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| 1 | Inhibition of SARS-CoV-2 (previously 2019-nCoV) infection by a highly potent pan-coronavirus fusion inhibitor targeting its spike protein that harbors a high capacity to mediate membrane fusion显示文摘The recent outbreak of coronavirus disease(COVID-19)caused by SARS-CoV-2 infection in Wuhan,China has posed a serious threat to global public health.To develop specific anti-coronavirus therapeutics and prophylactics,the molecular mechanism that underlies viral infection must first be defined.Therefore,we herein established a SARS-CoV-2 spike(S)protein-mediated cell-cell fusion assay and found that SARS-CoV-2 showed a superior plasma membrane fusion capacity compared to that of SARS-CoV.We solved the X-ray crystal structure of six-helical bundle(6-HB)core of the HR1 and HR2 domains in the SARS-CoV-2 S protein S2 subunit revealing that several mutated amino acid residues in the HR1 domain may be associated with enhanced interactions with the HR2 domain.We previously developed a pan-coronavirus fusion inhibitor,EK1,which targeted the HR!domain and could inhibit infection by divergent human coronaviruses tested,including SARS-CoV and MERS-CoV.Here we generated a series of lipopeptides derived from EK1 and found that EK1C4 was the most potent fusion inhibitor against SARS-CoV-2 S protein-mediated membrane fusion and pseudovirus infection with IC50s of 1.3 and 15.8 nM,about 241-and 149-fold more potent than the original EK1 peptide,respectively.EK1C4 was also highly effective against membrane fusion and infection of other human coronavirus pseudoviruses tested,including SARS-CoV and MERS-CoV,as well as SARSr-CoVs,and potently inhibited the replication of 5 live human coronaviruses examined,including SARS-CoV-2.Intranasal application of EK1C4 before or after challenge with HCoV-OC43 protected mice from infection,suggesting that EK1C4 could be used for prevention and treatment of infection by the currently circulating SARS-CoV-2 and other emerging SARSr-CoVs. | Shuai Xia Meiqin Liu Chao Wang Wei Xu Qiaoshuai Lan Siliang Feng Feifei Qi Linlin Bao Lanying Du Shuwen Liu Chuan Qin Fei Sun Zhengli Shi Yun Zhu Shibo Jiang Lu Lu | 2020 | Cell Research2020，30，4： | 81 |
| 2 | Reactive capillary hemangiomas: a novel dermatologic toxicity following anti-PD-1 treatment with SHR-1210显示文摘Objective: SHR-1210 is a new and promising anti-PD-1 agent for solid tumors. During the phase I study of SHR-1210, we encountered a novel but prevalent immune-related dermatologic toxicity: reactive capillary hemangiomas(RCHs). Thus we tried to summarize the features of RCHs and estimate their relationship with tumor response.Methods: This prospective observational study systematically enrolled 98 patients with advanced solid tumors from April 27th,2016 to June 8th, 2017 in the context of the phase I clinical study of SHR-1210. This report focused on the skin toxicities. Patients underwent entire skin inspection every two weeks while taking medication. The clinical course of RCHs was recorded and their association with tumor response was estimated. The data cut-off date was November 15th, 2017.Results: After a median follow-up of 242(range, 29–567) days, RCHs were observed in 85.7%(84/98) of patients on cutaneous/mucosal surfaces; 84.5%(71/84) of the RCHs were evaluated as grade 1 adverse events. No grade 3 or 4 RCHs were observed. The time of onset of RCHs was dose dependent and shortest in the 400 mg-dose cohort(P < 0.001). Spontaneous and complete regression of RCHs was observed both during and after treatment. The objective response rate of tumors for patients with RCHs was 28.9%(24/83). However, no responders were observed among the patients without RCHs.Conclusions: RCHs were prevalent but manageable during treatment with SHR-1210. It might add to the expanding literature regarding immune-related dermatologic adverse events. | Xuelian Chen Lanying Ma Xi Wang Hongnan Mo Dawei Wu Bo Lan Dong Qu Hongtu Zhang Jing Huang Binghe Xu | 2019 | Cancer Biology & Medicine2019，16，1： | 53 |
| 3 | The Hardy Rubber Tree Genome Provides Insights into the Evolution of Polyisoprene Biosynthesis显示文摘Eucommia ulmoides,也叫的强壮的橡胶树,是一棵经济地重要的树;然而,它的染色体顺序的缺乏 ?限制基本生物研究和这植物种的应用研究。这里,我们在场它的 1.2-Gb 染色体的一个高质量的集会(支架 N50 ?=? 1.88 Mb ) 与至少 26 ? 为 E 的 723 预言的基因。ulmoides,顺序 Garryales 的首先定序的染色体,它用联合定序的 Illumina 的综合策略被获得,定序的 PacBio,和印射的 BioNano。作为到 lamiids 和 campanulids 的姐妹 taxon, E。ulmoides 经历了三倍由核心 eudicots 而是没有进一步整个染色体的复制分享了的一个古老的染色体 ? 在最后 1.25 亿年里。E。ulmoides 为涉及压力回答和第二等的代谢物的生合成的多重基因展出高表达式层次或基因数字扩大,它可以说明它的可观的环境适应性。与橡胶树(Hevea brasiliensis ) 相对照,它生产 cis 聚异式戊二我烯, E。ulmoides 演变综合经由 farnesyl diphosphate synthases (FPS ) 的长链的 trans 聚异式戊二我烯。而且, FPS 和橡胶延伸 factor/small 橡胶粒子蛋白质基因家庭从 H 独立地被扩展。brasiliensis 系。这些结果提供新卓见进 E. 的生物学 ? ulmoides 和聚异式戊二我烯生合成的起源。 | Ta-na Wuyun Lin Wang Huimin Liu Xuewen Wang Liangsheng Zhang Jeffrey L. Bennetzen Tiezhu Li Lirong Yang Panfeng Liu Lanying Du Lu Wang Mengzhen Huang Jun Qing Iili Zhu Wenquan Bao Hongguo Li Qingxin Du Jingle Zhu Hong Yang Shuguang Yang Hui Liu Hui Yue Jiang Hu Suoliang Yu Yu Tian Fan Liang Jingjing Hu Depeng Wang Ruiwen Gao Dejun Li Hongyan Du | 2018 | Molecular Plant2018，11，3： | 24 |
| 4 | Study on the recovery of hydrogen from refinery (hydrogen+methane) gas mixtures using hydrate technology显示文摘A novel technique for separating hydrogen from (H2 + CH4) gas mixtures through hydrate formation/dissociation was proposed. In this work, a systematic experimental study was performed on the separation of hydrogen from (H2 + CH4) feed mixtures with various hydrogen contents (mole fraction x = 40%-90%). The experimental results showed that the hydrogen content could be enriched to as high as ~94% for various feed mixtures using the proposed hydrate technology under a temperature slightly above 0℃ and a pressure below 5.0 MPa. With the addition of a small amount of suitable additives, the rate of hydrate formation could be increased significantly. Anti-agglomeration was used to disperse hydrate particles into the condensate phase. Instead of preventing hydrate growth (as in the kinetic inhibitor tests), hydrates were allowed to form, but only as small dispersed particles. Anti-agglomeration could keep hydrate particles suspended in a range of condensate types at 1℃ and 5 MPa in the water-in-oil emulsion. | WANG XiuLin CHEN GuangJin YANG LanYing ZHANG LinWei | 2008 | Science China Chemistry2008，51，2： | 17 |
| 5 | Identification of an ideal adjuvant for receptor-binding domain-based subunit vaccines against Middle East respiratory syndrome coronavirus显示文摘 | Naru Zhang Rudragouda Channappanavar Cuiqing Ma Lili Wang Jian Tang Tania Garron Xinrong Tao Sumaiya Tasneem Lu Lu Chien-Te K Tseng Yusen Zhou Stanley Perlman Shibo Jiang Lanying Du | 2016 | Cellular & Molecular Immunology2016，13，2： | 12 |
| 6 | A Complete Embryonic Developmental Table of Microhyla fissipes(Amphibia,Anura,Microhylidae)显示文摘Access to embryonic developmental stages is essential basic work for understanding how organisms develop. In this study, seven egg clutches(range 209–564 eggs) of ornamented pygmy frog Microhyla fissipes(Amphibia, Anura, Microhylidae) were obtained from seven breeding pairs in laboratory. One egg clutch of them was observed for the embryonic development, and the staging table of normal development was constructed based on morphological and physiological characteristics. Forty-five developmental stages were defined for M. fissipes, and two major developmental periods were designated: 1) early embryonic development period(stages 1–28), from fertilization to operculum completion stage, lasted for 82.6 hours at water temperature(WT) 23–25℃; 2) larval development period(stages 29–45), from operculum completion to tail complete absorption stage, took 38 days at WT 22–26.5℃, showing that the embryos of this species develop rapidly. In addition, the tadpoles were transparent, which is similar to those in field. These characteristics suggest that M. fissipes would be a good model to study developmental biology, adaptive mechanisms from aquatic to terrestrial phases, environmental toxicology, and human disease. | Shouhong WANG Lanying ZHAO Lusha LIU Dengwei YANG Janak Raj KHATIWADA Bin WANG Jianping JIANG | 2017 | Asian Herpetological Research2017，18，2： | 5 |
| 7 | Advanced prediction for multiple disaster sources of laneway under complicated geological conditions显示文摘The driving safety in the laneway is often controlled by multiple disaster sources which include fault fracture zone, water-bearing body, goaf and collapse column. The advanced prediction of them has become a hotspot. Based on analysis of physical characteristics of the disaster sources and comparative evaluation of accuracy of the main advanced geophysical detection methods, we proposed a comprehen- sive judging criterion that tectonic interface can be judged by the elastic wave energy anomaly, strata water abundance can be discriminated by apparent resistivity response difference and establish a reason- able advanced prediction system. The results show that the concealed disaster sources are detected effec- tively with the accuracy rate of 80% if we use advanced prediction methods of integrated geophysics combined with correction of seismic and electromagnetic parameters, moreover, applying geological data, we may then distinguish types of the disaster sources and fulfill the qualitative forecast. Therefore, the advanced prediction system pays an important referential and instructive role in laneway driving project. | Wang Bo Liu Shengdong Liu Jing Huang Lanying Zhao Ligui | 2011 | Mining Science and Technology2011，21，5： | 5 |
| 8 | Contaminant removal from low-concentration polluted river water by the bio-rack wetlands显示文摘The bio-rack is a new approach for treating low-concentration polluted river water in wetland systems.A comparative study of the efficiency of contaminant removal between four plant species in bio-rack wetlands and between a bio-rack system and control system was conducted on a small-scale (500 mm length × 400 mm width × 400 mm height) to evaluate the decontamination effects of four different wetland plants.There was generally a significant difference in the removal of total nitrogen (TN),ammonia nitrogen (NH 3-N) and total phosphorus (TP),but no significant difference in the removal of permanganate index (COD Mn) between the bio-rack wetland and control system.Bio-rack wetland planted with Thalia dealbata had higher nutrient removal rates than wetlands planted with other species.Plant fine-root (root diameter 3 mm) biomass rather than total plant biomass was related to nutrient removal efficiency.The study suggested that the nutrient removal rates are influenced by plant species,and high fine-root biomass is an important factor in selecting highly effective wetland plants for a bio-rack system.According to the mass balance,the TN and TP removal were in the range of 61.03-73.27 g/m2 and 4.14-5.20 g/m2 in four bio-rack wetlands during the whole operational period.The N and P removal by plant uptake constituted 34.9%-43.81% of the mass N removal and 62.05%-74.81% of the mass P removal.The study showed that the nitrification/denitrification process and plant uptake process are major removal pathways for TN,while plant uptake is an effective removal pathway for TP. | Ji Wang Lanying Zhang Shaoyong Lu Xiangcan Jint Shu Gan | 2012 | Journal of Environmental Sciences2012，24，6： | 4 |
| 9 | Construction of the Chinese Veteran Clinical Research (CVCR) Platform for the assessment of non-communicable diseases显示文摘 | Tan Jiping Li Nan Gao Jing Guo Yuhe Hu Wei Yang Jinsheng Yu Baocheng Yu Jianmin Du Wei Zhang Wenjun Cui Lianqi Wang Qingsong Xia Xiangnan Li Jianjun Zhou Peiyi Zhang Baohe Liu Zhiying Zhang Shaogang Sun Lanying Liu Nan Deng Ruixiang Dai Wenguang Yi Fang Chen Wenjun Zhang Yongqing Xue Shenwu Cui Bo Zhao Yiming Wang Luning | 2014 | Chinese Medical Journal2014，，3： | 3 |
| 10 | Biochemical genetic structure and identification of hairtail fish(Trichiurus) populations in Chinese coastal waters显示文摘Biochemicalgeneticstructureandidentificationofhairtailfish(Trichiurus)populationsinChinesecoastalwaters￥WangKeling;ZhangPeiju... | Wang Keling Zhang Peijun Liu Lanying You Feng Liu Jing Xu Cheng and Wang Jianfei (Institute of Oceanology, Academia Sinica, Qingdao 266071, China) | 1994 | Acta Oceanologica Sinica1994，13，4： | 2 |
| 11 | A study of phosphataseactivity in anaerobic sludge digestion显示文摘 | Wang Zhenglan Guo Yue Li Lanying | 1990 | Water Research1990，24，7： | 1 |
| 12 | Carrier concentration profiling in magnetic GaMnSb/GaSb investigated by electrochemistry capacitance-voltage profiler显示文摘Depth profiles of carrier concentrations in Ga-MnSb/GaSb are investigated by electrochemistry capacitance-voltage profiler and electrolyte of Tiron. The carrier concentration in GaMnSb/GaSb measured by this method is coincident with the results of Hall and X-ray diffraction measurements. It is indicated that most of the Mn atoms in GaMnSb take the site of Ga, play a role of acceptors, and provide shallow acceptor level(s). | ZHANG Xiulan ZHANG Fuqiang SONG Shulin CHEN Nuofu WANG Zhanguo LIN Lanying | 2002 | Chinese Science Bulletin2002，47，21： | 1 |
| 13 | Synthesis and Spectral Properties of Novel Water-soluble Indocyanine Dyes as Fluorescent Dyes for Proteins Detection显示文摘二新奇水溶性的 indocyanine 染料被综合。他们的化学结构被 1H NMR,红外, MS 和紫外力的技术证实。在不同溶剂的准备染料的吸收被测量。二染料展出了否定 solvatochromism,与吸收和排放最大值在的蓝移动(牛的浆液白朊) protonic 溶剂相对非 protonic 溶剂。处于免费状态和 BSA 的染料的荧光性质被调查。为 Dye2 的荧光紧张的重要改进面对 BSA 被观察。Dye2 能作为荧光灯被建议为在水的答案的 BSA 察觉的染料。 | Fu, Yile Wang, Lanying Zhang, Xianghan Lu, Tianqin Xie, Qianjie Shi, Zhen | 2011 | Chinese Journal of Chemistry2011，29，3： | 1 |
| 14 | Investigation of the fundamental differences between polyamide-imide (PAl) and polyetherimide (PEI) membranes for isopropanol dehydration via pervaporation显示文摘 | Yan Wang Lanying Jiang Takeshi Matsuura | | 0，，1： | 1 |
| 15 | Polyimides membranes for pervaporation and biofuels separation显示文摘 | Lanying Jiang Yan Wang Tai-Shung Chung | | 0，，11： | 1 |
| 16 | Isolation, identification and antioxidative capacity of water-soluble phenylpropanoid compounds from Rhodiola crenulata显示文摘 | Danjun Chen Junting Fan Peng Wang Lanying Zhu Yang Jin Yan Peng Shuhu Du | 2012 | Food Chemistry2012，，4： | 1 |
| 17 | The effect of delay between heat treatment and cold storage on alleviation of chilling injury in banana fruit显示文摘 | Haibo Wang Zhaoqi Zhang Lanying Xu Xuemei Huang Xuequn Pang | 2012 | J Sci Food Agric2012，，13： | 1 |
| 18 | Fine analysis on advanced detection of transient electromagnetic method显示文摘Fault fracture zones and water-bearing bodies in front of the driving head are the main disasters in mine laneways,thus it is important to perform their advanced detection and prediction in advance in order to provide reliable technical support for the excavation.Based on the electromagnetic induction theory,we analyzed the characteristics of primary and secondary fields with a positive and negative wave form of current,proposed the fine processing of the advanced detection with variation rate of apparent resistivity and introduced in detail the computational formulae and procedures.The result of physical simulation experiments illustrate that the tectonic interface of modules can be judged by first-order rate of apparent resistivity with a boundary error of 5%,and the position of water body determined by the fine analysis method agrees well with the result of borehole drilling.This shows that in terms of distinguishing structure and aqueous anomalies,the first-order rate of apparent resistivity is more sensitive than the secondorder rate of apparent resistivity.However,some remaining problems are suggested for future solutions. | Wang Bo Liu Shengdong Yang Zhen Wang Zhijun Huang Lanying | 2012 | International Journal of Mining Science and Technology2012，22，5： | 1 |
| 19 | Structure, morphology and properties of Fe-doped ZnO films prepared by facing-target magnetron sputtering system显示文摘 | Changzheng Wang Zhong Chen Ying He Lanying Li Dong Zhang | 2009 | Applied Surface Science2009，，15： | 1 |
| 20 | Polyimides membranes for pervaporation and biofuels separation显示文摘 | JIANG Lanying WANG Yan CHUNG T S | 2009 | Progress in Polymer Science2009，34，11： | 1 |
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