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| 1 | Early tectonic uplift of the northern Tibetan Plateau显示文摘The Hexi Corridor is the northmost foreland basin of the Tibetan Plateau and its formation is controlled by the northern marginal fault of Tibet, Altyn Tagh Fault (ATF)-North Qilian Shan marginal Fault (NQF), and the southern Kuantan Shan-Longshou Shan Fault (KLF). So its study is important to understanding the mechanism of Tibet formation and its influence on global climate change. The oldest Cenozoic sediments in the Corridor is the Huoshaogou Formation which consists of terrigenous fine conglomerate, sandstone, sandy mudstone and mudstone, depositing in alluvial to lacustrine and fan delta sedimentary environments. Detailed paleomagnetic measurements of this sequence at Yumen clearly reveal eleven pairs of normal and reversed polarities. Fossil mammals found around the section support that most of the observed polarities can be well correlated with chrons between 13n and 18r of the standard geomagnetic polarity time scale, yielding ages of 40.2-33.35 Ma. The mean declinations of this sequence and its immediately above stratigraphy indicate an 18.3° rapid clockwise rotation of the Hexi Corridor. Since this sequence has been strongly folded and is capped by an angular unconformity, we think that the presence of the thick alluvial fan conglomeration at the bottom of the foreland basin may indicate the initial deformation and uplift of the northern Qilian Shan. This process could occur at latest at 40.2 Ma, driven by the faults NQF and KLF that thrust onto the Hexi corridor respectively from its southern and northern margins. These faults are in an early response to the collision of India with Asia, while the unconformable termination and rotation of the Huoshaogou Formation at ~33.35 Ma indicate other early episode of rapid tectonic deformation and uplift of the northern Tibet. | DAI Shuang FANG Xiaomin SONG Chunhui GAO Junping GAO Donglin LI Jijun | 2005 | Chinese Science Bulletin2005，50，15： | 30 |
| 2 | Biochar-based materials and their applications in removal of organic contaminants from wastewater:state-of-the-art review显示文摘As a class of famous carbon materials,biochars(BCs)and their derivative materials with excellent physicochemical properties and diversified functionalities present great potential in wastewater treatment fields.This review focuses on the latest development in reported biochar-based materials as superior adsorbents or catalysts for removing harmful organic contaminants from wastewater.The construction and properties of biochar-based materials are briefly introduced at the beginning.As one of the major factors affecting the properties of BCs,the wide diversity of feedstocks,such as agricultural and forest residues,industrial by-products as well as municipal wastes,endows BCs different chemical compositions and structures.Woody and herbaceous BCs usually have higher carbon contents,larger surface areas and strong aromaticity,which is in favor of the organic contaminant removal.Driven by the desire of more cost-effective materials,several types of biochar-based hybrid materials,such as magnetic BC composites(MBC),nanometal/nanometallic oxides/hydroxide BC composites and layered nanomaterial-coated BCs,as well as physically/chemically activated BCs,have also been developed.With the help of foreign materials,these types of hybrid BCs have excellent capacities to remove a wide range of organic contaminants,including organic dyestuff,phenols and chemical intermediates,as well as pharmaceutically active compounds,from aquatic solutions.Depending on the different types of biochar-based materials,organic contaminants can be removed by different mechanisms,such as physical adsorption,electrostatic interaction,π-πinteraction and Fenton process,as well as photocatalytic degradation.In summary,the low cost,tunable surface chemistry and excellent physical-chemical properties of BCs allow it to be a potential material in organic contaminant removal.The combination of BCs with foreign materials endows BCs more functionalities and broader development opportunities.Considering the urgent demand of practical wastewater treatment,we hope more researches will focus on the applications and commercialization of biochar-based materials. | Qiang Huang Shuang Song Zhe Chen Baowei Hu Jianrong Chen Xiangke Wang | 2019 | Biochar2019，1，1： | 24 |
| 3 | Current status of diagnosis and treatment of bladder cancer in China-Analyses of Chinese Bladder Cancer Consortium database显示文摘Objective:To investigate current status of diagnosis and treatment of bladder cancer in China.Methods:A database was generated by Chinese Bladder Cancer Consortium(CBCC).From January 2007 to December 2012,14,260 cases from 44 CBCC centers were included.Data of diagnosis,treatment and pathology were collected.Results:The average age was 63.5 year-old and most patients were male(84.3%).The most common histologic types were urothelial carcinoma(91.4%),adenocarcinoma(1.8%),and squamous carcinoma(1.9%).According to 1973 and 2004 WHO grading system,42.0%,41.0%,and 17.0% of patients were grade 1,2,and 3,and 16.0%,48.7%,and 35.3% of patients were papillary urothelial neoplasms of low malignant potential,low,and high grade,respectively.Non-muscle invasive bladder cancer(NMIBC)and muscle invasive bladder cancer(MIBC)were 25.2% and 74.1%,respectively(0.8% not clear).Carcinoma in situ was only 2.4%.Most patients were diagnosed by white-light cystoscopy with biopsy(74.3%).Fluorescence and narrow band imaging cystoscopy had additional detection rate of 1.0% and 4.0%,respectively.Diagnostic transurethral resection(TUR)provided detection rate of 16.9%.Most NMIBCs were treated with TUR(89.2%).After initial TUR,2.6%accepted second TUR,and 45.7%,69.9%,and 58.7% accepted immediate,induced,and maintenance chemotherapy instillation,respectively.Most MIBCs were treated with radical cystectomy(RC,59.7%).Laparoscopic RCs were 35.1%,while open RC 63.4%.Extended and standard pelvic lymph node dissection were 7% and 66%,respectively.Three most common urinary diversions were orthotopic neobladder(44%),ileal conduit(31%),and ureterocutaneostomy(23%).Only 2.3% of patients accepted neo-adjuvant chemotherapy and only 18%of T3 and T4 patients accepted adjuvant chemotherapy.Conclusion:Disease characteristics are similar to international reports,while differences of diagnosis and treatment exist.This study can provide evidences for revisions of the guideline on bladder cancer in China. | Kaiwen Li Tianxin Lin 无 Wei Xue Xin Mu Enci Xu Xu Yang Fubao Chen Guangyong Li Lulin Ma Guoliang Wang Chaozhao Liang Haoqiang Shi Ming Li Mao Tang Xueyi Xue Yisong Lv Yaoliang Deng Chengyang Li Zhiwen Chen Xiaozhou Zhou Fengshuo Jin Xudong Liu Jinxin Wei Lei Shi Xin Gou Weiyang He Liqun Zhou Lin Cai Baiye Jin Guanghou Fu Xiangbo Kong Hongyan Sun Ye Tian Lang Feng Tiejun Pan Yiyi Wu Dongwen Wang Hailong Hao Benkang Shi Yaofeng Zhu Qiang Wei Ping Han Changli Wu Dawei Tian Zhangqun Ye Zheng Liu Zhiping Wang Junqiang Tian Lin Qi Minfeng Chen Wei Li Jinchun Qi Gongxian Wang Longlong Fu Zhaolin Sun Guangheng Luo Zhoujun Shen Zhaowei Zhu Jinchun Xing Zhun Wu Dong Wei Xin Chen Yanqun Na Hongfeng Guo Chunxi Wang Zhihua Lu Chuize Kong Yang Liu Jin Yang Jianyun Hu Xin Gao Jielin Li Changjun Yin Pu Li Shan Chen Zhen Du Jiongming Li Yongji Yan Xu Zhang Shuang Huang Fangjian Zhou Zhiling Zhang Yinghao Sun Shuxiong Zeng Song Cen Jiaquan Zhou Hanzhong Li Jin Wen Jian Huang | 2015 | Asian Journal of Urology2015，2，2： | 21 |
| 4 | Kinematics and dynamics of a particle on a non-simple harmonic vibrating screen显示文摘 | Lijun Wang Zhenjun Ding Shuang Meng Huijun Zhao Huiqiang Song | 2017 | Particuology2017，15，3： | 14 |
| 5 | GSA:Genome Sequence Archive显示文摘With the rapid development of sequencing technologies towards higher throughput and lower cost, sequence data are generated at an unprecedentedly explosive rate. To provide an efficient and easy-to-use platform for managing huge sequence data, here we present Genome Sequence Archive(GSA; http://gffzzdbc7b6aaae734bddho0wx5pucqbfp6bcq.ffgz.tsg.suse.edu.cn/gsa or http://gffzz4eaf941a184140e3ho0wx5pucqbfp6bcq.ffgz.tsg.suse.edu.cn), a data repository for archiving raw sequence data. In compliance with data standards and structures of the International Nucleotide Sequence Database Collaboration(INSDC), GSA adopts four data objects(Bio Project, Bio Sample,Experiment, and Run) for data organization, accepts raw sequence reads produced by a variety of sequencing platforms, stores both sequence reads and metadata submitted from all over the world,and makes all these data publicly available to worldwide scientific communities. In the era of big data, GSA is not only an important complement to existing INSDC members by alleviating the increasing burdens of handling sequence data deluge, but also takes the significant responsibility for global big data archive and provides free unrestricted access to all publicly available data in support of research activities throughout the world. | Yanqing Wang Fuhai Song Junwei Zhu Sisi Zhang Yadong Yang Tingting Chen Bixia Tang Lili Dong Nan Ding Qian Zhang Zhouxian Bai Xunong Dong Huanxin Chen Mingyuan Sun Shuang Zhai Yubin Sun Lei Yu Li Lan Jingfa Xiao Xiangdong Fang Hongxing Lei Zhang Zhang Wenming Zhao | 2017 | Genomics, Proteomics & Bioinformatics2017，15，1： | 13 |
| 6 | One-pot synthesis of graphene oxide and Ni-Al layered double hydroxides nanocomposites for the efficient removal of U(VI) from wastewater显示文摘Graphene oxide and Ni-Al layered double hydroxides(GO@LDH) nanocomposites were synthesized via a one-pot hydrothermal process,and characterized by X-ray diffraction(XRD),Fourier transformed infrared spectroscopy(FTIR),scanning electron microscopy(SEM),transmission electron microscopy(TEM),X-ray photoelectron spectroscopy(XPS) and Raman spectroscopy in detail.The exploration of U(VI) sorption on GO@LDH surface was performed as a function of ionic strength,solution pH,contact time,U(VI) initial concentrations and temperature.Results of Langmuir isotherms showed that the sorption capacity of GO@LDH(160 mg/g) was much higher than those of LDH(69 mg/g) and GO(92 mg/g).The formed surface complexes between surface oxygen-containing functional groups of GO@LDH and U(VI) turned out to be the interaction mechanism of U(VI) with GO@LDH.According to the thermodynamic studies results,the sorption interaction was actually a spontaneous and endothermic chemical process.The sorption isotherms were better fitted with the Langmuir model compared with other models,which suggested the interaction was mainly dominated by mono layer coverage.The GO@LDH nanocomposites provide potential applications as adsorbents in the enrichment of radionuclides from wastewater in nuclear waste management and environmental remediation. | Shujun Yu Jian Wang Shuang Song Kunyu Sun Jun Li Xiangxue Wang Zhongshan Chen Xiangke Wang | 2017 | Science China Chemistry2017，60，3： | 12 |
| 7 | Late Eocene pollen records and palaeoenvironmental changes in northern Tibetan Plateau显示文摘The Eocene palaeovegetation landscape and palaeoclimate reconstructed from the pollen records in the Jiuquan Basin, northwest China provide some important information on the early uplift of the Tibetan Plateau and the origin and evolution of the aridification in northwest China. The records show the arid-semiarid scrubs with open forest palynofloras controlled by the subtropical high existed in northwest China during the 40.2-33.4 Ma. Four pollen assemblages are found: Nitrariadites-Cheno-podipollis-Pinaceae assemblage (40.2-37.9 Ma) is followed by Chenopodipollis-Nitrariadites assemblage (37.9-34.6 Ma), Pinuspollenites & Abietineaepollenites-Chenopodipollis assemblage (34.6-33.9 Ma), and Chenopodipollis-Nitrariadites assemblage (33.9-33.4 Ma). The percentage of thermophilic types is in anti-correlation with that of the dry types, which means the palaeoclimate is relatively warmwet or cold-dry during most of that time. Such aridity may be related to the water vapor reduction and the planetary wind system movement northward in response to the cooling caused by small-ephemeral icesheets. | MIAO YunFa FANG XiaoMin SONG ZhiChen WU FuLi HAN WenXia DAI Shuang SONG ChunHui | 2008 | Science China Earth Sciences2008，51，8： | 10 |
| 8 | Intracellular CMTM2 negatively regulates human immunodeficiency virus type-1 transcription through targeting the transcription factors AP-1 and CREB显示文摘背景象 CKLF 一样奇迹 transmembrane 包含域的家庭(CMTM ) 蛋白质的一个新奇家庭正在连接 chemokines 和 TM4SF。不同成员展出多样的生物功能。在这研究,调整人的免疫不全病毒 type-1 (HIV-1 ) 上的细胞内部的 CMTM2 的效果抄写是 evaluated.Methods 调整全身的 HIV-1 provirus 和 HIV-1 上的 CMTM2 的效果渴望终端重复(LTR ) 指导了抄写被酶试金估计。抄写因素试金用 AP-1 的酶记者 plasmids, CRE,和 NF-B 被进行探索可以被 CMTM2 调整的发信号的小径。在 CMTM2 和抄写因素 AP-1 之间的潜在的关系被西方的弄污进一步分析当 HIV-1 transcription.CMTM2 的一个否定管理者在两全身的 HIV-1 provirus 和 HIV-1 上施加了一个镇压行动,在从水流的结果学习的 导致PMA 的 ERK1/2 phosphorylation.Results 上调查 CMTM2 的效果的分析表明 CMTM2 行动 指导LTR transcription.Transcription 因素试金证明 CMTM2 有选择地禁止了基础 AP-1 和 CREB 交流 HIV-1 的合作表示梭织,有势力 AP-1 和 CREB 使活跃之物,不能颠倒 调停CMTM2 的 AP-1 和 CREB 抑制,在否定地调整细胞内部的 CMTM2 能否定地调整的这二发信号的 pathways.Conclusion 上建议一个有势力和 CMTM2 的特定的效果 HIV-1 抄写,至少部分地,由指向 AP-1 和 CREB 小径。进一步探索机制可以导致新方法控制 HIV-1 复制。 | SONG Hong-shuo SHI Shuang LU Xiao-zhi GAO Feng YAN Ling WANG Ying ZHUANG Hui | 2010 | Chinese Medical Journal2010，，17： | 9 |
| 9 | Green fluorescent protein (GFP) transgenic pig produced by somatic cell nuclear transfer显示文摘Transgenic somatic cell nuclear transfer is a very promising route for producing transgenic farm ani-mals. Research on GFP transgenic pigs can provide useful information for breeding transgenic pigs, human disease models and human organ xenotransplantation. In this study, a liposomal transfection system was screened and transgenic embryos were reconstructed by nuclear transfer of GFP positive cells into enucleated in vitro matured oocytes. The development of reconstructed embryos both in vitro and in vivo was observed, and GFP expression was determined. The results showed that porcine fe-tal-derived fibroblast cells cultured with 4.0 μL/mL liposome and 1.6 μg/mL plasmid DNA for 6 h re-sulted in the highest transfection rate (3.6%). The percentage of GFP reconstructed embryos that de-veloped in vitro to the blastocyst stage was 10%. Of those the GFP positive percentage was 48%. Re-constructed transgenic embryos were transferred to 10 recipients. 5 of them were pregnant, and 3 de-livered 6 cloned piglets in which 4 piglets were transgenic for the GFP as verified by both GFP protein expression and GFP DNA sequence analysis. The percentage of reconstructed embryos that resulted in cloned piglets was 1.0%; while the percentage of piglets that were transgenic was 0.7%. This is the first group of transgenic cloned pigs born in China, marking a great progress in Chinese transgenic cloned pig research. | LIU ZhongHua SONG Jun WANG ZhenKun TIAN JiangTian KONG QingRan ZHENG Zhong YIN Zhi GAO Li MA HaiKun SUN Shuang LI YuTian WANG HongBin R S PRATHER | 2008 | Chinese Science Bulletin2008，53，7： | 8 |
| 10 | Fingered Intrusion of Shallow Saucer-shaped Igneous Sills: Insights from the Jiaojiang Sag, East China Sea显示文摘An extensive suite of igneous sills was intruded into the Tertiary sedimentary section of the Jiaojiang sag,East China Sea.This suite has been well imaged offshore through 2D and 3D seismic surveys,showing a close relationship with CO2 content in nearby gas discoveries.A new observational model,which incorporates simple upward propagation,simple horizontal propagation,and transgressive propagation,was proposed to interpret these sill intrusions.In this model,the source magma of the saucer-shaped sills was injected from their lowest points near the center.The transgressive propagation can be interpreted as a combination of the vertical and horizontal propagation.Most shallow sub-volcanic intrusions in the Jiaojiang sag exhibit fingered characteristics,both vertically and horizontally.The vertical fingered propagation produced saucer-shaped sills arranged in the flower style.Along the brims of lower sills could usually be found the upper sills,which are interpreted to have formed simultaneously with or later than the lower feeder sills.In the second type,the chilled paths of the older sills were reutilized by subsequent intrusions.The horizontal fingered propagation formed sheet intrusions that exhibit groove,lobate,tubular,and crevasse splaylike geometry in plan view.In 3D view,the sheet intrusions have still preserved the lower center and higher rim that similar with the sub-rounded saucer-shaped sills.Although fracture propagation may be important,flow inflation was the key mechanism of magma intrusion.Further consideration of the mechanisms underlying sill formation may help explain the fingered characteristics of sill propagation. | GUO Rui ZHANG Gongcheng ZHANG Jinwei ZHAO Xingbin LIU Junbang YUAN Dawei SONG Shuang | 2013 | Acta Geologica Sinica(English Edition)2013，87，5： | 8 |
| 11 | Genome-wide identification and analysis of the DREB genes and their expression profiles under abiotic stresses in Chinese jujube(Ziziphus jujuba Mill.)显示文摘CBF/DREB proteins play a critical role in abiotic stress-mediated gene expression and represent attractive regulons for plant breeding programs.However,no study has been conducted for CBF/DREB protein-related genes in jujube(Ziziphus jujuba Mill.).In this study,twenty-five ZjDREB genes were identified and annotated from the jujube(Z.jujuba‘Dongzao’)genome.Detailed analysis,including gene classification,annotation,phylogenetic evaluation,conserved motif determination and expression profiling were performed on all genes.Phylogenetic analysis showed that ZjDREB proteins were divided into five subgroups(A1–A5),but lacking a subgroup A6 corresponding to AtDREBs.The ZjDREB genes were distributed in nine of twelve chromosomes in the genome.Additionally,the expression patterns of the DREB genes under different abiotic stresses were investigated using q RT-PCR.Nineteen ZjDREB genes were down-regulated under low temperature,in contrast six ZjDREB genes(01,03,05,11,23 and 24)were up-regulated.Under drought,salinity and high temperature conditions,expression of ZjDREB03,09,10,14,15,17 and 20 genes were induced and showed similar expression patterns,suggesting that various stress conditions share common elements in the signaling pathway.The results suggest that the family of DREB genes play an important role in abiotic stresses in jujube,and provide a foundation for further functional studies of this important class of transcriptional regulators. | Heying Zhou Jiping Jia Decang Kong Zhendong Zhang Shuang Song Yingyue Li Xiaoming Pang | 2019 | Journal of Forestry Research2019，30，4： | 8 |
| 12 | Discriminated sgRNAs-Based SurroGate System Greatly Enhances the Screening Efficiency of Plant Base-Edited Cells显示文摘The development of CRISPR/Cas9-mediated base editing has made genomic modification more efficient. However, selection of genetically modified cells from millions of treated cells, especially plant cells, is still challenging. In this study, an efficient surrogate reporter system based on a defective hygromycin resistance gene was established in rice to enrich base-edited cells. After step-by-step optimization, the Discriminated sgRNAs-based SurroGate system (DisSUGs) was established by artificially differentiating the editing abilities of a wild-type single guide RNA (sgRNA) targeting the surrogate reporter gene and an enhanced sgRNA targeting endogenous sites. The DisSUGs enhanced the efficiency of screening base-edited cells by 3- to 5-fold for a PmCDA1-based cytosine-to-tyrosine base editor (PCBE), and 2.5- to 6.5-fold for an adenine base editor (ABE) at endogenous targets. These targets showed editing efficiencies of <25% in the conventional systems. The DisSUGs greatly enhanced the frequency of homozygous substitutions and expanded the activity window slightly for both a PCBE and an ABE. Analyses of the total number of single-nucleotide variants from whole-genome sequencing revealed that, compared with the no-enrichment PCBE strategy, the DisSUGs did not alter the frequency of genome-wide sgRNA-independent off-target mutations, but slightly increased the frequency of target-dependent off-target mutations. Collectively, the DisSUGs developed in this study greatly enhances the efficiency of screening plant base-edited cells and will be a useful system in future applications. | Wen Xu Yongxing Yang Ya Liu Guiting Kang Feipeng Wang Lu Li Xinxin Lv Si Zhao Shuang Yuan Jinling Song Ying Wu Feng Feng Xiaoqing He Chengwei Zhang Wei Song Jiuran Zhao Jinxiao Yang | 2020 | Molecular Plant2020，13，1： | 8 |
| 13 | Association of genotypes of rs671 within ALDH2 with risk for gastric cardia adenocarcinoma in the Chinese Han population in high-and low-incidence areas显示文摘Objective: This study aimed to determine if gastric cardia adenocarcinoma(GCA) risk was associated with the lys(A or *2) allele at the rs671(glu504lys) polymorphism within the aldehyde dehydrogenase 2(ALDH2) gene in a Chinese Han population. We also aimed to investigate ALDH2 genotypic distributions between subjects from high- and low-incidence areas for both GCA and esophageal squamous cell carcinoma(ESCC).Methods: We designed a case-control study including 2,686 patients with GCA and 3,675 control subjects from high- and lowincidence areas for both GCA and ESCC in China. Taq Man allele discrimination assay was used to genotype the rs671 polymorphism. χ~2 test and binary logistic regression analysis were used to estimate the odds ratios for the development of GCA,and multivariate ordinal logistic regression was used to analyze ALDH2 genotypic distributions among different groups.Results: Compared with ALDH2*1/*1 homozygotes, ALDH2*1/*2 and ALDH2*2/*2 carriers did not increase the risk for GCA in the Chinese Han population(P>0.05). Interestingly, the ratio of homozygous or heterozygous ALDH2 *2 carriers in highincidence areas for both GCA and ESCC was lower than that in low-incidence areas(P<0.001).Conclusions: Genotypes of rs671 at ALDH2 may not increase GCA susceptibility in Chinese Han populations. In addition, the ALDH2 genotypic distribution differs between Chinese Han populations from high- and low-incidence areas for both GCA and ESCC. Our findings may shed light on the possible genetic mechanism for the dramatic geographic differences of GCA occurrence in China. | Lian-Qun Zhang Xin Song Xue-Ke Zhao Jia Huang Peng Zhang Lu-Wen Wang Hui Meng Jian-Wei Ku Guo-Qiang Kong Tao Jiang Xin-Min Li Xiao-Long Lv Teng Ma Guo Yuan Min-Jie Wu Shou-Jia Hu Shuang Lv Tang-Juan Zhang Ling-Fen Ji Zong-Min Fan Neng-Chao Wang Yao-Wen Zhang Fu-You Zhou Li-Dong Wang | 2017 | Cancer Biology & Medicine2017，14，1： | 7 |
| 14 | Effect of Stokes drift on upper ocean mixing显示文摘Stokes drift is the main source of vertical vorticity in the ocean mixed layer. In the ways of Coriolis-Stokes forcing and Langmuir circulations, Stokes drift can substantially affect the whole mixed layer. A modified Mellor-Yamada 2.5 level turbulence closure model is used to parameterize its effect on upper ocean mixing conventionally. Results show that comparing surface heating with wave breaking, Stokes drift plays the most important role in the entire ocean mixed layer, especially in the subsurface layer. As expected, Stokes drift elevates both the dissipation rate and the turbulence energy in the upper ocean mixing. Also, influence of the surface heating, wave breaking and wind speed on Stokes drift is investigated respectively. Research shows that it is significant and important to assessing the Stokes drift into ocean mixed layer studying. The laboratory observations are supporting numerical experiments quantitatively. | LI Shuang SONG Jinbao SUN Qun | 2008 | Acta Oceanologica Sinica2008，27，2： | 7 |
| 15 | Effect of Langmuir circulation on upper ocean mixing in the South China Sea显示文摘Effect of Langmuir circulation(LC) on upper ocean mixing is investigated by a two-way wave-current coupled model.The model is coupled of the ocean circulation model ROMS(regional ocean modeling system) to the surface wave model SWAN(simulating waves nearshore) via the model-coupling toolkit.The LC already certified its importance by many one-dimensional(1D) research and mechanism analysis work.This work focuses on inducing LC's effect in a three-dimensional(3-D) model and applying it to real field modeling.In ROMS,the Mellor-Yamada turbulence closure mixing scheme is modified by including LC's effect.The SWAN imports bathymetry,free surface and current information from the ROMS while exports significant wave parameters to the ROMS for Stokes wave computing every 6 s.This coupled model is applied to the South China Sea(SCS) during September 2008 cruise.The results show that LC increasing turbulence and deepening mixed layer depth(MLD) at order of O(10 m) in most of the areas,especially in the north part of SCS where most of our measurements operated.The coupled model further includes wave breaking which will brings more energy into water.When LC works together with wave breaking,more energy is transferred into deep layer and accelerates the MLD deepening.In the north part of the SCS,their effects are more obvious.This is consistent with big wind event in the area of the Zhujiang River Delta.The shallow water depth as another reason makes them easy to influence the ocean mixing as well. | LI Shuang SONG Jinbao FAN Wei | 2013 | Acta Oceanologica Sinica2013，32，3： | 6 |
| 16 | The Lyman-alpha Solar Telescope(LST) for the ASO-S mission——Ⅱ. design of LST显示文摘As one of the three payloads for the Advanced Space-based Solar Observatory(ASO-S)mission,the Lyman-alpha(Lyα)Solar Telescope(LST)is composed of three instruments:a Solar Corona Imager(SCI),a LyαSolar Disk Imager(SDI)and a full-disk White-light Solar Telescope(WST).When working in-orbit,LST will simultaneously perform high-resolution imaging observations of all regions from the solar disk to the inner corona up to 2.5 R⊙(R⊙stands for the mean solar radius)with a spatial resolution of 4.8′′and 1.2′′for coronal and disk observations,respectively,and a temporal resolution of 30–120 s and 1–120 s for coronal and disk observations,respectively.The maximum exposure time can be up to20 s due to precise pointing and image stabilization function.Among the three telescopes of LST,SCI is a dual-waveband coronagraph simultaneously and independently observing the inner corona in the HI Lyα(121.6±10 nm)line and white light(WL)(700±40 nm)wavebands by using a narrowband Lyαbeam splitter and has a field of view(FOV)from 1.1 to 2.5 R⊙.The stray-light suppression level can attain<10^-6 B⊙(B⊙is the mean brightness of the solar disk)at 1.1 R⊙and≤5×10^-8 B⊙at 2.5 R⊙.SDI and WST are solar disk imagers working in the Lyαline and 360.0 nm wavebands,respectively,which adopt an off-axis two-mirror reflective structure with an FOV up to 1.2 R⊙,covering the inner coronal edge area and relating to coronal imaging.We present the up-to-date design for the LST payload. | Bo Chen Hui Li Ke-Fei Song Quan-Feng Guo Pei-Jie Zhang Ling-Ping He Shuang Dai Xiao-Dong Wang Hai-Feng Wang Chun-Long Liu Hong-Ji Zhang Guang Zhang Yunqi Wang Shi-Jie Liu Hong-Xin Zhang Lei Liu Shi-Lei Mao Yang Liu Jia-Hao Peng Peng Wang Liang Sun Yang Liu Zhen-Wei Han Yan-Long Wang Kun Wu Guang-Xing Ding Peng Zhou Xin Zheng Ming-Yi Xia Qing-Wen Wu Jin-Jiang Xie Ya Chen Shu-Mei Song Hong Wang Bo Zhu Chang-Bo Chu Wen-Gang Yang Li Feng Yu Huang Wei-Qun Gan Ying Li Jing-Wei Li Lei Lu Jian-Chao Xue Bei-Li Ying Ming-Zhe Sun Cheng Zhu Wei-Min Bao Lei Deng Zeng-Shan Yin | 2019 | Research in Astronomy and Astrophysics2019，19，11： | 6 |
| 17 | A numerical study on seasonal variations of the thermocline in the South China Sea based on the ROMS显示文摘On the basis of the regional ocean modeling system(ROMS), the seasonal variations of the thermocline in the South China Sea(SCS) were numerically investigated. The simulated hydrodynamics are in accordance with previous studies: the circulation pattern in the SCS is cyclonic in winter and anticyclonic in summer, and such a change is mostly driven by the monsoon winds. The errors between the modeled temperature profiles and the observations obtained by cruises are quite small in the upper layers of the ocean, indicating that the ocean status is reasonably simulated. On the basis of the shapes of the vertical temperature profiles, five thermocline types(shallow thermocline, deep thermocline, hybrid thermocline, double thermocline, and multiple thermocline) are defined herein. In winter, when the northeasterly monsoon prevails, most shallow shelf seas in the northwest of the SCS are well mixed, and there is no obvious thermocline. The deep region generally has a deep thermocline, and the hybrid or double thermocline often occurs in the areas near the cold eddy in the south of the SCS. In summer, when the southwesterly monsoon prevails, the shelf sea area with a shallow thermocline greatly expands. The distribution of different thermocline types shows a relationship with ocean bathymetry: from shallow to deep waters, the thermocline types generally change from shallow or hybrid to deep thermocline, and the double or multiple thermocline usually occurs in the steep regions. The seasonal variations of the three major thermocline characteristics(the upper bound depth, thickness, and intensity) are also discussed. Since the SCS is also an area where tropical cyclones frequently occur, the response of thermocline to a typhoon process in a short time scale is also analyzed. | FAN Wei SONG Jinbao LI Shuang | 2014 | Acta Oceanologica Sinica2014，33，7： | 6 |
| 18 | Development and utilization of a new chemically-induced soybean library with a high mutation density显示文摘Mutagenized populations have provided important materials for introducing variation and identifying gene function in plants. In this study, an ethyl methanesulfonate(EMS)-induced soybean(Glycine max) population,consisting of 21,600 independent M_2 lines, was developed.Over 1,000 M_(4(5))families, with diverse abnormal phenotypes for seed composition, seed shape, plant morphology and maturity that are stably expressed across different environments and generations were identified. Phenotypic analysis of the population led to the identification of a yellow pigmentation mutant, gyl, that displayed significantly decreased chlorophyll(Chl) content and abnormal chloroplast development. Sequence analysis showed that gyl is allelic to Minn Gold, where a different single nucleotide polymorphism variation in the Mg-chelatase subunit gene(ChlI1a) results in golden yellow leaves. A cleaved amplified polymorphic sequence marker was developed and may be applied to marker-assisted selection for the golden yellow phenotype in soybean breeding. We show that the newly developed soybean EMS mutant population has potential for functional genomics research and genetic improvement in soybean. | Zhongfeng Li Lingxue Jiang Yansong Ma Zhongyan Wei Huilong Hong Zhangxiong Liu Jinhui Lei Ying Liu Rongxia Guan Yong Guo Longguo Jin Lijuan Zhang Yinghui Li Yulong Ren Wei He Ming Liu Nang Myint Phyu Sin Htwe Lin Liu Bingfu Guo Jian Song Bing Tan Guifeng Liu Maiquan Li Xianli Zhang Bo Liu Xuehui Shi Sining Han Sunan Hua Fulai Zhou Lili Yu Yanfei Li Shuang Wang Jun Wang Ruzhen Chang Lijuan Qiu | 2017 | Journal of Integrative Plant Biology2017，59，1： | 6 |
| 19 | Anxiety symptoms in patients with Mayer-Rokitansky-Küster-Hauser syndrome:a cross-sectional study显示文摘Background:As a congenital malformation that results in infertility and an inability to have vaginal intercourse,Mayer-Rokitansky-Küster-Hauser(MRKH)syndrome places a considerable psychological burden on patients,which results in anxiety symptoms.However,only single case studies or a few small to medium-sized cross-sectional studies were identified to focus on anxiety symptoms in MRKH patients.Thus,the aim of this study was to explore the status of anxiety symptoms and the related factors in patients with MRKH syndrome.Methods:This cross-sectional study involving 141 patients with MRKH syndrome and 178 healthy women was conducted from January 2018 to December 2018.All participants were required to complete a demographic questionnaire and the Generalized Anxiety Disorder 7-item scale(GAD-7),Patient Health Questionnaire-9,Eysenck Personality Questionnaire-Revised,Short Scale for Chinese,and Chinese Version of the Female Sexual Function Index.The main outcome was the anxiety symptoms measured by the GAD-7.Main outcome was compared between the MRKH syndrome group and the healthy control group.Then,we explored the related factors by comparing patients with and without anxiety symptoms.Results:Of the respondents,24.1%experienced moderate to severe anxiety symptoms.Patients with MRKH syndrome manifested more severe anxiety symptoms than healthy women.Negative self-evaluation of femininity(odds ratio[OR]2.706,95%confidence interval[CI]1.010-7.247),neurotic personality traits(OR 1.100,95%CI 1.029-1.175),and coexisting depressive symptoms(OR 4.422,95%CI 1.498-13.049)were more prevalent in anxious patients.Conclusion:The findings stress the importance of anxiety symptom screening in MRKH patients and identify patients at risk of anxiety symptoms,providing a possible basis for future intervention. | Shuang Song Na Chen Yan-Ping Duan Jia Kang Shan Deng Hong-Xin Pan Lan Zhu | 2020 | Chinese Medical Journal2020，，4： | 6 |
| 20 | Interpretation of the Traditional Chinese Medicine portion of the diagnosis and treatment protocol for corona virus disease 2019(Trial Version 7)显示文摘The TCM protocol in the Diagnosis and Treatment Protocol for corona virus disease 2019(COVID-19)(Trial Version 7) has been updated from previous versions. The protocol was formulated under the direct leadership of the National Administration of Traditional Chinese Medicine, based on the experience of a panel of experts, supported by evidence from fever clinics and from the outcomes of emergency(EM) observation rooms and inpatients throughout China(especially in Wuhan, Hubei Province) in combination with the latest scientific research results and data. The present interpretation of the TCM protocol is based on an overall understanding of the revised content, and aims to guide and standardize its clinical application to provide a reference for clinicians. | Song Ping Zhao Linhua Li Xiuyang Su Jiansen Jiang Zhaoyuan Song Bin Liu Wenke Tang Shuang Lei Ye Ding Qiyou Yang Ze Lin Jiaran Wei Yu Tong Xiaolin | 2020 | Journal of Traditional Chinese Medicine2020，40，3： | 5 |
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