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| 1 | Cationic nanocarriers induce cell necrosis through impairment of Na^+/K^+-ATPase and cause subsequent inflammatory response显示文摘有积极表面费用的 Nanocarriers 以他们限制了他们的临床的应用的毒性著名。位于他们的毒性下面的机制例如煽动性的反应的正式就职,仍然保持大部分未知。在我们发现了 cationic nanocarriers 的那注射的现在的学习,包括 cationic liposomes, PEI,和 chitosan,导致了坏死的房间的快速的外观。cationic nanocarriers 导致的房间坏死依赖于他们的积极表面费用,但是不要求 RIP1 和 Mlkl。相反,细胞内部的 Na + 超载被发现伴随房间死亡。在文化媒介或有 Na +/K+-ATPase 阳离子绑定地点禁止者 ouabain 的房间的预告的处理的 Na + 的弄空,从房间坏死的保护的房间。而且,有 cationic nanocarriers 的处理在 vitro 并且在 vivo 禁止了 Na +/K+-ATPase 活动。计算模拟证明 cationic 搬运人能与 Na +/K+-ATPase 的阳离子绑定地点交往。有 ouabain 的小剂量的老鼠 pretreated 在 cationic nanocarriers 的致命的剂量的注射以后显示出改进幸存。进一步的分析建议 cationic nanocarriers 和 mitochondrial DNA 的产生的漏导致的那房间坏死能在 vivo 触发严重发炎,它被包含 TLR9 并且 MyD88 发信号的一条小径调停。一起拿,我们的结果揭示由此的新奇机制 cationic nanocarriers 通过和 mitochondrial 的随后的暴露的和 Na +/K+-ATPase, 的相互作用导致尖锐房间坏死是的联系损坏的分子的模式调停的一个关键事件煽动性的回答。我们的学习为评估 nanocarriers 的 biocompatibility 并且为药交货设计更好、更安全的有重要含意。 | Xiawei Wei Bin Shao Zhiyao He Tinghong Ye Min Luo Yaxiong Sang Xiao Liang Wei Wang Shuntao Luo Shengyong Yang Shuang Zhang Changyang Gong Maling Gou Hongxing Deng Yinglan Zhao Hanshuo Yang Senyi Deng Chengjian Zhao Li Yang Zhiyong Qian Jiong Li Xun Sun Jiahuai Han Chengyu Jiang Min Wu Zhirong Zhang | 2015 | Cell Research2015，25，2： | 21 |
| 2 | Clinical and laboratory survey of 65 Chinese patients with Leigh syndrome显示文摘Background Leigh syndrome is an inherited neurodegenerative disease that emerges in infancy and childhood and presents with a clinically heterogeneous variety of neuromuscular and non-neuromuscular disorders. It can result from the inheritance of mutations in either nuclear or mitochondrial DNA. In the current study, we performed a retrospective study in 65 patients in order to investigate the clinical and genetic characteristics of Leigh syndrome in Chinese patients. Methods Sixty-five unrelated cases (35 men and 30 women) who were hospitalized in the past 12 years were reviewed. Diagnosis was based on both the clinical presentation and the characteristic neuropathologic findings of bilateral symmetric necrotizing lesions in the basal ganglia and brain stem as detected using cranial computed tomography (CT) scan or magnetic resonance imaging (MRI). The differential diagnosis of organic acidurias and fatty acid ?-oxidation defects were performed. Specific point mutations and deletions in mitochondrial DNA (T8993G, T8993C, T9176C, A8344G, A3243G) were screened by PCR-restriction analysis and Southern blot. The SURF1 gene was sequenced. Skeletal muscle biopsies were performed in 17 (26.2%) of the patients. The diagnosis was confirmed by autopsy in 6 (9.2%) patients. Results The patients had various forms of metabolic encephalomyopathy. Fifty-nine (90.8%) of the patients had the typical neuroradiological features of Leigh syndrome, including symmetrical necrotizing lesions scattered within the basal ganglia, thalamus and brain stem. Twenty (30.8%) patients were confirmed by genetic, biochemical analysis and autopsy. Specific point mutations in mitochondrial DNA were found in 5 cases (7.7%). Of these, the A8344G mutation was detected in 2 patients. The T8993G, T8993C, and A3243G point mutations were identified in 3 other patients, respectively. SURF1 mutations associated with cytochrome c oxidase deficiency were identified in 8 (12.3%) families by DNA sequencing. A G604C mutation was identified in 6 (9.2%) patients. The genotypes of 52 patients remained unknown. Conclusions Leigh syndrome presents as a diverse array of clinical features and can result from specific mutations in nuclear or mitochondrial DNA. In this study, SURF1 mutations associated with cytochrome c oxidase deficiency were identified in 8 (12.3%) out of 65 patients with Leigh syndrome. It indicates that SURF1 mutations might be a common cause of Leigh syndrome in China. The etiology of Leigh syndrome in Chinese patients represents a persistent challenge to clinicians. | YANG Yan-ling SUN Fang ZHANG Yao QIAN Ning YUAN Yun WANG Zhao-xia QI Yu XIAO Jiang-xi WANG Xiao-ying QI Zhao-yue ZHANG Yue-hua JIANG Yu-wu BAO Xin-hua QIN Jiong WU Xi-ru | 2006 | Chinese Medical Journal2006，，5： | 17 |
| 3 | Clinical risk score for invasive fungal diseases in patients with hematological malignancies undergoing chemotherapy:China Assessment of Antifungal Therapy in Hematological Diseases (CAESAR) study显示文摘Invasive fungal disease (IFD) is a major infectious complication in patients with hematological malignancies.In this study,we examined 4889 courses of chemotherapy in patients with hematological diseases to establish a training dataset (n=3500) by simple random sampling to develop a weighted risk score for proven or probable IFD through multivariate regression,which included the following variables: male patients,induction chemotherapy for newly diagnosed or relapsed disease,neutropenia,neutropenia longer than 10 days,hypoalbuminemia,central-venous catheter,and history of IFD.The patients were classified into three groups,which had low (0-10,~1.2%),intermediate (11-15,6.4%),and high risk (> 15,17.5%) of IFD.In the validation set (n=1389),the IFD incidences of the groups were ~1.4%,5.0%,and 21.4%.In addition,we demonstrated that antifungal prophylaxis offered no benefits in low-risk patients,whereas benefits were documented in intermediate (2.1% vs.6.6%,P=0.007) and high-risk patients (8.4% vs.23.3%,P=0.007).To make the risk score applicable for clinical settings,a pre-chemo risk score that deleted all unpredictable factors before chemotherapy was established,and it confirmed that anti-fungal prophylaxis was beneficial in patients with intermediate and high risk of IFD.In conclusion,an objective,weighted risk score for IFD was developed,and it may be useful in guiding antifungal prophylaxis. | Ling Wang Ying Wang Jiong Hu Yuqian Sun He Huang Jing Chen Jianyong Li Jun Ma Juan Li Yingmin Liang Jianmin Wang Yan Li Kang Yu Jianda Hu Jie Jin Chun Wang Depei Wu Yang Xiao Xiaojun Huang | 2019 | Frontiers of Medicine2019，13，3： | 10 |
| 4 | Expert Consensus on the Care and Management of Patients with Cognitive Impairment in China显示文摘The cognitive disease consensus was prepared by panels of health and public representatives based on actual clinical practice in Geriatric Departments in Chinese hospitals and a systematic literature review. This consensus reflects the medical knowledge accumulated by those experts and provides information about professional medical care and advice.A multidisciplinary panel of specialists(neurologists,psychiatrists, and nursing specialists) reports an expert consensus on the medical knowledge accumulated from those experts and provides information about professional medical care and advice. The recommendations focus on the care and management of older adults with mild cognitive impairment,the objectives and methods of maintaining cognition and training, the assessments and measures of daily care for patients at different stages of dementia, the assessments and coping strategies for the behavioral and psychological symptoms of dementia, principles and suggestions for an appropriate living environment, arrangements for recreational activities, the care and management of patients with endstage dementia, and suggestions for addressing stress in caregivers. | 无 Yuliang Han Jianjun Jia Xia Li Yang Lv Xuan Sun Shanshan Wang Yongjun Wang Zhiwen Wang Jintao Zhang Jiong Zhou Yuying Zhou | 2020 | Neuroscience Bulletin2020，36，3： | 7 |
| 5 | Nrf2 is associated with the regulation of basal transcription activity of the BRCA1 gene显示文摘BRCA1 是仔细与乳癌的致病有关。BRCA1 倡导者的活动被 transcriptional 因素调整。抄写因素 Nrf2 (原子 factor-erythroid-2p45-related 因素 2 ) 是有势力 transcriptional 使活跃之物并且在许多 cytoprotective 基因的可诱导的表示起一个中央作用。在这份报告,我们发现 Nrf2 的在表示上刺激了 BRCA1 表示, Nrf2 击倒稀释 BRCA1 表示。Nrf2 也与 CBP 和 p300 交往了形成活跃抄写建筑群,它能在 BRCA1 倡导者上把地点绑在 ARE (抗氧化剂反应元素) 并且由导致 histone acetylation 激活它的抄写。我们发现能导致乳癌的发展的更好的理解。 | Qiaoqiao wang Jiyu Li Xinmiao Yang Hefen Sun Shuiping Gao Hua Zhu Jiong Wu Wei Jin | 2013 | Acta Biochimica et Biophysica Sinica2013，45，3： | 5 |
| 6 | Concentrations of heavy metals and polycyclic aromatic hydrocarbons in needles of Masson pine (Pinus massoniana L.) growing nearby different industrial sources显示文摘Emissions from industrial activities pose a serious threat to human health and impose the need for monitoring both inorganic and organic pollutants in industrial areas. We selected Masson pine (Pinus massoniana L.) as potential biomonitor and collected the current (C) and previous year (C+1) needles from three industrial sites dominated by petrochemical, ceramics manufacturing, and iron and steel smelting plants and one remote site to determine heavy metals (Cu, Cd, Pb, Zn, Cr, Ni and Co) and polycyclic aromatic hydrocarbons (PAHs) in unwashed and water-washed needles. Both unwashed and washed C+1 needles showed generally higher concentrations of heavy metals and PAHs than C needles, although the washed needles more clearly spotlighted the accumulation effect of PAHs over exposure time. Water-washing resulted in a significant decrease in needle PAH concentrations with more significant effects shown in C needles. By contrast, needle heavy metal concentrations were much less affected by washing. Although heavy metals and PAHs might differ in adsorption and uptake strategies, their higher concentrations in the needles at the industrial sites indicated conspicuous contamination due to industrial emissions there. The PAH distribution patterns in pine needles accorded with the real types of energy consumption in the study sites and were efficiently used for pinpointing local pollutant sources. | Fangfang Sun Dazhi Wen Yuanwen Kuang Jiong Li Jianli Li Weidong Zuo | 2010 | Journal of Environmental Sciences2010，22，7： | 4 |
| 7 | Estimation of PM_(10) in the trafc-related atmosphere for three road types in Beijing and Guangzhou, China显示文摘The levels of roadside PM10in Beijing, China, were investigated in 2011 and 2012 on a seasonal basis to estimate the population exposure to particulates for three road types. The measurements of PM10 were also conducted in the southern Chinese megacity of Guangzhou for comparison purposes. The results showed that roadside PM10in Beijing correlated strongly with the PM10background in the urban atmosphere. The levels of PM10in street canyons were markedly higher than those along the open roads and in crossroad areas because of limited ventilation. An elevation of PM10was observed in April, which was possibly due to the sand storms that frequently occur in the spring. Based on these observations, roadside PM10in Beijing could have multiple origins and was to some extent dispersiongoverned. In Guangzhou, the roadside PM10did not closely relate to the background values. The PM10 pollution was greatly afected by local trafc conditions. The simulation of PM10 for diferent road types was completed during the study period using the Motor Vehicle Emissions Factor Model(MOBILE6.2) as an emission model and the California Line Source Dispersion Model(CALINE4) and Operational Street Pollution Model(OSPM) as dispersion models. The MOBILE6.2/CALINE4 software package was demonstrated to be sufcient for the simulation of PM10in the open roads and crossroad areas in both Beijing and Guangzhou, and the simulation results of roadside PM10 in the street canyons by the MOBILE6.2/OSPM package were in close agreement with those of the measurements. | Yu Wang Jiong Li Xiang Cheng Xiaoxiu Lun Dezhi Sun Xingzu Wang | 2014 | Journal of Environmental Sciences2014，26，1： | 3 |
| 8 | A multicenter retrospective cohort study of ketogenic diet therapy in 481 children with infantile spasms显示文摘Background:Ketogenic diet(KD)therapy is one of the main treatments for drug-resistant epilepsy.However,the KD therapy has been applied in only a small number of infantile spasm cases.In this large multicenter study,we investigated the efficacy of KD therapy in the treatment of infantile spasms.Methods:In this retrospective,multicenter cohort study,clinical data from main epilepsy centers were analyzed.Patients were classified into different groups according to age,type of drug and whether glucocorticoid was used before initiation of KD.Results:From October 2014 to March 2020,481 patients(308 males and 173 females)with infantile spasms were treated with the KD therapy.The age of the patients ranged from 2 months to 20 years,with a mean age of 1 year and 10 months.The number of anti-seizure medications(ASMs)used before KD initiation ranged 0-6,with a median of 3.In different time from initiation(1,3,6,and 12 months),the rates of seizure freedom after KD were 6.9,11.6;16.0 and 16.8%,respectively(x^(2)=27.1772,P<0.0001).There was a significant difference in the rate of seizure freedom between 3 months and 1 month(x^(2)=6.5498,P=0.0105)groups,and 6 months and 3 months(x^(2)=3.8478,P=0.0498)groups,but not between 12 months and 6 months(x^(2)=0.1212,P=0.7278)groups.The rates of effectiveness were 44.7;62.8,49.1 and 32.0%(x^(2)=93.2674,P<0.0001),respectively.The retention rates were 94.0,82.5,55.7 and 33.1%(x^(2)=483.7551,P<0.0001),correspondingly.The rate of effectiveness and the retention rate of KD were significantly different among the 1,3,6 and 12 months.KD treatment was the first choice in 25 patients(5.2%),55 patients(11.4%)started KD after the failure of the first ASM,158 patients(32.8%)started KD after the failure of the second ASM,157 patients(32.6%)started KD after the failure of the third drug,and 86 patients(17.9%)started KD after the failure of the fourth and more.The KD effect was not related to the number of ASMs used before KD startup(P>0.05).Two hundred and eighteen patients(45.3%)failed to respond to corticotropin or glucocorticoid before initiation.There was no significant difference in the effectiveness rate at different time points between the group of KD therapy after glucocorticoid failure and the group after non-hormone failure (x^(2)=0.8613,P=0.8348).The rate of adverse events of KD in 1,3,6,and 12 months after KD initiation were 22.3,21.7,16.8 and 6.9%,respectively.The adverse events mainly occurred during the first 3 months of KD,and the main adverse events were gastrointestinal disturbance and constipation.Conclusions:The efficacy of the KD treatment for infantile spasms was not affected by age,medication,and glucocorticoid use before initiation.KD is one of the effective treatments for infantile spasms. | Yuanzhen Ye Dan Sun Hua Li Jianmin Zhong Rong Luo Baomin Li Dengna Zhu Dan Li Shaoping Huang Yuwu Jiang Nong Xiao Yucai Chen Yuqin Zhang Mei Yu Xiaoyun Shen Li Gao Guo Zheng Congmin Zhao Baoqiang Yuan Jianxiang Liao Jiong Qin CAAE KD group | 2022 | Acta Epileptologica2022，5，1： | 2 |
| 9 | Characterization of DNA damage response deficiency in pancreatic cancer patients from China显示文摘To the editor,Pancreatic ductal adenocarcinoma(PDAC)has the worst prognosis among all common malignant solid tumors,with a 5-year overall survival(OS)rate of less than 10%[1].Few effective targets for anticancer ther-apy have been confirmed in pancreatic cancer.Recently,it was substantiated that pancreatic cancer patients carry-ing deleterious mutations of the DNA damage response(DDR)genes are more likely to benefit from platinum-based chemotherapy[2]and poly(adenosine diphosphate-ribose)polymerase(PARP)inhibitor[3]. | Xiaofei Zhang Tiebo Mao Bei Zhang Haiyan Xu Jiujie Cui Feng Jiao Dongqin Chen Yu Wang Jiong Hu Qing Xia Shumin Li Ming Yue Jingyu Ma Jiayu Yao Yongchao Wang Xiao Zhang Shiqing Chen Yuezong Bai Yuexiang Wang Xuebin Zhang Qiang Liu Yongwei Sun Deliang Fu Yingbin Liu Lei Xiong Liwei Wang | 2022 | Cancer Communications2022，42，1： | 2 |
| 10 | Histones released by NETosis enhance the infectivity of SARS-CoV-2 by bridging the spike protein subunit 2 and sialic acid on host cells显示文摘Neutrophil extracellular traps(NETs)can capture and kill viruses,such as influenza viruses,human immunodeficiency virus(HIV),and respiratory syncytial virus(RSV),thus contributing to host defense.Contrary to our expectation,we show here that the histones released by NETosis enhance the infectivity of SARS-CoV-2,as found by using live SARS-CoV-2 and two pseudovirus systems as well as a mouse model.The histone H3 or H4 selectively binds to subunit 2 of the spike(S)protein,as shown by a biochemical binding assay,surface plasmon resonance and binding energy calculation as well as the construction of a mutant S protein by replacing four acidic amino acids.Sialic acid on the host cell surface is the key molecule to which histones bridge subunit 2 of the S protein.Moreover,histones enhance cell-cell fusion.Finally,treatment with an inhibitor of NETosis,histone H3 or H4,or sialic acid notably affected the levels of sgRNA copies and the number of apoptotic cells in a mouse model.These findings suggest that SARS-CoV-2 could hijack histones from neutrophil NETosis to promote its host cell attachment and entry process and may be important in exploring pathogenesis and possible strategies to develop new effective therapies for COVID-19. | Weiqi Hong Jingyun Yang Jun Zou Zhenfei Bi Cai He Hong Lei Xuemei He Xue Li Aqu Alu Wenyan Ren Zeng Wang Xiaohua Jiang Kunhong Zhong Guowen Jia Yun Yang Wenhai Yu Qing Huang Mengli Yang Yanan Zhou Yuan Zhao Dexuan Kuang Junbin Wang Haixuan Wang Siyuan Chen Min Luo Ziqi Zhang Tiangi Lu Li Chen Haiying Que Zhiyao He Qiu Sun Wei Wang Guobo Shen Guangwen Lu Zhiwei Zhao Li Yang Jinliang Yang Zhenling Wang Jiong Li Xiangrong Song Lunzhi Dai Chong Chen Jia Geng Maling Gou Lu Chen Haohao Dong Yong Peng Canhua Huang Zhiyong Qian Wei Cheng Changfa Fan Yuquan Wei Zhaoming Su Aiping Tong Shuaiyao Lu Xiaozhong Peng Xiawei Wei | 2022 | Cellular & Molecular Immunology2022，19，5： | 2 |
| 11 | Spectrum of a class of fourth order left-definite differential operators显示文摘左明确的微分操作员被学习的第四份订单的一个班的光谱。由在 Krein 空格使用不定的微分操作符的理论;在之间的关系左明确;权利明确的操作员,下列结论被获得:如果第四与一个自我伴随边界条件订微分操作员,那是左明确的;权利不定,当时,所有它的特征值是真实的,;在那里存在无穷地能干地数许多积极;下面无界从的否定特征值;上面,别让有限的簇指; | GAO Yun-lan SUN Jiong | 2008 | Applied Mathematics(A Journal of Chinese Universities)2008，23，1： | 2 |
| 12 | miR-511 promotes the proliferation of human hepatoma cells by targeting the 3'UTR of B cell translocation gene 1 (BTG1) mRNA显示文摘miR-511 的异常表示涉及癌症的发展,但是在 hepatocellular 癌(HCC ) 的 miR-511 的角色不是记录的井。在这研究,我们在 hepatocarcinogenesis 探索了 miR-511 的分子的机制。我们生物信息学分析的结果建议了那 B 房间 translocation 基因 1 (BTG1 ) , anti-proliferative 基因家庭的一个成员,是 miR-511 的通常认为的目标之一。miR-511 的表示层次比在相应 peritumor 纸巾在 30 临床的 HCC 纸巾是显著地更高的,并且否定地在 HCC 纸巾 BTG1 与那些被相关(r=-0.6105, P < 0.01 ) 。在人的 hepatoma 房间线 HepG2 和 H7402, miR-511 的 overexpression dose-dependently 禁止了 BTG1 的表示,而 dose-dependently 增加的 miR-511 击倒 BTG1 的表示。酶记者基因试金证实 miR-511 指向了 BTG1 mRNA 的 3UTR。在 hepatoma 房间, miR-511 的 overexpression 显著地减少了导致 BTG1 的 G 1 阶段逮捕,它被 BTG1 的 overexpression 救。而且, miR-511 的 overexpression 支持了 hepatoma 房间的增长,它被 BTG1 的 overexpression 救。相反地, miR-511 击倒禁止的房间增长,它被颠倒由 BTG1 击倒。在结论, miR-511 由指向 BTG1 mRNA 的 3UTR 在 vitro 支持人的 hepatoma 房间的增长。 | Shu-qin ZHANG Zhe YANG Xiao-li CAI Man ZHAO Ming-ming SUN Jiong LI Guo-xing FENG Jin-yan FENG Li-hong YE Jun-qi NIU Xiao-dong ZHANG | 2017 | Acta Pharmacologica Sinica2017，38，8： | 2 |
| 13 | Two-interval Sturm-Liouville operators in direct sum spaces withinner product multiples显示文摘 | SUN Jiong WANG Aiping Zettl A | 2007 | Results in Mathematics2007，50，12： | 1 |
| 14 | A Direct Method for Solving Sine-Gordon Type Equation显示文摘 | SIRENDAOREJI SUN JIONG | 2002 | Physics Letters A2002，，298： | 1 |
| 15 | Subtyping-based platform guides precision medicine for heavily pretreated metastatic triple-negative breast cancer:The FUTURE phase II umbrella clinical trial显示文摘Triple-negative breast cancer(TNBC)is a heterogeneous disease and lacks effective treatment.Our previous study classified TNBCs into four subtypes with putative therapeutic targets.Here,we report the final results of FUTURE,a phase II umbrella trial designed to explore whether the subtyping-based strategy may improve the outcomes in metastatic TNBC patients.A total of 141 patients with a median of three previous lines of therapies in the metastatic setting were enrolled in seven parallel arms.Confirmed objective responses were achieved in 42 patients(29.8%;95%confidence interval[CI],22.4–38.1).The median values of progression-free survival and overall survival were 3.4(95%CI:2.7–4.2)and 10.7(95%CI:9.1–12.3)months,respectively.Given Bayesian predictive probability,efficacy boundaries were achieved in four arms.Furthermore,integrated genomic and clinicopathological profiling illustrated associations of clinical and genomic parameters with treatment efficacy,and the efficacy of novel antibody–drug conjugates was explored in preclinical TNBC models of subtypes for which treatment was futile.In general,the FUTURE strategy recruits patients efficiently and provides promising efficacy with manageable toxicities,outlining a direction for further clinical exploration. | Yin Liu Xiu-Zhi Zhu Yi Xiao Song-Yang Wu Wen-Jia Zuo Qiang Yu A-Yong Cao Jun-Jie Li Ke-Da Yu Guang-Yu Liu Jiong Wu Tao Sun Jiu-Wei Cui Zheng Lv Hui-Ping Li Xiao-Yu Zhu Yi-Zhou Jiang Zhong-Hua Wang Zhi-Ming Shao | 2023 | Cell Research2023，33，5： | 1 |
| 16 | On self-adjointness of the products of two second-order differential operators显示文摘 | CAO Zhijiang SUN Jiong Edmunds D E | | 0，，： | 1 |
| 17 | Auxiliary equation method for solving nonlinear partial differential equations显示文摘 | Sirendaoreji SUN Jiong | 2003 | Physics Letters A2003，309，56： | 1 |
| 18 | Completeness of Eigenfunctions of Sturm-Liouville Problems with Transmi-ssion Conditions 显示文摘 | Aiping Wang Jiong Sun Pengfei Gao | 2005 | J Speetral Math Appl2005，，： | 1 |
| 19 | On the self-adjoint extentions of symmetric ordinary differential operators with middle deficiency indices显示文摘 | Sun Jiong | 1986 | Acta Mathematica Sinica New Series1986，2，2： | 1 |
| 20 | A direct method for solving Sine-Gordon type equations显示文摘 | Sirendaoreji Sun Jiong | 2003 | Physics Letters A2003，309，： | 1 |
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