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| 1 | aunalysis of the Genome Sequence of the Medicinal Plant Salvia miltiorrhiza显示文摘 | Haibin Xu Jingyuan Song Hongmei Luo Yujun Zhang Qiushi Li Yingjie Zhu Jiang Xu Ying Li Chi Song Bo Wang Wei Sun Guoan Shen Xin Zhang Jun Qian Aijia Ji Zhichao Xu Xiang Luo Liu He Chuyuan Li Chao Sun Haixia Yah Guanghong Cui Xiwen Li Xian 'en Li Jianhe Wei Juyan Liu Yitao Wang Alice Hayward David Nelson Zemin Ning Reuben J. Peters Xiaoquan Qi Shilin Chen | 2016 | Molecular Plant2016，9，6： | 70 |
| 2 | Visual representation and characterization of three-dimensional hydrofracturing cracks within heterogeneous rock through 3D printing and transparent models显示文摘 | Peng Liu Yang Ju Pathegama G. Ranjith Zemin Zheng Li Wang Ayai Wanniarachchi | 2016 | International Journal of Coal Science & Technology2016，3，3： | 21 |
| 3 | Melatonin alleviates intervertebral disc degeneration by disrupting the IL-1β/NF-κB-NLRP3 inflammasome positive feedback loop显示文摘The inflammatory response is induced by the overexpression of inflammatory cytokines, mainly interleukin(IL)-1β, and is one of the main causes of intervertebral disc degeneration(IVDD). NLR pyrin domain containing 3(NLRP3) inflammasome activation is an important source of IL-1β. As an anti-inflammatory neuroendocrine hormone, melatonin plays various roles in different pathophysiological conditions. However, its roles in IVDD are still not well understood and require more examination. First, we demonstrated that melatonin delayed the progression of IVDD and relieved IVDD-related low back pain in a rat needle puncture IVDD model;moreover, NLRP3 inflammasome activation(NLRP3, p20, and IL-1β levels) was significantly upregulated in severely degenerated human discs and a rat IVDD model. Subsequently, an IL-1β/NF-κB-NLRP3 inflammasome activation positive feedback loop was found in nucleus pulposus(NP) cells that were treated with IL-1β. In these cells, expression of NLRP3 and p20 was significantly increased, NF-κB signaling was involved in this regulation, and mitochondrial reactive oxygen species(mt ROS)production increased. Furthermore, we found that melatonin disrupted the IL-1β/NF-κB-NLRP3 inflammasome activation positive feedback loop in vitro and in vivo. Melatonin treatment decreased NLRP3, p20, and IL-1β levels by inhibiting NF-κB signaling and downregulating mt ROS production. Finally, we showed that melatonin mediated the disruption of the positive feedback loop of IL-1β in vivo. In this study, we showed for the first time that IL-1β promotes its own expression by upregulating NLRP3 inflammasome activation. Furthermore, melatonin disrupts the IL-1β positive feedback loop and may be a potential therapeutic agent for IVDD. | Fan Chen Guowei Jiang Hui Liu Zemin Li Yuxin Pei Hua Wang Hehai Pan Haowen Cui Jun Long Jianru Wang Zhaomin Zheng | 2020 | Bone Research2020，8，2： | 18 |
| 4 | Weldability, microstructure and mechanical properties of laser-welded selective laser melted 304 stainless steel joints显示文摘Laser welding is a promising process for joining small components produced by selective laser melting (SLM) to fabricate the large-scale and complex-shaped parts. In the work, the morphology, microstructure, microhardness, tensile properties and corrosion resistance of the laser welded stress-relieved SLMed 304 stainless steel joints are investigated, as the different sections of stress-relieved SLMed 304 stainless steel are joined. Results show that the SLMed 304 stainless steel plates have a good laser weldability. The microstructure of laser-welded joints consists of the cellular dendrites in austenite matrix within columnar grains, exhibiting a coarser dendrite structure, lower microhardness (~220HV) and tensile properties (tensile strength of ~750 MPa, and area reduction of ~27.6%), but superior corrosion resistance to those of SLMed plates. The dendrite arm spacing of the joints varies from ~3.7μm in center zone, to ~5.0 (xm in fusion zone, to ~2.5 in epitaxial zone. The SLMed anisotropy shows a negligible effect on the microstructure and performance of the laser-welded joints. The laser welding along the building directions of the SLMed base plates can induce a slightly finer dendritic structure and higher tensile properties. | Jingjing Yang Yun Wang Fangzhi Li Wenpu Huang Guanyi Jing Zemin Wang Xiaoyan Zeng | 2019 | Journal of Materials Science & Technology2019，35，9： | 14 |
| 5 | Simultaneous incorporation of PTH(1-34) and nano-hydroxyapatite into Chitosan/Alginate Hydrogels for efficient bone regeneration显示文摘Tissue regeneration based on the utilization of artificial soft materials is considered a promising treatment for bone-related diseases.Here,we report cranial bone regeneration promoted by hydrogels that contain parathyroid hormone(PTH)peptide PTH(1-34)and nano-hydroxyapatite(nHAP).A combination of the positively charged natural polymer chitosan(CS)and negatively charged sodium alginate led to the formation of hydrogels with porous structures,as shown by scanning electron microscopy.Rheological characterizations revealed that the mechanical properties of the hydrogels were almost maintained upon the addition of nHAP and PTH(1-34).In vitro experiments showed that the hydrogel containing nHAP and PTH(1-34)exhibited strong biocompatibility and facilitated osteogenic differentiation of rat bone marrow mesenchymal stem cells(rBMSCs)via the Notch signaling pathway,as shown by the upregulated expression of osteogenic-related proteins.We found that increasing the content of PTH(1-34)in the hydrogels resulted in enhanced osteogenic differentiation of BMSCs.Implantation of the complex hydrogel into a rat cranial defect model led to efficient bone regeneration compared to the rats treated with the hydrogel alone or with nHAP,indicating the simultaneous therapeutic effect of nHAP and PTH during the treatment process.Both the in vitro and in vivo results demonstrated that simultaneously incorporating nHAP and PTH into hydrogels shows promise for bone regeneration,suggesting a new strategy for tissue engineering and regeneration in the future. | Zhiyuan Zou Le Wang Zhifei Zhou Qing Sun Delong Liu Yan Chen Hao Hu Yu Cai Sixiong Lin Zhengran Yu Bizhi Tan Wei Guo Zemin Ling Xuenong Zou | 2021 | Bioactive Materials2021，6，6： | 7 |
| 6 | Microstructural evolution and mechanical properties of 300M steel produced by low and high power selective laser melting显示文摘300 M ultra-high strength steel has been widely used in critical structural components for aviation and aerospace vehicles,owing to its high strength,excellent transverse plasticity,fracture toughness and fatigue resistance.Herein,low and high power selective laser melting(SLM)of 300 M steel and their microstructural evolution and mechanical properties have been reported.The results show that the optimal energy density range with the highest relative density for SLMed 300 M steel is between 60 and160 J/mm^3.Furthermore,molten pools for deposition exhibit a conduction mode with semi-elliptical shape at a lower laser power of 300~600 W but a keyhole mode with'U'shape at a higher laser power of 800~1900 W.The heterogeneous microstructure of as-built samples is cha racterized by a skin-core structure which is that tempered troostite with the coarse non-equiaxed grains in the molten pool is wrapped by tempered sorbite with the fine equiaxed grains in the heat-affected zone.The skin-core structure of SLMed 300 M steel has the characteristics of hard inside and soft outside.The average microhardness of samples varies from 385 to 341 HV when laser power increases from 300 to 1900 W.Interestingly,ultimate tensile strength(1156-1193 MPa)and yield tensile strength(1085-1145 MPa)of dense samples fabricated at diffe rent laser powers vary marginally.But,the elongation(6.8-9.1%)of SLMed 300 M steel is greatly affected by the laser power. | Guanyi Jing Wenpu Huang Huihui Yang Zemin Wang | 2020 | Journal of Materials Science & Technology2020，47，13： | 5 |
| 7 | Mass change study on Arctic glacier Pedersenbreen, during 1936-1990-2009显示文摘Pedersenbreen is a small polythermal valley glacier, located in Svalbard, which has been one of the two glaciers monitored by Chinese Arctic expedition members since 2004. This study estimates its area and volume and analyzes its change during 1936-1990-2009, using field collected GPS/GPR data in 2009 and historical topographic maps published by the Norwegian Polar Institute. We have found that Pedersenbreen is just like many other valley glaciers in Svalbard, having experienced a significant recession since the end of Little Ice Age in the early 20th century. The glacier tongue has retreated more than 0.6 km, while ice volume has decreased by approximately 13%. The overall thinning rate of Pedersenbreen has shown acceleration during the recent decades. Further analysis shows that the ice tongue in the downstream area of Pedersenbreen is melting at the highest rate, while a simultaneous accumulation occurred in the upstream. However, as global temperatures increase, the accumulation area is reducing year by year. | AI SongTao WANG ZeMin TAN Zhi E DongChen YAN Ming | 2013 | Chinese Science Bulletin2013，58，25： | 5 |
| 8 | Differential expression of immune-related genes between healthy volunteers and type 2 diabetic patients with spleen-deficiency pattern显示文摘OBJECTIVE: To investigate the clinical differentiation of spleen-deficiency pattern(SDP), a group of symptoms and signs defined in terms of Traditional Chinese Medicine for its clinical practice.METHODS: Peripheral venous blood(> 3 m L) was collected from each of six type 2 diabetes mellitus(T2DM)-SDP patients and six healthy volunteers. After the isolation of peripheral white blood cells(PWBCs), total RNA was extracted, and quality control was performed on all RNA samples. Microarray experiments were conducted using the Agilent human whole genome gene chip, and genes demonstrating differential expression were screened. Bioinformatics analysis was conducted on these genes using several online databases.RESULTS: We screened a total of 175 differentially expressed genes(DEGs), of which 111(63%) were down-regulated and 64(37%) were up-regulated in T2DM-SDP patients compared with healthy controls. Among the 175 genes, 158 had biological function annotations: 46(29%) were directly related to an individual's immune regulation or response, 25(16%) were associated with substance and energy metabolism of PWBCs which could also indirectly influence immunity, and the remaining87(55%) were involved in a variety of PWBC biological processes that might eventually influence the immune function. Kyoto Encyclopedia of Genes and Genomes pathway enrichment analysis revealed that the DEGs were predominantly enriched in seven immune-related pathways. Hierarchical cluster analysis identified gene expression patterns that were distinguishable between the two study groups.CONCLUSION: Our results suggest that T2DM-SDP patients experience significant hypoimmunity and/or immune dysfunctions, and possess a specific gene expression profile. These findings offer new insights into SDP and the clinical pattern differentiation of T2DM-SDP. | Chen Longhui Yang Zemin Chen Weiwen Li Ruliu Lin Chuanquan Guan Lihua Zhu Zhangzhi Chen Ruifang Li Saimei Zhao Lingbo Zeng Jinhao Wang Jianhua | 2015 | Journal of Traditional Chinese Medicine2015，35，6： | 5 |
| 9 | Serine metabolism orchestrates macrophage polarization by regulating the IGF1–p38 axis显示文摘Serine metabolism is reportedly involved in immune cell functions, but whether and how serine metabolism regulates macrophage polarization remain largely unknown. Here, we show that suppressing serine metabolism, either by inhibiting the activity of the key enzyme phosphoglycerate dehydrogenase in the serine biosynthesis pathway or by exogenous serine and glycine restriction, robustly enhances the polarization of interferon-γ-activated macrophages (M(IFN-γ)) but suppresses that of interleukin-4-activated macrophages (M(IL-4)) both in vitro and in vivo. Mechanistically, serine metabolism deficiency increases the expression of IGF1 by reducing the promoter abundance of S-adenosyl methionine-dependent histone H3 lysine 27 trimethylation. IGF1 then activates the p38-dependent JAK–STAT1 axis to promote M(IFN-γ) polarization and suppress STAT6-mediated M(IL-4) activation. This study reveals a new mechanism by which serine metabolism orchestrates macrophage polarization and suggests the manipulation of serine metabolism as a therapeutic strategy for macrophage-mediated immune diseases. | Xiao Shan Penghui Hu Lina Ni Long Shen Yanan Zhang Zemin Ji Yan Cui Meihua Guo Haoan Wang Liyuan Ran Kun Yang Ting Wang Lei Wang Bin Chen Zhi Yao Vingjie Wu Qiujing Yu | 2022 | Cellular & Molecular Immunology2022，19，11： | 5 |
| 10 | Direct Comparative Analyses of 10X Genomics Chromium and Smart-seq2显示文摘Single-cell RNA sequencing(scRNA-seq)is generally used for profiling transcriptome of individual cells.The droplet-based 10X Genomics Chromium(10X)approach and the plate-based Smart-seq2 full-length method are two frequently used scRNA-seq platforms,yet there are only a few thorough and systematic comparisons of their advantages and limitations.Here,by directly comparing the scRNA-seq data generated by these two platforms from the same samples of CD45cells,we systematically evaluated their features using a wide spectrum of analyses.Smart-seq2 detected more genes in a cell,especially low abundance transcripts as well as alternatively spliced transcripts,but captured higher proportion of mitochondrial genes.The composite of Smart-seq2 data also resembled bulk RNA-seq data more.For 10X-based data,we observed higher noise for mRNAs with low expression levels.Approximately 10%30%of all detected transcripts by both platforms were from non-coding genes,with long non-coding RNAs(lncRNAs)accounting for a higher proportion in 10X.10X-based data displayed more severe dropout problem,especially for genes with lower expression levels.However,10X-data can detect rare cell types given its ability to cover a large number of cells.In addition,each platform detected distinct groups of differentially expressed genes between cell clusters,indicating the different characteristics of these technologies.Our study promotes better understanding of these two platforms and offers the basis for an informed choice of these widely used technologies. | Xiliang Wang Yao He Qiming Zhang Xianwen Ren Zemin Zhang | 2021 | Genomics, Proteomics & Bioinformatics2021，19，2： | 4 |
| 11 | 宝钢1号高炉改进性大修的设计显示文摘介绍了宝钢1号高炉改造性大修设计的主要内容,着重论述了高炉一代炉役设计寿命由8年提高到12年并争取达到15年时在炉体各部位结构设计中,如炉体耐材砌筑、冷却结构、冷却水系统、炉体检测及炉体辅助设备等方面采取的一些改进措施。 | WANG Zemin(Beijing Central Engineering and Research Incorporation of Iron and Steel Industry) | 1998 | 钢铁1998，33，4： | 4 |
| 12 | Dual functional transparent film for proximity and pressure sensing显示文摘在过去几年,触觉的察觉到的技术的快速的开发显著地作出贡献到直觉的触摸控制和聪明的人机器的相互作用的实现。除了察觉到的物理触觉或压力,最近作为互补功能察觉到能扩大普通单个功能的触觉的传感器的察觉模式。在这个工作,我们在场一透明,矩阵结构集成在一台设备察觉到的最近和压力的能力的双功能的电容的传感器,并且电容的象素的孤立的反应提供的优秀空间分辨率使我们能认识到与快反应,高稳定性和高可逆性接近对象和装载压力的精确地点鉴定。 | Bo Zhang Zemin Xiang Siwei Zhu Qiyi Hu Yuanzhi Cao Junwen Zhong Qize Zhong Bo Wang Yunsheng Fang Bin Hu Jun Zhou Zhonglin wang | 2014 | Nano Research2014，7，10： | 4 |
| 13 | Re-evaluating the role of epithelial-mesenchymal-transition in cancer progression显示文摘Epithelial-mesenchymal transition(EMT) and mesenchymal-epithelial transition(MET) are essential for embryonic development and also important in cancer progression. In a conventional model, epithelial-like cancer cells transit to mesenchymal-like tumor cells with great motility via EMT transcription factors; these mesenchymallike cells migrate through the circulation system, relocate to a suitable site and then convert back to an epithelial-like phenotype to regenerate the tumor. However, recent findings challenge this conventional model and support the existence of a stable hybrid epithelial/mesenchymal(E/M) tumor population. Hybrid E/M tumor cells exhibit both epithelial and mesenchymal properties, possess great metastatic and tumorigenic capacity and are associated with poorer patient prognosis. The hybrid E/M model and associated regulatory networks represent a conceptual change regarding tumor metastasis and organ colonization. It may lead to the development of novel treatment strategies to ultimately stop cancer progression and improve disease-free survival. | Andrew Sulaiman Zemin Yao Lisheng Wang | 2018 | The Journal of Biomedical Research2018，32，2： | 4 |
| 14 | Transpositional behaviour of the Ds element in the Ac/Ds system in rice显示文摘Insertional mutagenesis based on maize Activator/Dissociator (Ac/Ds) transposons is becoming a ma- jor approach used to produce a saturated mutant collection in rice. In this research, Ds-T-DNA trans- formed homozygotes were crossed with Ac-T-DNA transformed homozygotes in order to establish an Ac/Ds transposon system in rice. The successive investigation of Ds transposition from F1 to F5 gen- erations indicated that the frequencies of germinal transposition increased over successive genera- tions and reached 54.2% in F3 generation. The Ds transposition pattern revealed that a Ds transposition induced an approximately 170-bp deletion of T-DNA sequence and another Ds transposition carried a 272-bp T-DNA sequence. Using thermal asymmetric interlaced PCR (TAIL-PCR), some flanking se- quences of the Ds element were amplified. Analyses of 17 Ds-flanking sequences showed that five Ds were inserted into gene regions. The Ds could transpose not only to the linked sites but also to the unlinked sites. The frequency of inter-chromosomal transposition of Ds was 33.3%. | LIU Fang ZHANG XiangQian ZHANG ZeMin CHEN ZhaoGui ZHU HaiTao WANG Jiang ZHANG JingLiu ZHANG GuiQuan | 2007 | Chinese Science Bulletin2007，52，20： | 4 |
| 15 | Continuous and comprehensive atmospheric observations in Beijing:a station to understand the complex urban atmospheric environment显示文摘Due to profound impact on climate and human health,air quality has attracted attention from all levels of the civil society.The key step in the provision of required tools for the society to tackle the complex air quality problem is to characterize it in a comprehensive manner with a long-term perspective.Here,we describe a continuous and comprehensive observation station and its accompanying state-ofthe-art instrumentation that was established to investigate the complex urban atmospheric environment in a rapidly developing Chinese Megacity.The station,located in downtown Beijing,aims to study air quality by identifying the major atmospheric pollutants and key processes determining their formation and loss mechanisms.A few hundreds of parameters are continuously measured with the state-of-the-art instruments,including trace gas concentrations,aerosol particle size distributions,and mass concentrations,covering aerosol particle chemical composition from molecules to micrometer-sized aerosol particles.This produced long-term,comprehensive big data with around 1�10^(11)bytes per year.In this paper,we provide an overview on the facilities of the station,the instrumentation used,the workflow of continuous observations and examples of results from 2018 to 2019 and a basis for establishing a modern long-term,comprehensive atmospheric urban observation station in other megacities. | Yongchun Liu Chao Yan Zemin Feng Feixue Zheng Xiaolong Fan Yusheng Zhang Chang Li Ying Zhou Zhuohui Lin Yishou Guo Ying Zhang Li Ma Wenshuo Zhou Zhikun Liu Lubna Dada Kaspar Dallenbach Jenni Kontkanen Runlong Cai Tommy Chan Biwu Chu Wei Du Lei Yao Yonghong Wang Jing Cai Juha Kangasluoma Tom Kokkonen Joni Kujansuu Anton Rusanen Chenjuan Deng Yueyun Fu Rujing Yin Xiaoxiao Li Yiqun Lu Yiliang Liu Chaofan Lian Dongsen Yang Weigang Wang Maofa Ge Yuesi Wang Douglas R.Worsnop Heikki Junninen Hong He Veli-Matti Kerminen Jun Zheng Lin Wang Jingkun Jiang Tuukka Petaja Federico Bianchi Markku Kulmala | 2020 | Big Earth Data2020，4，3： | 3 |
| 16 | Ultrathin hexagonal boron nitride as a van der Waals,force initiator activated graphene for engineering efficient non-metal electrocatalysts of Li-CO_(2) battery显示文摘Reasonably regulating electronic coupling to promote charge transfer and exciton separation has been regarded a promising approach in catalysis.The material engineering of van der Waals heterojunction(vdWsH)based on two-dimensional(2D)materials would be a potential way to optimize the as-prepared extrinsic physicochemical characteristics.However,it was still an almost uncultivated land waiting for exploration in catalysis.Herein,we introduced the inert h-boron nitride(h-BN)in non-metal reduced graphene oxide(GN)catalysts and constructed BN-GN vdWsH.The theoretical calculation demonstrated that the h-BN can effectively modify the electronic properties of graphene.With the introduction of h-BN,the BN-GN vdWsH can obviously enhance the catalytic activity of Li-CO_(2) battery.The existence of BN-GN vdWsH can reduce the overpotential more than 700 mV compared with reduced graphene oxide during the CO_(2) reduction reaction(CO_(2)RR)and CO_(2) evolution reaction(CO_(2)ER),and it extended cyclic stability more than three times,which was one structure design made it work as a high efficient electrocatalyst,catalytic materials. | Zemin Sun Di Wang Liu Lin Yuhui Liu Mengwei Yuan Caiyun Nan Huifeng Li Genban Sun Xiaojing Yang | 2022 | Nano Research2022，15，2： | 3 |
| 17 | GPS-based regional ionospheric models and their suitability in Antarctica显示文摘There are a number of ionospheric models available for research and application, such as the polynomial model, generalized trigonometric series function model, low degree spherical harmonic function model, adjusted spherical harmonic function model, and spherical cap harmonic function analysis. Using observations from more than 40 continuously operating stations across Antarctica in 2010, five models are compared with regard to their precision and applicability to polar regions. The results show that all the models perform well in Antarctica with 0.1 TECU of residual mean value and 2 TECU of root mean square error. | AN Jiachun WANG Zemin NING Xinguo | 2014 | Advances in Polar Science2014，25，1： | 2 |
| 18 | Chromate reduction by resting cells of Achromobacter sp. Ch-1 under aerobic conditions显示文摘 | Zemin Ma Wenjie Zhu Huaizhong Long Liyuan Chai Qingwei Wang | 2007 | Process Biochemistry2007，，6： | 2 |
| 19 | Analyses and Solutions of Errors on GPS/GLONASS Positioning显示文摘This paper focuses mainly on the major errors and their reduction approaches pertaining to combined GPS/GLONASS positioning.To determine the difference in the time reference systems,different receiver clock offsets are introduced with respect to GPS and GLONASS system time.A more desirable method for introducing a independent unknown parameter of fifth receiver,which can be canceled out when forming difference measurements,is discussed.The error of orbit integration and the error of transformation parameters are addressed in detail.Results of numerical integration are given.To deal with the influence of ionospheric delay,a method for forming dual_frequency ionospheric free carrier phase measurements is detailed. | ZHANG Yongjun WANG Zemin | 2002 | Geo-Spatial Information Science2002，5，2： | 2 |
| 20 | Effects of circular beam oscillation technique on formability and solidification behaviour of selective laser melted Inconel 718:From single tracks to cuboid samples显示文摘The inherent drawbacks of selective laser melting technique including serious micro-pore and element microsegregation problems destroy the mechanical property of the component.To overcome this problem,a new approach,circular beam oscillation,was successfully applied in the SLMed Inconel 718 samples including single tracks,thin walls and cuboid samples.On one hand,circular beam oscillation reduces the micro-pores in molten pools and cuboid samples,increasing the relative density of the cuboid sample to 99.95%.On the other hand,circular beam oscillation suppresses the element microsegregation,reducing the formation of Laves phases in SLMed Inconel 718 samples.Moreover,circular beam oscillation enhances the<001>texture of thin walls and the<101>texture of cuboid samples.The improvement of formability and microstructure of the SLMed samples with oscillation is closely related to cooling rate,thermal gradient and stirring effect during the solidification process.Therefore,circular beam oscillation shows the possibility to overcome the key bottlenecks of the traditional SLM technology and to realize a further industrial application of SLM technology. | Huihui Yang Guanyi Jing Piao Gao Zemin Wang Xiangyou Li | 2020 | Journal of Materials Science & Technology2020，47，16： | 2 |
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