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| 1 | Reproductive management through integration of PGD and MPS-based noninvasive prenatal screening/diagnosis for a family with GJB2-associated hearing impairment显示文摘A couple with a proband child of GJB2(encoding the gap junction protein connexin 26)-associated hearing impairment and a previous pregnancy miscarriage sought for a reproductive solution to bear a healthy child. Our study aimed to develop a customized preconception-to-neonate care trajectory to fulfill this clinical demand by integrating preimplantation genetic diagnosis(PGD), noninvasive prenatal testing(NIPT), and noninvasive prenatal diagnosis(NIPD) into the strategy. Auditory and genetic diagnosis of the proband child was carried out to identify the disease causative mutations. The couple then received in-vitro-fertilization treatment, and eight embryos were obtained for day 5 biopsy. PGD was performed by short-tandem-repeat linkage analysis and Sanger sequencing of GJB2 gene. Transfer of a GJB2 c.235del C heterozygous embryo resulted in a singleton pregnancy. At the 13 th week of gestation, genomic DNA(g DNA) from the trio family and cell-free DNA(cf DNA) from maternal plasma were obtained for assessment of fetal chromosomal aneuploidy and GJB2 mutations. NIPT and NIPD showed the absence of chromosomal aneuploidy and GJB2-associated disease in the fetus, which was later confirmed by invasive procedures and postnatal genetic/auditory diagnosis. This strategy successfully prevented the transmission of hearing impairment in the newborn, thus providing a valuable experience in reproductive management of similar cases and potentially other monogenic disorders. | XIONG WenPing WANG DaYong GAO Yuan GAO Ya WANG HongYang GUAN Jing LAN Lan YAN JunHao ZONG Liang YUAN Yuan DONG Wei HUANG SeXin WU KeLiang WANG YaoShen WANG ZhiLi PENG HongMei LU YanPing XIE LinYi ZHAO Cui WANG Li ZHANG QiuJing GAO Yun LI Na YANG Ju YIN ZiFang HAN Bing WANG Wei CHEN Zi-Jiang WANG QiuJu | 2015 | Science China(Life Sciences)2015，58，9： | 12 |
| 2 | Characterization of flavor fingerprinting of red sufu during fermentation and the comparison of volatiles of typical products显示文摘Traditional Chinese red sufu is a popular condiment,and typical flavor is an important indicator of sensory qualities in commercial products.In this study,the volatile aroma analysis of Wangzhihe red sufu(WRS)from different fermentation stages and four typical red sufu products from different locations was carried out by gas chromatography-mass spectrometry(GC–MS),gas chromatography-mass spectrometry/olfactory(GC–MS/O),electronic nose(E-nose)and sensory evaluation.Results showed that 106 volatile compounds were identified in Wangzhihe red sufu during fermentation process,in which phenolics and alcohols were dominant at molded and salted phetze stages,while esters and alcohols became predominate at post-fermentation stage.The volatile aroma substances varied at each fermentation stage.Furthermore,86 volatiles,including 16 aroma-active compounds,were detected in four typical red sufu products.The multivariate analysis results showed the difference in samples from different fermentation stages and typical red sufu products according to GC–MS and E-nose analysis.Combined with flavor omics,discriminant model was established for effective discrimination of samples from different fermentation stages and locations,as well as references to sufu maturity extent.The study presented a new strategy for quality evaluation of red sufu,which could be the supplement to quality evaluation standards. | Peng Wang Xiaoran Ma Wenping Wang Dandan Xu Xin Zhang Jian Zhang Yong Sun | 2019 | Food Science and Human Wellness2019，8，4： | 7 |
| 3 | CFD Study on Local Fluid-to-Wall Heat Transfer in Packed Beds and Field Synergy Analysis显示文摘To reach the target of smaller pressure drop and better heat transfer performance, packed beds with small tube-to-particle diameter ratio(D/dp<10) have now been considered in many areas. Fluid-to-wall heat transfer coefficient is an important factor determining the performance of this type of beds. In this work, local fluid-to-wall heat transfer characteristic in packed beds was studied by Computational Fluid Dynamics(CFD) at different Reynolds number for D/dp=1.5, 3.0 and 5.6. The results show that the fluid-to-wall heat transfer coefficient is oscillating along the bed with small tube-to-particle diameter ratio. Moreover, this phenomenon was explained by field synergy principle in detail. Two arrangement structures of particles in packed beds were recommended based on the synergy characteristic between flow and temperature fields. This study provides a new local understanding of fluid-to-wall heat transfer in packed beds with small tube-to-particle diameter ratio. | PENG Wenping XU Min HUAI Xiulan LIU Zhigang | 2016 | Journal of Thermal Science2016，25，2： | 3 |
| 4 | Risk analysis of power systems for both real and reactive power显示文摘With the high penetration of renewable energy sources,the reliability of power systems becomes more vulnerable than ever because of the greater uncertainty and intermittence in power generation.Reactive power plays an important role in the power system reliability,because it is closely related to the system voltage stability and voltage collapse.However,reactive power-related reliability issues are seldom emphasized in conventional power reliability evaluations.This article investigates power system reliability of real and reactive power.Real and reactive power shortages and the associated voltage violations due to system failures are considered on reliability evaluation of power systems.A three-stage load-shedding technique for post contingencies is implemented to determine the contributions of real and reactive power on the system reliability and to find an optimal way to release network violation.The results provide the detailed information on power system planning and operation for system planners and operators from real and reactive power aspects. | Wenping QIN Peng WANG Xiaoqing HAN Fanhua MENG | 2013 | Journal of Modern Power Systems and Clean Energy2013，1，2： | 1 |
| 5 | 2020 Roadmap on gas-involved photo-and electro-catalysis显示文摘Green reactions not only provide us chemical products without any pollution,but also offer us the viable technology to realize difficult tasks in normal conditions.Photo-,photoelectro-,and electrocatalytic reactions are indeed powerful tools to help us to embrace bright future.Especially,some gas-involved reactions are extremely useful to change our life environments from energy systems to liquid fuels and cost-effective products,such as H2 evolution(H2 production),02 evolution/reduction,CO2 reduction,N2 reduction(or N2 fixation) reactions.We can provide fuel cells clean H2 for electric vehicles from H2 evolution reaction(HER),at the same time,we also need highly efficient 02 reduction reaction(ORR) in fuel cells for improving the reaction kinetics.Moreover,we can get the clean oxidant O2 from water through O2 evolution reaction(OER),and carry out some reactions without posing any pollution to reaction systems.Furthermore,we can translate the greenhouse gas CO2 into useful liquid fuels through CO2 reduction reaction(CRR).Last but not the least,we can get ammonia from N2 reduction reaction(NRR),which can decrease energy input compared to the traditional Hubble process.These reactions,such as HER,ORR,OER,CRR and NRR could be realized through solar-,photoelectro-and electro-assisted ways.For them,the catalysts used play crucial roles in determining the efficiency and kinds of products,so we should consider the efficiency of catalysts.However,the cost,synthetic methods of catalysts should also be considered.Nowadays,significant progress has been achieved,however,many challenges still exist,reaction systems,catalysts underlying mechanisms,and so on.As extremely active fields,we should pay attention to them.Under the background,it has motivated us to contribute with a roadmap on ’GasInvolved Photo-and Electro-Catalysis’. | Yulu Yang Yang Tang Haomin Jiang Yongmei Chen Pingyu Wan Maohong Fan Rongrong Zhang Sana Ullah Lun Pan Ji-Jun Zou Mengmeng Lao Wenping Sun Chao Yang Gengfeng Zheng Qiling Peng Ting Wang Yonglan Luo Xuping Sun Alexander S.Konev Oleg V.Levin Panagiotis Lianos Zhuofeng Hu Zhurui Shen Qinglan Zhao Ying Wang Nadia Todorova Christos Trapalis Matthew V.Sheridan Haipeng Wang Ling Zhang Songmei Sun Wenzhong Wang Jianmin Ma | 2019 | Chinese Chemical Letters2019，30，12： | 1 |
| 6 | Laser direct writing derived robust carbon nitride films with efficient photon-to-electron conversion for multifunctional photoelectrical applications显示文摘Carbon nitride,an emerging polymeric semiconductor,has attracted attention in research ranging from photocatalysis to photodetection due to its favorable visible light response and high physicochemical stability.For its practical device application,the fabrication of high-quality carbon nitride films on substrates is essential.However,conventional methodologies to achieve high polymerization of carbon nitride are often accompanied by its decomposition,significantly compromising the film quality.Herein,we report an ultrafast fabrication of carbon nitride film by laser direct writing(LDW).The instantaneous high temperature and pressure during LDW can efficiently boost the polymerization of carbon nitride and suppress its decomposition,resulting in high-quality carbon nitride film with excellent mechanical stability with the substrate.Due to the efficient photon-to-electron conversion,it exhibits an outstanding photoelectrochemical water splitting and optoelectronic detection capability,even under strong acid/alkaline conditions.This study thus offers a facile and efficient LDW strategy for the rapid fabrication of carbon nitride film photoelectrodes,demonstrating its great feasibility in multifunctional photoelectrical applications,including but not limited to photoelectrochemical water splitting and optoelectronic detection. | Haotian Tan Wenping Si Wei Peng Yuqing Wang Daolan Liu Liqun Wang Chongyun Jiang Lu Di Ji Liang Feng Hou | 2022 | Carbon Energy2022，4，6： | 1 |
| 7 | A non-ACE2 competing human single-domain antibody confers broad neutralization against SARS-CoV-2 and circulating variants显示文摘The current COVID-19 pandemic has heavily burdened the global public health system and may keep simmering for years.The frequent emergence of immune escape variants have spurred the search for prophylactic vaccines and therapeutic antibodies that confer broad protection against SARS-CoV-2 variants.Here we show that the bivalency of an affinity maturated fully human singledomain antibody(n3113.1-Fc)exhibits exquisite neutralizing potency against SARS-CoV-2 pseudovirus,and confers effective prophylactic and therapeutic protection against authentic SARS-CoV-2 in the host cell receptor angiotensin-converting enzyme 2(ACE2)humanized mice.The crystal structure of n3113 in complex with the receptor-binding domain(RBD)of SARS-CoV-2,combined with the cryo-EM structures of n3113 and spike ecto-domain,reveals that n3113 binds to the side surface of up-state RBD with no competition with ACE2.The binding of n3113 to this novel epitope stabilizes spike in up-state conformations but inhibits SARS-CoV-2 S mediated membrane fusion,expanding our recognition of neutralization by antibodies against SARS-CoV-2.Binding assay and pseudovirus neutralization assay show no evasion of recently prevalent SARS-CoV-2 lineages,including Alpha(B.1.1.7),Beta(B.1.351),Gamma(P.1),and Delta(B.1.617.2)for n3113.1-Fc with Y58L mutation,demonstrating the potential of n3113.1-Fc(Y58L)as a promising candidate for clinical development to treat COVID-19. | Zhenlin Yang Yulu Wang Yujia Jin Yuanfei Zhu Yanling Wu Cheng Li Yu Kong Wenping Song Xiaolong Tian Wuqiang Zhan Ailing Huang Shanshan Zhou Shuai Xia Xiaoxu Tian Chao Peng Cuicui Chen Yibing Shi Gaowei Hu Shujuan Du Yuyan Wang Youhua Xie Shibo Jiang Lu Lu Lei Sun Yuanlin Song Tianlei Ying | 2021 | Signal Transduction and Targeted Therapy2021，6，12： | 1 |
| 8 | Visualization of supramolecular assembly by aggregation-induced emission显示文摘Supramolecular architectures are constructed by the self-assembly of small building blocks via the use of metal-ligand coordination,π–πstacking interactions,hydrogen bonding,host-guest interactions,and other noncovalent driving forces,which confer unique dynamic reversibility and stimulus responsiveness to the supramolecular materials and also lead to the demand of expensive and complex equipment for the characterization of supramolecular assembly processes.Fortunately,the self-assembly processes bring the monomeric chromophores together,offering possibilities to establish ties between the supramolecular assembly and aggregation-induced emission(AIE)techniques.Compared to conventional luminescent molecules,AIE luminogens(AIEgens)exhibit significant fluorescence enhancement upon the restriction of molecular motions,thus displaying the advantages of signal amplification and low background noises.Given the above,the real-time,sensitive,and in situ visualization of the formation of self-assemblies and their stimuli responsiveness based on AIE becomes accessible.Here,we review recent works that encompass the visualization of supramolecular assembly-related behaviors by means of AIE characteristics of chromophores.The organization of this review will be by different types of supramolecular architectures,including metallacycles/cages,micelles/vesicles,supramolecular polymers,and supramolecular gels.An overview of future opportunities and challenges for the real-time monitoring of supramolecular assembly by AIE is also provided. | Wu-Jie Guo Tuokai Peng Wenping Zhu Shixiang Ma Guang Wang Ying Li Bin Liu Hui-Qing Peng | 2023 | Aggregate2023，4，2： | 0 |
| 9 | Semisynthesis of homogeneous spike RBD glycoforms from SARS-CoV-2 for profiling the correlations between glycan composition and function显示文摘Vaccines have been the primary remedy in the global fight against coronavirus disease 2019(COVID-19).The receptor-binding domain(RBD)of the spike protein,a critical viral immunogen,is affected by the heterogeneity of its glycan structures and relatively low immunogenicity.Here,we describe a scalable synthetic platform that enables the precise synthesis of homogeneously glycosylated RBD,facilitating the elucidation of carbohydrate structure–function relationships.Five homogeneously glycosylated RBDs bearing biantennary glycans were prepared,three of which were conjugated to T-helper epitope(Tpep)from tetanus toxoid to improve their weak immune response.Relative to natural HEK293-derived RBD,synthetic RBDs with biantennary N-glycan elicited a higher level of neutralising antibodies against SARS-CoV-2 in mice.Furthermore,RBDs containing T_(pep)elicited significant immune responses in transgenic mice expressing human angiotensin-converting enzyme 2.Our collective data suggest that trimming the N-glycans and T_(pep)conjugation of RBD could potentially serve as an effective strategy for developing subunit vaccines providing efficient protection. | Farong Ye Cheng Li Feng-Liang Liu Xinliang Liu Peng Xu Rong-Hua Luo Wenping Song Yong-Tang Zheng Tianlei Ying Biao Yu Ping Wang | 2024 | National Science Review2024，11，2： | 0 |
| 10 | Forecasting time series with optimal neural networks using multi-objective optimization algorithm based on AICc显示文摘In this letter,time series forecasting using optimal neural networks with optimal performance of generalization and stability is studied.After analyzing the reasons for over-fitting and instability of neural networks,in order to find the optimal NNs (neural networks)architecture,we consider minimizing three objective index:average training AICc (ATRAICc),average testing AICc (ATEAICc)and testing error variance AICc (VAAICc)based on Akaike information criterion theory.Then we built a multi-objective optimization model and proved the existence and uniqueness theorem of optimal solution.After determining the searching interval, a multi-objective optimization algorithm for optimal neural network architecture based on AICc (ONNAICc)with optimal generalization and stability is constructed to solve above model. | Muzhou HOU Yunlei YANG Taohua LIU Wenping PENG | 2018 | Frontiers of Computer Science2018，12，6： | 0 |
| 11 | Design and experiment of a novel pneumatic soft arm based on a deployable origami exoskeleton显示文摘T Soft arms have shown great application potential because of their flexibility and compliance in unstructured environments.However,soft arms made from soft materials exhibit limited cargo-loading capacity,which restricts their ability to manipulate objects.In this research,a novel soft arm was developed by coupling a rigid origami exoskeleton with soft airbags.The joint module of the soft arm was composed of a deployable origami exoskeleton and three soft airbags.The motion and load performance of the soft arm of the eight-joint module was tested.The developed soft arm withstood at least 5 kg of load during extension,contraction,and bending motions;exhibited bistable characteristics in both fully contracted and fully extended states;and achieved a bending angle of more than 240°and a contraction ratio of more than 300%.In addition,the high extension,contraction,bending,and torsional stiffnesses of the soft arm were experimentally demonstrated.A kinematic-based trajectory planning of the soft arm was performed to evaluate its error in repetitive motion.This work will provide new design ideas and methods for flexible manipulation applications of soft arms. | Yuwang LIU Wenping SHI Peng CHEN Yi YU Dongyang ZHANG Dongqi WANG | 2023 | Frontiers of Mechanical Engineering2023，18，4： | 0 |
| 12 | Variable Curvature Modeling Method of Soft Continuum Robots with Constraints显示文摘The inherent compliance of continuum robots holds great promise in the fields of soft manipulation and safe human–robot interaction.This compliance reduces the risk of damage to the manipulated object and its surroundings.However,continuum robots possess theoretically infinite degrees of freedom,and this high flexibility usually leads to complex deformations when subjected to external forces and positional constraints.Describing these complex deformations is the main challenge in modeling continuum robots.In this study,we investigated a novel variable curvature modeling method for continuum robots,considering external forces and positional constraints.The robot configuration curve is described using the developed mechanical model,and then the robot is fitted to the curve.A ten-section continuum robot prototype with a length of 1 m was developed in order to validate the model.The feasibility and accuracy of the model were verified by the ability of the robot to reach target points and track complex trajectories with a load.This work was able to serve as a new perspective for the design analysis and motion control of continuum robots. | Yuwang Liu Wenping Shi Peng Chen Liang Cheng Qing Ding Zhaoyan Deng | 2023 | Chinese Journal of Mechanical Engineering2023，36，6： | 0 |
| 13 | A case of ischemic-hypoxic encephalopathy due to oral succinylcholine ingestion显示文摘Dear Editor,Cases of succinylcholine poisoning are rarely seen in clinic,and severe brain damage due to ingestion of succinylcholine is even rarer.Here,we report on a patient who poisoned herself via oral ingestion of succinylcholine,discuss the clinical characteristics,pathogenesis,and treatment of the succinylcholine-related ischemic-hypoxic encephalopathy that this patient suffered,and review the relevant literature.This study aimed to improve clinicians'understanding of ischemic-hypoxic encephalopathy due to succinylcholine chloride toxicity. | Yunyun Wang Wenjie Shang Huafu Ni Huaiwu Yuan Yujie Su Wenping Gong Guoping Peng | 2022 | Chronic Diseases and Translational Medicine2022，8，2： | 0 |
| 14 | Development and Evaluation of a Promising Biomarker for Diagnosis of Latent and Active Tuberculosis Infection显示文摘Background:Diagnosing latent tuberculosis(TB)infection(LTBI)and active TB(ATB)is crucial for preventing disease progression and transmission.However,current diagnostic tests have limitations in terms of accuracy and sensitivity,making it challenging to diagnose these different infection states.Therefore,this study intends to develop a promising biomarker for LTBI and ATB diagnosis to overcome the limitations of the current diagnostic tests.Methods:We developed a novelmultiepitope-based diagnostic biomarker(MEBDB)fromLTBI region of differentiation antigens using bioinformatics and immunoinformatics.Immune responses induced byMEBDM were detected using enzyme-linked immunosorbent spot and cytometric bead assays.This study was conducted from April 2022 to December 2022 in the SeniorDepartment of Tuberculosis at the 8thMedical Center of PLA General Hospital,China.Blood samples were collected from participants with ATB,individuals with LTBI,and healthy controls(HCs).The diagnostic efficacy of MEBDB was evaluated using receiver operating characteristic curves.Results:A novel MEBDB,designated as CP19128P,was generated.CP19128P comprises 19 helper T lymphocyte epitopes,12 cytotoxic T lymphocyte epitopes,and 8 B-cell epitopes.In silico simulations demonstrated that CP19128P possesses strong affinity for Toll-like receptors and elicits robust innate and adaptive immune responses.CP19128P generated significantly higher levels of tumor necrosis factor(TNF-α),interleukin 4(IL-4),and IL-10 in ATB patients(n=7)and LTBI(n=8)individuals compared with HCs(n=62)(P<0.001).Moreover,CP19128P-induced specific cytokines could be used to discriminate LTBI and ATB from healthy subjects with high sensitivity and specificity.Combining IL-2 with IL-4 or TNF-α could differentiate LTBI from HCs(the area under the receiver operating characteristic curve[AUC],0.976[95% confidence interval[CI],0.934-1.000]or 0.986[0.956-1.000]),whereas combining IL-4 with IL-17A or TNF-α could differentiate ATB from HCs(AUC,0.887[0.782-0.993]or 0.984[0.958-1.000]).Conclusions:Our study revealed that CP19128P is a potential MEBDBfor the diagnosis of LTBI andATB.Our findings suggest a promising strategy for developing novel,accurate,and sensitive diagnostic biomarkers and identifying new targets for TB diagnosis and management. | Cong Peng Fan Jiang Yinping Liu Yong Xue Peng Cheng Jie Wang Liang Wang Wenping Gong | 2024 | Infectious Diseases & Immunity2024，4，1： | 0 |
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