-PNI,as well as a more comprehensive evaluation of the literature concerning the SC interactions with macrophages and fibroblasts that can influence SC behavior and,ultimately,repair of the injured nerve. | Wen-Rui Qu Zhe Zhu Jun Liu De-Biao Song Heng Tian Bing-Peng Chen Rui Li Ling-Xiao Deng | 2021 | Neural Regeneration Research2021，16，1： | 8 |
| 13 | Whole genome sequencing of 10K patients with acute ischaemic stroke or transient ischaemic attack: design, methods and baseline patient characteristics显示文摘Background and purpose Stroke is the second leading cause of death worldwide and the leading cause of mortality and long-term disability in China,but its underlying risk genes and pathways are far from being comprehensively understood.We here describe the design and methods of whole genome sequencing(WGS)for 10914 patients with acute ischaemic stroke or transient ischaemic attack from the Third China National Stroke Registry(CNSR-III).Methods Baseline clinical characteristics of the included patients in this study were reported.DNA was extracted from white blood cells of participants.Libraries are constructed using qualified DNA,and WGS is conducted on BGISEQ-500 platform.The average depth is intended to be greater than 30×for each subject.Afterwards,Sentieon software is applied to process the sequencing data under the Genome Analysis Toolkit best practice guidance to call genotypes of single nucleotide variants(SNVs)and insertion-deletions.For each included subject,21 fingerprint SNVs are genotyped by MassARRAY assays to verify that DNA sample and sequencing data originate from the same individual.The copy number variations and structural variations are also called for each patient.All of the genetic variants are annotated and predicted by bioinformatics software or by reviewing public databases.Results The average age of the included 10914 patients was 62.2±11.3 years,and 31.4%patients were women.Most of the baseline clinical characteristics of the 10914 and the excluded patients were balanced.Conclusions The WGS data together with abundant clinical and imaging data of CNSR-III could provide opportunity to elucidate the molecular mechanisms and discover novel therapeutic targets for stroke. | Si Cheng Zhe Xu Yang Liu Jinxi Lin Yong Jiang Yilong Wang Xia Meng Anxin Wang Xinying Huang Zhimin Wang Guohua Chen Songdi Wu Zhengchang Jia Yongming Chen Xuerong Qiu Jun Wu Binbin Song Weizhong Ji Zhongping An Wenjun Xue Lili Zhao Yu Geng Hongyan Li Hao Li Yongjun Wang | 2021 | Stroke & Vascular Neurology2021，6，2： | 8 |
| 14 | Characterization of odorous charge and photochemical reactivity of VOC emissions from a full-scale food waste treatment plant in China显示文摘Food waste treatment plants(FWTPs) are usually associated with odorous nuisance and health risks, which are partially caused by volatile organic compound(VOC) emissions. This study investigated the VOC emissions from a selected full-scale FWTP in China. The feedstock used in this plant was mainly collected from local restaurants. For a year, the FWTP was closely monitored on specific days in each season. Four major indoor treatment units of the plant, including the storage room, sorting/crushing room, hydrothermal hydrolysis unit, and aerobic fermentation unit, were chosen as the monitoring locations.The highest mean concentration of total VOC emissions was observed in the aerobic fermentation unit at 21,748.2–31,283.3 μg/m3, followed by the hydrothermal hydrolysis unit at 10,798.1–23,144.4 μg/m3. The detected VOC families included biogenic compounds(oxygenated compounds, hydrocarbons, terpenes, and organosulfur compounds) and abiogenic compounds(aromatic hydrocarbons and halocarbons). Oxygenated compounds,particularly alcohols, were the most abundant compounds in all samples. With the use of odor index analysis and principal components analysis, the hydrothermal hydrolysis and aerobic fermentation units were clearly distinguished from the pre-treatment units, as characterized by their higher contributions to odorous nuisance. Methanthiol was the dominant odorant in the hydrothermal hydrolysis unit, whereas aldehyde was the dominant odorant in the aerobic fermentation unit. Terpenes, specifically limonene, had the highest level of propylene equivalent concentration during the monitoring periods. This concentration can contribute to the increase in the atmospheric reactivity and ozone formation potential in the surrounding air. | Zhe Ni Jianguo Liu Mingying Song Xiaowei Wang Lianhai Ren Xin Kong | 2015 | Journal of Environmental Sciences2015，27，3： | 7 |
| 15 | Establishment and gene expression profiling of LKB1 stable knockdown lung cancer cell line显示文摘背景肺癌症是在中国的癌症相关的死亡的领先的原因。变化分析表明 LKB1 inactivation 在 30% non-small-cell 肺癌症(NSCLC ) 是在场的,显示它象肿瘤 suppressor 的角色。然而,分子的机制仍然不是清楚的。我们试图建立 LKB1 稳定的击倒的 NSCLC 房间线,在基因表示检测改变并且识别基因的学习由 LKB1.Methods LKB1 稳定的击倒的 H1299 房间线调整了用 lentiviral 被建立短发卡 RNA。为了识别击倒的效果, LKB1 mRNA 和蛋白质,表示水平与量的即时 PCR 并且西方的弄污被评估。我们与 2-deoxyglucose 对待房间线决定 LKB1 蛋白质功能是否被影响。基因 microarray 分析被执行在 LKB1 稳定的击倒的 H1299 cells.Results LKB1 mRNA 检测基因表示改变,蛋白质表示显著地在 LKB1 稳定的击倒的 H1299 房间线被压制。2-DG 处理几乎没在 AMPK 的 phosphorylation 上有很少影响,它是 LKB1 的下游的目标,显示 LKB1 的功能的损失。microarray 数据显示出那 LKB1 击倒导致了 1243 种基因的表达式改变,包括涉及房间移植,房间增长和房间 apoptosis.Conclusions 的那些, LKB1 稳定的击倒的 H1299 房间线的建立向我们提供一个大工具调查 LKB1 通过 microarray 调整的各种各样的基因。LKB1 调整的房间增长和迁居相关的基因的发现为解开是批评的 LKB1 在肺癌症的发展和转移的角色的分子的机制。 | SUN Lin-lin ZHONG Dian-sheng WU Song BAI Hua CHEN Zhe | 2011 | Chinese Medical Journal2011，，13： | 7 |
| 16 | Characterization of inflammatory factor-induced changes in mesenchymal stem cell exosomes and sequencing analysis of exosomal microRNAs显示文摘BACKGROUND Treatments utilizing stems cells often require stem cells to be exposed to inflammatory environments,but the effects of such environments are unknown.AIM To examine the effects of inflammatory cytokines on the morphology and quantity of mesenchymal stem cell exosomes(MSCs-exo)as well as the differential expression of microRNAs(miRNAs)in the exosomes.METHODS MSCs were isolated from human umbilical tissue by enzymatic digestion.Exosomes were then collected after a 48-h incubation period in a serum-free medium with one of the following the inflammatory cytokines:None(control),vascular cell adhesion molecule-1(VCAM-1),tumor necrosis factor(TNF)α,and interleukin(IL)6.The morphology and quantity of each group of MSC exosomes were observed and measured.The miRNAs in MSCs-exo were sequenced.We compared the sequenced data with the miRBase and other non-coding databases in order to detect differentially expressed miRNAs and explore their target genes and regulatory mechanisms.In vitro tube formation assays and Western blot were performed in endothelial cells which were used to assess the angiogenic potential of MSCs-exo after inflammatory cytokine stimulation.RESULTS MSCs-exo were numerous,small,and regularly shaped in the VCAM-1 group.TNFαstimulated MSCs to secrete larger and irregular exosomes.IL6 led to a reduced quantity of MSCs-exo.Compared to the control group,the TNFαand IL6 groups had more downregulated differentially expressed miRNAs,particularly angiogenesis-related miRNAs.The angiogenic potential of MSCs-exo declined after IL6 stimulation.CONCLUSION TNFαand IL6 may influence the expression of miRNAs that down-regulate the PI3K-AKT,MAPK,and VEGF signaling pathways;particularly,IL6 significantly down-regulates the PI3K-AKT signaling pathway.Overall,inflammatory cytokines may lead to changes in exosomal miRNAs that abnormally impact cellular components,molecular function,and biological processes. | Chen Huang Wen-Feng Luo Yu-Feng Ye Li Lin Zhe Wang Ming-Hua Luo Qi-De Song Xue-Ping He Han-Wei Chen Yi Kong Yu-Kuan Tang | 2019 | World Journal of Stem Cells2019，11，10： | 7 |
| 17 | XELOX doublet regimen versus EOX triplet regimen as first-line treatment for advanced gastric cancer:An open-labeled,multicenter,randomized,prospective phase III trial(EXELOX)显示文摘Background:There is no consensus on whether triplet regimen is better than doublet regimen in the first-line treatment of advanced gastric cancer(AGC).We aimed to compare the efficacy and safety of oxaliplatin plus capecitabine(XELOX)and epirubicin,oxaliplatin,plus capecitabine(EOX)regimens in treating AGC.Methods:This phase III trial enrolled previously untreated patients with AGC whowere randomly assigned to receive the XELOXor EOXregimen.The primary endpoint was non-inferiority in progression-free survival(PFS)for XELOX as compared with EOX on an intention-to-treat basis.Results:Between April 10,2015 andAugust 20,2020,448AGCpatientswere randomized to receive XELOX(n=222)or EOX(n=226).The median PFS(mPFS)was 5.0 months(95%confidence interval[CI]=4.5-6.0 months)in the XELOX arm and 5.5 months(95%CI=5.0-6.0 months)in the EOX arm(hazard ratio[HR]=0.989,95%CI=0.812-1.203;P_(non-inferiority)=0.003).There was no significant difference inmedian overall survival(mOS)(12.0 vs.12.0months,P=0.384)or objective response rate(37.4%vs.45.1%,P=0.291)between the two groups.In patients with poorly differentiated adenocarcinoma and liver metastasis,the EOX arm had a significantly longer mOS(P=0.021)and a trend of longer mPFS(P=0.073)than the XELOX arm.The rate of grade 3/4 adverse events(AEs)was 42.2%(90/213)in the XELOX arm and 72.5%(156/215)in the EOX arm(P=0.001).The global health-related quality of life(QoL)score was significantly higher in the XELOX arm than in the EOX arm during chemotherapy.Conclusions:This non-inferiority trial demonstrated that the doublet regimen was as effective as the triplet regimen and had a better safety profile and QoL as a first-line treatment for AGC patients.However,the triplet regimen might have a survival advantage in patients with poorly differentiated adenocarcinoma and liver metastasis. | Xiao-Dong Zhu Ming-Zhu Huang Yu-Sheng Wang Wan-Jing Feng Zhi-Yu Chen Yi-Fu He Xiao-Wei Zhang Xin Liu Chen-Chen Wang Wen Zhang Jie-Er Ying Jun Wu Lei Yang Yan-Ru Qin Jian-Feng Luo Xiao-Ying Zhao Wen-Hua Li Zhe Zhang Li-Xin Qiu Qi-Rong Geng Jian-Ling Zou Jie-Yun Zhang Hong Zheng Xue-Feng Song Shu-Sheng Wu Cheng-Yan Zhang Zhe Gong Qin-Qin Liu Xiao-Feng Wang Qi Xu Qi Wang Jian-Mei Ji Jian Zhao Wei-Jian Guo | 2022 | Cancer Communications2022，42，4： | 6 |
| 18 | Elective neck dissection or "watchful waiting": optimal management strategy for early stage NO tongue carcinoma using decision analysis techniques显示文摘背景尽管舌头癌症是头和颈的普通疾病,在选任的颈解剖并且“警惕等待”之间的颈治疗的选择与早舞台为病人仍然保持争论没有口头的舌头 carcinoma.Methods 根据头和颈癌症的当前的状态,一个决定分析模型被创造为早舌头 cancer.Expected 价值( EV )比较二治疗策略根据遇见了定义 criteria.Sensitivity | SONG Tao BI Nan GUI Lai PENG Zhe | 2008 | Chinese Medical Journal2008，，17： | 5 |
| 19 | Occurrence of the Iron–rich Melt in the Heijianshan Iron Deposit, Eastern Tianshan, NW China: Insights into the Origin of Volcanic Rock–hosted Iron Deposits显示文摘Long-standing controversy persists over the presence and role of iron–rich melts in the formation of volcanic rock-hosted iron deposits. Conjugate iron–rich and silica–rich melt inclusions observed in thin-sections are considered as direct evidence for the presence of iron-rich melt, yet unequivocal outcrop-scale evidence of iron-rich melts are still lacking in volcanic rock-hosted iron deposits. Submarine volcanic rock-hosted iron deposits, which are mainly distributed in the western and eastern Tianshan Mountains in Xinjiang, are important resources of iron ores in China, but it remains unclear whether iron-rich melts have played a role in the mineralization of such iron ores. In this study, we observed abundant iron-rich agglomerates in the brecciated andesite lava of the Heijianshan submarine volcanic rock–hosted iron deposit, Eastern Tianshan, China. The iron-rich agglomerates occur as irregular and angular masses filling fractures of the host brecciated andesite lava. They show concentric potassic alteration with silicification or epidotization rims, indicative of their formation after the wall rocks. The iron-rich agglomerates have porphyritic and hyalopilitic textures, and locally display chilled margins in the contact zone with the host rocks. These features cannot be explained by hydrothermal replacement of wall rocks(brecciated andesite lava) which is free of vesicle and amygdale, rather they indicate direct crystallization of the iron-rich agglomerates from iron-rich melts. We propose that the iron-rich agglomerates were formed by open-space filling of volatile-rich iron-rich melt in fractures of the brecciated andesite lava. The iron-rich agglomerates are compositionally similar to the wall-rock brecciated andesite lava, but have much larger variation. Based on mineral assemblages, the iron-rich agglomerates are subdivided into five types, i.e., albite-magnetite type, albite-K-feldsparmagnetite type, K-feldspar–magnetite type, epidote-magnetite type and quartz-magnetite type, representing that products formed at different stages during the evolution of a magmatic-hydrothermal system. The albite-magnetite type represents the earliest crystallization product from a residual ironrich melt; the albite-K-feldspar-magnetite and K-feldspar-magnetite types show features of magmatichydrothermal transition, whereas the epidote-magnetite and quartz-magnetite types represent products of hydrothermal alteration. The occurrence of iron-rich agglomerates provides macroscopic evidence for the presence of iron-rich melts in the mineralization of the Heijianshan iron deposit. It also indicates that iron mineralization of submarine volcanic rock-hosted iron deposits is genetically related to hydrothermal fluids derived from iron-rich melts. | LI Houmin LI Lixing DING Jianhua LI Yanhe SONG Zhe MENG Jie MA Yubo | 2018 | Acta Geologica Sinica(English Edition)2018，92，2： | 5 |
| 20 | Extinction and Positivity for a Doubly Nonlinear Degenerate Parabolic Equation显示文摘这篇论文的目的是为起始的边界价值问题和 u_t = div (|▽ u ~m|^(p-2 )▽ u ~ m ) 的 Cauchy 问题的答案讨论扑灭和确实。弱答案将为 1 是绝灭的,这被证明 < 1 + 1/m 和愿望是的 p ≤为 p 积极 < 为大 t 的 1 + 1/m,在此 m < 0。 | Hong Jun YUAN Song Zhe LIAN Chun Ling CAO Wen Jie GAO Xiao Jing XU | 2007 | Acta Mathematica Sinica,English Series2007，23，10： | 5 |
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