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| 1 | AXL is a candidate receptor for SARS-CoV-2 that promotes infection of pulmonary and bronchial epithelial cells显示文摘The current coronavirus disease 2019(COVID-19)pandemic presents a global public health challenge.The viral pathogen responsible,severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),binds to the host receptor ACE2 through its spike(S)glycoprotein,which mediates membrane fusion and viral entry.Although the role of ACE2 as a receptor for SARS-CoV-2 is clear,studies have shown that ACE2 expression is extremely low in various human tissues,especially in the respiratory tract.Thus,other host receptors and/or co-receptors that promote the entry of SARS-CoV-2 into cells of the respiratory system may exist.In this study,we found that the tyrosine-protein kinase receptor UFO(AXL)specifically interacts with the N-terminal domain of SARS-CoV-2 S.Using both a SARS-CoV-2 virus pseudotype and authentic SARS-CoV-2,we found that overexpression of AXL in HEK293T cells promotes SARS-CoV-2 entry as efficiently as overexpression of ACE2,while knocking out AXL significantly reduces SARS-CoV-2 infection in HI 299 pulmonary cells and in human primary lung epithelial cells.Soluble human recombinant AXL blocks SARS-CoV-2 infection in cells expressing high levels of AXL.The AXL expression level is well correlated with SARS-CoV-2 S level in bronchoalveolar lavage fluid cells from COVID-19 patients.Taken together,our findings suggest that AXL is a novel candidate receptor for SARS-CoV-2 which may play an important role in promoting viral infection of the human respiratory system and indicate that it is a potential target for future clinical intervention strategies. | Shuai Wang Zongyang Qiu Yingnan Hou Xiya Deng Wei Xu Tingting Zheng Peihan Wu Shaofang Xie Weixiang Bian Chong Zhang Zewei Sun Kunpeng Liu Chao Shan Aifu Lin Shibo Jiang Youhua Xie Qiang Zhou Lu Lu Jing Huang Xu Li | 2021 | Cell Research2021，31，2： | 39 |
| 2 | The willow genome and divergent evolution from poplar after the common genome duplication显示文摘 | Xiaogang Dai Quanjun Hu Qingle Cai Kai Feng Ning Ye Gerald A Tuskan Richard Milne Yingnan Chen Zhibing Wan Zefu Wang Wenchun Luo Kun Wang Dongshi Wan Mingxiu Wang Jun Wang Jianquan Liu Tongming Yin | 2014 | Cell Research2014，24，10： | 28 |
| 3 | Numerical study on non-uniform heat transfer deterioration of supercritical RP-3 aviation kerosene in a horizontal tube显示文摘The convective heat transfer of supercritical-pressure RP-3(Rocket Propellant 3)aviation kerosene in a horizontal circular tube has been numerically studied,focusing mainly on the non-uniform heat transfer deterioration along the circumferential direction.The governing equations of mass,momentum and energy have been solved using the pressure-based segregated solver based on the finite volume method.The re-normalization group(RNG)k-εturbulence model with an enhanced wall treatment was selected.Considering the heat conduction in the solid wall,the mechanism of heat transfer deterioration and the buoyancy effect on deteriorated heat transfer were discussed.The evolution of secondary flow was analyzed.Effects of the outer-wall heat flux,mass flux,pressure and tube thermal conductivity on heat transfer were investigated.Moreover,the buoyancy criterion and the heat transfer correlation were obtained.Results indicate that the poor flow performance of near-wall fluid causes the pseudo-film boiling,further leads to the heat transfer deterioration.The strong buoyancy has an effect of enhancing the heat transfer at the bottom of tube,and weakening the heat transfer at the top of tube,which results in the non-uniform inner-wall temperature and heat flux distributions.Decreasing the ratio of outer-wall heat flux and mass flux,increasing the pressure could weaken the heat transfer difference along the circumferential direction,while the effect of thermal conductivity of tube on the circumferential parameters distributions is more complicated.When the buoyancy criterion of(Grq/Grth)max≤0.8 is satisfied,the effect of buoyancy could be ignored.The new correlations work well for non-uniform heat transfer predictions. | Yanhong Wang Yingnan Lu Sufen Li Ming Dong | 2020 | Chinese Journal of Chemical Engineering2020，28，6： | 7 |
| 4 | The Arabidopsis Anaphase-Promoting Complex/Cyclosome Subunit 1 is Critical for Both Female Gametogenesis and Embryogenesis显示文摘Anaphase-promoting complex/cyclosome (APC/C), a multisubunit E3 ligase, plays a critical role in cell cycle control, but the functional characterization of each subunit has not yet been completed. To investigate the function of APC1 in Arabidopsis, we analyzed four mutant alleles of APC1, and found that mutation in APC1 resulted in significantly reduced plant fertility, accumulation of cyclin B, and disrupted auxin distribution in embryos. The three mutant alleles apc1-1, apc1-2 and apc1-3 shared variable defects in female gametogenesis including degradation, abnormal nuclear number, and disrupted polarity of nuclei in the embryo sac as well as in embryogenesis, in which embryos were arrested at multiple stages. All of these defects are similar to those previously identified in apc4. The mutant apc1-4, in which the T-DNA was inserted after the transmembrane domain at the C-terminus, showed much more severe phenotypes; that is, most of the ovules were arrested at the one-nucleate female gametophyte stage (stage FG1). In the apc1 apc4 double mutants, the fertility was further reduced by one-third in apc1-1/+ apc4-1/+, and in some cases no ovules even survived in siliques of apc1-4/+ apc4-1/+. Our data thus suggest that APC1, an essential component of APC/C, plays a synergistic role with APC4 both in female gametogenesis and in embryogenesis. | Yanbing Wang Yingnan Hou Hongya Gu Dingming Kang Zhang-Liang Chen Jingjing Liu Li-Jia Qu | 2013 | Journal of Integrative Plant Biology2013，55，1： | 7 |
| 5 | Development of a large-scale remote sensing ecological index in arid areas and its application in the Aral Sea Basin显示文摘The Aral Sea Basin in Central Asia is an important geographical environment unit in the center of Eurasia.It is of great significance to the ecological protection and sustainable development of Central Asia to carry out dynamic monitoring and effective evaluation of the eco-environmental quality of the Aral Sea Basin.In this study,the arid remote sensing ecological index(ARSEI)for large-scale arid areas was developed,which coupled the information of the greenness index,the salinity index,the humidity index,the heat index,and the land degradation index of arid areas.The ARSEI was used to monitor and evaluate the eco-environmental quality of the Aral Sea Basin from 2000 to 2019.The results show that the greenness index,the humidity index and the land degradation index had a positive impact on the quality of the ecological environment in the Aral Sea Basin,while the salinity index and the heat index exerted a negative impact on the quality of the ecological environment.The eco-environmental quality of the Aral Sea Basin demonstrated a trend of initial improvement,followed by deterioration,and finally further improvement.The spatial variation of these changes was significant.From 2000 to 2019,grassland and wasteland(saline alkali land and sandy land)in the central and western parts of the basin had the worst ecological environment quality.The areas with poor ecological environment quality are mainly distributed in rivers,wetlands,and cultivated land around lakes.During the period from 2000 to 2019,except for the surrounding areas of the Aral Sea,the ecological environment quality in other areas of the Aral Sea Basin has been improved in general.The correlation coefficients between the change in the eco-environmental quality and the heat index and between the change in the eco-environmental quality and the humidity index were–0.593 and 0.524,respectively.Climate conditions and human activities have led to different combinations of heat and humidity changes in the eco-environmental quality of the Aral Sea Basin.However,human activities had a greater impact.The ARSEI can quantitatively and intuitively reflect the scale and causes of large-scale and long-time period changes of the eco-environmental quality in arid areas;it is very suitable for the study of the eco-environmental quality in arid areas. | WANG Jie LIU Dongwei MA Jiali CHENG Yingnan WANG Lixin | 2021 | Journal of Arid Land2021，13，1： | 5 |
| 6 | Rh-doped PdAg nanoparticles as efficient methanol tolerance electrocatalytic materials for oxygen reduction显示文摘Direct methanol fuel cells(DMFCs)have received extensive attention on their high efficiency,high reliability,and no carbon emission.Unfortunately,the poor methanol tolerance and sluggish oxygen reduction reaction(ORR)at cathode have seriously hindered their further development.Herein we report the synthesis of a new class of Rh-doped PdAg alloy nanoparticles(NPs)for boosting ORR activity with high methanol tolerance capacity concurrently.The ORR mass activity of typical Rh_4Pd_(40)Ag_(56)NPs is 4.2 times higher than that of commercial Pt catalyst.Moreover,it shows a great methanol tolerance capability by maintaining 92.4%in ORR mass activity in alkaline solution with 0.1 mol L^(à1)methanol,against a big decrease of almost 100%for commercial Pt.Even after 30,000 potential cycles with 1.0 mol L^(à1)methanol,Rh_4Pd_(40)Ag_(56)NPs still retain ORR mass activity of up to 68.3%.DFT calculations reveal that excellent ORR performance with excellent methanol tolerance originates the active d-band-pinning engineering for an efficient site-independent electron-transfer.A generalized d-band mediated fine electron-transfer tuning path has blueprinted for effectively minimizing intrinsic ORR barriers with high current density.The present work highlights the key role of Rh doping in enhancing the ORR activity and methanol tolerance ability of PdAg NPs for future high-performance DMFCs. | Yingjun Sun Bolong Huang Nuoyan Xu Yingjie Li Mingchuan Luo Chunji Li Yingnan Qin Lei Wang Shaojun Guo | 2019 | Science Bulletin2019，64，1： | 4 |
| 7 | Research Progress on Northern Leaf Blight in Corn显示文摘The northern corn leaf blight is one of the most serious diseases in maize production. The research progress on etiology, generation law and control strategy, antigen identification, resistance mechanism and inheritance of this disease was discussed. And the research work which should be enhanced in China was pointed out, such as mechanism of resistance inheritance, developing function marker, gene mining, screening resistance resource and dominant physiological race in different areas. | ZHAO Yingnan WANG Zhenhua | 2009 | Journal of Northeast Agricultural University(English Edition)2009，16，2： | 2 |
| 8 | Fluorescent probe gold nanodots to quick detect Cr(VI) via oxidoreduction quenching process显示文摘A method is described here for the quickly(<30 s) accurate determination of Cr(VI)(Cr_2O_7^(2-)), based on fluorescent probes gold nanodots(AuNDs, excitation/emission peaks at 395/604 nm) coated with glutathione(GSH). The fluorescence of the AuNDs responses linearly to Cr(VI) concentrations, ranging widely from 1 nM to 10 m M with detection limit as low as 0.35 nM. At the same time, the AuNDs is demonstrated highly selective for Cr(VI) detection over other acid group ions and metal ions without any masking reagent. These make probability for practical use. The quenching mechanism is investigated deeply via fluorescent lifetime, XPS and TEM analysis. Different from most reported quenching explanation of aggregation derived from charge attraction, these results verify the redox reaction between Cr_2O_7^(2-)and sulfhydryl(–S) of GSH. The Au(I)–S bonds of AuNDs broke, accompanies with the oxidation of –S to form S–S bonds. As a result, AuNDs cross linked to each other. In the end, the fluorescence quenched. Attractively, the present study provides a new strategy for pollutant detection, such as from harmful Cr(VI) of Cr_2O_7^(2-)to nontoxic Cr(III). | Yueqi Zhao Yuanqing Sun Yingnan Jiang Shanliang Song Tianxin Zhao Yue Zhao Xinyu Wang Baoquan Li Bai Yang Quan Lin | 2019 | Science China Chemistry2019，62，1： | 1 |
| 9 | Endogenous auxin and its manipulation influence in vitro shoot organogenesis of citrus epicotyl explants显示文摘Endogenous auxin is an important regulator of in vivo organ development,but its role in in vitro organogenesis is unclear.It has been observed that the basal end of epicotyl cuttings of juvenile citrus seedlings produces fewer shoots than the apical end.Here,we report that elevated endogenous auxin levels in the basal end of citrus epicotyl cuttings are inhibitory for in vitro shoot organogenesis.Using transgenic citrus plants expressing an auxin-inducible GUS reporter gene,we have observed elevated levels of auxin at the basal end of stem cuttings that are mediated by polar auxin transport.Depleting endogenous auxin or blocking polar auxin transport enhances shoot organogenesis.An auxin transport inhibitor,N-1-naphthylphthalamic acid(NPA),can also enhance shoot organogenesis independent of its action on polar auxin transport.Finally,we demonstrate that the promotional effects of depleting endogenous auxin or blocking polar auxin transport on shoot organogenesis are cytokinin-dependent.Our study thus provides meaningful insights into possible roles of endogenous auxin and polar auxin transport,as well as auxin–cytokinin interactions,in in vitro shoot organogenesis.Meanwhile,our results may also provide practical strategies for improving in vitro shoot organogenesis for citrus and many other plant species. | Wei Hu Sabrina Fagundez Lorenzo Katin-Grazzini Yanjun Li Wei Li Yingnan Chen Xiaomin Wang Ziniu Deng Shenxi Xie Richard J McAvoy Yi Li | 2017 | Horticulture Research2017，4，1： | 1 |
| 10 | Recycling the magnesium alloy AZ91D in solid stare显示文摘 | Wang Jianyih Lin Yingnan Chang Tienchan | 2006 | Mater Trans2006，47，： | 1 |
| 11 | Inhibition of the growth of two blue-green algae species ( Microsystis aruginosa and Anabaena spiroides ) by acidification treatments using carbon dioxide显示文摘 | Xin Wang Chunbo Hao Feng Zhang Chuanping Feng Yingnan Yang | 2011 | Bioresource Technology2011，，10： | 1 |
| 12 | Production of total polyphenol from fermented soybean curd residue by Lentinus edodes 显示文摘 | Min Shi Yingnan Yang Qinghong Wang | 2012 | International Journal of Food Science & Technology2012，47，6： | 1 |
| 13 | Rapid response of brain metastasis to crizotinib in a patient with KLC1-ALK fusion and MET gene amplification positive non-small cell lung cancer:a case report显示文摘Non-small cell lung cancer(NSCLC) ranks as the leading cause of cancer-related death in the world. Brain metastasis(BM) is a common complication of NSCLC, with 25%–40% of patients developing BM during the course of the disease. A significant strategy of local disease control in the central nervous system is radiation therapy. With the development of precision medicine,the concept of treating lung cancer BM has gradually changed. In this case, we performed a surgical procedure to obtain enough tumor tissue for the detection of the target gene and other related experiments after the patient was informed. Finally, we found that the patient had both hepatocyte growth factor receptor(MET) gene amplification and kinesin light chain 1-anaplastic lymphoma kinase fusion(KLC1-ALK) through next-generation sequencing and showed sensitivity to the targeted therapy of crizotinib. The patient exhibited good response. Our case was successful and underwent targeted therapy with the guidance of precise diagnosis. | Peng Wang Pei Xiao Yingnan Ye Pengpeng Liu Lei Han Li Dong Chunhua She Jinpu Yu | 2017 | Cancer Biology & Medicine2017，14，2： | 1 |
| 14 | Preparation of zirconi- um diboride ultrafine hollow spheres by a combined sol-gel and bo- ro/carbothermal reduction technique 显示文摘 | Cao Yingnan Du Shuang Wang Junkai | 2014 | J Sol ~? el Sci Technol2014，72，1： | 1 |
| 15 | Separation and preconcentration of trace indium(Ⅲ) from environmental samples with nanometer-size titanium dioxide显示文摘 | Zhang Lei Wang Yingnan Guo Xingjia | 2009 | Hydrometallurgy2009，95，： | 1 |
| 16 | A Facile Synthesis of ZnCo2O4 Nanocluster Particles and the Performance as Anode Materials for Lithium Ion Batteries显示文摘ZnCo_2O_4 nanocluster particles(NCPs) were prepared through a designed hydrothermal method, with the assistance of a surfactant, sodium dodecyl benzene sulfonate. The crystalline structure and surface morphology of ZnCo_2O_4 were investigated by XRD, XPS, SEM, TEM, and BET analyses. The results of SEM and TEM suggest a clear nanocluster particle structure of cubic ZnCo_2O_4(*100 nm in diameter), which consists of aggregated primary nanoparticles(*10 nm in diameter), is achieved. The electrochemical behavior of synthesized ZnCo_2O_4 NCPs was investigated by galvanostatic discharge/charge measurements and cyclic voltammetry. The ZnCo_2O_4 NCPs exhibit a high reversible capacity of 700 mAh g^(-1) over 100 cycles under a current density of 100 mA g^(-1) with an excellent coulombic efficiency of 98.9% and a considerable cycling stability. This work demonstrates a facile technique designed to synthesize ZnCo_2O_4 NCPs which show great potential as anode materials for lithium ion batteries. | Yue Pan Weijia Zeng Lin Li Yuzi Zhang Yingnan Dong Dianxue Cao Guiling Wang Brett L.Lucht Ke Ye Kui Cheng | 2017 | Nano-Micro Letters2017，9，2： | 1 |
| 17 | Separation and pre- concentration of trace indium( Ⅲ) from environmental sampleswith nanometer-size titanium dioxide 显示文摘 | Zhang Lei Wang Yingnan Guo Xingjia | 2009 | Hydrometallurgy2009，95，： | 1 |
| 18 | Integrated assessment of oxidative stress and DNA damage in earthworms ( Eisenia fetida ) exposed to azoxystrobin显示文摘 | Yingnan Han Lusheng Zhu Jinhua Wang Jun Wang Hui Xie Shumin Zhang | 2014 | Ecotoxicology and Environmental Safety2014，，： | 1 |
| 19 | Photocatalytic degradation of methamidophos by UV irradiation in the presence of nano-TiO 2显示文摘 | Lei Zhang Fei Yan Yingnan Wang Xingjia Guo Peng Zhang | 2006 | Inorganic Materials2006，，12： | 1 |
| 20 | Single cell transcriptomic analysis identifies novel vascular smooth muscle subsets under high hydrostatic pressure显示文摘Although some co-risk factors and hemodynamic alterations are involved in hypertension progression,their direct biomechanical effects are unclear.Here,we constructed a high-hydrostatic-pressure cell-culture system to imitate constant hypertension and identified novel molecular classifications of human aortic smooth muscle cells(HASMCs)by single-cell transcriptome analysis.Under 100-mmHg(analogous to healthy human blood pressure)or 200-mmHg(analogous to hypertension)hydrostatic pressure for 48 h,HASMCs showed six distinct vascular SMC(VSMC)clusters according to differential gene expression and gene ontology enrichment analysis.Especially,two novel HASMC subsets were identified,named the inflammatory subset,with CXCL2,CXCL3 and CCL2 as markers,and the endothelial-function inhibitory subset,with AKR1C2,AKR1C3,SERPINF1 as markers.The inflammatory subset promoted CXCL2&3 and CCL2 chemokine expression and secretion,triggering monocyte migration;the endothelial-function inhibitory subset secreted SERPINF1 and accelerated prostaglandin F2αgeneration to inhibit angiogenesis.The expression of the two VSMC subsets was greatly increased in arterial media from patients with hypertension and experimental animal models of hypertension.Collectively,we identified high hydrostatic pressure directly driving VSMCs into two new subsets,promoting or exacerbating endothelial dysfunction,thereby contributing to the pathogenesis of cardiovascular diseases. | Zhenzhen Chen Haizeng Zhang Yingnan Bai Changting Cui Shuangyue Li Wenjie Wang Yue Deng Qiannan Gao Lu Wang Wei Qi Lijun Zhang Yan Yang Bin Geng Jun Cai | 2021 | Science China(Life Sciences)2021，64，10： | 1 |
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