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| 1 | Re-Os isotope dating of molybdenites in the Huang-shaping Pb-Zn-W-Mo polymetallic deposit, Hunan Province, South China and its geological significance显示文摘The large-scale Huangshaping Pb-Zn-W-Mo polymetallic deposit is located in the central Nanling min- eralization zone, South China. Six molybdenite samples from the Huangshaping deposit were selected for Re-Os isotope measurement in order to define the mineralization age of the deposit. It yields a Re-Os isochron age of 154.8±1.9 Ma (2σ ), which is in accordance with the Re-Os model ages of 150.9― 156.9 Ma. This age is about 7 Ma younger than their host granite porphyry, which was dated as 161.6±1.1 Ma by zircon U-Pb method using LA-ICPMS. All these ages demonstrate that the Huang- shaping granite and related Pb-Zn-W-Mo deposit occurred in the middle Yanshanian period, when many other granitoid and related ore deposits emplaced and formed, e.g. the Qitianling granite and Furong tin deposit, the Qianlishan granite and giant Shizhuyuan W-Sn-Mo-Bi deposit and Jinchuantang Sn-Bi deposit in the nearby area. They constitute the main part of the magmatic-metallogenic belt of southern Hunan, and represent the large-scale metallogeny in middle Yanshanian in the area. The lower rhenium content in molybdenite of Huangshaping deposit suggests that the ore-forming material was mainly of crust origin. | YAO JunMing HUA RenMin QU WenJun QI HuaWen LIN JinFu DU AnDao | 2007 | Science China Earth Sciences2007，50，4： | 29 |
| 2 | Bioconjugated Silica Nanoparticles: Development and Applications显示文摘Advanced bioanalysis,including accurate quantitation,has driven the need to understand biology and medicine at the molecular level.Bioconjugated silica nanoparticles have the potential to address this emerging challenge.Particularly intriguing diagnostic and therapeutic applications in cancer and infectious disease as well as uses in gene and drug delivery,have also been found for silica nanoparticles.In this review,we describe the synthesis,bioconjugation,and applications of silica nanoparticles in different bioanalysis formats,such as selective tagging,barcoding,and separation of a wide range of biomedically important targets.Overall,we envisage that further development of these nanoparticles will provide a variety of advanced tools for molecular biology,genomics,proteomics and medicine. | Lin Wang Wenjun Zhao Weihong Tan | 2008 | Nano Research2008，1，2： | 15 |
| 3 | Membrane fouling in ultrafiltration of natural water after pretreatment to different extents显示文摘The combined fouling during ultrafiltration(UF) of surface water pretreated to different extents was investigated to disclose the roles of polysaccharides, proteins, and inorganic particles in UF membrane fouling. Both reversible and irreversible fouling decreased with enhanced pretreatment(biologically active carbon(BAC) treatment and sand filtration). The sand filter effluent fouled the membrane very slowly. The UF membrane removed turbidity to less than 0.1 nephelometric turbidity unit(NTU), reduced polysaccharides by 25.4%–29.9%, but rejected few proteins. Both polysaccharides and inorganic particles were detected on the fouled membranes, but inorganic particles could be effectively removed by backwashing. The increase of turbidity in the sand filter effluent to 3.05 NTU did not significantly increase the fouling rate, but an increase in the turbidity in the BAC effluent to6.11 NTU increased the fouling rate by more than 100%. The results demonstrated that the polysaccharide, not the protein, constituents of biopolymers were responsible for membrane fouling. Membrane fouling was closely associated with a small fraction of polysaccharides in the feed water. Inorganic particles exacerbated membrane fouling only when the concentration of fouling–inducing polysaccharides in the feed water was relatively high. The combined fouling was largely reversible, and polysaccharides were the predominant substances responsible for irreversible fouling. | Lu Ao Wenjun Liu Lin Zhao Xiaomao Wang | 2016 | Journal of Environmental Sciences2016，28，5： | 12 |
| 4 | Salusins protect myocardium against ischemic injury by alleviating endoplasmic reticulum stress显示文摘Salusins are regulatory peptides that affect cardiovascular function. We previously reported that salusin-α and -β protected cultured cardiomyocytes from serum deprivation-induced cell death through upregulating glucose-regulated protein 78 (GRP78), an endoplasmic reticulum (ER) resident protein whose overexpression acts as a marker and suppressor of ER stress. The present study examined whether salusin-α and -β inhibit ER stress in ischemic myocardium. In a rat model of myocardial infarction created by ligating the left anterior descending coronary artery (LAD), salusin-α or -β was intravenously injected at 5 or 15 nmol kg 1 15 min prior to 2 h of LAD occlusion. The high dose of salusin-α and -β significantly improved heart function and hemodynamics in LAD-occluded rats, but had no effects in sham-operated rats. The arrhythmias caused by LAD occlusion were markedly attenuated by salusin-α and -β. The apoptotic rate in ischemic myocardium was reduced from 31.5%±3.7% to 19.8%±2.2% and 12.3%±2.2%, and the infarct size was reduced from 53.4%±4.0% of the risk area to 26.5%±9.7% and 23.7%±8.9% by 15 nmol kg 1 salusin-α and -β, respectively. Furthermore, salusin-α and -β prevented the activation of GRP78 and ER stress-specific apoptotic effectors caspase-12 and CHOP (C/EBP homologous protein), and attenuated the reduction of an ER stress-associated antiapoptotic protein Bcl-2 in ischemic cardiac tissue. The salusins also inhibited the ER stress induced by tunicamycin in cultured rat H9c2 cardiomyocytes. These results indicate that salusins protect myocardium against ischemic injury by inhibiting ER stress and ER stress-associated apoptosis. | WANG JianFei WANG Yin SHAN ShiFu HU TianTian CHEN HuYan TIAN Jing REN AnJing ZHOU Xu YUAN WenJun LIN Li | 2012 | Science China(Life Sciences)2012，55，4： | 11 |
| 5 | Dual-Material Electron Beam Selective Melting:Hardware Development and Validation Studies显示文摘Electron beam selective melting(EBSM) is an additive manufacturing technique that directly fabricates three-dimensional parts in a layerwise fashion by using an electron beam to scan and melt metal powder. In recent years, EBSM has been successfully used in the additive manufacturing of a variety of materials. Previous research focused on the EBSM process of a single material. In this study, a novel EBSM process capable of building a gradient structure with dual metal materials was developed, and a powder-supplying method based on vibration was put forward. Two different powders can be supplied individually and then mixed. Two materials were used in this study: Ti6Al4 V powder and Ti47Al2Cr2 Nb powder. Ti6Al4 V has excellent strength and plasticity at room temperature, while Ti47Al2Cr2 Nb has excellent performance at high temperature, but is very brittle. A Ti6Al4V/Ti47Al2Cr2 Nb gradient material was successfully fabricated by the developed system. The microstructures and chemical compositions were characterized by optical microscopy, scanning microscopy, and electron microprobe analysis. Results showed that the interface thickness was about 300 μm. The interface was free of cracks, and the chemical compositions exhibited a staircase-like change within the interface. | Chao Guo Wenjun Ge Feng Lin | 2015 | Engineering2015，1，1： | 11 |
| 6 | Inhibition of lung cancer cell proliferation mediated by human mesenchymal stem cells显示文摘人的间充质的干细胞(hMSCs ) 主要为他们的潜在的临床的使用被学习。最近,癌症研究的领域里的许多注意对 hMSCs 被给予了。在这研究,我们由使用一个合作文化系统和调节 hMSCs 的媒介在 vitro 并且在 vivo 在肺癌症房间线 SK-MES-1 和 A549 的增长上调查了 hMSCs 的影响。我们的结果证明 hMSCs 能禁止 SK-MES-1 和 A549 房间的增长,并且经由一些可溶的因素在 vitro 导致肿瘤房间的 apoptosis。动物学习证明从 hMSCs 的这些可溶的因素能由 preliminarily 与调节 hMSCs 的媒介对待肿瘤细胞压制 tumorigenesis 和肿瘤 angiogenesis。在肿瘤房间的脉管的 endothelial 生长因素的 downregulated 表示可能是在肿瘤 angiogenesis 的干扰的机制,它被西方的污点分析和 immunohistochemistry 试金验证。一起拿,我们的结果建议 hMSCs 能由 secreting 一些禁止肿瘤细胞生长可溶的因素。 | Lin Li Hui Tian Zhitao Chen Weiming Yue Shuhai Li Wenjun Li | 2011 | Acta Biochimica et Biophysica Sinica2011，43，2： | 11 |
| 7 | New Re-Os Isotopic Constrains on the Formation of the Metalliferous Deposits of the Lower Cambrian Niutitang Formation显示文摘The Terreneuvian Epoch(541–521 Ma)is also an important period for metallogenesis in South China, as was represented by the widespread occurrences of Ni-Mo polymetallic layers on the antecedent shallow platform margin and the V-enriched black shales in deeper slope-basin settings. In this study, we have measured Re-Os isochron ages of Ni-Mo polymetallic layers(Songlin, Niuchang, Sancha, Chuanpengwan), V-rich black shales(Bahuang), and non-metalliferous black shales(Shuidong) in the basal Niutitang Formation in Guizhou and Hunan province, South China. The Ni-Mo polymetallic layers and V-enriched black shales have similar Re-Os isochron ages, suggesting concurrent deposition of these two types of metalliferous ores. This suggestion is consistent with the traditional stratigraphic correlation by using the nodular phosphorite bed directly underlying these metalliferous layers as a stratigraphic marker. Furthermore, the metalliferous ores and non-metalliferous black shales have similar initial ^(187)Os/^(188) Os ratios of 0.8–0.9, arguing for a dominant seawater origin with minor contribution of hydrothermal activity. Furthermore, Re-Os isotopic data also imply that Ni-Mo and V ore might have derived from the same source. We suggest that the spatial distribution of metalliferous ores can be explained by the development of non-sulfidic anoxic-suboxic wedge(NSASW) in the slope-basin and sulfidic wedge in the previous platform margin. Upwelling of deep water first transects the mildly reduced, organic rich NSASW, in which V(V) is reduced to V(IV), and is preferentially removed from seawater by organometallic complex formation. As a result, V-rich black shale deposits in the slope-basin of Yangtze Platform. Further movement of deep water into the sulfidic platform margin results in Ni-Mo polymetallic layer formation. | Yong Fu Lin Dong Chao Li Wenjun Qu Haoxiang Pei Wenlang Qiao Bing Shen | 2016 | Journal of Earth Science2016，27，2： | 9 |
| 8 | Distribution of IgG galactosylation as a promising biomarker for cancer screening in multiple cancer types显示文摘 | Shifang Ren Zejian Zhang Congjian Xu Lin Guo Renquan Lu Yihong Sun Jianming Guo Ruihuan Qin Wenjun Qin Jianxin Gu | 2016 | Cell Research2016，26，8： | 8 |
| 9 | Whole genome sequencing of 10K patients with acute ischaemic stroke or transient ischaemic attack: design, methods and baseline patient characteristics显示文摘Background and purpose Stroke is the second leading cause of death worldwide and the leading cause of mortality and long-term disability in China,but its underlying risk genes and pathways are far from being comprehensively understood.We here describe the design and methods of whole genome sequencing(WGS)for 10914 patients with acute ischaemic stroke or transient ischaemic attack from the Third China National Stroke Registry(CNSR-III).Methods Baseline clinical characteristics of the included patients in this study were reported.DNA was extracted from white blood cells of participants.Libraries are constructed using qualified DNA,and WGS is conducted on BGISEQ-500 platform.The average depth is intended to be greater than 30×for each subject.Afterwards,Sentieon software is applied to process the sequencing data under the Genome Analysis Toolkit best practice guidance to call genotypes of single nucleotide variants(SNVs)and insertion-deletions.For each included subject,21 fingerprint SNVs are genotyped by MassARRAY assays to verify that DNA sample and sequencing data originate from the same individual.The copy number variations and structural variations are also called for each patient.All of the genetic variants are annotated and predicted by bioinformatics software or by reviewing public databases.Results The average age of the included 10914 patients was 62.2±11.3 years,and 31.4%patients were women.Most of the baseline clinical characteristics of the 10914 and the excluded patients were balanced.Conclusions The WGS data together with abundant clinical and imaging data of CNSR-III could provide opportunity to elucidate the molecular mechanisms and discover novel therapeutic targets for stroke. | Si Cheng Zhe Xu Yang Liu Jinxi Lin Yong Jiang Yilong Wang Xia Meng Anxin Wang Xinying Huang Zhimin Wang Guohua Chen Songdi Wu Zhengchang Jia Yongming Chen Xuerong Qiu Jun Wu Binbin Song Weizhong Ji Zhongping An Wenjun Xue Lili Zhao Yu Geng Hongyan Li Hao Li Yongjun Wang | 2021 | Stroke & Vascular Neurology2021，6，2： | 8 |
| 10 | Diallyl trisulfide induces apoptosis and inhibits proliferation of A549 cells in vitro and in vivo显示文摘肺癌症是在整个世界的癌症相关的死亡的领先的原因。在最近的年里,肺的腺癌在频率超过了有鳞的房间癌并且是在许多国家的肺癌症的占优势的形式。流行病学的调查显示出在消费和死亡从许多癌症评估的大蒜(瞀或蒜之类 sativum ) 之间的一种反的关系。Diallyl trisulfide (DATS ) 是导出大蒜的混合物之一(是也知道:organosulfer 混合物,振荡) 。DATS 能导致 apoptosis 并且禁止许多癌症细胞线的生长。我们的学习证明 DATS 导致的 apoptotic 事件是通过导致了 Bax/Bcl-2 和 caspase-3, -8, 和 -9 的活动的比率的起来规定的 anti-apoptotic Bcl-2 的重要减少的线粒体依赖者 caspase 串联。最后, DATS 导致了 apoptosis 并且在一个集中依赖者和时间依赖者举止禁止了增长。由与 A549 异种皮移植建立女 BALB/c 裸体老鼠的一个动物模特儿,没有与控制组相比引起重量损失或任何另外的副作用,而且,我们在裸体老鼠发现 DATS 的那口头的 gavage A549 异种皮移植的显著地延迟的生长。在 vitro 并且在 vivo 的所有证据建议 DATS 能是理想的反癌症药。 | Wenjun Li Hui Tian Lin Li Shuhai Li Weiming Yue Zhitao Chen Lei Qi Wensi Hu Yingchao Zhu Bin Hao Cun Gao Libo Si Fei Gao | 2012 | Acta Biochimica et Biophysica Sinica2012，44，7： | 6 |
| 11 | A bio-inspired approach for cognitive radio networks显示文摘The recent increasing interest in cognitive radio networks has motivated the study and development of new approaches capable of coping with the intrinsic challenges of this kind of network,such as dynamic spectrum availability,distributed and heterogeneous network architectures,and soaring complexity.The bio-inspired approaches,with appealing characteristics such as autonomy,adaptation and collective intelligence of collaborative individuals,have been extensively studied.This paper presents a comprehensive survey of bio-inspired approaches for cognitive radio networks,emphasizing their domains of application.Specifically,ant colony optimization and particle warm optimization are further investigated with examples and numerical simulation. | HE ZhiQiang NIU Kai QIU Tao SONG Tao XU WenJun GUO Li LIN JiaRu | 2012 | Chinese Science Bulletin2012，57，28： | 5 |
| 12 | Isothermal corrosion Fe_3Si alloy in liquid zinc显示文摘The isothermal corrosion testing, microscopic examination and the performance of Fe3Si alloy as materials of construction for bath hardware in continuous hot-dipping lines were studied. The corrosion of Fe3Si alloy in molten zinc was controlled by at- tacking the grain boundaries preferentially. Aluminum reacted with iron of Fe3Si alloy firstly while the samples were immersed in molten zinc, although aluminum contents in the molten zinc were very low. The phase of reaction product was thought to be Fe2Al5. The corrosion rate of the Fe3Si alloy in molten zinc was determined to be approximately 2.9×10?3 mm/h, therefore the liquid zinc cor- rosion resistance of Fe3Si alloy was very weak. | Wenjun Wang Junping Lin Yanli Wang Guoliang Chen | 2007 | Journal of University of Science and Technology Beijing2007，14，1： | 4 |
| 13 | Post-marketing safety surveillance and reevaluation of Motherwort injection:A clinical study of 10094 cases显示文摘OBJECTIVE:To investigate the safety profiles of Motherwort injection(MI).METHODS:A multi-center,prospective and drugderived hospital intensive monitoring method was conducted to assess the safety of MI in real world applications.This study was based on a very large population after the injection was approved and marketed in China.All patients using the injection in participating hospitals were monitored to determine the incidence,pattern,severity and outcome of associated adverse events.RESULTS:The post-marketing surveillance was performed in 10 094 female patients from April to December,2015.The incidence of adverse drug reactions(ADRs) was 0.79‰(8/10 094).Among the 8 patients,the reported adverse events mainly included systemic abnormalities,such as fever,chills and eyelid edema;skin and appendages disorders,such as pruritus and rash;gastrointestinal disorders,such as nausea,abdominal distension and pain;heart rate and rhythm disorders,such as palpitation and increased heart rate.All of these ADRs were mild in severity.CONCLUSION:In this study the ADRs incidence rate of MI is very low,which supports that it is generally safe for use in obstetric and gynecological diseases.However,the total number of 8 ADRs recorded over a relatively short time span seems limited,and the low number of reports could not represent an absolute guarantee of safety. | Cao Shan Zhang Wenhao Zhao Ziwei Heng Mingli Bu Huaien Wang Hongwu Liu Xinghui Wang Zhong Cai Yan Ma Yuyan Cui Shihong Deng Jihong Ding Guifeng Ding Yajuan Dong Linhong Duan Zhentao Fan Ling Fan Yang Fu Fen He Jing Ji Shuying Jin Lin Li Hong Li Hongying Liao Tao Lu Wei Luo Xiucui Lü Zhihui Ma Fengchun Ma Dafeng Shi Tianyun Sun Juying Sun Xiaotong Teng Hong Wang Jinhua Wang Ruihua Wang Ying Wang Zhengling Xi Jie Xu Minjuan Xu Zhihong Yan Qian Yang Cuirong Yang Yimei Yin Jie Yu Jinhua Yuan Wenjun Zhang Guanli Zhang Meihua Zhao Renfeng Zhong Yonghong Zhou Jian | 2018 | Journal of Traditional Chinese Medicine2018，38，4： | 4 |
| 14 | Distribution and sources of polycyclic aromatic hydrocarbons and phthalic acid esters in water and surface sediment from the Three Gorges Reservoir显示文摘After the impoundment of the Three Gorges Reservoir(TGR), the hydrological situation of the reservoir has changed greatly. The concentration and distribution of typical persistent organic pollutants in water and sediment have also changed accordingly. In this study, the concentration, distribution and potential sources of 16 polycyclic aromatic hydrocarbons(PAHs) and 6 phthalic acid esters(PAEs) during the water drawdown and impoundment periods were investigated in water and sediment from the TGR. According to our results, PAHs and PAEs showed temporal and spatial variations. The mean ΣPAH and ΣPAE concentrations in water and sediment were both higher during the water impoundment period than during the water drawdown period. The water samples from the main stream showed larger ΣPAH concentration fluctuations than those from tributaries. Both the PAH and PAE concentrations meet the Chinese national water environmental quality standard(GB 3838-2002). PAH monomers with 2–3 rings and 4 rings were dominant in water, and 4-ring and 5–6-ring PAHs were dominant in sediment. Di-n-butyl phthalate(DBP) and di-2-ethylhexyl phthalate(DEHP)were the dominant PAE pollutants in the TGR. DBP and DEHP had the highest concentrations in water and sediment, respectively. The main source of PAHs in water from the TGR was petroleum and emissions from coal and biomass combustion, whereas the main sources of PAHs in sediments included coal and biomass combustion, petroleum, and petroleum combustion. The main source of PAEs in water was domestic waste, and the plastics and heavy chemical industries were the main sources of PAEs in sediment. | Li Lin Lei Dong Xiaoyang Meng Qingyun Li Zhuo Huang Chao Li Rui Li Wenjun Yang John Crittenden | 2018 | Journal of Environmental Sciences2018，30，7： | 4 |
| 15 | MS1 is essential for male fertility by regulating the microsporocyte cell plate expansion in soybean显示文摘Male sterility is an essential trait in hybrid seed production,especially for monoclinous and autogamous food crops.Soybean male-sterile ms1 mutant has been known for more than 50 years and could be instrumental in making hybrid seeds.However,the gene responsible for the male-sterile phenotype has remained unknown.Here,we report the map-based cloning and characterization of the MS1 gene in soybean.MS1 encodes a kinesin protein and localizes to the nucleus,where it is required for the male meiotic cytokinesis after telophase Ⅱ.We further substantiated that MS1 colocalizes with microtubules and is essential for cell plate formation in soybean male gametogenesis through immunostaining.Both ms1 and CRISPR/Cas9 knockout mutants show complete male sterility but are otherwise phenotypically normal,making them perfect tools for producing hybrid seeds.The identification of MS1 has the practical potential for assembling the sterility system and speeding up hybrid soybean breeding. | Xiaolong Fang Xiaoyuan Sun Xiangdong Yang Qing Li Chunjing Lin Jie Xu Wenjun Gong Yifan Wang Lu Liu Limei Zhao Baohui Liu Jun Qin Mengchen Zhang Chunbao Zhang Fanjiang Kong Meina Li | 2021 | Science China(Life Sciences)2021，64，9： | 4 |
| 16 | Development of multi-fingered dexterous hand for grasping manipulation显示文摘In this paper,a developed multi-fingered dexterous hand with flexible tactile skin is described.The dexterous hand has 5-fingers with 6-DOFs and each finger is equipped with a small harmonic drive gear and a fine high-power mini actuator.To achieve the goal of grasping with high accuracy,each fingertip is covered with the tactile array sensors for determination of the force between the finger and the grasped object.Some preliminary experiments are conducted to illustrate the performance of the grasping of the developed dexterous hand. | LIN GuoDong LI ZhiJun LIU Lan SU Hang YE WenJun | 2014 | Science China(Information Sciences)2014，57，12： | 3 |
| 17 | Down-regulation of heparanase leads to the inhibition of invasion and proliferation of A549 cells in vitro and in vivo显示文摘Heparanase 是降级的哺乳动物的 endoglycosidase 在房间表面并且在细胞外的矩阵的 heparan 硫酸盐。heparanase 的表示在许多人的恶意的肿瘤被检测并且仔细把侵略,转移,和 angiogenesis 与肿瘤联系了。然而, heparanase 的特定的角色和它调整非小的房间肺癌症(NSCLC ) 的恶意的潜力的机制房间仍然保持不清楚。在现在的学习, heparanase 的表示在由 antisense oligodeoxynucleotide 的 NSCLC 房间线是下面调整的。结果证明 heparanase 的下面规定导致了重要抑制侵略并且在 vitro 并且在 vivo 的 A549 房间的 proliferative 潜力。进一步的研究证明 heparanase 的下面规定显著地禁止了 A549 房间的 angiogenic 潜力,它可能是为在在 vivo 的 BALB/c 裸体老鼠的 A549 房间增长的抑制负责的机制。这些调查结果证明 heparanase 在调整 A549 房间的侵略,增长,和 angiogenesis 起必要作用。 | Zhitao Chen Liangming Zhu Xiaohua Li Hui Tian Yusong Fang Haibo Liu Shuhai Li Lin Li Weiming Yue Wenjun Li | 2013 | Acta Biochimica et Biophysica Sinica2013，45，3： | 3 |
| 18 | Toxic Effects of Three Heavy Metallic Ions on Rana zhenhaiensis Tadpoles显示文摘Heavy metal pollution is widespread in some areas of China and results in contamination of land, water, and air with which all living organisms interact. In this study, we used three heavy metallic ions(Cu2+, Pb2+ and Zn2+) to assess their toxicity effects on mortality, blood biomarker and growth traits(body length and body mass) of Rana zhenhaiensis tadpoles. The results showed that the toxicity levels of the three metallic ions were different when conducted with different experiment designs. For acute toxicity tests, Cu2+ was the most toxic with the highest tadpole mortality. The mortalities of tadpoles showed significant differences among the treatments at the same exposure time endpoints(24, 48, 72 and 96h). Results from repeated measures ANOVA indicated that metallic ion concentration, exposure time and their interactions significantly affected the mortalities of R. zhenhaiensis tadpoles. Also, the toxicity effects of all binary combinations of the three metallic ion treatments showed synergism. The half lethal concentrations(LC50) decreased with increasing exposure time during the experimental period, and the safe concentration(SC) values of Cu2+, Pb2+ and Zn2+ were different from each other. Combined and compared LC50 values with previous data reported, it is suggestes that the toxicity levels of metal pollution to anuran tadpoles should be species-and age-related. For blood biomarker tests, Zn2+ was the most toxic with the highest total frequencies of abnormal erythrocytic nucleus. All three metallic ions caused higher abnormal erythrocytic nucleus compared with control groups. In a chronic toxicity test, Pb2+ was the most toxic with lowest growth traits. Survival rate(except for 18 days), total body length and body mass showed significant differences among the treatments. These findings indicated that tadpoles of R. zhenhaiensis should be as a bioindicator of heavy metals pollution. | Li WEI Guohua DING Sainan GUO Meiling TONG Wenjun CHEN Jon FLANDERS Weiwei SHAO Zhihua LIN | 2015 | Asian Herpetological Research2015，6，2： | 3 |
| 19 | The expression of N-cadherin/catenins/actin complex in human lung normal and carcinoma cells显示文摘The difference between human normal and carcinoma lung cells was studied with regard to the protein expression level and localization of the cadherin/catenin/actin complex. Results demonstrated that normal lung cell RF expressed high levels of N-cadherin, β-catenin, α-catenin. These 3 proteins were colocalized at AJs and their submembrane adhesion plaques where they link the Rho-phalloidin-positive actin stress fibers, indicating the existence of N-cadherin/catenin/actin complexes at the AJs. Aberrant expression of AJ proteins and the actin cytoskelecton in carcinoma PG cells was observed: (1) inhibition of N-cadherin and to a degree of inhibition of α-catenin protein expression; (2) varied protein modification of β-catenin in cytoplasm soluble fraction and altered distribution of immunofluorescence: majorly in the cytoplasm and minorly on the membrane; (3) disassembly of actin stress fibers and formation of actin bodies in the cytoplasm. The data suggest that inhibited expression of AJ proteins is correlated with the disruption of the AJ complexes and the actin cytoskeleton in carcinoma PG cells, and responsible for its metastasis behaviors. | Wenjun Zhang Zhongxiang Lin Zhiqian Zhang Ying Hu | 1998 | Chinese Science Bulletin1998，43，9： | 3 |
| 20 | Structural engineering of sulfur-doped carbon encapsulated bismuth sulfide core-shell structure for enhanced potassium storage performance显示文摘Owing to the high theoretical capacity,metal sulfides have emerged as promising anode materials for potassium-ion batteries(PIBs).However,sluggish kinetics,drastic volume expansion,and polysulfide dissolution during charge/discharge result in unsatisfactory electrochemical performance.Herein,we design a core-shell structure consisting of an active bismuth sulfide core and a highly conductive sulfur-doped carbon shell(Bi2S3@SC)as a novel anode material for PIBs.Benefiting from its unique core-shell structure,this Bi2S3@SC is endowed with outstanding potassium storage performance with high specific capacity(626 mAh·g^(-1)under 50 mA·g^(-1))and excellent rate capability(268.9 mAh·g^(-1)at 1 A·g^(-1)).More importantly,a Bi2S3@SC//KFe[Fe(CN)6]full cell is successfully fabricated,which achieves a high reversible capacity of 257 mAh·g^(-1)at 50 mA·g^(-1)over 50 cycles,holding great potentials in practical applications.Density functional theory(DFT)calculations reveal that potassium ions have a low diffusion barrier of 0.54 eV in Bi2S3 due to the weak van der Waals interactions between layers.This work heralds a promising strategy in the structural design of high-performance anode materials for PIBs. | Changlai Wang Jian Lu Huigang Tong Shuilin Wu Dongdong Wang Bin Liu Ling Cheng Zhiyu Lin Lin Hu Hui Wang Wenjun Zhang Qianwang Chen | 2021 | Nano Research2021，14，10： | 2 |
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