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| 1 | A complete sequence and comparative analysis of a SARS-associated virus(Isolate BJ01)显示文摘The genome sequence of the Severe Acute Respiratory Syndrome (SARS)-associated virus provides essential information for the identification of pathogen(s), exploration of etiology and evolution, interpretation of transmission and pathogenesis, development of diagnostics, prevention by future vaccination, and treatment by developing new drugs. We report the complete genome sequence and comparative analysis of an isolate (BJ01) of the coronavirus that has been recognized as a pathogen for SARS. The genome is 29725 nt in size and has 11 ORFs (Open Reading Frames). It is composed of a stable region encoding an RNA-dependent RNA polymerase (composed of 2 ORFs) and a variable region representing 4 CDSs (coding sequences) for viral structural genes (the S, E, M, N proteins) and 5 PUPs (putative uncharacterized proteins). Its gene order is identical to that of other known coronaviruses. The sequence alignment with all known RNA viruses places this virus as a member in the family of Coronaviridae. Thirty putative substitutions have been identified by comparative analysis of the 5 SARS- associated virus genome sequences in GenBank. Fifteen of them lead to possible amino acid changes (non-synonymous mutations) in the proteins. Three amino acid changes, with predicted alteration of physical and chemical features, have been detected in the S protein that is postulated to beinvolved in the immunoreactions between the virus and its host. Two amino acid changes have been detected in the Mprotein, which could be related to viral envelope formation. Phylogenetic analysis suggests the possibility of non-human origin of the SARS-associated viruses but provides noevidence that they are man-made. Further efforts should focus on identifying the etiology of the SARS-associated virus and ruling out conclusively the existence of otherpossible SARS-related pathogen(s). | QIN E'de ZHU Qingyu YU Man FAN Baochang CHANG Guohui SI Bingyin YANG Bao PENG Wenming JIANG Tao LIU Bohua DENG Yongqiang LIU Hong ZHANG Yu WANG Cui LI Yuquan GAN Yonghua LI Xiaoyu L Fushuang TAN Gang CAO Wuchun, YANG Ruifu Institute of Microbiology and Epidemiology, Chinese Academy of Military Medical Sciences, Beijing 100071, China WANG Jian, LI Wei, XU Zuyuan, LI Yan, WU Qingfa, LIN Wei, CHEN Weijun, TANG Lin, DENG Yajun, HAN Yujun, LI Changfeng, LEI Meng, LI Guoqing, LI Wenjie, L Hong, SHI Jianping, TONG Zongzhong, ZHANG Feng, LI Songgang, LIU Bin, LIU Siqi, DONG Wei, WANG Jun, Gane K-S Wong, YU Jun & YANG Huanming* Beijing Genomics Institute, Chinese Academy of Sciences, Beijing 101300 National Center for Genome Information, Beijing 101300, China | 2003 | Chinese Science Bulletin2003，48，10： | 121 |
| 2 | Age-related rhesus macaque models of COVID-19显示文摘Background:Since December 2019,an outbreak of the Corona Virus disease 2019(COVID-19)caused by severe acute respiratory syndrome coronavirus(SARS-CoV-2)in Wuhan,China,has become a public health emergency of international concern.The high fatality of aged cases caused by SARS-CoV-2 was a need to explore the possible age-related phenomena with non-human primate models.Methods:Three 3-5 years old and two 15 years old rhesus macaques were intratracheally infected with SARS-CoV-2,and then analyzed by clinical signs,viral replication,chest X-ray,histopathological changes and immune response.Results:Viral replication of nasopharyngeal swabs,anal swabs and lung in old monkeys was more active than that in young monkeys for 14 days after SARS-CoV-2 challenge.Monkeys developed typical interstitial pneumonia characterized by thickened alveolar septum accompanied with inflammation and edema,notably,old monkeys exhibited diffuse severe interstitial pneumonia.Viral antigens were detected mainly in alveolar epithelial cells and macrophages.Conclusion:SARS-CoV-2 caused more severe interstitial pneumonia in old monkeys than that in young monkeys.Rhesus macaque models infected with SARS-CoV-2 provided insight into the pathogenic mechanism and facilitated the development of vaccines and therapeutics against SARS-CoV-2 infection. | Pin Yu Feifei Qi Yanfeng Xu Fengdi Li Peipei Liu Jiayi Liu Linlin Bao Wei Deng Hong Gao Zhiguang Xiang Chong Xiao Qi Lv Shuran Gong Jiangning Liu Zhiqi Song Yajin Qu Jing Xue Qiang Wei Mingya Liu Guanpeng Wang Shunyi Wang Haisheng Yu Xing Liu Baoying Huang Wenling Wang Li Zhao Huijuan Wang Fei Ye Weimin Zhou Wei Zhen Jun Han Guizhen Wu Qi Jin Jianwei Wang Wenjie Tan Chuan Qin | 2020 | Animal Models and Experimental Medicine2020，3，1： | 22 |
| 3 | Characteristics of atmospheric single particles during haze periods in a typical urban area of Beijing:A case study in October,2014显示文摘To investigate the composition and possible sources of particles, especially during heavy haze pollution, a single particle aerosol mass spectrometer(SPAMS) was deployed to measure the changes of single particle species and sizes during October of 2014, in Beijing. A total of 2,871,431 particles with both positive and negative spectra were collected and characterized in combination with the adaptive resonance theory neural network algorithm(ART-2a). Eight types of particles were classified: dust particles(dust, 8.1%), elemental carbon(EC, 29.0%), organic carbon(OC, 18.0%), EC and OC combined particles(ECOC, 9.5%),Na-K containing particles(Na K, 7.9%), K-containing particles(K, 21.8%), organic nitrogen and potassium containing particles(KCN, 2.3%), and metal-containing particles(metal,3.6%). Three haze pollution events(P1, P2, P3) and one clean period(clean) were analyzed,based on the mass and number concentration of PM_(2.5)and the back trajectory results from the hybrid single particle Lagrangian integrated trajectory model(Hysplit-4 model). Results showed that EC, OC and K were the major components of single particles during the three haze pollution periods, which showed clearly increased ratios compared with those in the clean period. Results from the mixing state of secondary species of different types of particles showed that sulfate and nitrate were more readily mixed with carbon-containing particles during haze pollution episodes than in clean periods. | Lang Liu Yanli Wang Shiyong Du Wenjie Zhang Lujian Hou Sverre Vedal Bin Han Wen Yang Mindong Chen Zhipeng Bai | 2016 | Journal of Environmental Sciences2016，28，2： | 19 |
| 4 | Three-dimensional bioprinting of multicell-laden scaffolds containing bone morphogenic protein-4 for promoting M2 macrophage polarization and accelerating bone defect repair in diabetes mellitus显示文摘Critical-sized bone defect repair in patients with diabetes mellitus remains a challenge in clinical treatment because of dysfunction of macrophage polarization and the inflammatory microenvironment in the bone defect region.Three-dimensional(3D)bioprinted scaffolds loaded with live cells and bioactive factors can improve cell viability and the inflammatory microenvironment and further accelerating bone repair.Here,we used modified bioinks comprising gelatin,gelatin methacryloyl(GelMA),and 4-arm poly(ethylene glycol)acrylate(PEG)to fabricate 3D bioprinted scaffolds containing BMSCs,RAW264.7 macrophages,and BMP-4-loaded mesoporous silica nanoparticles(MSNs).Addition of MSNs effectively improved the mechanical strength of GelMA/gelatin/PEG scaffolds.Moreover,MSNs sustainably released BMP-4 for long-term effectiveness.In 3D bioprinted scaffolds,BMP-4 promoted the polarization of RAW264.7 to M2 macrophages,which secrete anti-inflammatory factors and thereby reduce the levels of pro-inflammatory factors.BMP-4 released from MSNs and BMP-2 secreted from M2 macrophages collectively stimulated the osteogenic differentiation of BMSCs in the 3D bioprinted scaffolds.Furthermore,in calvarial critical-size defect models of diabetic rats,3D bioprinted scaffolds loaded with MSNs/BMP-4 induced M2 macrophage polarization and improved the inflammatory microenvironment.And 3D bioprinted scaffolds with MSNs/BMP-4,BMSCs,and RAW264.7 cells significantly accelerated bone repair.In conclusion,our results indicated that implanting 3D bioprinted scaffolds containing MSNs/BMP-4,BMSCs,and RAW264.7 cells in bone defects may be an effective method for improving diabetic bone repair,owing to the direct effects of BMP-4 on promoting osteogenesis of BMSCs and regulating M2 type macrophage polarization to improve the inflammatory microenvironment and secrete BMP-2. | Xin Sun Zhenjiang Ma Xue Zhao Wenjie Jin Chenyu Zhang Jie Ma Lei Qiang Wenhao Wang Qian Deng Han Yang Jinzhong Zhao Qianqian Liang Xiaojun Zhou Tao Li Jinwu Wang | 2021 | Bioactive Materials2021，6，3： | 12 |
| 5 | Future changes in coverage of 1.5℃ and 2℃warming thresholds显示文摘The areas covered by 1.5 ℃ and 2.0 ℃ warming thresholds under RCP2.6, RCP4.5, and RCP8.5 were analyzed based on 22 CMIP5 models. More than 90% of the model runs are in agreement that by the end of the 21 st century, near-surface air temperature changes over ~5%(~2%), ~40%(~18%), and ~92%(~86%)of the globe will cross the 1.5 ℃(2.0 ℃) threshold under RCP2.6, RCP4.5, and RCP8.5, respectively. Under RCP8.5, nearly the whole of North America, Europe + Russia, Africa, and Asia–Russia will cross the 1.5 ℃(2.0 ℃) threshold in ~2050(~2060), while the coverage rates over South America and Oceania are ~80%(~75%) and ~50%(~30%), respectively. The threshold-onset time(TOT) for 2 ℃ warming is earliest over Europe + Russia and North America, followed by Africa, Asia–Russia, South America, and finally Oceania under the RCP4.5 and RCP8.5 scenarios. The TOT for 1.5 ℃ is ~10–30 years ahead of that for 2.0 ℃. | di tian wenjie dong han zhang yan guo shili yang tanlong dai | 2017 | Science Bulletin2017，62，21： | 10 |
| 6 | A novel anticancer property of Lycium barbarum polysaccharide in triggering ferroptosis of breast cancer cells显示文摘Breast cancer is one of the most malignant tumors and is associated with high mortality rates among women.Lycium barbarum polysaccharide(LBP)is an extract from the fruits of the traditional Chinese herb,L.barbarum.LBP is a promising anticancer drug,due to its high activity and low toxicity.Although it has anticancer properties,its mechanisms of action have not been fully established.Ferroptosis,which is a novel anticancer strategy,is a cell death mechanism that relies on iron-dependent lipid reactive oxygen species(ROS)accumulation.In this study,human breast cancer cells(Michigan Cancer Foundation-7(MCF-7)and MD Anderson-Metastatic Breast-231(MDA-MB-231))were treated with LBP.LBP inhibited their viability and proliferation in association with high levels of ferroptosis.Therefore,we aimed to ascertain whether LBP reduced cell viability through ferroptosis.We found that the structure and function of mitochondria,lipid peroxidation,and expression of solute carrier family 7 member 11(SLC7 A11,also known as x CT,the light-chain subunit of cystine/glutamate antiporter system X_(c)^(-))and glutathione peroxidase 4(GPX4)were altered by LBP.Moreover,the ferroptosis inhibitor,Ferrostatin-1(Fer-1),rescued LBP-induced ferroptosis-associated events including reduced cell viability and glutathione(GSH)production,accumulation of intracellular free divalent iron ions and malondialdehyde(MDA),and down-regulation of the expression of x CT and GPX4.Erastin(x CT inhibitor)and RSL3(GPX4 inhibitor)inhibited the expression of x CT and GPX4,respectively,which was lower after the co-treatment of LBP with Erastin and RSL3.These results suggest that LBP effectively prevents breast cancer cell proliferation and promotes ferroptosis via the x CT/GPX4 pathway.Therefore,LBP exhibits novel anticancer properties by triggering ferroptosis,and may be a potential therapeutic option for breast cancer. | Xing DU Jingjing ZHANG Ling LIU Bo XU Hang HAN Wenjie DAI Xiuying PEI Xufeng FU Shaozhang HOU | 2022 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2022，23，4： | 10 |
| 7 | Sulfur dioxide and o-xylene co-treatment in biofilter:Performance, bacterial populations and bioaerosols emissions显示文摘Sulfur dioxide(SO_2) and benzene homologs are frequently present in the off-gas during the process of sewage sludge drying. A laboratory scale biofilter was set up to co-treat SO_2 and o-xylene in the present study. SO_2 and o-xylene could be removed simultaneously in a single biofilter. Their concentration ratio in the inlet stream influenced the removal efficiencies. It is worth noting that the removal of SO_2 could be enhanced when low concentrations of o-xylene were introduced into the biofilter. Pseudomonas sp., Paenibacillus sp., and Bacillus sp. were the main functional bacteria groups in the biofilter. Sulfur-oxidizing bacteria(SOB) and o-xylene-degrading bacteria(XB) thrived in the biofilter and their counts as well as their growth rate increased with the increase in amount of SO_2 and o-xylene supplied. The microbial populations differed in counts and species due to the properties and components of the compounds being treated in the biofilter. The presence of mixed substrates enhanced the diversity of the microbial population. During the treatment process, bioaerosols including potentially pathogenic bacteria, e.g., Acinetobacter lwoffii and Aeromonas sp., were emitted from the biofilter. Further investigation is needed to focus on the potential hazards caused by the bioaerosols emitted from waste gas treatment bioreactors. | Yongli Sun Song Xue Lin Li Wenjie Ding Junxin Liu Yunping Han | 2018 | Journal of Environmental Sciences2018，30，7： | 7 |
| 8 | Incidence and mortality of corpus uteri cancer in China,2008-2012显示文摘Objective: To analyze the incidence and mortality rates of corpus uteri cancer in China using 2008-2012 data from the National Central Cancer Registry(NCCR) of China.Methods: We analyzed 2008-2012 data from 135 cancer registries using NCCR screening methods and criteria.The Chinese standard population in 2000 and Segi’s world population were applied to determine age-standardized incidence and mortality rates. The annual percentage change(APC) in rate was calculated using the Joinpoint Regression Program.Results: The crude incidence of corpus uteri cancer was 9.58/100,000, making corpus uteri cancer the ninth most common malignancy in females. The crude mortality was 2.97/100,000, making corpus uteri cancer the 13 th leading cause of death from malignant tumors in females. The incidence was higher in urban than in rural areas, but the mortality was higher in rural than in urban areas. The crude incidence was higher in eastern areas than in middle and western areas, while the crude mortality was higher in middle areas than in eastern and western areas.During 2003-2012, the age-standardized incidence rate based on the Chinese standard population in 2000(ASIRC)with uterine cancer increased significantly by 3.0% annually, while the age-standardized mortality rate based on the Chinese standard population in 2000(ASMRC) decreased by 0.4% annually, but the decrease was not statistically significant. The APC in incidence rate in the age groups of 30-44 years was 4.2%, which was statistically significant;increases/decreases in other age groups were not statistically significant. From 2003 to 2004, the age groups of 60-74 years showed high incidence, while from 2005 to 2012, the age groups of 45-59 years had high incidence.Conclusions: The incidence and mortality rates of corpus uteri cancer in China from 2008 to 2012 were relatively low compared with other countries. However, the significant increase in incidence rates and marked decrease in patient age suggest the need to strengthen China’s efforts toward prevention and control of corpus uteri cancer. | Yunfeng Xi Wenrui Wang Wenjie Chen Ke Han Liying Qiao Wanqing Chen | 2019 | Chinese Journal of Cancer Research2019，31，3： | 7 |
| 9 | Changes in different organic matter fractions during conventional treatment and advanced treatment显示文摘XAD-8 resin isolation of organic matter in water was used to divide organic matter into the hydrophobic and hydrophilic fractions. A pilot plant was used to investigate the change in both fractions during conventional and advanced treatment processes. The treatment of hydrophobic organics (HPO), rather than hydrophilic organicas (HPI), should carry greater emphasis due to HPO's higher trihalomethane formation potential (THMFP) and haloacetic acid formation potential (HAAFP). The removal of hydrophobic matter and its transmission into hydrophilic matter reduced ultimate DBP yield during the disinfection process. The results showed that sand filtration, ozonation, and biological activated carbon (BAC) filtration had distinct influences on the removal of both organic fractions. Additionally, the combination of processes changed the organic fraction proportions present during treatment. The use of ozonation and BAC maximized organic matter removal efficiency, especially for the hydrophobic fraction. In sum, the combination of pre-ozonation, conventional treatment, and O 3 -BAC removed 48% of dissolved organic carbon (DOC), 60% of HPO, 30% of HPI, 63% of THMFP, and 85% of HAAFP. The use of conventional treatment and O 3 -BAC without pre-ozonation had a comparable performance, removing 51% of DOC, 56% of HPO, 45% of HPI, 61% of THMFP, and 72% of HAAFP. The effectiveness of this analysis method indicated that resin isolation and fractionation should be standardized as an applicable test to help assess water treatment process efficiency. | Chao Chen Xiaojian Zhang Lingxia Zhu Wenjie He Hongda Han | 2011 | Journal of Environmental Sciences2011，23，4： | 7 |
| 10 | A draft sequence of the rice (Oryza sativa ssp. indica) genome显示文摘The sequence of the rice genome holds fundamental information for its biology, including physiology, genetics, development, and evolution, as well as information on many beneficial phenotypes of economic significance. Using a 'whole genome shotgun' approach, we have pro-duced a draft rice genome sequence of Oryza sativa ssp. in-dica, the major crop rice subspecies in China and many other regions of Asia. The draft genome sequence is constructed from over 4.3 million successful sequencing traces with an accumulative total length of 2214.9 Mb. The initial assembly of the non-redundant sequences reached 409.76 Mb in length, based on 3.30 million successful sequencing traces with a total length of 1797.4 Mb from an indica variant cultivar 93-11, giving an estimated coverage of 95.29% of the rice genome with an average base accuracy of higher than 99%. The coverage of the draft sequence, the randomness of the sequence distribution, and the consistency of BIG-ASSEM-BLER, a custom-designed software package | YU Jun, HU Songnian, WANG Jun,LI Songgang WONG Ka-Shu Gane, LIU Bin,DENG Yajun, DAI Li, ZHOU Yan,ZHANG Xiuqing, CAO Mengliang, LIU Jing,SUN Jiandong , TANG Jiabin, CHEN Yanjiong,HUANG Xiaobing, LIN Wei, YE Chen, TONG Wei,CONG Lijuan, GENG Jianing, HAN Yujun, LI Lin,LI Wei, HU Guangqiang, HUANG Xiangang,LI Wenjie, LI Jian, LIU Zhanwei, LI Long,LIU Jianping, Ql Qiuhui, LIU Jinsong, LI Li,WANG Xuegang, LU Hong, WU Tingling,ZHU Miao, Nl Peixiang, HAN Hua, DONG Wei,REN Xiaoyu, FENG Xiaoli, GUI Peng,LI Xianran, WANG Hao, XU Xin, ZHAI Wenxue,XU Zhao, ZHANG Jinsong, HE Sijie,ZHANG Jianguo, XU Jichen, ZHANG Kunlin,ZHENG Xianwu, DONG Jianhai, ZENG Wanyong,TAO Lin, CHEN Xuewei, HE Jun, LIU Daofeng,TIAN Wei, TIAN Chaoguang, XIA Hongai,LI Gang, GAO Hui, LI Ping, CHEN Wei ,WANG Xudong, ZHANG Yong, HU Jianfei,WANG Jing, LIU Song, YANG Jian,ZHANG Guangyu, XIONG Yuqing, LI Zhijie,MAO Long, ZHOU Chengshu, ZHU Zhen,CHEN Runsheng, HAO Bailin,ZHENG Weimou, CHEN Shouyi, QUO Wei,LI Guojie, LIU Siqi, HUANG Guyang,TAO Ming, WANG Jian, ZHU Lihuang,YUAN Longping& YANG HuanmingBeijing Genomics Institute/Center of Genomics & Bioinformatics, Chinese Academy of Sciences, Beijing 101300, China Hangzhou Genomics Institute/Institute of Bioinformatics of Zhejiang University/Key Laboratory of Bioinformatics of Zhejiang Province, Hangzhou 310007, China Institute of Genetics, Chinese Academy of Sciences, Beijing 100101, China National Hybrid Rice R & D Center, Changsha 410125, China Laboratory of Bioinformatics, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China College of Life Sciences, Peking University, Beijing 100871, China Institute of Theoretical Physics, Chinese Academy of Sciences, Beijing 1Q0080, China Digital China Ltd., Beijing 100080, China Institute of Computing Technology, Chinese Academy of Sciences, Beijing 100080, China Medical College, Xi’an Jiaotong University, Xi’an 710061, ChinaThese authors contributed equally to this work.Corresponding author.Corresponden | 2001 | Chinese Science Bulletin2001，46，23： | 6 |
| 11 | Microarray microRNA profiling of urinary exosomes in a 5XFAD mouse model of Alzheimer’s disease显示文摘Background:Alzheimer's disease(AD)is an incurable and irreversible neurodegen-erative disease,without a clear pathogenesis.Therefore,identification of candidates before amyloid-βplaque(Aβ)deposition proceeds is of major significance for earlier intervention in AD.Methods:To explore the potential noninvasive earlier biomarkers of AD in a 5XFAD mouse model,microRNAs(miRNAs)from urinary exosomes in 1-month-old pre-Aβaccumulation 5XFAD mice models and their littermate controls were profiled by mi-croarray analysis.The differentially expressed miRNAs were further analyzed via droplet digital PCR(ddPCR).Results:Microarray analysis demonstrated that 48 differentially expressed miRNAs(18 upregulated and 30 downregulated),of which six miRNAs-miR-196b-5p,miR-339-3p,miR-34a-5p,miR-376b-3p,miR-677-5p,and miR-721-were predicted to display gene targets and important signaling pathways closely associated with AD pathogenesis and verified by ddPCR.Conclusions:Urinary exosomal miRNAs showing differences in expression prior to Aβ-plaque deposition were identified.These exosomal miRNAs represent potential noninvasive biomarkers that may be used to prevent AD in clinical applications. | Zhiqi Song Yajin Qu Yanfeng Xu Ling Zhang Li Zhou Yunlin Han Wenjie Zhao Pin Yu Yu Zhang Xianglei Li Chuan Qin | 2021 | Animal Models and Experimental Medicine2021，4，3： | 6 |
| 12 | Reemergent Cases of COVID-19—Xinfadi Wholesales Market,Beijing Municipality,China,June 11,2020显示文摘No new local coronavirus disease 2019(COVID-19)cases were reported in Beijing for over 56 days before the reemergent COVID-19 cases that were reported on June 11,2020,and more than 200 confirmed cases have been reported as of June 20 in Beijing.All confirmed COVID-19 cases were associated with Xinfadi Wholesale Market.Here,we reported the phylogenetic characteristics of the COVID-19 viruses(also known as severe acute respiratory syndrome coronavirus 2,SARS-CoV-2,and human coronavirus 2019,HCoV-19)sequenced from the clinical specimens of 2 human cases and 1 environmental sample. | Wenjie Tan Peihua Niu Xiang Zhao Yang Pan Yong Zhang Lijuan Chen Li Zhao Yanhai Wang Dayan Wang Jun Han George FGao Chun Huang Wenbo Xu Guizhen Wu | 2020 | China CDC weekly2020，2，27： | 6 |
| 13 | Hot Working Characteristic of Superaustenitic Stainless Steel 254SMO显示文摘Hot deformation characteristic of superaustenitic stainless steel 254SMO has been studied by isothermal compression testing in the temperature range of 950–1,200 °C and strain rate range of 0.01–10 s-1.The activation energy of 496 kJ/mol was calculated by a hyperbolic-sine type equation over the entire range of strain rates and temperatures.In order to obtain optimum hot working conditions,processing maps consisting of power dissipation map and instability map were constructed at different strains.The power dissipation map exhibits two domains with relatively high efficiencies of power dissipation.The first domain occurs in the temperature range of 990–1,070 °C and the strain rate range of0.01–0.1 s-1.Microstructure observation in this domain indicates the partial dynamic recrystallization(DRX) accompanied with precipitation of tetragonal sigma phase.The second domain occurs in the temperature range of 1,140–1,200 °C and the strain rate range of 0.01–1 s-1with a peak efficiency of power dissipation of 39%,and in this domain,the microstructure observation reveals the full DRX.The instability map shows that flow instability occurs at the temperatures below 1,140 °C and the strain rates above 0.1 s-1. | Enxiang Pu Wenjie Zheng Jinzhong Xiang Zhigang Song Han Feng Yuliang Zhu | 2014 | Acta Metallurgica Sinica(English Letters)2014，27，2： | 6 |
| 14 | Description of the First Strain of 2019-nCoV,C-Tan-nCoV Wuhan Strain-National Pathogen Resource Center,China,2020显示文摘The recent outbreak of novel coronavirus-infected pneumonia(NCIP)in China(1)has attracted much attention domestically and internationally.As the outbreak occurred,China carried out emergency responses quickly,notified the World Health Organization(WHO)in a timely manner,and shared the viral gene sequence with international communities immediately after pathogenic identification. | Qiang Wei Yanhai Wang Juncai Ma Jun Han Mengnan Jiang Li Zhao Fei Ye Jingdong Song Bo Liu Linhuan Wu Wenjie Tan Guizhen Wu George FGao Jianjun Liu | 2020 | China CDC weekly2020，2，6： | 5 |
| 15 | Gravimetric analysis for PM_(2.5) mass concentration based on year-round monitoring at an urban site in Beijing显示文摘Daily PM_(2.5)(particulate matter with an aerodynamic diameter of below 2.5 μm) mass concentrations were measured by gravimetric analysis in Chinese Research Academy of Environmental Sciences(CRAES), in the northern part of the Beijing urban area, from December 2013 to April 2015. Two pairs of Teflon(T1/T2) and Quartz(Q1/Q2) samples were obtained, for a total number of 1352 valid filters. Results showed elevated pollution in Beijing,with an annual mean PM_(2.5)mass concentration of 102 μg/m^3. According to the calculated PM_(2.5)mass concentration, 50% of our sampling days were acceptable(PM_(2.5)< 75 μg/m^3), 30% had slight/medium pollution(75–150 μg/m^3), and 7% had severe pollution(> 250 μg/m^3). Sampling interruption occurred frequently for the Teflon filter group(75%) in severe pollution periods,resulting in important data being missing. Further analysis showed that high PM_(2.5)combined with high relative humidity(RH) gave rise to the interruptions. The seasonal variation of PM_(2.5)was presented, with higher monthly average mass concentrations in winter(peak value in February, 422 μg/m^3), and lower in summer(7 μg/m^3 in June). From May to August, the typical summer period, least severe pollution events were observed, with high precipitation levels accelerating the process of wet deposition to remove PM_(2.5). The case of February presented the most serious pollution, with monthly averaged PM_(2.5)of 181 μg/m^3 and 32% of days with severe pollution. The abundance of PM_(2.5)in winter could be related to increased coal consumption for heating needs. | Yanli Wang Wen Yang Bin Han Wenjie Zhang Mindong Chen Zhipeng Bai | 2016 | Journal of Environmental Sciences2016，28，2： | 5 |
| 16 | First Human Infection Case of Monkey B Virus Identified in China,2021显示文摘Monkey B virus(BV),initially isolated in 1932,is currently designated as Macacine alphaherpesvirus 1 by the International Committee on Taxonomy of Viruses(1).BV is an alphaherpesvirus enzootic in macaques of the genus Macaca,normally transmitted horizontally via direct contact and exchange of bodily secretions,just like herpes simplex virus(HSV)in humans. | Wenling Wang Wenjie Qi Jingyuan Liu Haijun Du Li Zhao Yang Zheng Guoxing Wang Yang Pan Baoying Huang Zhaomin Feng Daitao Zhang Peng Yang Jun Han Quanyi Wang Wenjie Tan | 2021 | China CDC weekly2021，3，29： | 4 |
| 17 | Radio interferometric localization of WSNs based on Doppler effect显示文摘A novel distributed localization method based on the Doppler effect for wireless sensor networks is proposed in this paper, which only relies on radio transceivers without the need of other auxiliary measurement equipments. Based on radio interference, each sensor node can obtain a multi-group of distance variations from itself to a mobile anchor through the measurement of the cumulative phase variations caused by Doppler effect, by which its position can be determined. The proposed method has the following advantages: the sensor node conducts localization in a completely distributed manner without information exchange or centralized processing, and the measurement result equals the actual distance without modulus operation, which is in reality measuring the distance with a ruler of radio wavelength, and will significantly reduce the system complexity and achieve high location accuracy. Analysis and simulation results demonstrate the effectiveness of our proposed method. | ZHANG WeiLe, YIN QinYe, HAN Wei & WANG WenJie School of Electronic and Information Engineering, Xi’an Jiaotong University, Xi’an 710049, China | 2010 | Science China(Information Sciences)2010，53，1： | 4 |
| 18 | Study on meso-mechanical behavior of sand based on its 2D geometrical model显示文摘A comprehensive study on the meso-mechanical behaviors of sand with its 2D geometrical models was presented in this study.Based on the 2D geometrical models,database of sand particles,quantitative analysis on the geometrical characteristics of the studied sand particles was performed.A new clump generation algorithm based on fewer multiple overlapping circles was provided to accurately model the shape of sand particles,and was used to build the discrete element method(DEM)numerical model of the sand sample for DEM biaxial tests.The macro-and meso-mechanical behaviors of the studied sand samples were systematically analyzed.Deformation was mainly localized in a X-shaped shear zone,in which the particles experienced large displacements and rotations.Development of stress-induced anisotropy in particle and void orientations,as well as the mesoscopic fabric,was significant during the shearing process.Continuous collapse,generation,reduction,and extension of force chains occurred during the shearing process,especially after the peak stress was reached.This led to the fluctuations in the evolution of deviatoric stress and volumetric strain at macroscale,as well as the fabric anisotropy at mesoscale. | XU WenJie FENG ZeKang YANG Han LIU GuangYu | 2020 | Science China(Technological Sciences)2020，63，5： | 4 |
| 19 | Injectable bioactive polymethyl methacrylate-hydrogel hybrid bone cement loaded with BMP-2 to improve osteogenesis for percutaneous vertebroplasty and kyphoplasty显示文摘Poly methyl methacrylate(PMMA)bone cement is used in augmenting and stabilizing fractured vertebral bodies through percutaneous vertebroplasty(PVP)and percutaneous kyphoplasty(PKP).However,applications of PMMA bone cement are limited by the high elasticity modulus of PMMA,its low biodegradability,and its limited ability to regenerate bone.To improve PMMA bio activity and biodegradability and to modify its elasticity modulus,we mixed PMMA bone cement with oxidized hyaluronic acid and carboxymethyl chitosan in situ cross-linking hydrogel loaded with bone morphogenetic protein-2(BMP-2)to achieve novel hybrid cement.These fabric ated PMMA-hydrogel hybrid cements exhibited lower setting temperatures,a lower elasticity modulus,and better biodegradability and biocompatibility than that of pure PMMA cement,while retaining acceptable setting times,mechanical strength,and inj ectability.In addition,we detected release of BMP-2 from the PMMA-hydrogel hybrid cements,significantly enhancing in vitro osteogenesis of bone marrow mesenchymal stem cells by up-regulating the gene expression of Runx2,Coll,and OPN.Use of PMMA-hydrogel hybrid cements loaded with BMP-2 on rabbit femoral condyle bone-defect models revealed their biodegradability and enhanced bone formation.Our study demonstrated the favorable mechanical properties,biocompatibility,and biodegradability of fabricated PMMA-hydrogel hybrid cements loaded with BMP-2,as well as their ability to improve osteogenesis,making them a promising material for use in PKP and PVP. | Xin Sun Xin Zhang Xin Jiao Jie Ma Xingzhen Liu Han Yang Kangping Shen Yaokai Gan Jinwu Wang Haiyan Li Wenjie Jin | 2022 | Bio-Design and Manufacturing2022，5，2： | 3 |
| 20 | Targeting polarized phenotype of microglia via IL6/JAK2/ STAT3 signaling to reduce NSCLC brain metastasis显示文摘Tumor-associated macrophages have emerged as crucial factors for metastases.Microglia are indispensable components of the brain microenvironment and play vital roles in brain metastasis(BM).However,the underlying mechanism of how activated microglia promote brain metastasis of non-small cell lung cancer(NSCLC)remains elusive. | Yu Jin Yalin Kang Minghuan Wang Bili Wu Beibei Su Han Yin Yang Tang Qianxia Li Wenjie Wei Qi Mei Guangyuan Hu Veronika Lukacs-Kornek Jian Li Kongming Wu Xianglin Yuan Wei Wang | 2022 | Signal Transduction and Targeted Therapy2022，7，3： | 3 |
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