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| 1 | Identification of immunoreactive proteins of Brucella melitensis by immunoproteomics显示文摘Infection with Brucella causes brucellosis, a chronic disease in humans, which induces abortion and sterility in livestock. Among the different Brucella species, Brucella melitensis is considered the most virulent and is the predominant species associated with outbreaks in China. To date, no safe human vaccine is available against Brucella infection. The currently used live vaccines against Brucella in livestock induce antibodies that interfere with the diagnosis of field infection in vaccinated animals, which is harmful to eradication programs. However, there is as yet no complete profile of immunogenic proteins of B. melitensis. Towards the development of a safer, equally efficacious, and field infection-distinguishable vaccine, we used immunoproteomics to identify novel candidate immunogenic proteins from B. melitensis M5. Eighty-eight immunoreactive protein spots from B. melitensis M5 were identified by Western blotting and were assigned to sixty-one proteins by mass spectrometry, including many new immunoreactive proteins such as elongation factor G, F0F1 ATP synthase subunit beta, and OMP1. These provide many candidate immunoreactive proteins for vaccine development. | ZHAO ZhongPeng YAN Fang JI WenHui LUO DeYan LIU Xin XING Li DUAN YueQiang YANG PengHui SHI XiuMin LI Zhong WANG XiLiang | 2011 | Science China(Life Sciences)2011，54，9： | 12 |
| 2 | Adjusting the SnZn defects in Cu_(2)ZnSn(S,Se)_(4) absorber layer via Ge^(4+) implanting for efficient kesterite solar cells显示文摘The development of kesterite photovoltaic solar cells has been hindered by large open-circuit voltage(V_(oc))deficit.Recently,Snzn deep point defect and associative defect cluster have been recognized as the main culprit for the Voc losses.Therefore,manipulating the deep-level donor of Snzn antisite defects is crucial for breaking through the bottleneck of present Cu_(2) ZnSn(S,Se)_(4)(CZTSSe)photovoltaic technology.In this study,the Snzn deep traps in CZTSSe absorber layer are suppressed by incorporation of Ge.The energy levels and concentration of Snzn defects measured by deep-level transient spectroscopy(DLTS)decrease significantly.In addition,the grain growth of CZTSSe films is also promoted due to Ge implantation,yielding the high quality absorber layer.Consequently,the efficiency of CZTSSe solar cells increases from 9.15%to 11.48%,largely attributed to the 41 mV Voc increment. | Yueqing Deng Zhengji Zhou Xin Zhang Lei Cao Wenhui Zhou Dongxing Kou Yafang Qi Shengjie Yuan Zhi Zheng Sixin Wu | 2021 | Journal of Energy Chemistry2021，30，10： | 4 |
| 3 | Towards intelligent design optimization: Progress and challenge of design optimization theories and technologies for plastic forming显示文摘Plastic forming is one of enabling and fundamental technologies in advanced manufacturing chains. Design optimization is a critical way to improve the performance of the forming system, exploit the advantages of high productivity, high product quality, low production cost and short time to market and develop precise, accurate, green, and intelligent(smart) plastic forming technology. However, plastic forming is quite complicated, relating to multi-physics field coupling,multi-factor influence, multi-defect constraint, and triple nonlinear, etc., and the design optimization for plastic forming involves multi-objective, multi-parameter, multi-constraint, nonlinear,high-dimensionality, non-continuity, time-varying, and uncertainty, etc. Therefore, how to achieve accurate and efficient design optimization of products, equipment, tools/dies, and processing as well as materials characterization has always been the research frontier and focus in the field of engineering and manufacturing. In recent years, with the rapid development of computing science, data science and internet of things(Io T), the theories and technologies of design optimization have attracted more and more attention, and developed rapidly in forming process. Accordingly, this paper first introduced the framework of design optimization for plastic forming. Then, focusing on the key problems of design optimization, such as numerical model and optimization algorithm,this paper summarized the research progress on the development and application of the theories and technologies about design optimization in forming process, including deterministic and uncertain optimization. Moreover, the applicability of various modeling methods and optimization algorithms was elaborated in solving the design optimization problems of plastic forming. Finally, considering the development trends of forming technology, this paper discusses some challenges of design optimization that may need to be solved and faced in forming process. | Heng LI Jingchao YANG Guangyao CHEN Xin LIU Zhao ZHANG Guangjun LI Wenhui LIU | 2021 | Chinese Journal of Aeronautics2021，34，2： | 4 |
| 4 | Landing site topographic mapping and rover localization for Chang’e-4 mission显示文摘This paper presents the techniques and results of landing-site topographic mapping and rover localization using orbital,descent and rover images in the Chang’e-4 mission.High-resolution maps of the landing site are generated from orbital and descent images.Local digital elevation models and digital orthophoto maps with 0.02 m resolution are generated at each waypoint.The location of the lander is determined as(177.588?E,45.457?S)using festure-matching techniques.The cross-site visual localization method is routinely used to localize the rover at each waypoint to reduce error accumulation from wheel slippage and IMU drift in dead reckoning.After the first five lunar days,the rover travels 186.66 m from the lander,according to the cross-site visual localization.The developed methods and results have been directly utilized to support the mission’s operations.The maps and localization information are also valuable for supporting multiple scientific explorations of the landing site. | Zhaoqin LIU Kaichang DI Jian LI Jianfeng XIE Xiaofeng CUI Luhua XI Wenhui WAN Man PENG Bin LIU Yexin WANG Sheng GOU Zongyu YUE Tianyi YU Lichun LI Jia WANG Chuankai LIU Xin XIN Mengna JIA Zheng BO Jia LIU Runzhi WANG Shengli NIU Kuan ZHANG Yi YOU Bing LIU Jiangang LIU | 2020 | Science China(Information Sciences)2020，63，4： | 3 |
| 5 | A COVID-19 Outbreak Emerging in a Food Processing Company——Harbin City,Heilongjiang Province,China,January-February 2021显示文摘Summary What is already known about this topic?The coronavirus disease 2019(COVID-19)epidemic in China had been effectively controlled for several months,but as the ambient temperature dropped,large gathering-initiated epidemics occurred in northern China,including Hebei,Liaoning,and Jilin provinces. | Lei Hou Hao Zhou Nanxi Meng Xue Yu Xin Wang Tuo Wang Jianfeng Zhang Yan Wang Shie Li Shuzhen Guo Jianxing Yu Muxin Chen Wenhui Shi Ning Xiao Chao Yang Jianxiang Liu | 2021 | China CDC weekly2021，3，32： | 2 |
| 6 | Rapid and specific isolation of intact mitochondria from Arabidopsis leaves显示文摘Mitochondria carry out many essential metabolic processes, the dynamic of which impacts most aspects of cellular physiology(Balk and Leaver, 2001;Rose and Sheahan, 2012). Therefore, characterizing the real-time metabolism of mitochondria is of great biological significance. | Lilan Luo Yajun He Qian Xu Wenhui Lyu Jijun Yan Peiyong Xin Dahan Zhang Jinfang Chu Jiayang Li Hong Yu | 2020 | Journal of Genetics and Genomics2020，47，1： | 1 |
| 7 | Three-dimensional electrical resistivity structure beneath the Cuonadong dome in the Northern Himalayas revealed by magnetotelluric data and its implication显示文摘The North Himalayan gneiss domes(NHGD),as one of the extensional structures widely distributed across the southern Tibetan Plateau,are an important window for studying post-collisional diastrophism and magmation as well as polymetallic mineralization.However,the deep mechanism for the formation of NHGD remains controversial.The magnetotelluric(MT)method was adopted to study the deep structure of the Cuonadong dome in the Northern Himalayas.The characteristics of the dome were explored by using the MT sounding curves and phase tensors.Three-dimensional(3D)MT inversion was performed to determine the electrical resistivity structure beneath the Cuonadong dome.The preferred 3D electrical resistivity model shows that an obvious low-resistivity anomaly develops beneath the Cuonadong dome which is overlaid by a high-resistivity body and surrounded by an apparent subcircular zone of low-resistivity anomalies.The integrated conductivity(longitudinal conductance)from depths of 1-20 km indicates that the average longitudinal conductance at the core of the Cuonadong dome is about 10,000 S.The high-conductivity anomaly at the core is found to be analogous to that of lava,mainly resulting from the crustal partial melting,and the estimated melt content is 11.0-17.3%.The high conductance surrounding the dome reaches 20,000 S on average,which is mainly attributed to saline fluids.MT results in this study support that the Cuonadong dome experienced magmatic diapirism.Taken together with previous geological and geochemical studies,we suggest that under the east-west(E-W)extensional tectonic setting in southern Tibet,deep crustal partial melting constantly accumulated beneath the dome,and therefore the magmatic diapirism resulted in the formation of the Cuonadong dome.In addition,the MT results also indicate that the development of the Cuonadong dome provides abundant mineralizing fluids and the space for migration of metallogenic fluids for(rare-metal)polymetallic mineralization. | Shuai XUE Zhanwu LU Wenhui LI Hongda LIANG Guangwen WANG Haiyan WANG Hongqiang LI Xin LI | 2022 | Science China Earth Sciences2022，65，8： | 1 |
| 8 | Homing and differentiation of mesenchymal stem cells delivered intravenously to ischemic myocardium in vivo: a time-series study显示文摘 | Wenhui Jiang Aiqun Ma Tingzhong Wang Ke Han Yu Liu Yanmin Zhang Anping Dong Yuan Du Xin Huang Jun Wang Xinjun Lei Xiaopu Zheng | 2006 | Pflügers Archiv - European Journal of Physiology2006，，1： | 1 |
| 9 | Analyzing Early Market Potential and Strategies for Carpooling in China: A Case Study of Wuhan 显示文摘 | Wenhui Xin Shtmying Zhu Hong Wang Yongfei Yah | 2009 | 978- 1-4244 -4639-1/09@ IEEE2009，，： | 1 |
| 10 | Preparation and properties of rare earth co-doped Ce 0.8 Sm 0.2? x Y x O 1.9 electrolyte materials for SOFC显示文摘 | Xueqing Sha Zhe Lü Xiqiang Huang Jipeng Miao Li Jia Xianshuang Xin Wenhui Su | 2006 | Journal of Alloys and Compounds2006，，1： | 1 |
| 11 | Pomelo Peel-Inspired 3D-Printed Porous Structure for Efficient Absorption of Compressive Strain Energy显示文摘The porous structure in pomelo peel is believed to be responsible for the protection of its fruit from damage during the free falling from a tree.The quantitative understanding of the relationship between the deformation behavior and the porous structure could pave the way for the design of porous structures for efficient energy absorption.Here,a universal feature of pore distribution in pomelo peels along the radial direction is extracted from three varieties of pomelos,which shows strong correlation to the deformation behavior of the peels under compression.Guided by the porous design found in pomelo peels,porous polyether-ether-ketone(PEEK)cube is additively manufactured and possesses the highest ability to absorb energy during compression as compared to the non-pomelo-inspired geometries,which is further confirmed by the finite element simulation.The nature-optimized porous structure revealed here could guide the design of lightweight and high-energy-dissipating materials/devices. | Baisong Yang Wenhui Chen Renlong Xin Xiaohong Zhou Di Tan Chuan Ding You Wu Liang Yin Chuyang Chen Shan Wang Zhenglei Yu Jonathan TPham Sheng Liu Yifeng Lei Longjian Xue | 2022 | Journal of Bionic Engineering2022，19，2： | 1 |
| 12 | Integrated UV-based photo microreactor-distillation technology toward process intensification of continuous ultra-high-purity electronic-grade silicon tetrachloride manufacture显示文摘Ultra-high-purity silicon tetrachloride(SiCl4)is demanded as an electronic-grade chemical to meet the stringent requirements of the rapidly developing semiconductor industry.The high requirement for ultra-high-purity SiCl4 has created the need for a high-efficient process for reducing energy consumption as well as satisfying product quality.In this paper,a mass of production technology of ultra-high-purity SiCl4 was successfully developed through chlorination reaction in the ultraviolet(UV)-based photo microreactor coupled with the distillation process.The influences of key operational parameters,including temperature,pressure,UV wavelength and light intensity on the product quality,especially for hydrogen-containing impurities,were quantified by the infrared transmittance of Fourier transform infrared spectroscopy(FT-IR)at 2185 cm^-1and 2160 cm^-1indicating that chara cteristic vib rational modes of Si-H bonds,as well as the operating conditions of distillation were also investigated as key factors for metal impurities removing.The advanced intensification of SiCl4 manufactured by the integration of photo microreactor and distillation achieves the products with superior specifications higher than the standard commercial products. | Ye Wan Wenhui Guo Jin Xiao Dazhou Yan Xiong Zhao Shuhu Guo Jianhua Liu Qifan Zhong Tao Yang Yu Zhao Xin Chang Xin Gao | 2020 | Chinese Journal of Chemical Engineering2020，28，9： | 1 |
| 13 | Studies on swelling behaviors, mechanical properties, network parameters and thermodynamic interaction of water sorption of 2-hydroxyethyl methacrylate/novolac epoxy vinyl ester resin copolymeric hydrogels显示文摘 | Zhihui Lin Wenhui Wu Jianquan Wang Xin Jin | 2006 | Reactive and Functional Polymers2006，，9： | 1 |
| 14 | β-Ga2O3 MOSFETs on the Si substrate fabricated by the ion-cutting process显示文摘β-Ga2O3 MOSFETs are demonstrated on heterogeneous Ga2O3-Al2O3-Si(GaOISi)substrate fabricated by ion-cutting process.Enhancement(E)-and depletion(D)-modeβ-Ga2O3 transistors are realized on by varying the channel thickness(Tch).E-mode GaOISi transistor with a Tchof 15 nm achieves a high threshold voltage VTHof^8 V.With the same T increase,GaOISi transistors demonstrate more stable ON-current IONand OFF-current IOFFperformance compared to the reported devices on bulk Ga2O3 wafer.Transistors on GaOISi achieve the breakdown voltage of 522 and 391 V at 25°C and 200°C,respectively. | YiBo Wang WenHui Xu TianGui You FengWen Mu HaoDong Hu Yan Liu Hao Huang Tadatomo Suga GenQuan Han Xin Ou Yue Hao | 2020 | Science China(Physics,Mechanics & Astronomy)2020，63，7： | 1 |
| 15 | Surface oxide analysis of lead-free solder particles 显示文摘 | Luo Xin Du Wenhui Lu Xiuzhen | 2013 | Soldering & Surface Mot nt Technology2013，25，1： | 1 |
| 16 | Research of processing techniques used in fabrication of solid oxide fuel cells and study of their selected properties显示文摘 | Jiang Liu Zhe Lü Wei Liu Li Pei Xin Zhao Li Jia Yanbin Song Xiaomei Liu Lanying He Wenhui Su | 1998 | Science in China Series A: Mathematics1998，，5： | 1 |
| 17 | Study of a wireless power transmission system for active capsule endo- scope 显示文摘 | Xin Wenhui Yan Guozheng Wang Wenxin | 2010 | International Journal of Medical Robotics and Computer Assisted Surgery2010，6，1： | 1 |
| 18 | Involvement of insulin in early development of mouse one-cell stage embryos显示文摘Recent studies have suggested that growth factors and hormones play important roles in cell prolif-eration and differentiation during early embryonic development. In the present study, we examined the expression and localization of insulin in the mouse oocytes and one-cell stage embryos by quantitative ELISA, RT-PCR, Western blot and immunofluorescence. In the mouse oocytes and one-cell stage em-bryos, expression of insulin was uniformly distributed in the cytoplasm. We also examined the expres-sion, activity and localization of mTOR (mammalian target of rapamycin) and p70S6K. The expression of mTOR and p70S6K was not significantly different at the cell cycle of mouse one-cell stage embryos. mTOR and S6K were distributed evenly in the cytoplasm at G1, G2 and M phase phase, but at S phase, the distribution of mTOR and S6K was around the pronucleus. At different phases, the activity of mTOR fluctuated. We also used the PI3K specific inhibitor-Wortmannin to investigate the cleavage rate of eggs. The result showed that the rate obviously decreased. When the mTOR specific inhibitor Rapa-mycin was used, the first mitotic division of the mouse one-cell stage embryo was delayed. These re-sults suggested that insulin was expressed both in mouse oocytes and one-cell stage embryos, and may play functional roles in regulation of mouse early embryogenesis by activating the signal pathway of PI3K/PKB/mTOR/S6K. | YU BingZhi, ZHANG Zhe, DENG Xin, XU XiaoYan, FENG Chen, LI YanXiao, CUI Cheng, SU WenHui, ZHAO HongMei & YU DaHai Department of Biochemical and Molecular Biology, China Medical University, Shenyang 110001, China | 2008 | Science China(Life Sciences)2008，51，9： | 1 |
| 19 | Geometric Mean Maximum FSVMI Model and Its Application in Carotid Artery Stenosis Risk Prediction显示文摘Carotid artery stenosis is a serious medical condition that can lead to stroke.Using machine learning method to construct classifier model,carotid artery stenosis can be diagnosed with transcranial doppler data.We propose an improved fuzzy support vector machine model to predict carotid artery stenosis,with the maximum geometric mean as the optimization target.The fuzzy membership function is obtained by combining information entropy with the normalized class-center distance.Experimental results showed that the proposed model was superior to the benchmark models in sensitivity and geometric mean criteria. | ZHANG Xueying GUO Yuling LI Fenglian WEI Xin HU Fengyun HUI Haisheng JIA Wenhui | 2021 | Chinese Journal of Electronics2021，30，5： | 0 |
| 20 | Efficient thermal dissipation in wafer-scale heterogeneous integration of single-crystalline��β-Ga_(2)O_(3)thin film on SiC显示文摘The semiconductor,β-Ga_(2)O_(3)is attractive for applications in high power electronic devices with low conduction loss due to its ultra-wide bandgap(∼4.9 eV)and large Baliga’s figure of merit.However,the thermal conductivity of��β-Ga_(2)O_(3)is much lower than that of other wide/ultra-wide bandgap semiconductors,such as SiC and GaN,which results in the deterioration of��β-Ga_(2)O_(3)-based device performance and reliability due to self-heating.To overcome this problem,a scalable thermal management strategy was proposed by heterogeneously integrating wafer-scale single-crystalline��β-Ga_(2)O_(3)thin films on a highly thermally conductive SiC substrate.Characterization of the transferred��β-Ga_(2)O_(3)thin film indicated a uniform thickness to within±2.01%,a smooth surface with a roughness of 0.2 nm,and good crystalline quality with an X-ray rocking curves(XRC)full width at half maximum of 80 arcsec.Transient thermoreflectance measurements were employed to investigate the thermal properties.The thermal performance of the fabricated��β-Ga_(2)O_(3)/SiC heterostructure was effectively improved in comparison with that of the��β-Ga_(2)O_(3)bulk wafer,and the effective thermal boundary resistance could be further reduced to 7.5 m 2 K/GW by a post-annealing process.Schottky barrier diodes(SBDs)were fabricated on both a��β-Ga_(2)O_(3)/SiC heterostructured material and a��β-Ga_(2)O_(3)bulk wafer.Infrared thermal imaging revealed the temperature increase of the SBDs on��β-Ga_(2)O_(3)/SiC to be one quarter that on the��β-Ga_(2)O_(3)bulk wafer with the same applied power,which suggests that the combination of the��-Ga_(2)O_(3)thin film and SiC substrate with high thermal conductivity promotes heat dissipation in��β-Ga_(2)O_(3)-based devices. | Wenhui Xu Tiangui You Yibo Wang Zhenghao Shen Kang Liu Lianghui Zhang Huarui Sun Ruijie Qian Zhenghua An Fengwen Mu Tadatomo Suga Genquan Han Xin Ou Yue Hao Xi Wang | 2021 | Fundamental Research2021，1，6： | 0 |
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