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| 1 | Durability of neutralizing antibodies and T-cell response post SARS-CoV-2 infection显示文摘The ongoing pandemic of coronavirus disease 19(COVID-19)is caused by a newly discoveredβcoronavirus named severe acute respiratory syndrome coronavirus 2(SARS-CoV-2).How long the adaptive immunity triggered by SARS-CoV-2 can last is of critical clinical relevance in assessing the probability of second infection and efficacy of vaccination.Here we examined,using ELISA,the IgG antibodies in serum specimens collected from 17 COVID-19 patients at 6–7 months after diagnosis and the results were compared to those from cases investigated 2 weeks to 2 months post-infection.All samples were positive for IgGs against the S-and N-proteins of SARS-CoV-2.Notably,14 samples available at 6–7 months post-infection all showed significant neutralizing activities in a pseudovirus assay,with no difference in blocking the cell-entry of the 614D and 614G variants of SARS-CoV-2.Furthermore,in 10 blood samples from cases at 6–7 months post-infection used for memory T-cell tests,we found that interferonγ-producing CD4+and CD8+cells were increased upon SARS-CoV-2 antigen stimulation.Together,these results indicate that durable anti-SARS-CoV-2 immunity is common in convalescent population,and vaccines developed from 614D variant may offer protection from the currently predominant 614D variant of SARS-CoV-2. | Yun Tan Feng Liu Xiaoguang Xu Yun Ling Weijin Huang Zhaoqin Zhu Mingquan Guo Yixiao Lin Ziyu Fu Dongguo Liang Tengfei Zhang Jian Fan Miao Xu Hongzhou Lu Saijuan Chen | 2020 | Frontiers of Medicine2020，14，6： | 6 |
| 2 | Safety and superior immunogenicity of heterologous boosting with an RBD-based SARS-CoV-2 mRNA vaccine in Chinese adults显示文摘Dear Editor,To May 2022,the COVID-19 pandemic has claimed more than 6.28 million lives,with more than 524 million confirmed cases worldwide.The recent emergence of highly transmissible Omicron variant of severe acute respiratory syndrome coronavirus 2(SARSCoV-2)has triggered another major surge in both confirmed cases and deaths.1 Ten COVID-19 vaccines have been approved by the World Health Organization(WHO)for emergency use,including the two mRNA vaccines,BNT162b2 and mRNA-1273,and two Chinese inactivated vaccines,CoronaVac and BBIBP-CorV.However,the rapid waning of vaccine-induced virus-neutralizing antibody titers and the continuous emergence of variants of concern(VOCs),including Alpha,Beta,Delta and Omicron,have created unprecedented challenges in the eradication of COVID-19 pandemic.2–4. | Xiaoqiang Liu Yuhua Li Zhongfang Wang Shouchun Cao Weijin Huang Lin Yuan Yi-Jiao Huang Yan Zheng Jingjing Chen Bo Ying Zuoyun Xiang Jin Shi Jincun Zhao Zhen Huang Cheng-Feng Qin | 2022 | Cell Research2022，32，8： | 5 |
| 3 | Research on Mobile Internet Mobile Agent System Dynamic Trust Model for Cloud Computing显示文摘This paper analyzes the reasons for the formation of security problems in mobile agent systems, and analyzes and compares the security mechanisms and security technologies of existing mobile agent systems from the perspective of blocking attacks. On this basis, the host protection mobile agent protection technology is selected, and a method to enhance the security protection of mobile agents (referred to as IEOP method) is proposed. The method first encrypts the mobile agent code using the encryption function, and then encapsulates the encrypted mobile agent with the improved EOP protocol IEOP, and then traces the suspicious execution result. Experiments show that using this method can block most malicious attacks on mobile agents, and can protect the integrity and confidentiality of mobile agents, but the increment of mobile agent tour time is not large. | Weijin Jiang Yang Wang Yirong Jiang Jiahui Chen Yuhui Xu Lina Tan | 2019 | China Communications2019，16，7： | 5 |
| 4 | Evolutionary Dynamics Modeling of Symbolic Social Network Structure Equilibrium显示文摘The use of symbol attributes on the side of symbolic social networks to analyze,understand,and predict the topology,function,and dynamic behaviour of complex networks,and has important theoretical significance for personalized recommendations,attitude prediction,user feature analysis,and clustering and application value.However,due to the huge scale of online social networks,this poses a challenge to traditional symbolic social network analysis methods.Based on the theory of structural equilibrium,this paper studies the evolutionary dynamics of symbolic social networks,proposes the energy function of weak structural equilibrium theory,and uses the evolution of evolutionary algorithms to obtain the weak imbalance of the network.The simulation experiment results show that the calculation method in this paper can get the optimal solution faster.It provides an idea for the study of real and complex social networks. | Weijin Jiang Sijian Lv Yirong Jiang Jiahui Chen Fang Ye Xiaoliang Liu | 2020 | China Communications2020，17，10： | 4 |
| 5 | A New Time-Aware Collaborative Filtering Intelligent Recommendation System显示文摘Aiming at the problem that the traditional collaborative filtering recommendation algorithm does not fully consider the influence of correlation between projects on recommendation accuracy,this paper introduces project attribute fuzzy matrix,measures the project relevance through fuzzy clustering method,and classifies all project attributes.Then,the weight of the project relevance is introduced in the user similarity calculation,so that the nearest neighbor search is more accurate.In the prediction scoring section,considering the change of user interest with time,it is proposed to use the time weighting function to improve the influence of the time effect of the evaluation,so that the newer evaluation information in the system has a relatively large weight.The experimental results show that the improved algorithm improves the recommendation accuracy and improves the recommendation quality. | Weijin Jiang Jiahui Chen Yirong Jiang Yuhui Xu Yang Wang Lina Tan Guo Liang | 2019 | Computers, Materials & Continua2019，，8： | 3 |
| 6 | Effect of BaNH,CaNH,Mg3N2 on the activity of Co in NH3 decomposition catalysis显示文摘Development of active and non-noble metal-based catalyst for H2 production via NH3 decomposition is crucial for the implementation of NH3 as a H2 carrier.Co-based catalysts have received increasing attention because of its high intrinsic activity and moderate cost.In this work,we examined the effect of BaNH,CaNH and Mg3 N2 on the catalytic activity of Co in the NH3 decomposition reaction.The H2 formation rate ranks the order as Co-BaNH>Co-CaNH>Co-Mg3 N2≈Co/CNTs within a reaction temperature range of 300-550℃.It is worth pointing out that the H2 formation rate of Co-BaNH at 500℃reaches20 mmolH2 gcat-1 min-1,which is comparable to those of the active Ru/Al2 O3(ca.17 mmolH2 gcat-1 min1)and Ru/AC(21 mmolH2 gcat-1 min-1)catalysts under the similar reaction conditions.In-depth research shows that Co-BaNH exhibits an obviously higher intrinsic activity and much lower Ea(46.2 kJ mol-1)than other Co-based catalysts,suggesting that BaNH may play a different role from CaNH,Mg3 N2 and CNTs during the catalytic process.Combined results of XRD,Ar-TPD and XAS show that a[Co-N-Ba]-like intermediate species is likely formed at the interface of Co metal and BaNH,which may lead to a more energy-efficient reaction pathway than that of neat Co metal for NH3 decomposition. | Pei Yu Han Wu Jianping Guo Peikun Wang Fei Chang Wenbo Gao Weijin Zhang Lin Liu Ping Chen | 2020 | Journal of Energy Chemistry2020，29，7： | 3 |
| 7 | Double lock of a potent human therapeutic monoclonal antibody against SARS-CoV-2显示文摘Receptor recognition and subsequent membrane fusion are essential for the establishment of successful infection by SARS-CoV-2.Halting these steps can cure COVID-19.Here we have identified and characterized a potent human monoclonal antibody,HB27,that blocks SARS-CoV-2 attachment to its cellular receptor at sub-nM concentrations.Remarkably,HB27 can also prevent SARS-CoV-2 membrane fusion.Consequently,a single dose of HB27 conferred effective protection against SARS-CoV-2 in two established mouse models.Rhesus macaques showed no obvious adverse events when administrated with10 times the effective dose of HB27.Cryo-EM studies on complex of SARS-CoV-2 trimeric S with HB27 Fab reveal that three Fab fragments work synergistically to occlude SARS-CoV-2 from binding to the ACE2 receptor.Binding of the antibody also restrains any further conformational changes of the receptor binding domain,possibly interfering with progression from the prefusion to the postfusion stage.These results suggest that HB27 is a promising candidate for immuno-therapies against COVID-19. | Ling Zhu Yong-Qiang Deng Rong-Rong Zhang Zhen Cui Chun-Yun Sun Chang-Fa Fan Xiaorui Xing Weijin Huang Qi Chen Na-Na Zhang Qing Ye Tian-Shu Cao Nan Wang Lei Wang Lei Cao Huiyu Wang Desheng Kong Juan Ma Chunxia Luo Yanjing Zhang Jianhui Nie Yao Sun Zhe Lv Neil Shaw Qianqian Li Xiao-Feng Li Junjie Hu Liangzhi Xie Zihe Rao Youchun Wang Xiangxi Wang Cheng-Feng Qin | 2021 | National Science Review2021，8，3： | 3 |
| 8 | In-plane coherent control of plasmon resonances for plasmonic switching and encoding显示文摘Considerable attention has been paid recently to coherent control of plasmon resonances in metadevices for potential applications in all-optical light-with-light signal modulation and image processing.Previous reports based on out-ofplane coherent control of plasmon resonances were established by modulating the position of a metadevice in standing waves.Here we show that destructive and constructive absorption can be realized in metallic nano-antennas through in-plane coherent control of plasmon resonances,which is determined by the distribution rule of electricalfield components of nano-antennas.We provide proof-of-principle demonstrations of plasmonic switching effects in a gold nanodisk monomer and dimer,and propose a plasmonic encoding strategy in a gold nanodisk chain.In-plane coherent control of plasmon resonances may open a new avenue toward promising applications in optical spectral enhancement,imaging,nanolasing,and optical communication in nanocircuits. | Liyong Jiang Tingting Yin Alexander M.Dubrovkin Zhaogang Dong Yuntian Chen Weijin Chen Joel K.W.Yang Zexiang Shen | 2019 | Light(Science & Applications)2019，8，1： | 2 |
| 9 | Three amino acid residues in the envelope of human immunodeficiency virus type 1 CRF07_BC regulate viral neutralization susceptibility to the human monoclonal neutralizing antibody IgG1b12显示文摘The CD4 binding site(CD4bs) of envelope glycoprotein(Env) is an important conserved target for anti-human immunodeficiency virus type 1(HIV-1) neutralizing antibodies. Neutralizing monoclonal antibodies IgG1 b12(b12) could recognize conformational epitopes that overlap the CD4 bs of Env. Different virus strains, even derived from the same individual, showed distinct neutralization susceptibility to b12. We examined the key amino acid residues affecting b12 neutralization susceptibility using single genome amplification and pseudovirus neutralization assay. Eleven amino acid residues were identified that affect the sensitivity of Env to b12. Through site-directed mutagenesis, an amino acid substitution at position 182 in the V2 region of Env was confirmed to play a key role in regulating the b12 neutralization susceptibility. The introduction of V182 L to a resistant strain enhanced its sensitivity to b12 more than twofold. Correspondingly, the introduction of L182 V to a sensitive strain reduced its sensitivity to b12 more than tenfold. Amino acid substitution at positions 267 and 346 could both enhance the sensitivity to b12 more than twofold. However, no additive effect was observed when the three site mutageneses were introduced into the same strain, and the sensitivity was equivalent to the single V182 L mutation. CRF07_BC is a major circulating recombinant form of HIV-1 prevalent in China. Our data may provide important information for understanding the molecular mechanism regulating the neutralization susceptibility of CRF07_BC viruses to b12 and may be helpful for a vaccine design targeting the CD4 bs epitopes. | Jianhui Nie Juan Zhao Qingqing Chen Weijin Huang Youchun Wang | 2014 | Virologica Sinica2014，29，5： | 2 |
| 10 | Distinguishing Between Natural and GAN-Generated Face Images by Combining Global and Local Features显示文摘With the development of face image synthesis and generation technology based on generative adversarial networks(GANs), it has become a research hotspot to determine whether a given face image is natural or generated. However, the generalization capability of the existing algorithms is still to be improved. Therefore,this paper proposes a general algorithm. To do so, firstly,the learning on important local areas, containing many face key-points, is strengthened by combining the global and local features. Secondly, metric learning based on the Arc Face loss is applied to extract common and discriminative features. Finally, the extracted features are fed into the classification module to detect GAN-generated faces.The experiments are conducted on two publicly available natural datasets(Celeb A and FFHQ) and seven GANgenerated datasets. Experimental results demonstrate that the proposed algorithm achieves a better generalization performance with an average detection accuracy over 0.99 than the state-of-the-art algorithms. Moreover, the proposed algorithm is robust against additional attacks, such as Gaussian blur, and Gaussian noise addition. | CHEN Beijing TAN Weijin WANG Yiting ZHAO Guoying | 2022 | Chinese Journal of Electronics2022，31，1： | 2 |
| 11 | Finite element modeling of electromagnetic properties in photonic bianisotropic structures显示文摘Given a constitutive relation of the bianisotropic medium,it is not trivial to study how light interacts with the photonic bianisotropic structure due to the limited available means of studying electromagnetic properties in bianisotropic media.In this paper,we study the electromagnetic properties of photonic bianisotropic structures using the finite element method.We prove that the vector wave equation with the presence of bianisotropic is self-adjoint under scalar inner product,we propose a balanced formulation of weak form in the practical implementation,which outperforms the standard formulation in finite element modeling.Furthermore,we benchmark our numerical results obtained from finite element simulation in three different scenarios.These are bianisotropy-dependent reflection and transmission of plane waves incident onto a bianisotropic slab,band structure of bianisotropic photonic crystals with valley-dependent phenomena,and the modal properties of bianisotropic ring resonators.The first two simulated results obtained from our modified weak form yield excellent agreements either with theoretical predictions or available data from the literature,and the modal properties in the last example,i.e.,bianisotropic ring resonators as a polarization-dependent optical insulator,are also consistent with the theoretical analyses. | Zhongfei XIONG Weijin CHEN Zhuoran WANG Jing XU Yuntian CHEN | 2021 | Frontiers of Optoelectronics2021，14，2： | 2 |
| 12 | Femtosecond laser-inscribed optical waveguides in dielectric crystals:a concise review and recent advances显示文摘Femtosecond laser inscription or writing has been recognized as a powerful technique to engineer various materials toward a number of applications.By efficient modification of refractive indices of dielectric crystals,optical waveguides with diverse configurations have been produced by femtosecond laser writing.The waveguiding properties depend not only on the parameters of the laser writing but also on the nature of the crystals.The mode profile tailoring and polarization engineering are realizable by selecting appropriate fabrication conditions.In addition,regardless of the complexity of crystal refractive index changes induced by ultrafast pulses,several three-dimensional geometries have been designed and implemented that are useful for the fabrication of laser-written photonic chips.Some intriguing devices,e.g.,waveguide lasers,wavelength converters,and quantum memories,have been made,exhibiting potential for applications in various areas.Our work gives a concise review of the femtosecond laser-inscribed waveguides in dielectric crystals and focuses on the recent advances of this research area,including the fundamentals,fabrication,and selected photonic applications. | Lingqi Li Weijin Kong Feng Chen | 2022 | Advanced Photonics2022，4，2： | 2 |
| 13 | Effects of doping FeCl3 on hydrogen storage properties of Li-N-H system显示文摘The effects of doping FeCl_3 on the LiNH_2-2LiH system were investigated systematically. FeCl_3 was prior to react with LiH during ball milling their mixtures. The metallic Fe, which is generated from metathesis reaction between FeCl_3 and LiH, plays an important role on improving the dehydrogenation kinetics of LiNH_2-2LiH system. The results indicated that the dehydrogenation peak and ending temperatures of the doped 1 mol%FeCl_3 sample shifted to low temperatures, and the dehydrogenation active energy changed from 102.45 k J/mol to 87.52 k J/mol. While increasing the amount of FeCl_3, an excess of LiCl, the by-product of metathesis reaction between FeCl_3 and Li H, can stabilize LiNH_2 and thus hinder hydrogen desorption. The dehydrogenation product is a new solid cubic phase solution of lithium imide-chloride. The high limit of the solid solution of LiCl and Li_2NH is near the molar ratio of 1:1. | Weijin Zhang Han Wang Hujun Cao Teng He Jianping Guo Guotao Wu Ping Chen | 2017 | Progress in Natural Science:Materials International2017，27，1： | 1 |
| 14 | Mobile Internet Mobile Agent System Dynamic Trust Model for Cloud Computing显示文摘In mobile cloud computing,trust is a very important parameter in mobile cloud computing security because data storage and data processing are performed remotely in the cloud.Aiming at the security and trust management of mobile agent system in mobile cloud computing environment,the Human Trust Mechanism(HTM)is used to study the subjective trust formation,trust propagation and trust evolution law,and the subjective trust dynamic management algorithm(MASTM)is proposed.Based on the interaction experience between the mobile agent and the execution host and the third-party recommendation information to collect the basic trust data,the public trust host selection algorithm is given.The isolated malicious host algorithm and the integrated trust degree calculation algorithm realize the function of selecting the trusted cluster and isolating the malicious host,so as to enhance the security interaction between the mobile agent and the host.Given algorithm simulation and verification were carried out to prove its feasibility and effectiveness. | Weijin Jiang Yang Wang Yirong Jiang Yuhui Xu Jiahui Chen Lina Tan Guo Liang | 2020 | Computers, Materials & Continua2020，，1： | 1 |
| 15 | Dispersion relation propagation length and mode conversion of surface plasmonpolaritons in silver double-nanowire systems显示文摘 | Sun Shulin Chen HungTing Zheng Weijin | 2013 | Opt Express2013，21，14： | 1 |
| 16 | Shape-induced phase transition of vortex domain structures in ferroelectric nanodots and their controllability by electrical and mechanical loads显示文摘Shape-induced phase transition of vortex domain structures(VDSs)in BaTiO_3(BT)nanodots under open circuit boundary condition have been investigated using an effective Hamiltonian method.Our calculation indicates the tetragonal VDS missing in cubic BT nanodots can be induced by varying the shape of a nanodot from cube to platelet.Interestingly,a novel VDS is found in BT nanoplatelets in our simulations.Further investigation shows that it is a result of compromise between the ground state and the symmetry of the shape of the nanodot.Furthermore,based on the novel VDS,routes of controlling VDSs governed by homogeneous electric field and uniform stress are discussed.In particular,our results show the possibility of designing multi-states devices based on a single VDS. | Jianyi Liu Weijin Chen Yue Zheng | 2017 | Theoretical & Applied Mechanics Letters2017，7，2： | 1 |
| 17 | In-situ weldalloying plasma arc welding of SiCp/Al MMCs 显示文摘 | Lei Yueheng Yuan Weijin Chen Xizhang | 2007 | Transactions Nonferrous Metals Society China2007，17，2： | 1 |
| 18 | SARS-CoV-2 spike-specific TFH cells exhibit unique responses in infected and vaccinated individuals显示文摘Long-term humoral immunity to SARS-CoV-2 is essential for preventing reinfection. The production of neutralizing antibody (nAb)and B cell differentiation are tightly regulated by T follicular help (T_(FH)) cells. However, the longevity and functional role of T_(FH) cellsubsets in COVID-19 convalescents and vaccine recipients remain poorly defined. Here, we show that SARS-CoV-2 infection andinactivated vaccine elicited both spike-specific CXCR3^(+) T_(FH) cell and CXCR3^(-) T_(FH) cell responses, which showed distinct responsepatterns. Spike- specific CXCR3^(+) T_(FH) cells exhibit a dominant and more durable response than CXCR3^(-) T_(FH) cells that positivelycorrelated with antibody responses. A third booster dose preferentially expands the spike-specific CXCR3^(+) T_(FH) cell subset inducedby two doses of inactivated vaccine, contributing to antibody maturation and potency. Functionally, spike-specific CXCR3^(+) T_(FH) cellshave a greater ability to induce spike-specific antibody secreting cells (ASCs) differentiation compared to spike-specific CXCR3^(-) T_(FH)cells. In conclusion, the persistent and functional role of spike-specific CXCR3^(+) T_(FH) cells following SARS-CoV-2 infection andvaccination may play an important role in antibody maintenance and recall response, thereby conferring long-term protection. Thefindings from this study will inform the development of SARS-CoV-2 vaccines aiming to induce long-term protective immunememory. | Rongzhang He Xingyu Zheng Jian Zhang Bo Liu Qijie Wang Qian Wu Ziyan Liur Fangfang Chang Yabin Hu Ting Xie Yongchen Liu Jun Chen Jing Yang Shishan Teng Rui Lu Dong Pan You Wang Liting Peng Weijin Huang Velislava Terzieva Wenpei Liu Youchun Wang Yi-Ping Li Xiaowang Qu | 2023 | Signal Transduction and Targeted Therapy2023，8，11： | 0 |
| 19 | Controlling polar-toroidal multi-order states in twisted ferroelectric nanowires显示文摘The toroidal order of electric dipoles in ferroelectric materials has attracted attention in the past decade due to fascinating properties and great potential for enabling novel memory devices,and functional devices in general.However,facile manipulation of toroidal order in ferroelectrics remains challenging.Here,using first-principles derived simulations,we demonstrate an efficient scheme to control the polar-toroidal multi-order(PTMO)states in ferroelectric nanowires.Two feasible strategies of controlling PTMO states by a combination of homogeneous electric field and torque are carried out in ferroelectric/paraelectric composite nanowires.This is possible based on trilinear coupling between polarization,toroidization and the twist force.As a result,switching of the toroidization of the nanowire can be readily achieved by reversal of the axial polarization.The torque threshold needed to control PTMO states is also calculated and found to be relatively small,indicating the feasibility of this method.Our study demonstrates facile control of PTMO states,including ferroelectric skyrmions,in ferroelectrics and is a step towards designing ferroelectric devices based on multi-order states. | Jianyi Liu Ye Ji Shuai Yuan Lili Ding Weijin Chen Yue Zheng | 2018 | npj Computational Materials2018，，1： | 0 |
| 20 | Mild-condition synthesis of A2ZnH4(A = K, Rb, Cs) and their effects on the hydrogen storage properties of 2LiH-Mg(NH2)2显示文摘In this paper, A2ZnH4(A = K, Rb and Cs) have been synthesized for the first time by a new approach involving in two-step reactions, in which the target samples can be produced under mild conditions(160 ℃ for 4 h). What’s more, the additive effects of A2ZnH4 on the hydrogen storage properties of 2LiH-Mg(NH2)2 composite have been investigated systematically. Experimental results show that K2ZnH4 has the best comprehensive modification effects among these hydrides. The 2LiH-Mg(NH2)2-0.1 K2ZnH4 sample shifts dehydrogenation peak temperature downwards by ca. 30 ℃ as compared to the pristine sample. In addition, about 70% extent of the theoretical hydrogen is able to desorb from the 0.1 K2ZnH4 doped sample at 140 ℃ within 2 h, however, only 20% extent of hydrogen is liberated from the pure sample under the same conditions. The improved desorption kinetics is indicated by the reduced dehydrogenation activation energy(Ea), the Ea of the 0.1 K2ZnH4 doped sample is around 68 ± 1.0 kJ mol-1 which is 28% lower than that of the pristine one. Furthermore, the dehydrogenation mechanism of the K2ZnH4 doped sample has been proposed. | Jirong Cui Weijin Zhang Hujun Cao Ping Chen | 2020 | Journal of Energy Chemistry2020，29，11： | 0 |
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