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| 1 | The influence of stage at diagnosis and molecular subtype on breast cancer patient survival: a hospital.based multi.center study显示文摘Background: Stage at diagnosis and molecular subtype are important clinical factors associated with breast cancer patient survival. However, subgroup survival data from a large study sample are limited in China.To estimate the survival differences among patients with different stages and various subtypes of breast cancer, we conducted a hospital-based multi-center study on breast cancer in Beijing, China.Methods: All resident patients diagnosed with primary, invasive breast cancer between January 1,2006 and December 31,2010 from four selected hospitals in Beijing were included and followed up until December 31,2015. Hospitalbased data of stage at diagnosis, hormone receptor status, and selected clinical characteristics, including body mass index(BMI), menopausal status, histological grade, and histological type, were collected from the medical records of the study subjects. Overall survival(OS) and cancer-specific survival(CSS) were estimated. Cox proportional hazards models were employed to evaluate the associations of stage at diagnosis and molecular subtype with patient survival.Results: The 5-year OS and CSS rates for all patients were 89.4% and 90.3%. Survival varied by stage and molecular subtype. The 5-year OS rates for patients with stage I, Ⅱ, Ⅲ, and IV diseases were 96.5%, 91.6%, 74.8%, and 40.7%,respectively, and the corresponding estimates of 5-year CSS rates were 97.1%, 92.6%, 75.6%, and 42.7%, respectively.The 5-year OS rates for patients with luminal A, luminal B, HER2, and triple-negative subtypes of breast cancer were92.6%, 88.4%, 83.6%, and 82.9%, respectively, and the corresponding estimates of 5-year CSS rates were 93.2%, 89.1 %,85.4%, and 83.5%, respectively. Multivariate analysis showed that stage at diagnosis and molecular subtype were important prognostic factors for breast cancer.Conclusions: Survival of breast cancer patients varied significantly by stage and molecular subtype. Cancer screening is encouraged for the early detection and early diagnosis of breast cancer. More advanced therapies and health care policies are needed on HER2 and triple-negative subtypes. | Tingting Zuo Hongmei Zeng Huichao Li Shuo Liu Lei Yang Changfa Xia Rongshou Zheng Fei Ma Lifang Liu Ning Wang Lixue Xuan Wanqing Chen | 2017 | Chinese Journal of Cancer2017，36，11： | 18 |
| 2 | A Transcriptional Network Promotes Anthocyanin Biosynthesis in Tomato Flesh显示文摘Dietary anthocyanins are important health-promoting antioxidants that make a major contribution to the quality of fruits. It is intriguing that most tomato cultivars do not produce anthocyanins in fruit. However, the purple tomato variety Indigo Rose, which has the dominant Aft locus combined with the recessive atv locus from wild tomato species, exhibits light-dependent anthocyanin accumulation in the fruit skin. Here, we report that Aft encodes a functional anthocyanin activator named SlAN2-like, while atv encodes a nonfunctional version of the anthocyanin repressor SlMYBATV. The expression of SlAN2-like is responsive to light, and the functional SlAN2-like can activate the expression of both anthocyanin biosynthetic genes and their regulatory genes, suggesting that SlAN2-like acts as a master regulator in the activation of anthocyanin biosynthesis. We further showed that cultivated tomatoes contain nonfunctional alleles of SlAN2-like and therefore fail to produce anthocyanins. Consistently, expression of a functional SlAN2-like gene driven by the fruit-specific promoter in a tomato cultivar led to the activation of the entire anthocyanin biosynthesis pathway and high-level accumulation of anthocyanins in both the peel and flesh. Taken together, our study exemplifies that efficient engineering of complex metabolic pathways could be achieved through tissue-specific expression of master transcriptional regulators. | Chuanlong Sun Lei Deng Minmin Du Jiuhai Zhao Qian Chen Tingting Huang Hongling Jiang Chang-Bao Li Chuanyou Li | 2020 | Molecular Plant2020，13，1： | 17 |
| 3 | GSA:Genome Sequence Archive显示文摘With the rapid development of sequencing technologies towards higher throughput and lower cost, sequence data are generated at an unprecedentedly explosive rate. To provide an efficient and easy-to-use platform for managing huge sequence data, here we present Genome Sequence Archive(GSA; http://gffzzdbc7b6aaae734bddhovcwuonu6vuo6c0v.ffgz.tsg.suse.edu.cn/gsa or http://gffzz4eaf941a184140e3hovcwuonu6vuo6c0v.ffgz.tsg.suse.edu.cn), a data repository for archiving raw sequence data. In compliance with data standards and structures of the International Nucleotide Sequence Database Collaboration(INSDC), GSA adopts four data objects(Bio Project, Bio Sample,Experiment, and Run) for data organization, accepts raw sequence reads produced by a variety of sequencing platforms, stores both sequence reads and metadata submitted from all over the world,and makes all these data publicly available to worldwide scientific communities. In the era of big data, GSA is not only an important complement to existing INSDC members by alleviating the increasing burdens of handling sequence data deluge, but also takes the significant responsibility for global big data archive and provides free unrestricted access to all publicly available data in support of research activities throughout the world. | Yanqing Wang Fuhai Song Junwei Zhu Sisi Zhang Yadong Yang Tingting Chen Bixia Tang Lili Dong Nan Ding Qian Zhang Zhouxian Bai Xunong Dong Huanxin Chen Mingyuan Sun Shuang Zhai Yubin Sun Lei Yu Li Lan Jingfa Xiao Xiangdong Fang Hongxing Lei Zhang Zhang Wenming Zhao | 2017 | Genomics, Proteomics & Bioinformatics2017，15，1： | 13 |
| 4 | Platelet-rich fibrin-induced bone marrow mesenchymal stem cell differentiation into osteoblast-like cells and neural cells显示文摘Bone marrow mesenchymal stem cells were allowed to develop for 14 days in a platelet-rich fibrin environment.Results demonstrated that platelet-rich fibrin significantly promoted bone marrow mesenchymal stem cell proliferation.In addition,there was a dose-dependent increase in Runt-related transcription factor-2 and bone morphogenetic protein-2 mRNA expression,as well as neuron-specific enolase and glial acidic protein.Results showed that platelet-rich fibrin promoted bone marrow mesenchymal stem cell proliferation and differentiation of osteoblast-like cells and neural cells in a dose-dependent manner. | Qi Li Yajun Geng Lei Lu Tingting Yang Mingrui Zhang Yanmin Zhou | 2011 | Neural Regeneration Research2011，6，31： | 12 |
| 5 | Population-based cancer incidence analysis in Beijing, 2008-2012显示文摘Objective: To analyze the incidence of cancer during 2008-2012 in Beijing, China, and compare the cancer spectrum with that during 1998-1999.Methods: Data from the Beijing Cancer Registry(BCR), which covered 12 million residents and 16 administrative regions in Beijing, were checked and evaluated on basis of the criteria of data quality from the National Central Cancer Registry(NCCR) of China. Incidences were calculated stratified by cancer type, sex, areas(urban/rural), and age. The Chinese census population in 1982 and the world Segi's population were used for calculating the age-standardized incidences.Results: A total of 177,101 new cancer cases were diagnosed in Beijing between 2008 and 2012. The crude incidence rate(CR) of all cancers was 282.64/100,000(290.71/100,000 in males and 274.45/100,000 in females). The age-standardized rates by Chinese standard population(ASR-China) and by world standard population(ASR-world) were 124.46/100,000 and 161.18/100,000, respectively. Female breast cancer was the most common cancer, followed by lung cancer, colorectal cancer, liver cancer, and stomach cancer, with the CR of 59.87/100,000, 59.21/100,000, 32.49/100,000, 19.81/100,000 and 17.96/100,000, respectively. In urban areas, female breast cancer(68.50/100,000) was still the most common cancer, followed by lung cancer(61.23/100,000), colorectal cancer(37.23/100,000), prostate cancer(20.49/100,000) and stomach cancer(20.07/100,000). In rural areas, lung cancer(55.94/100,000) was the most common cancer, followed by female breast cancer(45.87/100,000), colorectal cancer(24.77/100,000), liver cancer(20.68/100,000) and stomach cancer(14.52/100,000). Great changes of the cancer spectrum were found from the period of 1998-1999 to the period of 2011-2012 in Beijing.Conclusions: The cancer burden in Beijing was heavier than the national average level. Cancer prevention and control strategies, especially for lung, colorectal, prostate and female thyroid cancers, should be enhanced. | Lei Yang Yannan Yuan Tingting Sun Huichao Li Ning Wang | 2015 | Chinese Journal of Cancer Research2015，27，1： | 12 |
| 6 | Chinese Stroke Association guidelines for clinical management of cerebrovascular disorders:executive summary and 2019 update of the management of high-risk population显示文摘Aim Cerebrovascular disease is the leading cause of death and disability in China,causing a huge burden among patients and their families.Hence,stroke prevention is critical,especially in the high-risk population.Here,we present the evidence-based guideline suitable for the Chinese population.Methods Literature search of PubMed and Cochrane library(from January 1964 to June 2019)was done.After thorough discussion among the writing group members,recommendations were listed and summarised.This guideline was reviewed and discussed by the fellow writing committees of the Chinese Stroke Association’s Stroke.Results This evidence-based guideline was written in three parts:controlling the risk factors of stroke,utilisation of antiplatelet agents and assessing the risks of first-ever stroke.All recommendations were listed along with the recommending classes and levels of evidence.Conclusions This guideline provides recommendations for primary prevention of cerebrovascular disease among high-risk population in China.Controlling related risk factors,appropriately using antiplatelet agents,assessing the risk of developing first-ever stroke should help reduce the rate of cerebrovascular disease in China. | Yilong Wang Shangrong Han Haiqiang Qin Huaguang Zheng Bin Jiang Yong Cao Yuan Gao Ling Guan Qian Jia Yong Jiang Yuming Jiao Shuya Li Yapeng Li Zixiao Li Wei Liu Xiaojuan Ru Dongling Sun Haixin Sun Penglian Wang Tingting Wang Lixia Zong Lei Guo Xuewei Xie Yuming Xu Yuyuan Xu Xiaomeng Yang Yingying Yang Mengyuan Zhou Wenzhi Wang Chinese Stroke Association Stroke Council Guideline Writing Committee | 2020 | Stroke & Vascular Neurology2020，5，3： | 11 |
| 7 | Adaptive Neural Network-Based Control for a Class of Nonlinear Pure-Feedback Systems With Time-Varying Full State Constraints显示文摘In this paper, an adaptive neural network(NN)control approach is proposed for nonlinear pure-feedback systems with time-varying full state constraints. The pure-feedback systems of this paper are assumed to possess nonlinear function uncertainties. By using the mean value theorem, pure-feedback systems can be transformed into strict feedback forms. For the newly generated systems, NNs are employed to approximate unknown items. Based on the adaptive control scheme and backstepping algorithm, an intelligent controller is designed. At the same time, time-varying Barrier Lyapunov functions(BLFs)with error variables are adopted to avoid violating full state constraints in every step of the backstepping design. All closedloop signals are uniformly ultimately bounded and the output tracking error converges to the neighborhood of zero, which can be verified by using the Lyapunov stability theorem. Two simulation examples reveal the performance of the adaptive NN control approach. | tingting gao yan-jun liu lei liu dapeng li | 2018 | IEEE/CAA Journal of Automatica Sinica2018，5，5： | 11 |
| 8 | Data Logic Structure and Key Technologies on Intelligent High-precision Map显示文摘Taking autonomous driving and driverless as the research object,we discuss and define intelligent high-precision map.Intelligent high-precision map is considered as a key link of future travel,a carrier of real-time perception of traffic resources in the entire space-time range,and the criterion for the operation and control of the whole process of the vehicle.As a new form of map,it has distinctive features in terms of cartography theory and application requirements compared with traditional navigation electronic maps.Thus,it is necessary to analyze and discuss its key features and problems to promote the development of research and application of intelligent high-precision map.Accordingly,we propose an information transmission model based on the cartography theory and combine the wheeled robot’s control flow in practical application.Next,we put forward the data logic structure of intelligent high-precision map,and analyze its application in autonomous driving.Then,we summarize the computing mode of“Crowdsourcing+Edge-Cloud Collaborative Computing”,and carry out key technical analysis on how to improve the quality of crowdsourced data.We also analyze the effective application scenarios of intelligent high-precision map in the future.Finally,we present some thoughts and suggestions for the future development of this field. | Jingnan LIU Jiao ZHAN Chi GUO Tingting LEI Ying LI | 2020 | Journal of Geodesy and Geoinformation Science2020，3，3： | 11 |
| 9 | Configurable Floating-Point FFT Accelerator on FPGA Based Multiple-Rotation CORDIC显示文摘Fast Fourier transform(FFT) accelerator and Coordinate rotation digital computer(CORDIC) algorithm play important roles in signal processing. We propose a configurable floating-point FFT accelerator based on CORDIC rotation, in which twiddle direction prediction is presented to reduce hardware cost and twiddle angles are generated in real time to save memory. To finish CORDIC rotation efficiently, a novel approach in which segmentedparallel iteration and compress iteration based on CSA are presented and redundant CORDIC is used to reduce the latency of each iteration. To prove the efficiency of our FFT accelerator, four FFT accelerators are prototyped into a FPGA chip to perform a batch-FFT. Experimental results show that our structure, which is composed of four butterfly units and finishes FFT with the size ranging from 64 to8192 points, occupies 33230(3%) REGs and 143006(30%)LUTs. The clock frequency can reach 122 MHz. The resources of double-precision FFT is only about 2.5 times of single-precision while the theoretical value is 4. What's more, only 13331 cycles are required to implement 8192-points double-precision FFT with four butterfly units in parallel. | CHEN Jiyang LEI Yuanwu PENG Yuanxi HE Tingting DENG Ziye | 2016 | Chinese Journal of Electronics2016，25，6： | 10 |
| 10 | The Epitope Study on the SARS-CoV Nucleocapsid Protein显示文摘The nucleocapsid protein (N protein) has been found to be an antigenic protein in a number of coronaviruses. Whether the N protein in severe acute respiratory syndrome-associated coronavirus (SARS-CoV) is antigenic remains to be elucidated. Using Western blot and Enzyme-linked Immunosorbent Assay (ELISA),the recombinant N proteins and the synthesized peptides derived from the N protein were screened in sera from SARS patients. All patient sera in this study displayed strong positive immunoreactivities against the recombinant N proteins,whereas normal sera gave negative immunoresponses to these proteins, indicating that the N protein of SARS-CoV is an antigenic protein. Furthermore, the epitope sites in the N protein were determined by competition experiments, in which the recombinant proteins or the synthesized peptides competed against the SARS-CoV proteins to bind to the antibodies raised in SARS sera. One epitope site located at the C-terminus was confirmed as the most antigenic region in this protein. A detailed screening of peptide with ELISA demonstrated that the amino sequence from Codons 371 to 407 was the epitope site at the C-terminus of the N protein. Understanding of the epitope sites could be very significant for developing an effective diagnostic approach to SARS. | Shuting Li, Liang Lin, Hao Wang, Jianning Yin, Yan Ren, Zhe Zhao, Jie Wen, Cuiqi Zhou, Xumin Zhang, Xiaolei Li, Jingqiang Wang, Zhengfeng Zhou, Jinxiu Liu, Jianmin Shao, Tingting Lei, Jianqiu Fang, Ningzhi Xu, and Siqi LiuBeijing Genomics Institute, Chinese Academy of Sciences, Beijing 101300, China & Beijing Proteomics Institute, Beijing 101300, China | 2003 | Genomics, Proteomics & Bioinformatics2003，1，3： | 9 |
| 11 | Recent progress and perspective of electrochemical CO_(2) reduction towards C_(2)-C_(5) products over non-precious metal heterogeneous electrocatalysts显示文摘Electroreduction of carbon dioxide(CO_(2)ER)into value-added chemical compounds has presented as a promising route for renewable carbon cycle,which alleviates global warming concern.Compared with traditional C1 products,high-value multicarbon products converted from atmospheric CO_(2) via CO_(2)ER have attracted dramatic interest due to their significant economic efficiency,however desired catalytic selectivity of multicarbon products is difficult to achieve because of the high thermodynamic barriers and complex reaction pathways.To replace currently used precious-metal based catalysts,developing highly efficient and precious-metal-free CO_(2)ER catalysts based on earth abundant elements is the top priority to meet the requirements of industrialization.Although certain progress has been made,there are still few systematic reports on the non-precious metal heterogeneous(NPMH)CO_(2)ER electrocatalysts for efficient conversion of CO_(2) to multicarbon products.Herein,we summarize the latest research advances in recent developments of NPMH electrocatalysts,including nanostructured Cu,Cu-based bimetallic catalysts,Cu-based complexes,and carbon-based Cu-free catalysts for electroreduction of CO_(2) into high-value multicarbon products.The corresponding CO_(2)ER performances are discussed in the order of the types of multicarbon products,specifically for ethanol(C2H5OH),ethylene(C2H4),ethane(C2H6),acetic acid(CH3COOH),propanol(C3H7OH),and other O^(2+)products with a special attention paid to understand the structure-activity relationship.Moreover,key strategies and characterization techniques for catalytic mechanism insights,and unsolved issues and future trends for enhancing the CO_(2)ER performance of NPMH electrocatalysts are highlighted,which provides a constructive guidance on the development of CO_(2)ER electrocatalysts with high activity and selectivity for multicarbon products. | Jiayi Chen Tingting Wang Zhongjian Li Bin Yang Qinghua Zhang Lecheng Lei Pingyun Feng Yang Hou | 2021 | Nano Research2021，14，9： | 7 |
| 12 | Immunity-and-matrix-regulatory cells derived from human embryonic stem cells safely and effectively treat mouse lung injury and fibrosis显示文摘Lung injury and fibrosis represent the most significant outcomes of severe and acute lung disorders,including COVID-19.However,there are still no effective drugs to treat lung injury and fibrosis.In this study,we report the generation of clinical-grade human embryonic stem cells(hESCs)-derived immunity-and matrix-regulatory cells(IMRCs)produced under good manufacturing practice requirements,that can treat lung injury and fibrosis in vivo.We generate IMRCs by sequentially differentiating hESCs with serum-free reagents.IMRCs possess a unique gene expression profile distinct from that of umbilical cord mesenchymal stem cells(UCMSCs),such as higher expression levels of proliferative,immunomodulatory and anti-fibrotic genes.Moreover,intravenous delivery of IMRCs inhibits both pulmonary inflammation and fibrosis in mouse models of lung injury,and significantly improves the survival rate of the recipient mice in a dose-dependent manner,likely through paracrine regulatory mechanisms.IMRCs are superior to both primary UCMSCs and the FDA-approved drug pirfenidone,with an excellent efficacy and safety profile in mice and monkeys.In light of public health crises involving pneumonia,acute lung injury and acute respiratory distress syndrome,our findings suggest that IMRCs are ready for clinical trials on lung disorders. | Jun Wu Dingyun Song Zhongwen Li Baojie Guo Yani Xiao Wenjing Liu Lingmin Liang Chunjing Feng Tingting Gao Yanxia Chen Ying Li Zai Wang Jianyan Wen Shengnan Yang Peipei Liu Lei Wang Yukai Wang Liang Peng Glyn Nigel Stacey Zheng Hu Guihai Feng Wei Li Yan Huo Ronghua Jin Ng Shyh-Chang Qi Zhou Liu Wang Baoyang Hu Huaping Dai Jie Hao | 2020 | Cell Research2020，30，9： | 7 |
| 13 | Combination of a crude oil-degrading bacterial consortium under the guidance of strain tolerance and a pilot-scale degradation test显示文摘Under the guidance of strain tolerance, a new combination method for crude oil-degrading bacterial consortium was studied. Firstly, more than 50 efficient crude oil-degrading and biosurfactant producing bacteria were isolated from petroleum-contaminated soil and water in Tianjin Binhai New Area Oilfield, China. Twenty-four of them were selected for further study. These strains were identified as belonging Pseudomonas aeruginosa, Bacillus subtilis, Brevibacillus brevis, Achromobacter sp., Acinetobacter venetianus, Lysinibacillus macroides, Klebsiella oxytoca, Stenotrophomonas rhizophila, Rhodococcus sp. and Bacillus thuringiensis. A shake-flask degradation test revealed that 12 of these strains could degrade over 50% of 1% crude oil concentration in 7 d. Of these, 8 strains were able to produce biosurfactants. Furthermore, environmental tolerance experiments indicated that the majority of the strains had the ability to adapt to extreme environments including high temperatures, alkaline environments and high salinity environments. A mixed bacterial agent comprising the strains WB2, W2, W3 and HA was developed based on the environmental tolerance tests and subjected to the pilot-scale degradation test indicating that this bacterial agent could degrade 85.2% of 0.8% crude oil concentration in 60 d. Our results suggest that the application of this mixed agent could remediate crude oil polluted soils in saline and alkaline environments. | Yilin Liu Chen Li Lei Huang Yun He Tingting Zhao Bo Han Xiaoqiang Jia | 2017 | Chinese Journal of Chemical Engineering2017，25，12： | 6 |
| 14 | Regulation of Leaf Angle by Auricle Development n Maize显示文摘 | Fanying Kong Tingting Zhang Jisheng Liu Siqi Heng Qingbiao Shi Haisen Zhang Zeli Wang Lei Ge Pinghua Li Xiaoduo Lu Gang Li | 2017 | Molecular Plant2017，10，3： | 5 |
| 15 | Characteristics and trends in incidence of childhood cancer in Beijing,China,2000-2009显示文摘Objective: To investigate the characteristics and incidence trends of childhood cancer in Beijing, China, from 2000 to 2009.Methods: A total of 1,274 cases with childhood cancer in Beijing from 2000 to 2009 were included in the study. All rates were age-standardized using the direct method to the world standard population and expressed per million person-years. Incidence trends were characterized by calculating annual percent change(APC) using Joinpoint Regression Program.Results: The crude incidence rate was 106.47 per million [age-standardized rate(ASR) 113.34] between 2000 and 2009 in Beijing with the most common diagnoses, leukemia(N=505, 39.64%, ASR 45.20), followed by central nervous system(CNS) tumors(N=228, 17.90%, ASR 19.28) and lymphoma(N=91, 7.14%, ASR 6.97). The incidence for all childhood cancers combined has increased during the study period, with an APC of 5.84% [95% confidence interval(95% CI): 1.0-10.9] after adjusted by world population. The ASR of all combined cancers in boys showed a slight, but no significant increase, with an APC of 5.33%(95% CI: –0.6-11.6); for girls, the trends increased significantly, with an APC of 6.54%(95% CI: 1.5-11.8).Conclusions: The incidence rate of childhood cancer in Beijing was higher than the average level of China and lower than that of western countries. The incidence trends of childhood cancer, especially leukemia among girls showed a significantly increase from 2000 to 2009. While among boys, no substantially change was seen during the observed time period. Some sex-specific trends by subcategories and trends of major cancers in different age groups by cancer site merit further investigation. | Lei Yang Yannan Yuan Tingting Sun Huichao Li Ning Wang | 2014 | Chinese Journal of Cancer Research2014，26，3： | 5 |
| 16 | Nanostructured N-doped carbon materials derived from expandable biomass with superior electrocatalytic performance towards V^(2+)/V^(3+) redox reaction for vanadium redox flow battery显示文摘Vanadium redox flow battery(VRFB)is one of the most promising large-scale energy storage systems,which ranges from kilowatt to megawatt.Nevertheless,poor electrochemical activity of electrode for two redox couples still restricts the extensive applications of VRFB.Compared with V^(2+)/V^(3+)redox reaction,V^(2+)/V^(3+)reaction plays a more significant role in voltage loss of VRFB owing to slow heterogeneous electron transfer rate.Herein,N-doped carbon materials derived from scaphium scaphigerum have been developed as negative electrocatalyst by hydrothermal carbonization and high-temperature nitridation treatments.The undoped carbon material hardly has electrocatalytic ability for V^(2+)/V^(3+)reaction.Based on this,N-doped carbon materials with urea as nitrogen source exhibit excellent electrocatalytic properties.And the material nitrided at 850°C(SSC/N-850)exhibits the best performance among those from700 to 1000℃.SSC/N-850 can accelerate the electrode process including V^(2+)/V^(3+)reaction and mass transfer of active ions due to the large reaction place,more active sites,and good hydrophilicity.The effect of catalyst on comprehensive performance of cell was evaluated.SSC/N-850 can improve the charge-discharge performance greatly.Utilization of SSC/N-850 can lessen the electrochemical polarization of cell,further resulting in increased discharge capacity and energy efficiency.Discharge capacity and energy efficiency increase by 81.5%and 9.8%by using SSC/N-850 as negative catalyst at 150 m A cm^(-2),respectively.Our study reveals that the developed biomass-derived carbon materials are the low-cost and efficient negative electrocatalyst for VRFB system. | Yingqiao Jiang Mengchen Du Gang Cheng Peng Gao Tingting Dong Jing Zhou Xiaojian Feng Zhangxing He Yuehua Li Lei Dai Wei Meng Ling Wang | 2021 | Journal of Energy Chemistry2021，30，8： | 3 |
| 17 | SENP1 regulates IFN-γ-STAT1 signaling throug STAT3-SOCS3 negative feedback loop显示文摘干扰素 --(IFN-) 由激活发信号的细胞内部的 JAKSTAT1 为发炎反应触发巨噬细胞。表明 1 的 cytokine (SOCS1 ) 和蛋白质酷氨酸磷酸酶的 Suppressor 能否定地调制 IFN- 发信号。这里,我们鉴别一个新奇否定反馈环由 STAT3SOCS3 调停了,它被 SENP1 紧经由蛋白质酷氨酸磷酸酶 1B (PTP1B ) 的 de-SUMOylation 控制,在 IFN- 发信号。SENP1 缺乏的巨噬细胞在 IFN- 发信号和 M1 巨噬细胞激活显示出缺点。在 SENP1 缺乏的巨噬细胞的 PTP1B 高度 SUMOylated,它减少 STAT3 的导致 PTP1B 的 de-phosphorylation。激活的 STAT3 然后经由在 SENP1 缺乏的巨噬细胞感应的 SOCS3 压制 STAT1 激活。因此, SENP1 缺乏的巨噬细胞显示减少的能力抵抗 Listeria monocytogenes 感染。这些结果在巨噬细胞极化揭示控制 SENP1 的 STAT1 和 STAT3 平衡的一个关键角色。 | Tingting Yu Yong Zuo Rong Cai Xian Huang Shuai Wu Chenxi Zhang Y. Eugene Chin Dongdong Li Zhenning Zhang Nansong Xia Qi Wang Hao Shen Xuebiao Yao Zhong-Yin Zhang Song Xue Lei Shen Jinke Cheng | 2017 | Journal of Molecular Cell Biology2017，9，2： | 3 |
| 18 | Modes of genetic adaptations underlying functional innovations in the rumen显示文摘The rumen is the hallmark organ of ruminants and hosts a diverse ecosystem of microorganisms that facilitates efficient digestion of plant fibers.We analyzed 897 transcriptomes from three Cetartiodactyla lineages:ruminants,camels and cetaceans,as well as data from ruminant comparative genomics and functional assays to explore the genetic basis of rumen functional innovations.We identified genes with relatively high expression in the rumen,of which many appeared to be recruited from other tissues.These genes show functional enrichment in ketone body metabolism,regulation of microbial community,and epithelium absorption,which are the most prominent biological processes involved in rumen innovations.Several modes of genetic change underlying rumen functional innovations were uncovered,including coding mutations,genes newly evolved,and changes of regulatory elements.We validated that the key ketogenesis rate-limiting gene(HMGCS2)with five ruminant-specific mutations was under positive selection and exhibits higher synthesis activity than those of other mammals.Two newly evolved genes(LYZ1 and DEFB1)are resistant to Gram-positive bacteria and thereby may regulate microbial community equilibrium.Furthermore,we confirmed that the changes of regulatory elements accounted for the majority of rumen gene recruitment.These results greatly improve our understanding of rumen evolution and organ evo-devo in general. | Xiangyu Pan Yudong Cai Zongjun Li Xianqing Chen Rasmus Heller Nini Wang Yu Wang Chen Zhao Yong Wang Han Xu Songhai Li Ming Li Cunyuan Li Shengwei Hu Hui Li Kun Wang Lei Chen Bin Wei Zhuqing Zheng Weiwei Fu Yue Yang Tingting Zhang Zhuoting Hou Yueyang Yan Xiaoyang Lv Wei Sun Xinyu Li Shisheng Huang Lixiang Liu Shengyong Mao Wenqing Liu Jinlian Hua Zhipeng Li Guojie Zhang Yulin Chen Xihong Wang Qiang Qiu Brian PDalrymple Wen Wang Yu Jiang | 2021 | Science China(Life Sciences)2021，64，1： | 3 |
| 19 | Genesis mechanism and Mg isotope difference between the Sinian and Cambrian dolomites in Tarim Basin显示文摘Dolomite genesis is a century-old mystery in sedimentology.To reveal the mechanism of dolomite genesis,two core problems need to be addressed.The first is the origin and migration mechanism of Mg^(2+)-rich fluids during the dolomitization process.The second is the kinetic barrier caused by Mg^(2+)hydration during dolomite precipitation at low temperatures.To address these problems,our study,based on detailed petrological,sedimentological,geochemical(major and trace elements),and isotopic(C-O-Mg)analysis,clarified the source and migration of Mg^(2+)-rich fluids and the kinetic barrier mechanism of lowtemperature dolomite precipitation in the Upper Sinian Qigebulake Formation and the Lower Cambrian Xiaoerbulake Formation in the Tarim Basin.First,we found that the Mg^(2+)-rich fluids required for the dolomitization of dolomite in the Xiaoerbulake Formation were primarily derived from the Early Cambrian marine fluid.At the interface of the sedimentary cycle,δ26Mg values fluctuated considerably,indicating that the sequence interface was the starting point and channel for the migration of dolomitized fluids.Sea level variation plays a major role in controlling the dolomitization process of the Xiaoerbulake Formation.Second,the Qigebulake Formation contains low-temperature dolomite with Mg^(2+)-rich fluids supplied by seawater,microorganisms,and sedimentary organic matter.Comprehensive analysis shows that the dolomite of the Qigebulake Formation was formed by microbial induction by anaerobic methane bacteria.Finally,the properties and sources of dolomitization fluids and the formation process of dolomite were the reasons for the difference in the Mg isotope composition of dolomite during the Sinian-Cambrian transition.This study reveals the genetic mechanism of the Sinian-Cambrian dolomite in the Tarim Basin and establishes a new method to explain the genesis of microbial dolomite by C-O-Mg isotopes,providing a reference for the reconstruction of the formation and evolution of dolomites. | Guangyou ZHU Xi LI Tingting LI Lei ZHOU Yuxuan WU Bing SHEN Meng NING | 2023 | Science China Earth Sciences2023，66，2： | 2 |
| 20 | Modified g-C_(3)N_(4) derived from ionic liquid and urea for promoting visible-light photodegradation of organic pollutants显示文摘In this work,modified g-C_(3)N_(4) was fabricated successfully by calcination of ionic liquid(IL) and urea.The addition of IL changed the polymerization mode of urea,induced the self-assembly of urea molecules,modified the morphological structure of the tightly packed g-C_(3)N_(4),and extended the electron conjugation system.When using 1-butyl-3-methylimidazolium chloride([Bmim]Cl) as a modifier,the heteroatom Cl could be inserted into the g-C_(3)N_(4) to optimize the electronic structure.The results of characterizations indicate that the unique structure of modified g-C_(3)N_(4) has an expanded electron delocalization range,introduces an interlayer charge transmission channel,promotes the charge transmission,reduces the band gap,enhances the absorption of visible light,and inhibits electron-hole recombination.Modified g-C_(3)N_(4) showed excellent photocatalytic performance for the degradation of rhodamine B and tetracycline.Furthermore,the effect of different anions in 1-butyl-3-methylimidazolium salts([Bmim]Cl,[Bmim]Br,[Bmim][BF_(4)],and [Bmim][PF_6]) on the structure and function of g-C_(3) N_(4) are discussed. | Hongbing Song Lei Liu Bingxiao Feng Haozhong Wang Meng Xiao Hengjun Gai Yubao Tang Xiaofei Qu Tingting Huang | 2021 | Chinese Journal of Chemical Engineering2021，34，12： | 2 |
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