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| 1 | Trends of foodborne diseases in China: lessons from laboratory- based surveillance since 2011显示文摘Foodborne 疾病是世界范围的最重要的公共健康问题之一。中国在食物链的所有方面面对各种各样、崭新的挑战。从从 2013 ~ 2016 的基于实验室的 foodborne 疾病监视系统的数据,以及不同区域和年龄,能在与多样的特征检测的病原体的模式与差别一起被发现。Vibrio parahaemolyticus 是在中国的传染腹泻的领先的原因,特别在在沿海的区域的成年人之中。沙门氏菌是为实质的社会经济的负担负责的严肃、广泛地分布式的病原体。Shigella 主要在 5 年下面在孩子之中与开发更少的区域在西北中国和内陆省(河南省) 被识别。从从 2011 ~ 2016 报导系统的 foodborne 疾病爆发的数据证明有毒的动物和为大多数死亡负责的植物因素在在西南区域的遥远的区域是有毒的蘑菇(54.7%) 。引起了报导的大多数案例(42.3%) 的生物危险被归因于 V。parahaemolyticus, foodborne 爆发的领先的原因。在这评论,我们在中国总结最近的监视途径到 foodborne 疾病并且在发达国家把结果与那些作比较。 | Jikai Liu Li Bai Weiwei Li Haihong Han Ping Fu Xiaochen Ma Zhenwang Bi Xiaorong Yang Xiuli Zhang Shiqi Zhen Xiaoling Deng Xiumei Liu Yunchang Guo | 2018 | Frontiers of Medicine2018，12，1： | 55 |
| 2 | Ice-Templated Fabrication of Porous Materials with Bioinspired Architecture and Functionality显示文摘CONSPECTUS:Biological porous materials,such as polar bear hair,wood,bamboo,and cuttlebone,exhibit outstanding thermal and mechanical properties due to their hierarchical architectures.Specifically,polar bears can retain thermal homeostasis in the extremely cold Arctic due to outstanding thermal insulation property of their porous hairs;wood and bamboo exhibit excellent mechanical strength,highly efficient water and nutrient transport capacity,and low density due to their hierarchically aligned porous architecture;cuttlebone can resist large hydrostatic pressure in the deep-sea environment due to its mechanically efficient porous structure with lamellar septa connected by asymmetrically S-shaped walls. | Meng Li Xuangeng Dai Weiwei Gao Hao Bai | 2022 | Accounts of Materials Research2022，3，11： | 2 |
| 3 | Physics issues in diffraction limited storage ring design显示文摘Diffraction limited electron storage ring is considered a promising candidate for future light sources,whose main characteristics are higher brilliance,better transverse coherence and better stability.The challenge of diffraction limited storage ring design is how to achieve the ultra low beam emittance with acceptable nonlinear performance.Effective linear and nonlinear parameter optimization methods based on Artificial Intelligence were developed for the storage ring physical design.As an example of application,partial physical design of HALS(Hefei Advanced Light Source),which is a diffraction limited VUV and soft X-ray light source,was introduced.Severe emittance growth due to the Intra Beam Scattering effect,which is the main obstacle to achieve ultra low emittance,was estimated quantitatively and possible cures were discussed.It is inspiring that better performance of diffraction limited storage ring can be achieved in principle with careful parameter optimization. | FAN Wei BAI ZhengHe GAO WeiWei FENG GuangYao LI WeiMin WANG Lin HE DuoHui | 2012 | Science China(Physics,Mechanics & Astronomy)2012，55，5： | 2 |
| 4 | Efficacy,safety and immunogenicity of hexavalent rotavirus vaccine in Chinese infants显示文摘A randomized,double-blind,placebo-controlled multicenter trial was conducted in healthy Chinese infants to assess the efficacy and safety of a hexavalent live human-bovine reassortant rotavirus vaccine(HRV)against rotavirus gastroenteritis(RVGE).A total of 6400 participants aged 6-12 weeks were enrolled and randomly assigned to either HRV(n?3200)or placebo(n?3200)group.All the subjects received three oral doses of vaccine four weeks apart.The vaccine efficacy(VE)against RVGE caused by rotavirus serotypes contained in HRV was evaluated from 14 days after three doses of administration up until the end of the second rotavirus season.VE against severe RVGE,VE against RVGE hospitalization caused by serotypes contained in HRV,and VE against RVGE,severe RVGE,and RVGE hospitalization caused by natural infection of any serotype of rotavirus were also investigated.All adverse events(AEs)were collected for 30 days after each dose.Serious AEs(SAEs)and intussusception cases were collected during the entire study.Our data showed that VE against RVGE caused by serotypes contained in HRV was 69.21%(95%CI:53.31-79.69).VE against severe RVGE and RVGE hospitalization caused by serotypes contained in HRV were 91.36%(95%CI:78.45-96.53)and 89.21%(95%CI:64.51-96.72)respectively.VE against RVGE,severe RVGE,and RVGE hospitalization caused by natural infection of any serotype of rotavirus were 62.88%(95%CI:49.11-72.92),85.51%(95%CI:72.74-92.30)and 83.68%(95%CI:61.34-93.11).Incidences of AEs from the first dose to one month post the third dose in HRV and placebo groups were comparable.There was no significant difference in incidences of SAEs in HRV and placebo groups.This study shows that this hexavalent reassortant rotavirus vaccine is an effective,well-tolerated,and safe vaccine for Chinese infants. | Zhiwei Wu Qingliang Li Yan Liu Huakun Lv Zhaojun Mo Fangjun Li Qingchuan Yu Fei Jin Wei Chen Yong Zhang Teng Huang Xiaosong Hu Wei Xia Jiamei Gao Haisong Zhou Xuan Bai Yueyue Liu Zhenzhen Liang Zhijun Jiang Yingping Chen Jiuwei Zhang Jialiang Du Biao Yang Bo Xing Yantao Xing Ben Dong Qinghai Yang Chen Shi Tingdong Yan Bo Ruan Haiyun Shi Xingliang Fan Dongyang Feng Weigang Lv Dong Zhang Xiangchu Kong Liuyifan Zhou Dinghong Que Hong Chen Zhongbing Chen Xiang Guo Weiwei Zhou Cong Wu Qingrong Zhou Yuqing Liu Jian Qiao Ying Wang Xinguo Li Kai Duan Yuliang Zhao Gelin Xu Xiaoming Yang | 2022 | Virologica Sinica2022，37，5： | 2 |
| 5 | Gold nanoparticles-mesoporous silica composite used as an enzyme immobilization matrix for amperometric glucose biosensor construction显示文摘 | BAI Yu YANG Hua YANG Weiwei | 2007 | Sensors and Actuators B2007，124，： | 1 |
| 6 | Research and applica- tion of a new emulsified collector on flotation 显示文摘 | Zhu Shuquan Bai Yana Xie Weiwei | 2009 | Procedia Earth and Planetary Science2009，1，1： | 1 |
| 7 | Hydrothermal synthesis of large-sized hydroxyapatite whiskers regulated by glutamic acid in solutions with low supersaturation of precipitation显示文摘 | Chengfeng Li Shuguang Liu Guochang Li Jiahai bai Weiwei Wang Qingyang Du | 2010 | Advanced Powder Technology2010，，4： | 1 |
| 8 | Energy-absorbing porous materials:Bioinspired architecture and fabrication显示文摘Energy-absorbing materials are widely used in transportations,sports,and the military applications.Particularly,porous materials,including natural and artificial materials,have attracted tremendous attentions due to their light weight and excellent energy absorption capability.This review summarizes the recent progresses in the natural and artificial energy-absorbing porous materials.First,we review the typical natural porous materials including cuttlebone,bighorn sheep horn,pomelo peel,and sunflower stem pith.The architectures,energy absorption abilities,and mechanisms of these typical natural materials and their bioinspired materials are summarized.Then,we provide a review on the fabrication methods of artificial energy-absorbing porous materials,such as conventional foaming and three-dimensional(3D)printing.Finally,we address the challenges and prospects for the future development of energy-absorbing porous materials.More importantly,our review provides a direct guidance for the design and fabrication of energy-absorbing porous materials required for various engineering applications. | Junheng Zhao Meng Li Jiewei Chen Weiwei Gao Hao Bai | 2024 | Nano Research2024，17，2： | 1 |
| 9 | Enzyme-free glucose sensor based on a three-dimensional gold film electrode显示文摘 | Yu Bai Weiwei Yang Ying Sun Changqing Sun | 2008 | Sensors & Actuators: B Chemical2008，，2： | 1 |
| 10 | Predicting plant-soil N cycling and soil N_(2)O emissions in a Chinese old-growth temperate forest under global changes:uncertainty and implications显示文摘Soil-emitted N_(2)O contributes to two-thirds of global N_(2)O emissions,and is sensitive to global change.We used DayCent model to simulate major plant-soil N cycling processes under different global change scenarios in a typical temperate mixed forest in north-eastern China.Simulated scenarios included warming(T),elevated atmospheric CO_(2) concentration([CO_(2)])(C),increased N deposition(N)and precipitation(P),and their full factorial combinations.The responses of plant-soil nitrogen cycling processes including net N mineralization,plant N uptake,gross nitrification,denitrification and soil N_(2)O emission were examined.Concurrent increase of elevated[CO_(2)]and N deposition displayed most strong interactive effects on most fluxes.Using the results from experimental studies for evaluation,simulation uncertainty was highest under elevated[CO_(2)]and increased precipitation among the four global change factors.N deposition had a fundamental impact on soil N cycle and N_(2)O emission in our studied forest.Despite forest soil acting as a N sink for added N,scenarios which included increased N deposition showed higher cumulative soil N_(2)O emissions(summed up from 2001 to 2100).In particular,the scenario which included T,P,and N had the largest cumulative soil N_(2)O emission,which was a 24.4% increase over that under ambient conditions.Our study points to the importance of the interactive effects of global change factors on plant-soil N cycling and the necessity of multi-factor manipulation experiments. | Weiwei Dai Edith Bai Wei Li Ping Jiang Guanhua Dai Xingbo Zheng | 2020 | Soil Ecology Letters2020，2，1： | 1 |
| 11 | Amperometric nitrite sensor based on hemoglobin/colloidal gold nanoparticles immobilized on a glassy carbon electrode by a titania sol-gel film显示文摘 | YANG Weiwei BAI Yu LI Yancai | 2005 | Anal Bioanal Chem2005，382，： | 1 |
| 12 | Research and application of radiant heating system with domestic components for large space structure显示文摘 | Luo Jijie Bai Xiaobu Hu Weiwei | 2002 | Nuantong Kongtiao2002，32，6： | 1 |
| 13 | A new species of ice crawlers from Burmese amber(Insecta:Grylloblattodea)显示文摘Modern grylloblattids are one of the least diverse insect orders.The single extant family is contrasted with 46 families described from the fossil records,which extend to the Late Carboniferous.The most ancient grylloblattid nymphs are known from the Lower Permian.Till now,there is no report on grylloblattid from Burmese amber,which is a very old amber locality.Herein,we describe Sylvalitoralis cheni Zhang,Bai & Yang,sp.nov.from Grylloblattina based on a nymph specimen from the mid-Cretaceous Myanmar(Burmese) amber. | Weiwei Zhang Mingxia Guo Xingke Yang Ming Bai | 2016 | Zoological Systematics2016，41，3： | 1 |
| 14 | Strategies for training optical neural networks显示文摘Deep learning has flourished in different areas in recent years,such as computer vision and natural language processing.However,with the end of Moore’s law,these applications that rely heavily on computing power are facing bottlenecks.Optical neural networks(ONNs)[1]use light to perform calculations[2,3]featuring high speed and low energy consumption,and they are widely regarded as the next-generation applicationspecific integrated circuit(ASIC)[4,5]for artificial intelligence. | Qipeng Yang Bowen Bai Weiwei Hu Xingjun Wang | 2022 | National Science Open2022，1，3： | 0 |
| 15 | Pathogen-associated T follicular helper cell plasticity is critical in anti-viral immunity显示文摘T follicular helper(Tfh)cells are critical in providing help for B cells in the germinal center reaction.Tfh cell plasticity,especially with regard to their expression of effector Th cytokines,has been described,but lacks in-depth analysis with genetic approaches.In this study,we systemically compared transcriptomic profiles of Tfh cells derived from various types of immune responses and found gene clusters corresponding to effector Th cells were differentially induced in response to pathogens or immune responses.Of special interest,a subset of Tfh cells producing IFN-γwas generated in an influenza virus infection,partially dependent on the innate cytokine IL-12.Lineage-tracing mouse model revealed unique developmental regulation of IFN-γ~+Tfh cells,while selective ablation of these cells impaired the induction of Ig G2c~+germinal center B cells and the control of influenza infection.These results indicate that pathogen-associated Tfh cell plasticity is necessary for host immunity,which has implications in vaccine design. | Han Feng Xiaohong Zhao Jenny Xie Xue Bai Weiwei Fu Hairong Chen Hong Tang Xiaohu Wang Chen Dong | 2022 | Science China(Life Sciences)2022，65，6： | 0 |
| 16 | Bovine HSD17B8 gene and its relationship with growth and meat quality traits显示文摘17 b-Hydroxysteroid dehydrogenase type 8(HSD17B8) is an important regulator of lipid and steroid metabolism. In the present study, we aimed to assess the effects of HSD17B8 on growth and meat quality traits in cattle. Transcription profile analysis showed that HSD17B8 was primarily expressed in the salpinx, liver, and testis.Meanwhile, we identified three SNPs(SNP1: intron1-A91G; SNP2: exon 1-A90G; and SNP3: intron 8-A86G)of the bovine HSD17B8 gene and investigated its haplotype frequencies and linkage disequilibrium. The detected SNPs were found associated with growth traits(body weight,body length, height at withers, heart girth, hip width, and average daily gain) in native cattle populations(Nanyangand Jiaxian) as well as the meat quality traits(Warner–Bratzler shear force, rib area, dressing percentage, carcass weight, and backfat thickness) in commercial breeds(Angus, Hereford, Limousin, Luxi, Simmental, and Jinnan).Our results provided evidence that polymorphisms in the HSD17B8 gene were associated with growth traits and meat quality traits. Moreover, our findings might be used for marker-assisted selection in beef cattle breeding program. | Yun Ma Ningbo Chen Fen Li Weiwei Fu Yapeng Han Yanlin Chang Xiangxiang Jiang Junya Li Yueyu Bai Xuxin Tan | 2015 | Science Bulletin2015，60，18： | 0 |
| 17 | Transplantation of neural stem progenitor cells from different sources for severe spinal cord injury repair in rat显示文摘Neural stem progenitor cell(NSPC)transplantation has been regarded as a promising therapeutic method for spinal cord injury(SCI)repair.However,different NSPCs may have different therapeutic effects,and it is therefore important to identify the optimal NSPC type.In our study,we compared the transcriptomes of human fetal brain-derived NSPCs(BNSPCs),spinal cord-derived NSPCs(SCNSPCs)and H9 embryonic stem-cell derived NSPCs(H9-NSPCs)in vitro and subsequently we transplanted each NSPC type on a collagen scaffold into a T8-9 complete SCI rat model in vivo.In vitro data showed that SCNSPCs had more highly expressed genes involved in nerve-related functions than the other two cell types.In vivo,compared with BNSPCs and H9-NSPCs,SCNSPCs exhibited the best therapeutic effects;in fact,SCNSPCs facilitated electrophysiological and hindlimb functional recovery.This study demonstrates that SCNSPCs may be an appropriate candidate cell type for SCI repair,which is of great clinical significance. | Bai Xu Man Yin Yaming Yang Yunlong Zou Wenbin Liu Lianyong Qiao Jixiang Zhang Zhan Wang Yayu Wu He Shen Minghan Sun Weiyuan Liu Weiwei Xue Yongheng Fan Qi Zhang Bing Chen Xianming Wu Ya Shi Falong Lu Yannan Zhao Zhifeng Xiao Jianwu Dai | 2023 | Bioactive Materials2023，，5： | 0 |
| 18 | Engineered human spinal cord-like tissues with dorsal and ventral neuronal progenitors for spinal cord injury repair in rats and monkeys显示文摘Transplanting human neural progenitor cells is a promising method of replenishing the lost neurons after spinal cord injury (SCI), but differentiating neural progenitor cells into the diverse types of mature functional spinal cord neurons in vivo is challenging. In this study, engineered human embryonic spinal cord-like tissues with dorsal and ventral neuronal characters (DV-SC) were generated by inducing human neural progenitor cells (hscNPCs) to differentiate into various types of dorsal and ventral neuronal cells on collagen scaffold in vitro. Transplantation of DV-SC into complete SCI models in rats and monkeys showed better therapeutic effects than undifferentiated hscNPCs, including pronounced cell survival and maturation. DV-SC formed a targeted connection with the host’s ascending and descending axons, partially restored interrupted neural circuits, and improved motor evoked potentials and the hindlimb function of animals with SCI. This suggests that the transplantation of pre-differentiated hscNPCs with spinal cord dorsal and ventral neuronal characteristics could be a promising strategy for SCI repair. | Bai Xu Dingyang Liu Weiyuan Liu Ge Long Wenbin Liu Yayu Wu Xinghui He Yeyu Shen Peipei Jiang Man Yin Yongheng Fan He Shen Liyang Shi Qi Zhang Weiwei Xue Chen Jin Zhenni Chen Bing Chen Jiayin Li Yali Hu Xing Li Zhifeng Xiao Yannan Zhao Jianwu Dai | 2023 | Bioactive Materials2023，，9： | 0 |
| 19 | Geophysical Evidence for Carbonate Platform Periphery Gravity Flows in the Xisha Islands,South China Sea显示文摘High-resolution bathymetric and partial seismic data were utilized to determine the characteristics and distribution of mass-transport deposits(MTDs)in the Xisha area,North of the South China Sea.Many isolated carbonate platforms are found in this area,providing mass-wasting materials as a sediment source for MTDs.The MTDs in the study area were divided into three types(slide,slump,and debris flow)based on their rheological properties.The MTDs were mostly distributed at the toe of the carbonate platform slope,where a large amount of carbonate debris accumulated.A total of 32 MTDs were identified on the carbonate platform slopes.A systematic assessment of the MTD morphometric parameters showed that their total area covered 2225.2 km2,with the largest MTD covering 354.1 km2.These MTDs differ largely from the MTDs of other areas,especially in terms of sediment compositions and deposit processes.Gullies and channels on the slope and reefs on the top of the platform act as sediment conduits and carbonate-producing sources,respectively,playing vital roles in the distribution and generation of gravity flow deposits.The development model proposed in this work states that reefs disintegrate into carbonate debris and mix with seawater to form gravity flows,which scour the seafloor and accumulate at the downslope,eventually resulting in failure.Sediments from these failures turn into gravity flows,flowing into submarine canyons and channels.The results of this research further our understanding of the development pattern of MTDs in a carbonate setting. | BAI Hongxin SUN Yue WANG Dawei WANG Weiwei WU Shiguo | 2022 | Journal of Ocean University of China2022，21，4： | 0 |
| 20 | Immunomodulatory activity of polysaccharides from Brassica rapa by activating Akt/NF-κB signaling显示文摘Objective:To investigate the immunomodulatory activity of polysaccharides from the roots of Brassica rapa.Methods:The crude polysaccharide from roots of B.rapa(BRP)was extracted and purified to further investigate the active fraction of BRT for inducing macrophage phagocytosis.Results:Effects on RAW264.7 cells demonstrated that BRP behaved better phagocytic capacity and had potent immunomodulatory activity,including increasing production of nitric oxide(NO),tumor necrosis factor a(TNFa)and upregulating mRNA levels of inducible NO synthase(iNOS)and TNFa.Furthermore,modulation of macrophage by BRP was indicated to be mediated via the activation of Akt and nuclear factor-kappa B(NF-κB).Conclusion:The beneficial effects of BRP could be used as an immunotherapeutic adjuvant in treatment of inflammatory diseases. | Weiwei Guo Qianxiao Zhang Yu Du Junting Guo Tingting Zhao Liping Bai Xiqiang An | 2022 | Chinese Herbal Medicines2022，14，1： | 0 |
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