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| 1 | Isoliquiritigenin inhibits TGF-β1-induced fibrogenesis through activating autophagy via PI3K/AKT/mTOR pathway in MRC-5 cells显示文摘Isoliquiritigenin(ISL),a natural flavonoid derived from the root of liquorice,has been reported to possess anti-inflammatory and antioxidant activities.Previous studies have found that ISL plays a crucial role in anti-fibrosis of adipose tissue and renal tissue;however,its effect on pulmonary fibrogenesis has not been demonstrated.In this study,we aimed to explore the roles and the underlying mechanisms of ISL in TGF-β1-induced fibrogenesis using human lung fibroblast-derived MRC-5 cells.Cell proliferation and migration were determined by MTT and wound healing assay,respectively.The expression levels of alpha-smooth muscle actin(α-SMA),collagen type I alpha 1(COLIA1)and fibronectin(FN),microtubule-associated protein light chain 3(LC3)and related signaling molecules were detected by quantitative real-time PCR,western blot and immunofluorescence assay,correspondingly.EGFP-LC3 transfection was used for autophagy analysis.The results showed that ISL inhibited the TGF-β1-induced proliferation and migration,and down-regulated the expressions ofα-SMA,COLIA1 and FN.ISL treatment led to up-regulation of LC3 in TGF-β1-treated MRC-5 cells,accompanied by significant decrease in the phosphorylation levels of phosphatidylinositol 3-kinase(PI3K),protein kinase B(AKT),and mammalian target of rapamycin(mTOR).In addition,the inhibitory effects of ISL on TGF-β1-induced fibrogenic features in MRC-5 cells were enhanced by pretreatment with autophagy activator Rapmycin and PI3K/AKT inhibitor LY294002 and reversed by autophagy inhibitor 3-methyladenine and PI3K/AKT activator IGF-1.Taken together,our results demonstrated that ISL could attenuate the fibrogenesis of TGF-β1-treated MRC-5 cells by activating autophagy via suppressing the PI3K/AKT/mTOR pathway.Therefore,ISL holds a great potential to be developed as a novel therapeutic agent for the treatment of pulmonary fibrosis. | Jinjuan He Hao Peng Meifang Wang Ying Liu Xingrong Guo Bin Wang Longjun Dai Xueqin Cheng Zhongji Meng Leyong Yuan Fenglin Cai Yijun Tang | 2020 | Acta Biochimica et Biophysica Sinica2020，52，8： | 16 |
| 2 | Artificial light-harvesting systems fabricated by supramolecular host–guest interactions显示文摘Artificial light-harvesting systems(LHSs) have drawn increasing research interest in recent times due to the energy crisis worldwide. Concurrently, macrocycle-based host–guest interactions have played an important role in the development of supramolecular chemistry. In recent years, studies towards artificial LHSs driven by macrocycle-based host–guest interactions are gradually being disclosed. In this mini-review, we briefly introduce the burgeoning progress of artificial LHSs driven by host–guest interactions. We believe that an increasing number of reports of artificial LHSs driven by host–guest interactions will appear in the near future and will provide a viable alternative for the future production of renewable energy. | Tangxin Xiao Weiwei Zhong Ling Zhou Lixiang Xu Xiao-Qiang Sun Robert B.P.Elmes Xiao-Yu Hu Leyong Wang | 2019 | Chinese Chemical Letters2019，30，1： | 4 |
| 3 | Numerical analysis on the crack propagation and failure characteristics of rocks with double fissures under the uniaxial compression显示文摘The fissures and rock bridges with different dips had different contributions to crack's initiation,propagation,convergence and penetration.In this paper,based on the rock fracture theory,the crack's propagation and evolution process on rock specimen with double fissures under uniaxial compression was simulated.As a result,the crack propagation and evolution law of rocks with different fissure dips(α=0°,15°,30°,45°,60°,75°,90°;β=45°)and different rock bridge dips(β=0°,30°,45°,60°,90°;α=45°)was obtained by numerical tests.Meanwhile,the fissure and rock bridge dips influence on the macro mechanical properties of rock was analyzed.Besides,the paper investigated the influences of different fissure dips and different rock bridge dips on the bridge transfixion.The study is of great significance to reveal the impact of different dips on the mechanical mechanism of multiple-fissures rock under specific conditions,and it also has important theoretical significance for the research on multiple-fissure rock. | Leyong Chen Jianjun Liu | 2015 | Petroleum2015，1，4： | 2 |
| 4 | Supramolecular polymers fabricated by orthogonal self-assembly based on multiple hydrogen bonding and macrocyclic host–guest interactions显示文摘Supramolecular polymers constructed by orthogonal self-assembly based on multiple hydrogen bonding and macrocyclic host-guest interactions have received increasing attention due to their elegant structures,outstanding properties,and potential applications.Hydrogen bonding endows these supramolecular polymers with good adaptability and reversibility,while macrocyclic host-guest interactions give them good selectivity and versatile stimuli-responsiveness.Therefore,functional supramolecular polymers fabricated by these two highly specific,noninterfering interactions in an orthogonal way have shown wide applications in the fields of molecular machines,electronics,soft materials,etc.In this review,we discuss the recent advances of functional supramolecular polymers fabricated by orthogonal self-assembly based on multiple hydroge n bonding and host-guest interactions.In particular,we focus on crown ether-and pillar[n]arene-based supramolecular polymers due to their compatibility with multiple hydrogen bonds in organic solution.The fabrication strategies,interesting properties,and potential applications of these advanced supramolecular materials are mainly concerned. | Tangxin Xiao Ling Zhou Xiao-Qiang Sun Feihe Huang Chen Lin Leyong Wang | 2020 | Chinese Chemical Letters2020，31，1： | 2 |
| 5 | Supramolecular Prodrug Micelles Constructed by Drug-Drug Conjugate with Water Soluble Pillar[6]arene for Controllable and Rapid Drug Release显示文摘The first attempt of constructing supramolecular prodrug micelles based on the host-guest interaction between water-soluble pillar[6]arene(WP6)and a novel doxorubicin(DOX)-based drug-drug conjugate(G)is reported,in which the drug-drug conjugate is synthesized by conjugating anticancer drug DOX with another drug isoniazide via the acid-cleavable hydrazone bond.The obtained WP6⊃G micelles are stable under physiological conditions,whereas the cumulative release of DOX is approximate to 100%within 30 min at pH 5.5 by simulating the endo-lysosomal environment at 37℃.Therefore,this WP6-based prodrug micelles can achieve efficient DOX ac-cumulation in the acidic tumor cells within a short period of time,which is very important and valuable;meanwhile it can also reduce the unexpected premature burst release under physiological condition.Furthermore,cellular in-ternalization and localization experiments demonstrated that these prodrug micelles enter cancer cells mainly via endocytosis and can lead to significant drug accumulation in SKOV3 cancer cells,implying its promising future for cancer therapy. | Yu Cao Xiaochun Zou Shuhan Xiong Yan Li Yingzhong Shen Xiaoyu Hu Leyong Wang | 2015 | Chinese Journal of Chemistry2015，33，3： | 2 |
| 6 | Novel supramolecular organocatalysts of hydroxyprolinamide based on calix[4]arene scaffold for the enantioselective Biginelli reaction显示文摘A series of novel supramolecular organocatalysts of hydroxyprolinamide based on the upper rim of calix[4]arene scaffold have been developed to catalyze enantioselective multi-component Biginelli reaction. Under the optimal conditions, the reactions occurred with moderate-to-excellent enantioselectivities (up to 98% ee). A plausible transition state constructed by the supra- molecular interaction of hydrogen bond and cation-π between catalysts and substrates has been proposed. | LI ZhengYi XING HuaiJie HUANG GuoLi SUN XiaoQiang JIANG JuLi WANG LeYong | 2011 | Science China Chemistry2011，54，11： | 2 |
| 7 | Stable pillar[5]arene-based pseudo[1]rotaxanes formed in polar solution显示文摘Mono-alkyl-functionalized pillar[5]arenes P1,P2,and P3 were synthesized by click reaction,which exhibited different self-assembly behavior in polar solvent DMSO.Stable pseudo[1]rotaxane was formed by the self-complexation from P1 or P2,whereas,concentration-dependent pseudorotaxane structures were generated by P3 which bearing more flexible side chain.Interestingly,the obtained pseudo[1]rotaxanes exhibited a dynamic fast assembly process upon adding NaBF_4,resulting in the formation of Na^+-induced pseudorotaxanes. | Xuan Wu Lei Gao Junzhao Sun Xiao-Yu Hu Leyong Wang | 2016 | Chinese Chemical Letters2016，27，11： | 1 |
| 8 | Two new triazolophanes: synthesis, structures, self-assembling, and anion complexation properties显示文摘 | Qunpeng Duan Wei Xia Chen Lin Yi Pan Leyong Wang | 2015 | Tetrahedron Letters2015，，26： | 1 |
| 9 | High-resolution and instantaneous imaging of latent fingerprints显示文摘Fingerprints can serve as an information storage platform for individuals and play an important role in forensic investigation and security[1].Most of them are invisible to the naked eye and are called latent fingerprints(LFPs).Conventional imaging techniques suffer from limitations like low resolution and sensitivity[2],restricting the recognition of LFPs to macroscopic features,such as shape,core,ending,bifurcation,island,pores,and so on,which correspond to levels 1 and 2.Features of level 3 including ridges and their edges,are challenging to recognize. | Ming Cheng Juli Jiang Jean-Claude Chambron Leyong Wang | 2023 | Chinese Chemical Letters2023，34，4： | 1 |
| 10 | Homo and copolymerization ofnorbornene and styrene with Pd and Ni based novel bridged dinuelear diimine complexes and MAO 显示文摘 | Mi Xia Ma Zhi Wang Leyong | 2003 | Maeromoleeular Chemistry and Physics2003，204，56： | 1 |
| 11 | Enhancing and tuning absorption properties of microwave absorbing materials using metamaterials 显示文摘 | Zou Yanhong Jiang Leyong | 2008 | Appl Phys Lett2008，93，26： | 1 |
| 12 | Cancer cell detection and imaging: MRI-SERS bimodal splat-shaped Fe_3O_4/Au nanocomposites显示文摘The development of multifunctional contrast agents contributes significant character in the diagnosis of cancer. However, still efforts are required to design and improve the biocompatibility of contrast agents for early detection of cancer. Herein, we synthesized splat shape Fe_3O_4/Au nanocomposites for multimode biomedical applications. Transmission electron microscopy(TEM) results showed that the splat-like Fe_3O_4/Au structure was in the range of 130 nm and homogeneously distributed in the aqueous medium. The nanocomposites were incubated with MCF-7 cells to investigate the magnetic resonance imaging(MRI) and surface-enhanced Raman scattering(SERS) activities. The excellent T_2 MRI and enhanced SERS properties were obtained without any cytotoxicity. These results demonstrated that assynthesized splat-shaped Fe_3O_4/Au nanocomposites may be a promising MRI/SERS dual probe for the tumor detection. | Xinmei Zhao Leyong Zeng Narayan Hosmane Yan Gong Aiguo Wu | 2019 | Chinese Chemical Letters2019，30，1： | 1 |
| 13 | Improved Microwave Absorption of Carbonyl Iron Powder by the Array of Subwavelength Metallic Cut Wires 显示文摘 | Zou Yanhong Qing Yongjun Jiang Leyong | 2010 | IEEE Journal of selected topics in quantum electronics2010，16，2： | 1 |
| 14 | An AIE singlet oxygen generation system based on supramolecular strategy显示文摘The design of supramolecular system s with efficient singlet oxygen generation has attracted considerable interests.Herein,an AIE-based singlet oxygen generation system with chemiluminescence properties is reported in aqueous media based on supramolecular host-guest assembly between a water-soluble pillar[5]arene(WP5)and an AIE photosensitizer(TPEDM).The formed supramolecular nanoparticles exhibit significant singlet oxygen generation ability as well as enhanced fluorescence.In addition,by introducing catalase,this H_(2) O_(2)-responsive supramolecular system shows increased~1 O_(2) generation efficiency compared with the blank nanoparticles.An efficient chemiluminescence system can also be achieved by entrapping an energy donor adamantane derivative(AMPPD).Moreover,the present system can function as nanoreactors to perform the photooxidation of dopamine to form polydopamine with visible light irradiation.This wo rk provides a new strategy for the construction of~1 O_(2) generation system based on supramolecular nanomaterials,which has potential applications in the fields such as chemiluminescence imaging and controlled photocatalysis. | Minzan Zuo Weirui Qian Min Hao Kaiya Wang Xiao-Yu Hu Leyong Wang | 2021 | Chinese Chemical Letters2021，32，4： | 1 |
| 15 | The emerging applications of pillararene architectures in supramolecular catalysis显示文摘Over the last decade,numerous research efforts have been devoted to pillar[n]arenes since their debut.The popularity of pillararenes is a reflection of current research trend in supramolecular and macrocyclic chemistry in general.Among the vast applications(such as chemosensors,drug delivery,transmembrance channels,and separation)of pillararenes,their utilization in catalysis is a relatively less explored area.However,soaring attention has been paid by researchers in recent years and this field has seen gradual increasing publications.Therefore,in this review we will discuss progress in the emerging applications of pillararene architectures in catalysis based on various reaction genre including reduction,oxidation,coupling,decomposition and others.Furthermore,this review not only focuses on the pillararenes based current progress in catalysis,but also provides the signs for future development in this research field. | Kaiya Wang Xueqi Tian Jacobs H.Jordan Krishnasamy Velmurugan Leyong Wang Xiao-Yu Hu | 2022 | Chinese Chemical Letters2022，33，1： | 1 |
| 16 | Diabetic wound healing activated by supramolecular cascade reaction显示文摘Diabetes is a chronic disease,and its complications such us diabetic foot ulcer and other chronic wounds often cause great pain to patients.Diabetic wounds are more prone to bacterial infection due to the environment of high blood sugar,resulting in difficult wound healing[1].Therefore,how to protect the wound and cure drug-resistant bacterial infections in diabetes is an important scientific problem that needs to be solved. | Fang-Fang Shen Yuguo Wang Leyong Wang | 2023 | Chinese Chemical Letters2023，34，1： | 1 |
| 17 | Enhancing and tuning absorption properties ot microwave absorbing materials using metamaterials 显示文摘 | Yanhong Zou Leyong Jiang Shuangchun Wen | 2008 | Applied Physics Letters2008，93，26： | 1 |
| 18 | Late Iransifion metal complexes bearing 2,9-bis (imino)-1,10-phenanthrolinyl ligands: synthesis, characterization and their ethylene activity显示文摘 | Wang Leyong Sun Wenhua Han Lingqin | 2002 | J Organomet Chem2002，658，12： | 1 |
| 19 | Synthesis of water-soluble Fe OOH nanospindles and their performance for magnetic resonance imaging显示文摘 | Leyong Zenga Wenzhi Rena Jianjun Zheng | 2012 | Applied Surface Science2012，258，： | 1 |
| 20 | TP53 polymorphisms are involved in inverse colorectal cancer comorbidity in Chinese schizophrenia patients显示文摘The inverse cancer comorbidity in schizophrenia patients may be related to the genetic factors,involving the regulation of apoptosis.The tumour suppressor gene TP53,involved in neural apoptosis,is one of the potential candidate genes associated with schizophrenia which might reduce colorectal cancer risk.We recruited 270 schizophrenia patients and 312 colorectal cancer patients without schizophrenia.To examine the genetic association between schizophrenia and colorectal cancer,we analysed eight SNPs(rs12951053,rs1625895,rs2909430,rs9895829,rs1042522,rs8079544,rs8064946,rs17806770)covering 14.35 kb in the region of TP53.We observed that one of the eight genetic polymorphisms showed statistically significant differences between the colorectal cancer subjects and the schizophrenia subjects(rs12951053,P=0.000 1,OR1.70,95%CI1.30-2.23).In addition,the haplotype of A-G(rs12951053-rs8064946),giving aglobal P=0.001 8,was the most significant.Our data indicate that the polymorphisms of rs12951053 in TP53confer reduced susceptibility to colorectal cancer and suggest a potential protective mechanism against colorectal cancer in the schizophrenia patients of Han Chinese origin. | Sun Liming Huang Guoxin Zhao Leyong Chen Xiaofen Chen Wenjiao | 2015 | 国际检验医学杂志2015，36，15： | 0 |
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