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| 1 | Isoliquiritigenin inhibits TGF-β1-induced fibrogenesis through activating autophagy via PI3K/AKT/mTOR pathway in MRC-5 cells显示文摘Isoliquiritigenin(ISL),a natural flavonoid derived from the root of liquorice,has been reported to possess anti-inflammatory and antioxidant activities.Previous studies have found that ISL plays a crucial role in anti-fibrosis of adipose tissue and renal tissue;however,its effect on pulmonary fibrogenesis has not been demonstrated.In this study,we aimed to explore the roles and the underlying mechanisms of ISL in TGF-β1-induced fibrogenesis using human lung fibroblast-derived MRC-5 cells.Cell proliferation and migration were determined by MTT and wound healing assay,respectively.The expression levels of alpha-smooth muscle actin(α-SMA),collagen type I alpha 1(COLIA1)and fibronectin(FN),microtubule-associated protein light chain 3(LC3)and related signaling molecules were detected by quantitative real-time PCR,western blot and immunofluorescence assay,correspondingly.EGFP-LC3 transfection was used for autophagy analysis.The results showed that ISL inhibited the TGF-β1-induced proliferation and migration,and down-regulated the expressions ofα-SMA,COLIA1 and FN.ISL treatment led to up-regulation of LC3 in TGF-β1-treated MRC-5 cells,accompanied by significant decrease in the phosphorylation levels of phosphatidylinositol 3-kinase(PI3K),protein kinase B(AKT),and mammalian target of rapamycin(mTOR).In addition,the inhibitory effects of ISL on TGF-β1-induced fibrogenic features in MRC-5 cells were enhanced by pretreatment with autophagy activator Rapmycin and PI3K/AKT inhibitor LY294002 and reversed by autophagy inhibitor 3-methyladenine and PI3K/AKT activator IGF-1.Taken together,our results demonstrated that ISL could attenuate the fibrogenesis of TGF-β1-treated MRC-5 cells by activating autophagy via suppressing the PI3K/AKT/mTOR pathway.Therefore,ISL holds a great potential to be developed as a novel therapeutic agent for the treatment of pulmonary fibrosis. | Jinjuan He Hao Peng Meifang Wang Ying Liu Xingrong Guo Bin Wang Longjun Dai Xueqin Cheng Zhongji Meng Leyong Yuan Fenglin Cai Yijun Tang | 2020 | Acta Biochimica et Biophysica Sinica2020，52，8： | 16 |
| 2 | Artificial light-harvesting systems fabricated by supramolecular host–guest interactions显示文摘Artificial light-harvesting systems(LHSs) have drawn increasing research interest in recent times due to the energy crisis worldwide. Concurrently, macrocycle-based host–guest interactions have played an important role in the development of supramolecular chemistry. In recent years, studies towards artificial LHSs driven by macrocycle-based host–guest interactions are gradually being disclosed. In this mini-review, we briefly introduce the burgeoning progress of artificial LHSs driven by host–guest interactions. We believe that an increasing number of reports of artificial LHSs driven by host–guest interactions will appear in the near future and will provide a viable alternative for the future production of renewable energy. | Tangxin Xiao Weiwei Zhong Ling Zhou Lixiang Xu Xiao-Qiang Sun Robert B.P.Elmes Xiao-Yu Hu Leyong Wang | 2019 | Chinese Chemical Letters2019，30，1： | 4 |
| 3 | Supramolecular polymers fabricated by orthogonal self-assembly based on multiple hydrogen bonding and macrocyclic host–guest interactions显示文摘Supramolecular polymers constructed by orthogonal self-assembly based on multiple hydrogen bonding and macrocyclic host-guest interactions have received increasing attention due to their elegant structures,outstanding properties,and potential applications.Hydrogen bonding endows these supramolecular polymers with good adaptability and reversibility,while macrocyclic host-guest interactions give them good selectivity and versatile stimuli-responsiveness.Therefore,functional supramolecular polymers fabricated by these two highly specific,noninterfering interactions in an orthogonal way have shown wide applications in the fields of molecular machines,electronics,soft materials,etc.In this review,we discuss the recent advances of functional supramolecular polymers fabricated by orthogonal self-assembly based on multiple hydroge n bonding and host-guest interactions.In particular,we focus on crown ether-and pillar[n]arene-based supramolecular polymers due to their compatibility with multiple hydrogen bonds in organic solution.The fabrication strategies,interesting properties,and potential applications of these advanced supramolecular materials are mainly concerned. | Tangxin Xiao Ling Zhou Xiao-Qiang Sun Feihe Huang Chen Lin Leyong Wang | 2020 | Chinese Chemical Letters2020，31，1： | 2 |
| 4 | Supramolecular Prodrug Micelles Constructed by Drug-Drug Conjugate with Water Soluble Pillar[6]arene for Controllable and Rapid Drug Release显示文摘The first attempt of constructing supramolecular prodrug micelles based on the host-guest interaction between water-soluble pillar[6]arene(WP6)and a novel doxorubicin(DOX)-based drug-drug conjugate(G)is reported,in which the drug-drug conjugate is synthesized by conjugating anticancer drug DOX with another drug isoniazide via the acid-cleavable hydrazone bond.The obtained WP6⊃G micelles are stable under physiological conditions,whereas the cumulative release of DOX is approximate to 100%within 30 min at pH 5.5 by simulating the endo-lysosomal environment at 37℃.Therefore,this WP6-based prodrug micelles can achieve efficient DOX ac-cumulation in the acidic tumor cells within a short period of time,which is very important and valuable;meanwhile it can also reduce the unexpected premature burst release under physiological condition.Furthermore,cellular in-ternalization and localization experiments demonstrated that these prodrug micelles enter cancer cells mainly via endocytosis and can lead to significant drug accumulation in SKOV3 cancer cells,implying its promising future for cancer therapy. | Yu Cao Xiaochun Zou Shuhan Xiong Yan Li Yingzhong Shen Xiaoyu Hu Leyong Wang | 2015 | Chinese Journal of Chemistry2015，33，3： | 2 |
| 5 | Novel supramolecular organocatalysts of hydroxyprolinamide based on calix[4]arene scaffold for the enantioselective Biginelli reaction显示文摘A series of novel supramolecular organocatalysts of hydroxyprolinamide based on the upper rim of calix[4]arene scaffold have been developed to catalyze enantioselective multi-component Biginelli reaction. Under the optimal conditions, the reactions occurred with moderate-to-excellent enantioselectivities (up to 98% ee). A plausible transition state constructed by the supra- molecular interaction of hydrogen bond and cation-π between catalysts and substrates has been proposed. | LI ZhengYi XING HuaiJie HUANG GuoLi SUN XiaoQiang JIANG JuLi WANG LeYong | 2011 | Science China Chemistry2011，54，11： | 2 |
| 6 | Stable pillar[5]arene-based pseudo[1]rotaxanes formed in polar solution显示文摘Mono-alkyl-functionalized pillar[5]arenes P1,P2,and P3 were synthesized by click reaction,which exhibited different self-assembly behavior in polar solvent DMSO.Stable pseudo[1]rotaxane was formed by the self-complexation from P1 or P2,whereas,concentration-dependent pseudorotaxane structures were generated by P3 which bearing more flexible side chain.Interestingly,the obtained pseudo[1]rotaxanes exhibited a dynamic fast assembly process upon adding NaBF_4,resulting in the formation of Na^+-induced pseudorotaxanes. | Xuan Wu Lei Gao Junzhao Sun Xiao-Yu Hu Leyong Wang | 2016 | Chinese Chemical Letters2016，27，11： | 1 |
| 7 | Two new triazolophanes: synthesis, structures, self-assembling, and anion complexation properties显示文摘 | Qunpeng Duan Wei Xia Chen Lin Yi Pan Leyong Wang | 2015 | Tetrahedron Letters2015，，26： | 1 |
| 8 | High-resolution and instantaneous imaging of latent fingerprints显示文摘Fingerprints can serve as an information storage platform for individuals and play an important role in forensic investigation and security[1].Most of them are invisible to the naked eye and are called latent fingerprints(LFPs).Conventional imaging techniques suffer from limitations like low resolution and sensitivity[2],restricting the recognition of LFPs to macroscopic features,such as shape,core,ending,bifurcation,island,pores,and so on,which correspond to levels 1 and 2.Features of level 3 including ridges and their edges,are challenging to recognize. | Ming Cheng Juli Jiang Jean-Claude Chambron Leyong Wang | 2023 | Chinese Chemical Letters2023，34，4： | 1 |
| 9 | Homo and copolymerization ofnorbornene and styrene with Pd and Ni based novel bridged dinuelear diimine complexes and MAO 显示文摘 | Mi Xia Ma Zhi Wang Leyong | 2003 | Maeromoleeular Chemistry and Physics2003，204，56： | 1 |
| 10 | An AIE singlet oxygen generation system based on supramolecular strategy显示文摘The design of supramolecular system s with efficient singlet oxygen generation has attracted considerable interests.Herein,an AIE-based singlet oxygen generation system with chemiluminescence properties is reported in aqueous media based on supramolecular host-guest assembly between a water-soluble pillar[5]arene(WP5)and an AIE photosensitizer(TPEDM).The formed supramolecular nanoparticles exhibit significant singlet oxygen generation ability as well as enhanced fluorescence.In addition,by introducing catalase,this H_(2) O_(2)-responsive supramolecular system shows increased~1 O_(2) generation efficiency compared with the blank nanoparticles.An efficient chemiluminescence system can also be achieved by entrapping an energy donor adamantane derivative(AMPPD).Moreover,the present system can function as nanoreactors to perform the photooxidation of dopamine to form polydopamine with visible light irradiation.This wo rk provides a new strategy for the construction of~1 O_(2) generation system based on supramolecular nanomaterials,which has potential applications in the fields such as chemiluminescence imaging and controlled photocatalysis. | Minzan Zuo Weirui Qian Min Hao Kaiya Wang Xiao-Yu Hu Leyong Wang | 2021 | Chinese Chemical Letters2021，32，4： | 1 |
| 11 | The emerging applications of pillararene architectures in supramolecular catalysis显示文摘Over the last decade,numerous research efforts have been devoted to pillar[n]arenes since their debut.The popularity of pillararenes is a reflection of current research trend in supramolecular and macrocyclic chemistry in general.Among the vast applications(such as chemosensors,drug delivery,transmembrance channels,and separation)of pillararenes,their utilization in catalysis is a relatively less explored area.However,soaring attention has been paid by researchers in recent years and this field has seen gradual increasing publications.Therefore,in this review we will discuss progress in the emerging applications of pillararene architectures in catalysis based on various reaction genre including reduction,oxidation,coupling,decomposition and others.Furthermore,this review not only focuses on the pillararenes based current progress in catalysis,but also provides the signs for future development in this research field. | Kaiya Wang Xueqi Tian Jacobs H.Jordan Krishnasamy Velmurugan Leyong Wang Xiao-Yu Hu | 2022 | Chinese Chemical Letters2022，33，1： | 1 |
| 12 | Diabetic wound healing activated by supramolecular cascade reaction显示文摘Diabetes is a chronic disease,and its complications such us diabetic foot ulcer and other chronic wounds often cause great pain to patients.Diabetic wounds are more prone to bacterial infection due to the environment of high blood sugar,resulting in difficult wound healing[1].Therefore,how to protect the wound and cure drug-resistant bacterial infections in diabetes is an important scientific problem that needs to be solved. | Fang-Fang Shen Yuguo Wang Leyong Wang | 2023 | Chinese Chemical Letters2023，34，1： | 1 |
| 13 | Late Iransifion metal complexes bearing 2,9-bis (imino)-1,10-phenanthrolinyl ligands: synthesis, characterization and their ethylene activity显示文摘 | Wang Leyong Sun Wenhua Han Lingqin | 2002 | J Organomet Chem2002，658，12： | 1 |
| 14 | Unprecedented synthesis of chiral calix[4](aza)crowns and its potent encapsulating methanol显示文摘Unprecedented synthesis of chiral (aza)crown ethers of calix[4]arene derivatives bearing a carboxyl amide bridge was described. The synthesis proceeds through condensation of the corresponding dinitriles with optically active 1,2-aminoalcohols,and is catalyzed by the ZnCl2 Lewis acid at elevated temperature in a very efficient one-pot process. The cavity of calix[4](aza)crowns can encapsulate methanol molecules by O-H...π interaction,which has been confirmed by X-ray crystal structures and ESI-MS. | ZhengYi Li MingYu Teng JieJie Ma Ji Huang LeYong Wang Yi Pan | 2009 | Science China Chemistry2009，52，4： | 0 |
| 15 | An amphiphilic molecule with a single fluorophore exhibits multiple stimuli-responsive behavior显示文摘Fluorescent materials that respond to multiple stimuli have broad applications ranging from sensing and bioimaging to information encryption.Herein,we report the design and synthesis of a single-fluorophorebased amphiphile DCSO,which shows temperature-,solvent-,humidity-,and radiation-dependent fluorescence.DCSO consists of a dicyanostilbene(DCS)group as a rigid hydrophobic core with oligo(ethylene glycol)(OEG)chains at both ends as a flexible hydrophilic periphery.The DCS group acts as a highly efficient fluorophore,while the OEG chain endows the molecule with thermo-responsiveness.Fluorescent colors can vary from blue to green to yellow in response to external stimuli.On the basis of light radiation,we demonstrate that this system can be applied to time-dependent information encryption,in which the correct information can only be read at a specific time under irradiation.This work further demonstrates the usefulness and application of single-fluorophore-based luminescent materials with multiple stimuli-responsive functions. | Dongxing Ren Lu Tang Zhiying Wu Qiaona Zhang Tangxin Xiao Robert B.P.Elmes Leyong Wang | 2023 | Chinese Chemical Letters2023，34，11： | 0 |
| 16 | Hydrogen-bonding-driven self-assembly nonporous adaptive crystals for the separation of benzene from BTX and cyclohexane显示文摘Benzene is a volatile organic compound that can seriously harm human health,while it can serve as a precursor to produce chemicals of more complex structures in chemical industry.Capturing benzene using adsorbents is of great importance for human health,when the separation of hydrocarbons including benzene from crude oil was referred to as one of the“seven chemical separations to change the world”.In this work,we reported the efficient and selective separation of benzene from BTX and cyclohexane by hydrogen bonding self-assembly nonporous adaptive crystals AdaOH for the first time under mild and user-friendly conditions.Separation of benzene and cyclohexane(v/v=1:1)can be achieved by AdaOH with a purity of benzene up to 96.8%.Separation of BTX(v/v;benzene:toluene:o-xylene:m-xylene:pxylene=1:1:1:1:1)can be achieved by AdaOH with a purity of benzene increased from 20%to 82.9%.Our results suggest that separation of benzene using the activated AdaOH as a non-porous adaptive crystal for selectively and efficiently capturing benzene can solve the challenge in separation of benzene from other chemicals such as cyclohexane in chemical industry,and can be helpful for removal of benzene that is released from the vehicles to air.The advantages of commercially availability,easy preparation,high separation efficiency and selectivity for benzene might endow this material with enormous potential for practical uses in areas like petrochemical industry. | Fei Zeng Lin-Li Tang Hui Yu Fan-Ping Xu Leyong Wang | 2023 | Chinese Chemical Letters2023，34，11： | 0 |
| 17 | The 10^(th)macrocylic arene supramolecular chemistry symposium显示文摘In the last few decades,there has been a rapid emergence and growing interest in synthetic macrocyclic arenes,such as calixarenes[1,2],cyclophanes[3],cyclotriveratrylenes[4],pillararenes[5-7],and other novel macrocyclic arenes[8-10].These molecules have garnered significant attention in supramolecular chemistry for their fascinating structures,intrinsic cavities,ease of structural and property modifications and wide range of applications[11-14]. | Shuquan Zhang Meijin Lin Andrew C.H.Sue Liping Cao Feng Wang Cheng Yang Tao Tu Feihe Huang Leyong Wang | 2023 | Chinese Chemical Letters2023，34，12： | 0 |
| 18 | Red/NIR emission carbonized polymer dots based on citric acid-benzoylurea and their application in lymph nodes imaging显示文摘Identification of lymph nodes(LNs)is critical for studies of the structure,the role in disease development,and the efficacy of disease treatment.Carbonized polymer dots(CPDs)are expected to be potential LNs-targeted imaging agents due to their excellent properties with special structure,better photoluminescence(PL)and great biocompatibility.Herein,a red/near infrared(NIR)emission CPDs(RCPDs)with one and two-photon bioimaging based on citric acid(CA)and benzoylurea(BU)are prepared.Notably,the RCPDs are capable of targeting LNs for imaging.Lymphocyte homing has been demonstrated to be the cellular mechanism of RCPDs target LNs imaging.This work has developed a new nanomaterial for targeted imaging of LNs,while the biological applications of CPDs have been expanded and deepened. | Feishi Shan Tingrui Zhang Chengshuang Liao Xue Yue Jing Zhang Li Yan Yanman Liu Zhixing Cao Min Wang Yahui Zhang Leyong Wang Zhouyu Wang Xiaoqi Yu | 2023 | Chinese Chemical Letters2023，34，11： | 0 |
| 19 | Construction of a sequential light-harvesting system via supramolecular copolymerization显示文摘The current energy crisis is a worldwide problem and the search for clean and economic energy production is a global challenge.In this context,the exploitation and utilization of solar energy is becoming more and more popular.Photosynthesis in nature sets an outstanding example to harvest,transfer and store solar energy[1].In most of the photosynthetic organisms such as purple photosynthetic bacteria,the rigid protein scaffolds serve as key elements to bind pigments and control their excitation energy transfer.Sequential energy transfer is especially intriguing in this field to make full use of full-band solar energy.To mimic natural photosynthesis[2]. | Hongwei Qian Tangxin Xiao Robert B.P.Elmes Leyong Wang | 2023 | Chinese Chemical Letters2023，34，8： | 0 |
| 20 | The 3^(rd) Xihua Chemistry and Biomedicine Forum显示文摘Serious diseases,particularly cancer,consistently pose significant threats to both national health and economic development[1].The cancer diagnosis methods such as fluorescent probes[2,3],as well as treatment techniques including photodynamic treatments[4]and targeted drugs[5]have attracted much attention in recent years.The development and practical application of these methods have become focal points within research works.Based on this,the 3rd Xihua Chemistry and Biomedicine Forum(XHCBF)was successfully convened by Xihua University in Chengdu from 3 to 6 July,2023. | Yahui Zhang Zhouyu Wang Leyong Wang Xiaoqi Yu | 2024 | Chinese Chemical Letters2024，35，2： | 0 |
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