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| 1 | UFMylation of RPL26 links translocation-associated quality control to endoplasmic reticulum protein homeostasis显示文摘Protein biogenesis at the endoplasmic reticulum(ER)in eukaryotic cells is monitored by a protein quality control system named ER-associated protein degradation(ERAD).While there has been substantial progress in understanding how ERAD eliminates defective polypeptides generated from erroneous folding,how cells remove nascent chains stalled in the translocon during co-translational protein insertion into the ER is unclear.Here we show that ribosome stalling during protein translocation induces the attachment of UFM1,a ubiquitin-like modifier,to two conserved lysine residues near the COOH-terminus of the 60S ribosomal subunit RPL26(uL24)at the ER.Strikingly,RPL26 UFMylation enables the degradation of stalled nascent chains,but unlike ERAD or previously established cytosolic ribosome-associated quality control(RQC),which uses proteasome to degrade their client proteins,ribosome UFMylation promotes the targeting of a translocation-arrested ER protein to lysosomes for degradation.RPL26 UFMylation is upregulated during erythroid differentiation to cope with increased secretory flow,and compromising UFMylation impairs protein secretion,and ultimately hemoglobin production.We propose that in metazoan,co-translational protein translocation into the ER is safeguarded by a UFMylation-dependent protein quality control mechanism,which when impaired causes anemia in mice and abnormal neuronal development in humans. | Lihui Wang Yue Xu Heather Rogers Layla Saidi Constance Tom Noguchi Honglin Li Jonathan Wilson Yewdell Nicholas Raymond Guydosh Yihong Ye | 2020 | Cell Research2020，30，1： | 5 |
| 2 | Effect of daily aspirin on risk of cancer metastasis: a study of incident cancers during randomised controlled trials显示文摘 | Peter M Rothwell Michelle Wilson Jacqueline F Price Jill FF Belch Tom W Meade Ziyah Mehta | 2012 | The Lancet . 2012 (9826)2012，，： | 2 |
| 3 | Long-term effect of aspirin on colorectal cancer incidence and mortality: 20-year follow-up of five randomised trials显示文摘 | Peter M Rothwell Michelle Wilson Carl-Eric Elwin Bo Norrving Ale Algra Charles P Warlow Tom W Meade | 2010 | 2010 (9754)2010，，9754： | 1 |
| 4 | The behaviour/practice debate : A discussion promp - ted by Tom Wilson's review of Reijo Savolainen's everyday infor - mation practices: A social phenomenological perspective显示文摘 | Wilson Tom | 2009 | Information Research: An Information Electronic Journal2009，14，2： | 1 |
| 5 | The in vivo expressed Mycobacterium tuberculosis (IVE-TB) antigen Rv2034 induces CD4 + T-cells that protect against pulmonary infection in HLA-DR transgenic mice and guinea pigs显示文摘 | Susanna Commandeur Susan J.F. van den Eeden Karin Dijkman Simon O. Clark Krista E. van Meijgaarden Louis Wilson Kees L.M.C. Franken Ann Williams Dennis Christensen Tom H.M. Ottenhoff Annemieke Geluk | 2014 | Vaccine2014，，： | 1 |
| 6 | High-speed closed-loop dual deformable-mirror phase-diversity testbed显示文摘 | James A Georges III Pam Dorrance Kurt Gleichman Julie Jonik Dean Liskow Harold Lapprich Vipul Naik Stuart Parker Rick Paxman Matt Warmuth Aaron Wilson Tom Zaugg | 2007 | SPIE2007，6711，： | 1 |
| 7 | Policy Interactions, Risk and Price Formation in Carbon Markets 显示文摘 | WILLIAM BLYTH DEREK BUNN JANNE KETTUNEN TOM WILSON | 2009 | Energy Policy2009，37，： | 1 |
| 8 | Long-term effect of aspirin on colorectal cancer incidence and mortality: 20-year follow-up of five randomised trials显示文摘 | Peter M Rothwell Michelle Wilson Carl-Eric Elwin Bo Norrving Ale Algra Charles P Warlow Tom W Meade | 2010 | The Lancet2010，，9754： | 1 |
| 9 | Short-term effects of daily aspirin on cancer incidence, mortality, and non-vascular death: analysis of the time course of risks and benefits in 51 randomised controlled trials显示文摘 | Peter M Rothwell Jacqueline F Price F Gerald R Fowkes Alberto Zanchetti Maria Carla Roncaglioni Gianni Tognoni Robert Lee Jill FF Belch Michelle Wilson Ziyah Mehta Tom W Meade | 2012 | The Lancet . 2012 (9826)2012，，： | 1 |
| 10 | Long-term effect of aspirin on colorectal cancer incidence and mortality: 20-year follow-up of five randomised trials显示文摘 | Peter M Rothwell Michelle Wilson Carl-Eric Elwin Bo Norrving Ale Algra Charles P Warlow Tom W Meade | 2010 | The Lancet . 2010 (9754)2010，，9754： | 1 |
| 11 | Towards an information management curriculum显示文摘 | WILSON TOM | 1989 | Journal of Information Science1989，，15： | 1 |
| 12 | Exploring models of information behaviour: ' theuncertainty' project 显示文摘 | Tom Wilson | 1999 | Information Processing and Management1999，35，4： | 1 |
| 13 | Models in information belmvior- research 显示文摘 | Wilson Tom | 1999 | Joumal of Docnentation1999，55，3： | 1 |
| 14 | An introduction to this special section: CO2 sequestration显示文摘 | Colin Sayers Tom Wilson | 2010 | The Leading Edge2010，29，2： | 1 |
| 15 | Current surgical management of congenital diaphragmatic hernia: A report from the congenital diaphragmatic hernia study group显示文摘 | Reese H Clark William D Hardin Ronald B Hirschl Tom Jaksic Kevin P Lally Max R Langham Jay M Wilson | 1998 | Journal of Pediatric Surgery1998，，7： | 1 |
| 16 | Policy interactions, risk and price formation in carbon markets显示文摘 | William Blyth Derek Bunn Janne Kettunen Tom Wilson | 2009 | Energy Policy2009，，12： | 1 |
| 17 | Decreased health-related physical fitness in adults with ankylosing spondylitis:a cross-sectional controlled study显示文摘 | Tom O'Dwyer Finbar O'Shea Fiona Wilson | 2016 | Physio- therapy2016，102，2： | 1 |
| 18 | The information user: Past, present and future显示文摘 | Wilson Tom | 2008 | Journal of Information Science2008，34，4： | 1 |
| 19 | Evaluating thepower investment options with uncertainty in climatepolicy显示文摘 | Ming Yang William Blyth Richard Bradley DerekBunn Charlie Clarke Tom Wilson | 2008 | Energy Economics2008，30，4： | 1 |
| 20 | 前沿杂志专题文章简介:碳埋存/EOR显示文摘政治家和科学家们在继续争论全球气候变暖的现实。长期以来被认为是科学幻想的事现在已变成了多学科研究的焦点。有意改变全球气候的技术挑战已激起了许多研究人员的好奇心和想象力。 | Tom Wilson Rick Miller 谢力(译) | 2006 | 国外石油动态2006，，24： | 0 |
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